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Signals from the midbrain-hindbrain boundary pattern neurons in the midbrain and hindbrain. A. Fibroblast growth factor (FGF) signals from the isthmic
organizer act in concert with sonic hedgehog (Shh) signals from the ventral midline to specify the identity and position of dopaminergic and serotonergic
neurons. The distinct fates of these two classes of neurons result from the different transcriptional profiles of cells in the midbrain (Otx2) and hindbrain
(Gbx2). (Adapted, with permission, from Wurst and Bally-Cuif 2001.)
B. Expression of the gene encoding FGF4 by cells at the midbrain-hindbrain boundary. (Image reproduced, with permission, from Gail Martin.)
C. Expression
of the Patterning
gene encoding
Shh by System,
cells at the
ventral midline
of Science,
the neural
tube
and by the notochord. (Image reproduced, with permission, from
Source:
the Nervous
Principles
of Neural
Fifth
Editon
T. Lints and J.
Dodd.)
Citation: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, Mack S. Principles of Neural Science, Fifth Editon; 2012 Available
at: http://mhmedical.com/ Accessed: May 12, 2017
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