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David Jaffe Ph.D.
Affiliation:
University of Texas at San Antonio
Biology
"Other"
Title: Professor
Rank:
Address:
1 UTSA Cir
San Antonio, TX 78249
Contact:
Email: [email protected]
Telephone: (210) 458-5843
Narrative
Research in Dr. Jaffe’s lab focuses on the hippocampal formation; a brain region important for
certain aspects of learning and memory. It is also one of the first brain structures affected by
Alzheimer's disease and medial temporal lobe epilepsy arises in the hippocampus, among other brain
structures.
The lab’s major area of interest is the CA3 region of the hippocampus. This subregion is where
information from two regions outside the hippocampus, the dentate gyrus and the entorhinal cortex,
converge. In addition, this area is also characterized by strong recurrent feedback between CA3
pyramidal neurons forming what is thought to be an autoassociative network. Artificial neural
networks composed of such circuits perform pattern completion. Under pathological conditions, this
circuity is what makes area CA3 highly susceptible to epilepsy.
Current work in the lab focuses on two questions:
What are the input/output characteristics of CA3 pyramidal neurons? The lab is interested in how the
morphology and distribution of ion channels in these cells interact to process, encode, and retrieve
synaptically-based information. Understanding how these cells integrate synaptic information is
important for understanding the functional role of this network during normal circumstances and
under pathophysiological conditions, for example in the case of epilepsy.
How the properties of neurons and synapses within area CA3 change in aged animals. It is well
known that aged animals are cognitively impaired and this correlates with a number of cellular
changes that occur with senescence. The lab is testing whether some of these changes might actually
be compensatory. That is, in response to pathophysiological changes that occur with age, such as the
loss of receptors associated with synaptic, certain changes in excitability or synaptic inhibition may
enhance functional aspects of the network as it ages.
Publications
1.
Sundt D, Gamper N, Jaffe DB. Spike propagation through the dorsal root ganglia in PubMed
an unmyelinated sensory neuron: a modeling study. J Neurophysiol. 2015 Dec;
114(6):3140-53.
2.
Wang B, Jaffe DB, Brenner R. Current understanding of iberiotoxin-resistant BK PubMed
channels in the nervous system. Front Physiol. 2014; 5:382.
3.
Du X, Hao H, Gigout S, Huang D, Yang Y, Li L, Wang C, Sundt D, Jaffe DB, Zhang H, PubMed
Gamper N. Control of somatic membrane potential in nociceptive neurons and its
implications for peripheral nociceptive transmission. Pain. 2014 Nov; 155(11):230622.
4.
Hemond P, Migliore M, Ascoli GA, Jaffe DB. The membrane response of hippocampal PubMed
CA3b pyramidal neurons near rest: Heterogeneity of passive properties and the
contribution of hyperpolarization-activated currents. Neuroscience. 2009 May 5;
160(2):359-70.
5.
Hemond P, Epstein D, Boley A, Migliore M, Ascoli GA, Jaffe DB. Distinct classes of PubMed
pyramidal cells exhibit mutually exclusive firing patterns in hippocampal area CA3b.
Hippocampus. 2008; 18(4):411-24.
6.
Zaika O, Tolstykh GP, Jaffe DB, Shapiro MS. Inositol triphosphate-mediated Ca2+ PubMed
signals direct purinergic P2Y receptor regulation of neuronal ion channels. J
Neurosci. 2007 Aug 15; 27(33):8914-26.
7.
Jaffe DB, Gutiérrez R. Mossy fiber synaptic transmission: communication from the
dentate gyrus to area CA3. Prog Brain Res. 2007; 163:109-32.
8.
Gamper N, Zaika O, Li Y, Martin P, Hernandez CC, Perez MR, Wang AY, Jaffe DB, PubMed
Shapiro MS. Oxidative modification of M-type K(+) channels as a mechanism of
cytoprotective neuronal silencing. EMBO J. 2006 Oct 18; 25(20):4996-5004.
9.
Zaika O, Lara LS, Gamper N, Hilgemann DW, Jaffe DB, Shapiro MS. Angiotensin II PubMed
regulates neuronal excitability via phosphatidylinositol 4,5-bisphosphate-dependent
modulation of Kv7 (M-type) K+ channels. J Physiol. 2006 Aug 15; 575(Pt 1):49-67.
PubMed
10. Hemond P, Jaffe DB. Caloric restriction prevents aging-associated changes in spike- PubMed
mediated Ca2+ accumulation and the slow afterhyperpolarization in hippocampal
CA1 pyramidal neurons. Neuroscience. 2005; 135(2):413-20.
11. Barea-Rodríguez EJ, Rivera DT, Jaffe DB, Martinez JL. Protein synthesis inhibition PubMed
blocks the induction of mossy fiber long-term potentiation in vivo. J Neurosci. 2000
Nov 15; 20(22):8528-32.
12. Jaffe DB, Carnevale NT. Passive normalization of synaptic integration influenced by PubMed
dendritic architecture. J Neurophysiol. 1999 Dec; 82(6):3268-85.
13. Chitwood RA, Hubbard A, Jaffe DB. Passive electrotonic properties of rat PubMed
hippocampal CA3 interneurones. J Physiol. 1999 Mar 15; 515 ( Pt 3):743-56.
14. Chitwood RA, Jaffe DB. Calcium-dependent spike-frequency accommodation in PubMed
hippocampal CA3 nonpyramidal neurons. J Neurophysiol. 1998 Aug; 80(2):983-8.
15. Migliore M, Cook EP, Jaffe DB, Turner DA, Johnston D. Computer simulations of PubMed
morphologically reconstructed CA3 hippocampal neurons. J Neurophysiol. 1995 Mar;
73(3):1157-68.
16. Brown TH, Jaffe DB. Calcium imaging in hippocampal neurons using confocal PubMed
microscopy. Ann N Y Acad Sci. 1994 Dec 15; 747:313-24.
17. Jaffe DB, Brown TH. Confocal imaging of dendritic Ca2+ transients in hippocampal PubMed
brain slices during simultaneous current- and voltage-clamp recording. Microsc Res
Tech. 1994 Nov 1; 29(4):279-89.
18. Jaffe DB, Brown TH. Metabotropic glutamate receptor activation induces calcium PubMed
waves within hippocampal dendrites. J Neurophysiol. 1994 Jul; 72(1):471-4.
19. Spruston N, Jaffe DB, Johnston D. Dendritic attenuation of synaptic potentials and PubMed
currents: the role of passive membrane properties. Trends Neurosci. 1994 Apr;
17(4):161-6.
20. Jaffe DB, Ross WN, Lisman JE, Lasser-Ross N, Miyakawa H, Johnston D. A model for PubMed
dendritic Ca2+ accumulation in hippocampal pyramidal neurons based on
fluorescence imaging measurements. J Neurophysiol. 1994 Mar; 71(3):1065-77.
21. Spruston N, Jaffe DB, Williams SH, Johnston D. Voltage- and space-clamp errors PubMed
associated with the measurement of electrotonically remote synaptic events. J
Neurophysiol. 1993 Aug; 70(2):781-802.
22. Jaffe DB, Johnston D, Lasser-Ross N, Lisman JE, Miyakawa H, Ross WN. The spread PubMed
of Na+ spikes determines the pattern of dendritic Ca2+ entry into hippocampal
neurons. Nature. 1992 May 21; 357(6375):244-6.
23. Johnston D, Williams S, Jaffe D, Gray R. NMDA-receptor-independent long-term PubMed
potentiation. Annu Rev Physiol. 1992; 54:489-505.
24. Aitken PG, Jaffe DB, Nadler JV. Cholecystokinin blocks some effects of kainic acid in PubMed
CA3 region of hippocampal slices. Peptides. 1991 Jan-Feb; 12(1):127-9.
25. Jaffe D, Johnston D. Induction of long-term potentiation at hippocampal mossy-fiber PubMed
synapses follows a Hebbian rule. J Neurophysiol. 1990 Sep; 64(3):948-60.
26. Jaffe DB, Aitken PG, Nadler JV. The effects of cholecystokinin and cholecystokinin PubMed
antagonists on synaptic function in the CA1 region of the rat hippocampal slice.
Brain Res. 1987 Jul 7; 415(1):197-203.
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