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In vivo studies of cellular mechanisms underlying memory formation The hippocampus plays critical roles in remembering where we are and what we have experienced. How these cognitive processes are implemented by hippocampal circuits is largely unknown. Previous recordings identified hippocampal neurons that are active when animals enter a specific location. It is still unclear whether or how such place activity is formed or altered when animals learn to recognize new environments or experience any changes in familiar environments. Using whole-cell patch clamp in freely moving rats, we found that spatially homogenous current injection to a silent hippocampal neuron leads to spatially tuned subthreshold depolarization and place fields formation. Cells return to silent states when stimulation is removed. A small constant current elicits a sharp, narrow-tuned place field, whereas larger current leads to broader tuning. This result suggests that a place field could be formed by regulating intrinsic excitability of hippocampal pyramidal neurons. In addition, silent cells show long-lasting activity in respond to past experience of encountering novel objects. Such reverberating activity is reminiscent of engram cell activity that reflects storage of the memory. Using two-photon imaging and whole-cell recordings, we focus on mechanisms underlying formation of memory to novel objects in the hippocampus and how these newly formed activity interacts with existing place activity that related to spatial memory.