The network of calcium regulation in muscle
... (Martonosi, 2000; Pette, 2001), together with fiber type specific proteolysis (Sultan et al., 2001), are involved in this adaptation, but the detailed mechanism of the process is unknown. ...
... (Martonosi, 2000; Pette, 2001), together with fiber type specific proteolysis (Sultan et al., 2001), are involved in this adaptation, but the detailed mechanism of the process is unknown. ...
Dual function of Swc5 in SWR remodeling ATPase activation and
... nucleosome along the chromosomes, transcription factors are excluded from inactive promoters and cryptic promoterlike sequences but are drawn to exposed DNA elements defined by the flanking nucleosomes to allow accurate, focused assembly (5–7). ATP-dependent chromatin remodelers utilize the energy f ...
... nucleosome along the chromosomes, transcription factors are excluded from inactive promoters and cryptic promoterlike sequences but are drawn to exposed DNA elements defined by the flanking nucleosomes to allow accurate, focused assembly (5–7). ATP-dependent chromatin remodelers utilize the energy f ...
Caroline Jeya Sheeba Daniel Sunder Singh
... Limbs emerge from the embryo flank as a mass of mesenchymal cells within an ectodermal jacket that will give rise to skeletal elements and connective tissues, structured along the dorsal-ventral (DV), anterior-posterior (AP) and proximal-distal (PD) axes. The apical ectodermal ridge (AER) and the zo ...
... Limbs emerge from the embryo flank as a mass of mesenchymal cells within an ectodermal jacket that will give rise to skeletal elements and connective tissues, structured along the dorsal-ventral (DV), anterior-posterior (AP) and proximal-distal (PD) axes. The apical ectodermal ridge (AER) and the zo ...
Matching catalytic activity to developmental function: Tolloid
... the imaginal discs; however, the tlr transcript is much more abundant. Despite several studies, the biological function(s) of Tlr remain ill defined. Embryos mutant for tlr show no significant defects in dorsal patterning, although it has recently been demonstrated that the level of Sog protein pres ...
... the imaginal discs; however, the tlr transcript is much more abundant. Despite several studies, the biological function(s) of Tlr remain ill defined. Embryos mutant for tlr show no significant defects in dorsal patterning, although it has recently been demonstrated that the level of Sog protein pres ...
Reducing Ryanodine Receptor Open Probability as a Means to
... Abstract—The aim of this work was to investigate whether it is possible to remove arrhythmogenic Ca2⫹ release from the sarcoplasmic reticulum that occurs in calcium overload without compromising normal systolic release. Exposure of rat ventricular myocytes to isoproterenol (1 mol/L) resulted in an ...
... Abstract—The aim of this work was to investigate whether it is possible to remove arrhythmogenic Ca2⫹ release from the sarcoplasmic reticulum that occurs in calcium overload without compromising normal systolic release. Exposure of rat ventricular myocytes to isoproterenol (1 mol/L) resulted in an ...
PDF - Retrovirology
... inhibit HIV-1 replication in non-permissive cell types. CBFβ is an evolutionarily conserved non-DNA binding component of the mammalian runt-related transcription factors (RUNX 1-3), which are critical in hematopoiesis, T cell differentiation, and skeletal development [6, 7]. CBFβ is an allosteric re ...
... inhibit HIV-1 replication in non-permissive cell types. CBFβ is an evolutionarily conserved non-DNA binding component of the mammalian runt-related transcription factors (RUNX 1-3), which are critical in hematopoiesis, T cell differentiation, and skeletal development [6, 7]. CBFβ is an allosteric re ...
University of Groningen Polymerization of the bacterial cell division
... every organism. Most bacteria and archaea divide symmetrically in a process that is subject to extensive regulation to ensure that both newly formed daughter cells contain a copy of the chromosome. Symmetric division, schematically depicted in Figure 1A, seems very simple yet is poorly understood on ...
... every organism. Most bacteria and archaea divide symmetrically in a process that is subject to extensive regulation to ensure that both newly formed daughter cells contain a copy of the chromosome. Symmetric division, schematically depicted in Figure 1A, seems very simple yet is poorly understood on ...
The transcription factors Nkx2.2 and Nkx2.9 play a
... Slightly later, when expression of Nkx2.9 stops in the neural tube at embryonic day (E) 10.5 (Briscoe et al., 1999), the essential requirement of Nkx2.2 to establish V3 neuronal fate becomes apparent. Alternatively, Nkx2.2 might play no role in setting up p3 progenitor cells and entirely different f ...
... Slightly later, when expression of Nkx2.9 stops in the neural tube at embryonic day (E) 10.5 (Briscoe et al., 1999), the essential requirement of Nkx2.2 to establish V3 neuronal fate becomes apparent. Alternatively, Nkx2.2 might play no role in setting up p3 progenitor cells and entirely different f ...
Aqua-BioSci. Monogr. (ABSM), Vol. 1, No. 2, pp. 1–57 (2008)
... fish cells seem to require more lipid than mammalian cells. Eel hepatocytes were cultured in a serum-free medium, as shown in Table 1B, for 2 to 3 weeks (Hayashi and Ooshiro 1986). Insulin, glucagon, prolactin, growth hormone, epidermal growth factor (EGF), and H2SeO3 were used for culture instead o ...
... fish cells seem to require more lipid than mammalian cells. Eel hepatocytes were cultured in a serum-free medium, as shown in Table 1B, for 2 to 3 weeks (Hayashi and Ooshiro 1986). Insulin, glucagon, prolactin, growth hormone, epidermal growth factor (EGF), and H2SeO3 were used for culture instead o ...
Ma et al 2009 - HKUST Institutional Repository
... Characterization of the properties of the Ca2+ transients The duration of each Ca2+ transient was determined by examining each individual transient in real time, via the PIM review software. To estimate the fold Ca2+ rise of each Ca2+ transient, the PIM review software was used to determine the rel ...
... Characterization of the properties of the Ca2+ transients The duration of each Ca2+ transient was determined by examining each individual transient in real time, via the PIM review software. To estimate the fold Ca2+ rise of each Ca2+ transient, the PIM review software was used to determine the rel ...
Ferritin and ferritin isoforms I: Structure–function relationships, synthesis, degradation and secretion
... interior of the protein shell the ferritin protein shell contains two main types of channels with strikingly different physical properties. The first type of channel comprises six hydrophobic channels with fourfold symmetry (12 Å long and 3 – 4 Å wide), which are lined by 12 leucine side-chains in t ...
... interior of the protein shell the ferritin protein shell contains two main types of channels with strikingly different physical properties. The first type of channel comprises six hydrophobic channels with fourfold symmetry (12 Å long and 3 – 4 Å wide), which are lined by 12 leucine side-chains in t ...
Calcium Signals from the Vacuole
... vacuoles isolated from sycamore suspension culture cells a clear dependence of InsP3-dependent Ca2+ release on culture age was observed, increasing in parallel to cell fresh weight over time [54]. It therefore seems possible that InsP3-depedent vacuolar Ca2+ release may only be detected with cells a ...
... vacuoles isolated from sycamore suspension culture cells a clear dependence of InsP3-dependent Ca2+ release on culture age was observed, increasing in parallel to cell fresh weight over time [54]. It therefore seems possible that InsP3-depedent vacuolar Ca2+ release may only be detected with cells a ...
Enzyme Substrates and Assays
... Handbook: A Guide to Fluorescent Probes and Labeling Technologies The Probes Handbook: A Guide to Fluorescent Probes and Labeling Technologies ...
... Handbook: A Guide to Fluorescent Probes and Labeling Technologies The Probes Handbook: A Guide to Fluorescent Probes and Labeling Technologies ...
Auxin: The Growth Hormone - Roberto Cezar | Fisiologista Vegetal
... produced by a cluster of cells located at sites where hydathodes will develop (Figure 19.5). Hydathodes are glandlike modifications of the ground and vascular tissues, typically at the margins of leaves, that allow the release of liquid water (guttation fluid) through pores in the epidermis in the p ...
... produced by a cluster of cells located at sites where hydathodes will develop (Figure 19.5). Hydathodes are glandlike modifications of the ground and vascular tissues, typically at the margins of leaves, that allow the release of liquid water (guttation fluid) through pores in the epidermis in the p ...
An intracellular replication niche for Vibrio cholerae in the amoeba
... total bacteria (with 103–104 bacteria per ml), they can contribute significantly to the biomass in aquatic environments (Yooseph et al., 2010). Such balanced biomass is based on rapid growth combined with high predation (Takemura et al., 2014). As predatory free-living amoebae and V. cholerae occur ...
... total bacteria (with 103–104 bacteria per ml), they can contribute significantly to the biomass in aquatic environments (Yooseph et al., 2010). Such balanced biomass is based on rapid growth combined with high predation (Takemura et al., 2014). As predatory free-living amoebae and V. cholerae occur ...
Vitreous and Developmental Vitreoretinopathies
... detach the posterior cortical vitreous from the retina, resulting in surgical complications such as retinal breaks. The interface between vitreous and retina consists of a complex formed by the posterior vitreous cortex and the internal limiting lamina (ILL), which includes the basal lamina of Mülle ...
... detach the posterior cortical vitreous from the retina, resulting in surgical complications such as retinal breaks. The interface between vitreous and retina consists of a complex formed by the posterior vitreous cortex and the internal limiting lamina (ILL), which includes the basal lamina of Mülle ...
89 calcium handling by the mammalian kidney
... is reabsorbed along the proximal convoluted tubule and an additional 10% is reabsorbed in the proximal straight tubule (Suki, 1979; Suki and Rouse, 1992; Costanzo and Windhager, 1992). Passive driving forces are the major determinants of Ca2+ transport in these nephron segments. Hence, Ca2+ reabsorp ...
... is reabsorbed along the proximal convoluted tubule and an additional 10% is reabsorbed in the proximal straight tubule (Suki, 1979; Suki and Rouse, 1992; Costanzo and Windhager, 1992). Passive driving forces are the major determinants of Ca2+ transport in these nephron segments. Hence, Ca2+ reabsorp ...
Myocyte Enhancer Factor 2 Transcription Factors in Heart
... et al., 1993; Martin et al., 1994), and a similar pattern of alternative splicing of an equivalent domain has been observed for Mef2a and Mef2c transcripts (Martin et al., 1993; McDermott et al., 1993; Zhu and Gulick, 2004). The Drosophila Mef2 primary transcript is also subject to regulated splicin ...
... et al., 1993; Martin et al., 1994), and a similar pattern of alternative splicing of an equivalent domain has been observed for Mef2a and Mef2c transcripts (Martin et al., 1993; McDermott et al., 1993; Zhu and Gulick, 2004). The Drosophila Mef2 primary transcript is also subject to regulated splicin ...
Modelling and treating dysregulated fibrosis in primary open angle
... I would also like to thank all the lovely people in our Molecular Neuroscience Group, which has expanded greatly during my time here. I owe many thanks to my former BMedSc students, Ben Mead and Simon Foale, who helped me gather some of the data presented in this thesis. Thanks are also due to our l ...
... I would also like to thank all the lovely people in our Molecular Neuroscience Group, which has expanded greatly during my time here. I owe many thanks to my former BMedSc students, Ben Mead and Simon Foale, who helped me gather some of the data presented in this thesis. Thanks are also due to our l ...
EAP actuators aid the quest for the "Holy Braille" of tactile displays
... between lines of braille cells and the gaps between cells within each line of cells. For example, the display might be an array of evenly spaced dots, with 2.5mm separation between the centers of all perpendicularly adjacent dots. However, braille text on such a display would not have the normal spa ...
... between lines of braille cells and the gaps between cells within each line of cells. For example, the display might be an array of evenly spaced dots, with 2.5mm separation between the centers of all perpendicularly adjacent dots. However, braille text on such a display would not have the normal spa ...
PDF
... Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy Kinglun Kingston Mak1, Henry M. Kronenberg2, Pao-Tien Chuang3, Susan Mackem4 and Yingzi Yang1,* Chondrocyte hypertrophy is an essential process required for endochondral bone formation. Proper regulation of chondrocyte ...
... Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy Kinglun Kingston Mak1, Henry M. Kronenberg2, Pao-Tien Chuang3, Susan Mackem4 and Yingzi Yang1,* Chondrocyte hypertrophy is an essential process required for endochondral bone formation. Proper regulation of chondrocyte ...
Pushing The Boundaries of Bioluminescence Using Synthetic
... join. Thank you for the freedom and flexibility I’ve had over my projects but also for the guidance that has shaped me into the scientist I am today. I have truly enjoyed my time in your lab. Next, thank you to all of my committee members: Bill Kobertz, Tony Carruthers, Celia Schiffer, and Alexei Bo ...
... join. Thank you for the freedom and flexibility I’ve had over my projects but also for the guidance that has shaped me into the scientist I am today. I have truly enjoyed my time in your lab. Next, thank you to all of my committee members: Bill Kobertz, Tony Carruthers, Celia Schiffer, and Alexei Bo ...
Opposite and redundant roles of the two Drosophila perilipins in
... including type-2 diabetes and partial lipodystrophy (Bickel et al., 2009; Gandotra et al., 2011). Besides Perilipin1, which has at least three isoforms, four other Perilipins have been found in mammals, namely ADRP/ Perilipin2, TIP47/Perilipin3, S3-12/Perilipin4 and OXPAT/ Perilipin5 (Bickel et al., ...
... including type-2 diabetes and partial lipodystrophy (Bickel et al., 2009; Gandotra et al., 2011). Besides Perilipin1, which has at least three isoforms, four other Perilipins have been found in mammals, namely ADRP/ Perilipin2, TIP47/Perilipin3, S3-12/Perilipin4 and OXPAT/ Perilipin5 (Bickel et al., ...
University of Birmingham Mannan core branching of lipo(arabino
... of three independent experiments and the bars represent mean after log transformation. Mean ± standard deviation of inocula were 99 ± 6, 149 ± 9, 99 ± 6, 134 ± 18, 144 ± 21 and 104 ± 13 cfu respectively. *P < 0.05, ***P < 0.0001, one-way ANOVA, Bonferroni’s multiple comparison test on log transforme ...
... of three independent experiments and the bars represent mean after log transformation. Mean ± standard deviation of inocula were 99 ± 6, 149 ± 9, 99 ± 6, 134 ± 18, 144 ± 21 and 104 ± 13 cfu respectively. *P < 0.05, ***P < 0.0001, one-way ANOVA, Bonferroni’s multiple comparison test on log transforme ...