The network of calcium regulation in muscle
... (Martonosi, 2000; Pette, 2001), together with
fiber type specific proteolysis (Sultan et al.,
2001), are involved in this adaptation, but the
detailed mechanism of the process is unknown.
Dual function of Swc5 in SWR remodeling ATPase activation and
... nucleosome along the chromosomes, transcription factors
are excluded from inactive promoters and cryptic promoterlike sequences but are drawn to exposed DNA elements defined by the flanking nucleosomes to allow accurate, focused
assembly (5–7). ATP-dependent chromatin remodelers utilize the energy f ...
Caroline Jeya Sheeba Daniel Sunder Singh
... Limbs emerge from the embryo flank as a mass of mesenchymal cells within an
ectodermal jacket that will give rise to skeletal elements and connective tissues, structured along
the dorsal-ventral (DV), anterior-posterior (AP) and proximal-distal (PD) axes. The apical
ectodermal ridge (AER) and the zo ...
Matching catalytic activity to developmental function: Tolloid
... the imaginal discs; however, the tlr transcript is much more
Despite several studies, the biological function(s) of Tlr
remain ill defined. Embryos mutant for tlr show no significant
defects in dorsal patterning, although it has recently been
demonstrated that the level of Sog protein pres ...
Reducing Ryanodine Receptor Open Probability as a Means to
... Abstract—The aim of this work was to investigate whether it is possible to remove arrhythmogenic Ca2⫹ release from the
sarcoplasmic reticulum that occurs in calcium overload without compromising normal systolic release. Exposure of rat
ventricular myocytes to isoproterenol (1 mol/L) resulted in an ...
PDF - Retrovirology
... inhibit HIV-1 replication in non-permissive cell types.
CBFβ is an evolutionarily conserved non-DNA binding
component of the mammalian runt-related transcription
factors (RUNX 1-3), which are critical in hematopoiesis, T
cell differentiation, and skeletal development [6, 7]. CBFβ
is an allosteric re ...
University of Groningen Polymerization of the bacterial cell division
... every organism. Most bacteria and archaea
divide symmetrically in a process that is subject
to extensive regulation to ensure that both
newly formed daughter cells contain a copy of
schematically depicted in Figure 1A, seems
very simple yet is poorly understood on ...
The transcription factors Nkx2.2 and Nkx2.9 play a
... Slightly later, when expression of Nkx2.9 stops in the neural
tube at embryonic day (E) 10.5 (Briscoe et al., 1999), the
essential requirement of Nkx2.2 to establish V3 neuronal fate
becomes apparent. Alternatively, Nkx2.2 might play no role in
setting up p3 progenitor cells and entirely different f ...
Aqua-BioSci. Monogr. (ABSM), Vol. 1, No. 2, pp. 1–57 (2008)
... fish cells seem to require more lipid than mammalian cells.
Eel hepatocytes were cultured in a serum-free medium, as shown in Table 1B, for 2 to 3
weeks (Hayashi and Ooshiro 1986). Insulin, glucagon, prolactin, growth hormone, epidermal
growth factor (EGF), and H2SeO3 were used for culture instead o ...
Ma et al 2009 - HKUST Institutional Repository
... Characterization of the properties of the Ca2+ transients
The duration of each Ca2+ transient was determined by examining each individual
transient in real time, via the PIM review software. To estimate the fold Ca2+ rise of
each Ca2+ transient, the PIM review software was used to determine the rel ...
Calcium Signals from the Vacuole
... vacuoles isolated from sycamore suspension culture cells a clear dependence of InsP3-dependent Ca2+
release on culture age was observed, increasing in parallel to cell fresh weight over time . It
therefore seems possible that InsP3-depedent vacuolar Ca2+ release may only be detected with cells a ...
Enzyme Substrates and Assays
Auxin: The Growth Hormone - Roberto Cezar | Fisiologista Vegetal
... produced by a cluster of cells located at sites where hydathodes will develop (Figure 19.5).
Hydathodes are glandlike modifications of the ground
and vascular tissues, typically at the margins of leaves, that
allow the release of liquid water (guttation fluid) through
pores in the epidermis in the p ...
Vitreous and Developmental Vitreoretinopathies
... detach the posterior cortical vitreous from the retina,
resulting in surgical complications such as retinal
breaks. The interface between vitreous and retina consists of a complex formed by the posterior vitreous cortex and the internal limiting lamina (ILL), which includes
the basal lamina of Mülle ...
An intracellular replication niche for Vibrio cholerae in the amoeba
... total bacteria (with 103–104 bacteria per ml), they can
contribute significantly to the biomass in aquatic
environments (Yooseph et al., 2010). Such balanced
biomass is based on rapid growth combined with
high predation (Takemura et al., 2014). As predatory
free-living amoebae and V. cholerae occur ...
89 calcium handling by the mammalian kidney
... is reabsorbed along the proximal convoluted tubule and an additional 10% is reabsorbed
in the proximal straight tubule (Suki, 1979; Suki and Rouse, 1992; Costanzo and
Windhager, 1992). Passive driving forces are the major determinants of Ca2+ transport in
these nephron segments. Hence, Ca2+ reabsorp ...
Modelling and treating dysregulated fibrosis in primary open angle
... I would also like to thank all the lovely people in our Molecular Neuroscience Group, which
has expanded greatly during my time here. I owe many thanks to my former BMedSc
students, Ben Mead and Simon Foale, who helped me gather some of the data presented in
this thesis. Thanks are also due to our l ...
Myocyte Enhancer Factor 2 Transcription Factors in Heart
... et al., 1993; Martin et al., 1994), and a similar pattern of
alternative splicing of an equivalent domain has been
observed for Mef2a and Mef2c transcripts (Martin et al.,
1993; McDermott et al., 1993; Zhu and Gulick, 2004). The
Drosophila Mef2 primary transcript is also subject to regulated splicin ...
... Indian hedgehog signals independently of PTHrP to promote
Kinglun Kingston Mak1, Henry M. Kronenberg2, Pao-Tien Chuang3, Susan Mackem4 and Yingzi Yang1,*
Chondrocyte hypertrophy is an essential process required for endochondral bone formation. Proper regulation of chondrocyte ...
EAP actuators aid the quest for the "Holy Braille" of tactile displays
... between lines of braille cells and the gaps between cells within each line of cells. For example, the display
might be an array of evenly spaced dots, with 2.5mm separation between the centers of all perpendicularly
adjacent dots. However, braille text on such a display would not have the normal spa ...
Pushing The Boundaries of Bioluminescence Using Synthetic
... join. Thank you for the freedom and flexibility I’ve had over my projects but also
for the guidance that has shaped me into the scientist I am today. I have truly
enjoyed my time in your lab.
Next, thank you to all of my committee members: Bill Kobertz, Tony
Carruthers, Celia Schiffer, and Alexei Bo ...
Opposite and redundant roles of the two Drosophila perilipins in
... including type-2 diabetes and partial lipodystrophy (Bickel et al.,
2009; Gandotra et al., 2011).
Besides Perilipin1, which has at least three isoforms, four other
Perilipins have been found in mammals, namely ADRP/
Perilipin2, TIP47/Perilipin3, S3-12/Perilipin4 and OXPAT/
Perilipin5 (Bickel et al., ...
University of Birmingham Mannan core branching of lipo(arabino
... of three independent experiments and the bars represent mean after log transformation. Mean ± standard deviation of inocula were 99 ± 6,
149 ± 9, 99 ± 6, 134 ± 18, 144 ± 21 and 104 ± 13 cfu respectively. *P < 0.05, ***P < 0.0001, one-way ANOVA, Bonferroni’s multiple comparison
test on log transforme ...
Amitosis (a- + mitosis) is absence of mitosis, the usual form of cell division in the cells of eukaryotes. There are several senses in which eukaryotic cells can be amitotic. One refers to capability for non-mitotic division and the other refers to lack of capability for division. In one sense of the word, which is now mostly obsolete, amitosis is cell division in eukaryotic cells that happens without the usual features of mitosis as seen on microscopy, namely, without nuclear envelope breakdown and without formation of mitotic spindle and condensed chromosomes as far as microscopy can detect. However, most examples of cell division formerly thought to belong to this supposedly ""non-mitotic"" class, such as the division of unicellular eukaryotes, are today recognized as belonging to a class of mitosis called closed mitosis. A spectrum of mitotic activity can be categorized as open, semi-closed, and closed mitosis, depending on the fate of the nuclear envelope. An exception is the division of ciliate macronucleus, which is not mitotic, and the reference to this process as amitosis may be the only legitimate use of the ""non-mitotic division"" sense of the term today. In animals and plants which normally have open mitosis, the microscopic picture described in the 19th century as amitosis most likely corresponded to apoptosis, a process of programmed cell death associated with fragmentation of the nucleus and cytoplasm. Relatedly, even in the late 19th century cytologists mentioned that in larger life forms, amitosis is a ""forerunner of degeneration"".Another sense of amitotic refers to cells of certain tissues that are usually no longer capable of mitosis once the organism has matured into adulthood. In humans this is true of various muscle and nerve tissue types; if the existing ones are damaged, they cannot be replaced with new ones of equal capability. For example, cardiac muscle destroyed by heart attack and nerves destroyed by piercing trauma usually cannot regenerate. In contrast, skin cells are capable of mitosis throughout adulthood; old skin cells that die and slough off are replaced with new ones. Human liver tissue also has a sort of dormant regenerative ability; it is usually not needed or expressed but can be elicited if needed.