Influence of the 4G/5G PAI-1 genotype on angiotensin II
... stimuli such as IL-1 and VLDL induced PAI-1 synthesis in cells containing the 4G sequence [13,16], this effect being explained through the binding of a transcriptional activator to both 4G and 5G alleles, while the 5G allele also binds a transcriptional repressor [13]. Whereas Ang II causes the rele ...
... stimuli such as IL-1 and VLDL induced PAI-1 synthesis in cells containing the 4G sequence [13,16], this effect being explained through the binding of a transcriptional activator to both 4G and 5G alleles, while the 5G allele also binds a transcriptional repressor [13]. Whereas Ang II causes the rele ...
CE - University of Pittsburgh
... LDL membrane receptor • Found in clathrin coated pits (endocytosis) • After endocytosis the receptor is recycled whilst the LDL is degraded to releasing lipid cargo. Cholesterol uptake down regulates the cells own production of cholesterol and down regulates LDL receptor synthesis • Mutations in LD ...
... LDL membrane receptor • Found in clathrin coated pits (endocytosis) • After endocytosis the receptor is recycled whilst the LDL is degraded to releasing lipid cargo. Cholesterol uptake down regulates the cells own production of cholesterol and down regulates LDL receptor synthesis • Mutations in LD ...
as Adobe PDF - Edinburgh Research Explorer
... In a surface view of the differentiation zone of a root, emerging root hair bulges are highly fluorescent. This is seen as fluorescent patches and ring structures on the less fluorescent background of the root surface (Fig. 1A). The corresponding brightfield picture can be seen in Figure 1B. At high ...
... In a surface view of the differentiation zone of a root, emerging root hair bulges are highly fluorescent. This is seen as fluorescent patches and ring structures on the less fluorescent background of the root surface (Fig. 1A). The corresponding brightfield picture can be seen in Figure 1B. At high ...
The PINK1 p.I368N mutation affects protein stability and ubiquitin
... direct a complex regulated, sequential mitochondrial quality control. Thereby, damaged mitochondria are identified and targeted to degradation in order to prevent their accumulation and eventually cell death. Homozygous or compound heterozygous loss of either gene function disrupts this protective p ...
... direct a complex regulated, sequential mitochondrial quality control. Thereby, damaged mitochondria are identified and targeted to degradation in order to prevent their accumulation and eventually cell death. Homozygous or compound heterozygous loss of either gene function disrupts this protective p ...
Direct redox modulation of p53 protein: potential sources of redox
... protein can be divided roughly into three distinct domains based on function. All regulatory post-translational ...
... protein can be divided roughly into three distinct domains based on function. All regulatory post-translational ...
Interaction with Autologous Platelets Multiplies Interleukin
... demonstrate that thrombin-activated platelets, but not thrombin alone, augment the production of IL-la and TNF-a by PBMC stimulated by LPS at low concentrations. Platelets not treated with thrombin, activated 25%-30% for P-selectin expression, enhanced IL-la production 6- to 14-fold and TNF-a produc ...
... demonstrate that thrombin-activated platelets, but not thrombin alone, augment the production of IL-la and TNF-a by PBMC stimulated by LPS at low concentrations. Platelets not treated with thrombin, activated 25%-30% for P-selectin expression, enhanced IL-la production 6- to 14-fold and TNF-a produc ...
NCAM Polypeptides in Heart Development: Association with Z Discs
... their binding initiates (Takeichi, 1990; Edelman and Crossin, 1991; Hynes, 1992; Damsky and Werb, 1992; Juliano and Haskill, 1993). There are many stages in early heart development when changes in the expression or function of cell-cell adhesion molecules (CAMs) ~ may mediate or sta- ...
... their binding initiates (Takeichi, 1990; Edelman and Crossin, 1991; Hynes, 1992; Damsky and Werb, 1992; Juliano and Haskill, 1993). There are many stages in early heart development when changes in the expression or function of cell-cell adhesion molecules (CAMs) ~ may mediate or sta- ...
Biology - BIOL - Auburn University Bulletin
... from a selected area of biological sciences. One hour is required for all majors. Course may be repeated for a maximum of 3 credit hours. BIOL 4967 HONORS SPECIAL PROBLEMS (1-3) LEC. Pr. Honors College Departmental approval and membership in the Honor College. Course may be repeated for a maximum of ...
... from a selected area of biological sciences. One hour is required for all majors. Course may be repeated for a maximum of 3 credit hours. BIOL 4967 HONORS SPECIAL PROBLEMS (1-3) LEC. Pr. Honors College Departmental approval and membership in the Honor College. Course may be repeated for a maximum of ...
Arabidopsis HAP2 (GCS1) is a sperm-specific gene
... Northern blotting was performed on 20 g of total pollen RNA probed with HAP2 cDNA. RT-PCR was performed on 1 g total pollen RNA using the HAP2 primers F, 5-TTAATGGCTTGTATACTCGCCGG-3 and R, 5ACGAAGGCAATGCGCGGTATTTGCC-3, and EF-1 controls F, 5GCCCCTTCGTCTCCCACTTC-3 and R, 5-CACTTCGCACCCTTCTT ...
... Northern blotting was performed on 20 g of total pollen RNA probed with HAP2 cDNA. RT-PCR was performed on 1 g total pollen RNA using the HAP2 primers F, 5-TTAATGGCTTGTATACTCGCCGG-3 and R, 5ACGAAGGCAATGCGCGGTATTTGCC-3, and EF-1 controls F, 5GCCCCTTCGTCTCCCACTTC-3 and R, 5-CACTTCGCACCCTTCTT ...
Correction: Mice humanised for the EGF receptor
... rearrangements and overexpression of the Egfr gene have been shown to occur at high frequency in human squamous cell carcinomas and glioblastomas (Olayioye et al., 2000; Yarden, 2001). The first in vivo evidence for a direct involvement of the EGFR in epithelial tumour development stems from the ana ...
... rearrangements and overexpression of the Egfr gene have been shown to occur at high frequency in human squamous cell carcinomas and glioblastomas (Olayioye et al., 2000; Yarden, 2001). The first in vivo evidence for a direct involvement of the EGFR in epithelial tumour development stems from the ana ...
Hao Shi1*, Florian Gatzke2, Julia M. Molle
...
...
Impaired Muscle Regeneration in MKP1/5DKO Mice
We have shown that MKP-1-deficient mice are inhibited in their ability to undergo
regenerative myogenesis[8]. In contrast, MKP-5-deficient mice exhibit an enhanced
regenerative capacity
patterning mechanisms controlling vertebrate limb development
... of patterning mechanisms that appear to be conserved during evolution. In the case of the vertebrate limb, a primordium (the limb bud) appears at specific locations in the developing embryo (Figure 1A), positioned by combinations of factors that provide positional cues. Later on, the limb bud, which ...
... of patterning mechanisms that appear to be conserved during evolution. In the case of the vertebrate limb, a primordium (the limb bud) appears at specific locations in the developing embryo (Figure 1A), positioned by combinations of factors that provide positional cues. Later on, the limb bud, which ...
Hao Shisup>1*sup>, Florian Gatzkesup>2sup>, Julia M. Molle
... muscle (Figure 1G). MKP1/5-DKO mice following injury had much higher numbers of small-sized myofibers as compared with wild type injured mice (Figure 1G). In addition, both myofiber crosssectional area and the number of myofibers with greater than 2 or more nuclei were significantly reduced in regen ...
... muscle (Figure 1G). MKP1/5-DKO mice following injury had much higher numbers of small-sized myofibers as compared with wild type injured mice (Figure 1G). In addition, both myofiber crosssectional area and the number of myofibers with greater than 2 or more nuclei were significantly reduced in regen ...
Responses of plant vascular systems to auxin transport
... One peculiarity of vascular tissue induction by IAA is that it occurs in a linear manner: locally applied IAA induces a new vascular strand extending basally from the site of application (Sachs, 1991). The observation is intriguing in three respects: first, the differentiation occurs along a narrow ...
... One peculiarity of vascular tissue induction by IAA is that it occurs in a linear manner: locally applied IAA induces a new vascular strand extending basally from the site of application (Sachs, 1991). The observation is intriguing in three respects: first, the differentiation occurs along a narrow ...
Cbp3–Cbp6 interacts with the yeast mitochondrial ribosomal tunnel
... as a docking site for a variety of biogenesis factors. This is well documented in bacteria (Kramer et al., 2009). The interactors of the tunnel exit of bacterial ribosomes can be classified into three different groups, namely (1) processing enzymes like ...
... as a docking site for a variety of biogenesis factors. This is well documented in bacteria (Kramer et al., 2009). The interactors of the tunnel exit of bacterial ribosomes can be classified into three different groups, namely (1) processing enzymes like ...
The secreted cell signal Folded Gastrulation regulates glial
... During gastrulation in Drosophila, ventral cells change shape, undergoing synchronous apical constriction, to create the ventral furrow (VF). This process is affected in mutant embryos lacking zygotic function of the folded gastrulation (fog) gene, which encodes a putative secreted protein. Fog is a ...
... During gastrulation in Drosophila, ventral cells change shape, undergoing synchronous apical constriction, to create the ventral furrow (VF). This process is affected in mutant embryos lacking zygotic function of the folded gastrulation (fog) gene, which encodes a putative secreted protein. Fog is a ...
Autophagy Contributes to Leaf Starch DegradationC
... and organelles (Klionsky and Emr, 2000). Three types of autophagy have been defined: macroautophagy, microautophagy, and chaperone-mediated autophagy (Massey et al., 2004). Macroautophagy (referred to hereafter as autophagy), the major type of autophagy, occurs when cytoplasmic constituents are engul ...
... and organelles (Klionsky and Emr, 2000). Three types of autophagy have been defined: macroautophagy, microautophagy, and chaperone-mediated autophagy (Massey et al., 2004). Macroautophagy (referred to hereafter as autophagy), the major type of autophagy, occurs when cytoplasmic constituents are engul ...
Plakoglobin domains that define its association with the
... intermediate filament cytoskeleton. A short stretch of 37 amino acids in the C terminus of desmocollin-1 was recently shown by Troyanovsky et al. (1994a) to be necessary for it to associate with plakoglobin and to recruit intermediate filaments to the plasma membrane. Using similar experiments, they ...
... intermediate filament cytoskeleton. A short stretch of 37 amino acids in the C terminus of desmocollin-1 was recently shown by Troyanovsky et al. (1994a) to be necessary for it to associate with plakoglobin and to recruit intermediate filaments to the plasma membrane. Using similar experiments, they ...
NUBBIN and JAGGED define stamen and carpel
... development, NUB is initially expressed in cell layers of both abaxial and adaxial halves (Fig. 1G), it then becomes restricted to the adaxial cell layers at stage 7 (Fig. 1H,I). NUB expression can also be seen on the adaxial side of initiating ovule primordia (Fig. 1J). In summary, NUB expression i ...
... development, NUB is initially expressed in cell layers of both abaxial and adaxial halves (Fig. 1G), it then becomes restricted to the adaxial cell layers at stage 7 (Fig. 1H,I). NUB expression can also be seen on the adaxial side of initiating ovule primordia (Fig. 1J). In summary, NUB expression i ...
neural crest specification: migrating into genomics
... the neural crest-forming region14,41, whereas blocking Slug and/or Snail function inhibits neural crest specification42,46 and migration46–48. The targets of Slug/Snail during premigratory neural crest development are not known. However, Slug and Snail have been shown to regulate EPITHELIAL–MESENCHY ...
... the neural crest-forming region14,41, whereas blocking Slug and/or Snail function inhibits neural crest specification42,46 and migration46–48. The targets of Slug/Snail during premigratory neural crest development are not known. However, Slug and Snail have been shown to regulate EPITHELIAL–MESENCHY ...
Intracellular control of developmental and regenerative axon growth
... robust axon growth from sensory neurons by activating their corresponding receptors (TrkA, TrkC). Brainderived neurotrophic factor (BDNF) promotes axon growth from RGCs and hippocampal neurons via its receptor TrkB. It is important to emphasize that although neurotrophins have spectacular axon growt ...
... robust axon growth from sensory neurons by activating their corresponding receptors (TrkA, TrkC). Brainderived neurotrophic factor (BDNF) promotes axon growth from RGCs and hippocampal neurons via its receptor TrkB. It is important to emphasize that although neurotrophins have spectacular axon growt ...
Autophagy Contributes to Leaf Starch DegradationC
... and organelles (Klionsky and Emr, 2000). Three types of autophagy have been defined: macroautophagy, microautophagy, and chaperone-mediated autophagy (Massey et al., 2004). Macroautophagy (referred to hereafter as autophagy), the major type of autophagy, occurs when cytoplasmic constituents are engul ...
... and organelles (Klionsky and Emr, 2000). Three types of autophagy have been defined: macroautophagy, microautophagy, and chaperone-mediated autophagy (Massey et al., 2004). Macroautophagy (referred to hereafter as autophagy), the major type of autophagy, occurs when cytoplasmic constituents are engul ...
Autophagy Contributes to Leaf Starch DegradationC
... and organelles (Klionsky and Emr, 2000). Three types of autophagy have been defined: macroautophagy, microautophagy, and chaperone-mediated autophagy (Massey et al., 2004). Macroautophagy (referred to hereafter as autophagy), the major type of autophagy, occurs when cytoplasmic constituents are engul ...
... and organelles (Klionsky and Emr, 2000). Three types of autophagy have been defined: macroautophagy, microautophagy, and chaperone-mediated autophagy (Massey et al., 2004). Macroautophagy (referred to hereafter as autophagy), the major type of autophagy, occurs when cytoplasmic constituents are engul ...
