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... 2 (Gale et al., 2002; Dellinger et al., 2008), podoplanin (Schacht et al., 2003), integrin alpha 9 (Huang et al., 2000), and the transcription factors Foxc2 (Petrova et al., 2004), Net (Ayadi et al., 2001), Vezf1 (Kuhnert et al., 2005), adrenomedullin (Fritz-Six et al., 2008) and Aspp1 (Hirashima et ...
... 2 (Gale et al., 2002; Dellinger et al., 2008), podoplanin (Schacht et al., 2003), integrin alpha 9 (Huang et al., 2000), and the transcription factors Foxc2 (Petrova et al., 2004), Net (Ayadi et al., 2001), Vezf1 (Kuhnert et al., 2005), adrenomedullin (Fritz-Six et al., 2008) and Aspp1 (Hirashima et ...
Actin as target for modification by bacterial protein toxins
... arranged actin subunits that are wound around each other forming a helix that can be described either as a two-start left-handed double helix with a half-pitch of about 360 Å or as a one-start genetic right-handed helix with a rotational translocation of 166 and an axial rise of 27.5 Å resulting ...
... arranged actin subunits that are wound around each other forming a helix that can be described either as a two-start left-handed double helix with a half-pitch of about 360 Å or as a one-start genetic right-handed helix with a rotational translocation of 166 and an axial rise of 27.5 Å resulting ...
presence of allhnase in isolated vacuoles and of alkyl
... Gentle overnight enzymic digestion of cell walls gave large numbers of viable protoplasts with very little cellular debris. Shaking, higher enzyme concentrations and the use of strong enzymes such as macerozyme gave fewer intact protoplasts and large amounts of cellular debris. Protoplasts could not ...
... Gentle overnight enzymic digestion of cell walls gave large numbers of viable protoplasts with very little cellular debris. Shaking, higher enzyme concentrations and the use of strong enzymes such as macerozyme gave fewer intact protoplasts and large amounts of cellular debris. Protoplasts could not ...
PRH/Hex - Biochemical Journal
... PRH protein based upon studies of the human and avian proteins. In addition we will review the mechanisms that PRH proteins from all species use to regulate gene expression and cell proliferation. Finally we will review the role of PRH in development, with particular focus on the importance of PRH i ...
... PRH protein based upon studies of the human and avian proteins. In addition we will review the mechanisms that PRH proteins from all species use to regulate gene expression and cell proliferation. Finally we will review the role of PRH in development, with particular focus on the importance of PRH i ...
Bovine pneumonic pasteurellosis, more commonly known as
... Exposure of cattle to stress factors or viral or other bacterial infections leads to proliferation of M. haemolytica in the upper respiratory tract. Once present in high levels, it enters the alveolar spaces through repeated aspiration of infected droplets and sloughed cells/tissues. Here, it initia ...
... Exposure of cattle to stress factors or viral or other bacterial infections leads to proliferation of M. haemolytica in the upper respiratory tract. Once present in high levels, it enters the alveolar spaces through repeated aspiration of infected droplets and sloughed cells/tissues. Here, it initia ...
Calcium at Fertilization and in Early Development
... to the demonstration that microinjection of InsP3 into sea urchin eggs caused their activation (605). A model of fertilization emerged in which the fertilizing sperm triggered production of InsP3 that then generated a propagating calcium wave (reviewed in Ref. 603). The debate at that time turned ar ...
... to the demonstration that microinjection of InsP3 into sea urchin eggs caused their activation (605). A model of fertilization emerged in which the fertilizing sperm triggered production of InsP3 that then generated a propagating calcium wave (reviewed in Ref. 603). The debate at that time turned ar ...
Potentiation of acid-sensing ion channels by sulfhydryl compounds
... activity may impact acidosis-induced neuronal death following stroke. ASICs also impact migration of malignant glioma cells, suggesting that ASIC activity may also play a role in the pathogenesis of brain tumors (11, 44). ASICs are modulated by several compounds in a subunitspecific manner. For exam ...
... activity may impact acidosis-induced neuronal death following stroke. ASICs also impact migration of malignant glioma cells, suggesting that ASIC activity may also play a role in the pathogenesis of brain tumors (11, 44). ASICs are modulated by several compounds in a subunitspecific manner. For exam ...
store-operated calcium channels
... directly deplete Ca2⫹ from the ER while bypassing receptors and associated biochemical signals. By inhibiting ongoing uptake, SERCA inhibitors unmask an ongoing Ca2⫹ “leak” from the ER, leading to luminal Ca2⫹ depletion without concomitantly generating IP3 (FIGURE 1A). The sources of the leak are no ...
... directly deplete Ca2⫹ from the ER while bypassing receptors and associated biochemical signals. By inhibiting ongoing uptake, SERCA inhibitors unmask an ongoing Ca2⫹ “leak” from the ER, leading to luminal Ca2⫹ depletion without concomitantly generating IP3 (FIGURE 1A). The sources of the leak are no ...
as Hotspot Ca 2+ Signaling Units
... responsible for the transfer of Ca2+ across the outer and the inner mitochondrial membrane (OMM and IMM respectively). Despite the surprisingly low affinity of the mitochondrial uptake systems (Kd around 10–20 mM) and the submicromolar global [Ca2+]c (which rarely exceed 2–3 mM) evoked by IP3-mediat ...
... responsible for the transfer of Ca2+ across the outer and the inner mitochondrial membrane (OMM and IMM respectively). Despite the surprisingly low affinity of the mitochondrial uptake systems (Kd around 10–20 mM) and the submicromolar global [Ca2+]c (which rarely exceed 2–3 mM) evoked by IP3-mediat ...
PDF - Blood Journal
... The platelet ␣IIb3 complex is a member of the integrin family of receptors, each of which is composed of an ␣ and a  subunit derived from separate genes. ␣IIb3 is important in platelet function, and both qualitative and quantitative disorders of ␣IIb3 result in the bleeding disorder Glanzmann th ...
... The platelet ␣IIb3 complex is a member of the integrin family of receptors, each of which is composed of an ␣ and a  subunit derived from separate genes. ␣IIb3 is important in platelet function, and both qualitative and quantitative disorders of ␣IIb3 result in the bleeding disorder Glanzmann th ...
Differential recruitment of Dishevelled provides signaling specificity
... stable transcriptional regulator that can be seen in the nucleus. Based on cell-culture assays, Drosophila Frizzled2 (DFz2) has been proposed to encode the Wg receptor (Bhanot et al. 1996), although confirmation awaits more definitive evidence. This observation also raises the possibility that anoth ...
... stable transcriptional regulator that can be seen in the nucleus. Based on cell-culture assays, Drosophila Frizzled2 (DFz2) has been proposed to encode the Wg receptor (Bhanot et al. 1996), although confirmation awaits more definitive evidence. This observation also raises the possibility that anoth ...
The contractile apparatus and mechanical properties of airway smooth muscle
... ATP to adenosine diphosphate (ADP) and inorganic phosphate (Pi). As the myosin rebinds to actin and releases the nucleotide, the conformational changes are reversed causing movement of the myosin relative to actin. The light-chain binding domain ("the neck region") pivots about a fulcrum near where ...
... ATP to adenosine diphosphate (ADP) and inorganic phosphate (Pi). As the myosin rebinds to actin and releases the nucleotide, the conformational changes are reversed causing movement of the myosin relative to actin. The light-chain binding domain ("the neck region") pivots about a fulcrum near where ...
University of Groningen The functional relationship between
... their increased hydrophobicity compared to the primary bile salts. Human biliary bile is a mixture of CA (35%), CDCA (35%), DCA (25%), LCA (1%), UDCA (2%) and a residual fraction containing six different oxo- and 3β-hydroxy- derivatives (2%). In contrast, fecal bile consists of DCA (34%), LCA (29%), ...
... their increased hydrophobicity compared to the primary bile salts. Human biliary bile is a mixture of CA (35%), CDCA (35%), DCA (25%), LCA (1%), UDCA (2%) and a residual fraction containing six different oxo- and 3β-hydroxy- derivatives (2%). In contrast, fecal bile consists of DCA (34%), LCA (29%), ...
life cycle, cell wall and cell signal transduction
... organism was initially classified as a protozoan, but there was ongoing controversy in the subsequent decades about whether to classify it as a protozoan or fungus (Chabe et al. 2011). The advent of gene sequencing techniques in the late 1980s finally settled the debate. In 1988, sequencing of the r ...
... organism was initially classified as a protozoan, but there was ongoing controversy in the subsequent decades about whether to classify it as a protozoan or fungus (Chabe et al. 2011). The advent of gene sequencing techniques in the late 1980s finally settled the debate. In 1988, sequencing of the r ...
Toxoplasma gondii Chitinase Induces Macrophage Activation
... have been described (Table 1), some of their characteristics were elucidated herein: (a) the optimal pH for chitinase activity is usually in the range of 4.0–7.0; (b) the optimal temperature is usually 50°C; and (c) their molecular mass is commonly between 15 and 50 kDa. Our research on a chitinase ...
... have been described (Table 1), some of their characteristics were elucidated herein: (a) the optimal pH for chitinase activity is usually in the range of 4.0–7.0; (b) the optimal temperature is usually 50°C; and (c) their molecular mass is commonly between 15 and 50 kDa. Our research on a chitinase ...
Sample pages 1 PDF
... basis of sequence similarity of motor domain, myosins are divided into at least 24 classes [22]. Among them, three classes of myosins, VIII, XI and XIII, are plant specific [73, 113]. The Arabidopsis thaliana genome encodes seventeen myosins, four myosin VIII and thirteen myosin XI classes, while tw ...
... basis of sequence similarity of motor domain, myosins are divided into at least 24 classes [22]. Among them, three classes of myosins, VIII, XI and XIII, are plant specific [73, 113]. The Arabidopsis thaliana genome encodes seventeen myosins, four myosin VIII and thirteen myosin XI classes, while tw ...
Endocytosis, Recycling, and Regulated Exocytosis of Glucose
... has also been implicated in caveolin-1-, IL-2Rβ-, and flotillindependent endocytotic processes.15 GLUT4, the major carrier of glucose into muscle and fat cells, is a recycling protein that is continuously removed from and recycled back to the PM.5 Both arms of this process are subject to regulation ...
... has also been implicated in caveolin-1-, IL-2Rβ-, and flotillindependent endocytotic processes.15 GLUT4, the major carrier of glucose into muscle and fat cells, is a recycling protein that is continuously removed from and recycled back to the PM.5 Both arms of this process are subject to regulation ...
Collagen in the Human Lung
... Collagen is an integral component of lung. It maintains alveolar, airway, and vascular stability, limits lung expansion, and contributes significantly to lung recoil at all lung volumes (1, 2). In the adult, the total amount of collagen and the concentration of collagen per unit lung mass remain con ...
... Collagen is an integral component of lung. It maintains alveolar, airway, and vascular stability, limits lung expansion, and contributes significantly to lung recoil at all lung volumes (1, 2). In the adult, the total amount of collagen and the concentration of collagen per unit lung mass remain con ...
Regional requirements for Dishevelled signaling during Xenopus
... mesoderm engages in convergent extension, narrowing and lengthening to adopt the elongate morphology appropriate for the forming body axis (Holtfreter, 1944; Keller and Danilchik, 1988; Schectman, 1942; Wilson and Keller, 1991). Such explant experiments have been central to our understanding of the ...
... mesoderm engages in convergent extension, narrowing and lengthening to adopt the elongate morphology appropriate for the forming body axis (Holtfreter, 1944; Keller and Danilchik, 1988; Schectman, 1942; Wilson and Keller, 1991). Such explant experiments have been central to our understanding of the ...
Evolutionary re-wiring of p63 and the epigenomic
... skin-centric studies, however the relevance of findings from such rodent studies to human skin physiology and disorders has often been overlooked and underappreciated. This is an important consideration given the fact that despite the similarities in the underlying anatomy and physiology, there also ...
... skin-centric studies, however the relevance of findings from such rodent studies to human skin physiology and disorders has often been overlooked and underappreciated. This is an important consideration given the fact that despite the similarities in the underlying anatomy and physiology, there also ...
Plant hormones and growth regulators
... relative to the controls (Marinos, 1962 ). The low Ca2+-induced effect was apparent as relatively gross discontinuities in the nuclear envelope, plasma membrane, and tonoplast, and later in the mitochondria. It is difficult to imagine that such lesions occur in the intact cell because they would imm ...
... relative to the controls (Marinos, 1962 ). The low Ca2+-induced effect was apparent as relatively gross discontinuities in the nuclear envelope, plasma membrane, and tonoplast, and later in the mitochondria. It is difficult to imagine that such lesions occur in the intact cell because they would imm ...
The Influence of Certain Trace Metals on Bacterial
... Escherichia coli is rapid and is complete some time before the onset of the stationary phase. In similar cultures of the Gram-positive Bacillus megaterium and B. subtilis ~3 growth and Mg2+ assimilation cease at the same time and when only part of the available Mg2+has been utilized; thereafter effl ...
... Escherichia coli is rapid and is complete some time before the onset of the stationary phase. In similar cultures of the Gram-positive Bacillus megaterium and B. subtilis ~3 growth and Mg2+ assimilation cease at the same time and when only part of the available Mg2+has been utilized; thereafter effl ...
VEGFR2 but not VEGFR3 governs integrity and remodeling of
... follicular cells, vascular density, and vascular diameter in thyroid gland by 62, 31, and 20% (Fig 2A–F). In contrast, PTU increased the height of follicular cells, vascular density, and vascular diameter in thyroid gland by 94, 45, and 194% (Fig 2A–F). Of note, neither T4 nor PTU induced any appare ...
... follicular cells, vascular density, and vascular diameter in thyroid gland by 62, 31, and 20% (Fig 2A–F). In contrast, PTU increased the height of follicular cells, vascular density, and vascular diameter in thyroid gland by 94, 45, and 194% (Fig 2A–F). Of note, neither T4 nor PTU induced any appare ...