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Interictal spikes as measured in the EEG result from the synchronized discharges of a group of hippocampal neurons. (Adapted, with permission, from Wong, Miles, and Traub 1984.) A. Rhythmic firing is evident in an intracellular recording from a pyramidal cell in a hippocampal slice. An extracellular recording from the same slice shows the synchronized discharge of many neurons. This type of synchronized activity underlies interictal spikes in the EEG. B. The hippocampal slice was perfused with bicuculline, which blocks the inhibition mediated by GABAA receptors in pyramidal cells and increases the occurrence ofSource: seizure-like activity. An intracellular recording fromScience, the sliceFifth shows several action potentials in one cell (top trace). On the next trial (lower Seizures and Epilepsy, Principles of Neural Editon trace) a hyperpolarizing current was injected to prevent the cell from firing, revealing shift that the sudden Citation: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth the AJ, large Mack paroxysmal S. Principlesdepolarization of Neural Science, Fifthproduces Editon; 2012 Available and long-lasting firing of neurons in a seizure focus. at: http://mhmedical.com/ Accessed: May 13, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved