Calcium Transients in the Garter Snake Vomeronasal Organ
... patterns of activity displayed a scattered appearance with a heterogeneous organization in which it was possible to find nonuniform foci of activity distributed in multiple epithelial regions separated by silent sectors. Within each lamina there were important variations in the amplitude and time co ...
... patterns of activity displayed a scattered appearance with a heterogeneous organization in which it was possible to find nonuniform foci of activity distributed in multiple epithelial regions separated by silent sectors. Within each lamina there were important variations in the amplitude and time co ...
The Role of Kv7 in Peripheral Neurons
... Follow this and additional works at: http://repository.upenn.edu/edissertations Part of the Biology Commons, Medicine and Health Sciences Commons, and the Neuroscience and Neurobiology Commons ...
... Follow this and additional works at: http://repository.upenn.edu/edissertations Part of the Biology Commons, Medicine and Health Sciences Commons, and the Neuroscience and Neurobiology Commons ...
Cumming BG, Parker AJ.
... search coil system (C -N-C Engineering) with the detector time constant set to 0.5 msec. The high-frequency noise level was no more than 61 analog-to-digital bit, (0.6 arcmin). However, there also appeared to be some slow drift in the signals over longer periods. The system was calibrated by present ...
... search coil system (C -N-C Engineering) with the detector time constant set to 0.5 msec. The high-frequency noise level was no more than 61 analog-to-digital bit, (0.6 arcmin). However, there also appeared to be some slow drift in the signals over longer periods. The system was calibrated by present ...
ORAL UPF/ TESI DOCT Nicotine addiction phenotypes in a BAC transgenic mouse
... nicotine addiction. Specifically, we focus on the cluster CHRNA5/A3/B4 of human chromosome 15, which human genetic studies have identified as a strong candidate for nicotine dependence and smoking-related behaviours. This cluster codifies for the alpha5, alpha3 and beta4 subunits of the nicotinic ac ...
... nicotine addiction. Specifically, we focus on the cluster CHRNA5/A3/B4 of human chromosome 15, which human genetic studies have identified as a strong candidate for nicotine dependence and smoking-related behaviours. This cluster codifies for the alpha5, alpha3 and beta4 subunits of the nicotinic ac ...
A Novel Functionally Distinct Subtype of Striatal Neuropeptide Y
... Statistical analysis. Input resistance was calculated from the slope of the current–voltage relationship using three points centered around zero current (⫾10 pA for Type I interneurons and ⫾160 pA for Type II interneurons). All action potential parameters were measured from spontaneous spikes if the ...
... Statistical analysis. Input resistance was calculated from the slope of the current–voltage relationship using three points centered around zero current (⫾10 pA for Type I interneurons and ⫾160 pA for Type II interneurons). All action potential parameters were measured from spontaneous spikes if the ...
What the young brain tells the spinal cord: top down modulation of
... The brain can endogenously and powerfully modulate the processing of somatosensory information in the spinal cord. In adults, the rostroventral medulla (RVM) can inhibit and facilitate somatosensory processing in the adult dorsal horn, providing powerful control of pain behaviours. In neonates, bala ...
... The brain can endogenously and powerfully modulate the processing of somatosensory information in the spinal cord. In adults, the rostroventral medulla (RVM) can inhibit and facilitate somatosensory processing in the adult dorsal horn, providing powerful control of pain behaviours. In neonates, bala ...
neuronal reward and decision signals: from theories to data
... mediated by neuronal reward prediction error signals which implement basic constructs of reinforcement learning theory. These signals are found in dopamine neurons, which emit a global reward signal to striatum and frontal cortex, and in specific neurons in striatum, amygdala, and frontal cortex pro ...
... mediated by neuronal reward prediction error signals which implement basic constructs of reinforcement learning theory. These signals are found in dopamine neurons, which emit a global reward signal to striatum and frontal cortex, and in specific neurons in striatum, amygdala, and frontal cortex pro ...
Orexin/Hypocretin: A Neuropeptide at the Interface of Sleep, Energy
... II. Orexin and orexin receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . A. Identification of orexin (Hypocretin) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . B. Orex ...
... II. Orexin and orexin receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . A. Identification of orexin (Hypocretin) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . B. Orex ...
AXOTOMIZED SPINAL COMMISSURAL INTERNEURONS OF THE ADULT FELINE:
... do this without you. You kept me sane and made me laugh when experiments weren’t working or papers weren’t being accepted, and listened to my endless talk about data and the lab when things were going well. Thank you. To my parents: thank you for your unwavering love and support for twenty-twoand-a- ...
... do this without you. You kept me sane and made me laugh when experiments weren’t working or papers weren’t being accepted, and listened to my endless talk about data and the lab when things were going well. Thank you. To my parents: thank you for your unwavering love and support for twenty-twoand-a- ...
Structure and dynamics of the corticothalamic driver pathway in the
... processes is the rodent whisker system. Rodents can solve highly complicated tasks with their whiskers alone, distributed receptors at the follicles require spatial integration and rhythmic movements suggest temporal processing components. The posterior group nucleus of the thalamus (PO) is in a key ...
... processes is the rodent whisker system. Rodents can solve highly complicated tasks with their whiskers alone, distributed receptors at the follicles require spatial integration and rhythmic movements suggest temporal processing components. The posterior group nucleus of the thalamus (PO) is in a key ...
Neck Muscle Responses to Stimulation of Monkey Superior
... following text) was delivered on 80 –90% of all trials between 500 and 1,000 ms after the onset of fixation. Stimulation was delivered either while the FP remained visible (fixation trials; 40 – 45% of all trials) or 200 ms after the FP was extinguished (fixation-blink trials, 40 – 45% of all trials ...
... following text) was delivered on 80 –90% of all trials between 500 and 1,000 ms after the onset of fixation. Stimulation was delivered either while the FP remained visible (fixation trials; 40 – 45% of all trials) or 200 ms after the FP was extinguished (fixation-blink trials, 40 – 45% of all trials ...
Understanding the process of multisensory integration
... Understanding the principles by which the brain combines information from different senses provides us with insight into the computational strategies used to maximize their utility. Prior studies of the superior colliculus (SC) neuron as a model suggest that the relative timing with which sensory cu ...
... Understanding the principles by which the brain combines information from different senses provides us with insight into the computational strategies used to maximize their utility. Prior studies of the superior colliculus (SC) neuron as a model suggest that the relative timing with which sensory cu ...
Cholinergic Cells and Pathways
... thalamus, subcortical, and cortical areas, hypothalamus, and limbic nuclei; they identified this system with the ARAS (which therefore corresponds to the Rinaldi-Himwich and Krnjevic pathways) and with the alerting EEG phenomena. The second pathway, the cholinergic limbic system, originates from the ...
... thalamus, subcortical, and cortical areas, hypothalamus, and limbic nuclei; they identified this system with the ARAS (which therefore corresponds to the Rinaldi-Himwich and Krnjevic pathways) and with the alerting EEG phenomena. The second pathway, the cholinergic limbic system, originates from the ...
Independent Functions of Slit–Robo Repulsion and Netrin– Frazzled
... idea that Netrin, secreted by midline cells, signals through DCC (Deleted in Colorectal Carcinoma)/UNC40/Frazzled receptors to attract commissural axons toward and across the midline, whereas Slit signals through Robo family receptors to prevent commissural axons from recrossing the midline, as well ...
... idea that Netrin, secreted by midline cells, signals through DCC (Deleted in Colorectal Carcinoma)/UNC40/Frazzled receptors to attract commissural axons toward and across the midline, whereas Slit signals through Robo family receptors to prevent commissural axons from recrossing the midline, as well ...
Relating normalization to neuronal populations across cortical areas
... sensory, motor, and cognitive processes. In every study where it has been investigated, neurons measured in the same brain area under identical conditions exhibit a range of normalization, ranging from suppression by nonpreferred stimuli (strong normalization) to additive responses to combinations o ...
... sensory, motor, and cognitive processes. In every study where it has been investigated, neurons measured in the same brain area under identical conditions exhibit a range of normalization, ranging from suppression by nonpreferred stimuli (strong normalization) to additive responses to combinations o ...
PDF
... of Slit (mAb C555.6D, 1:300 dilution; Developmental Studies Hybridoma Bank) (Rothberg et al., 1990) was used to visualize extracellular Slit protein Fig. 1. Slit proteolysis during embryogenesis. (A,B) Slit proteolysis during embryogenesis. (A) Developmental western blot of whole embryo lysate probe ...
... of Slit (mAb C555.6D, 1:300 dilution; Developmental Studies Hybridoma Bank) (Rothberg et al., 1990) was used to visualize extracellular Slit protein Fig. 1. Slit proteolysis during embryogenesis. (A,B) Slit proteolysis during embryogenesis. (A) Developmental western blot of whole embryo lysate probe ...
Spinal sympathetic interneurons: Their identification and roles after
... were significantly larger than those of correlated neurons, and they were often larger than the excitatory fields for renal sympathetic nerve activity. Excitatory fields are defined as the area of body surface from which stimulation of sensory receptors evoked excitation of the neuron. Once identified n ...
... were significantly larger than those of correlated neurons, and they were often larger than the excitatory fields for renal sympathetic nerve activity. Excitatory fields are defined as the area of body surface from which stimulation of sensory receptors evoked excitation of the neuron. Once identified n ...
Apparent Loss and Hypertrophy of Interneurons in a Mouse Model
... objective, counting only neurons with a clearly identifiable nucleus. This value was expressed as the number of detectable neurons per section and corrected by the method of Abercrombie (1946). The same sections were examined under a 1003 objective, and measurements of cross-sectional area were made ...
... objective, counting only neurons with a clearly identifiable nucleus. This value was expressed as the number of detectable neurons per section and corrected by the method of Abercrombie (1946). The same sections were examined under a 1003 objective, and measurements of cross-sectional area were made ...
A role for sleep in brain plasticity
... chiasm [47]. These morphological and functional changes in LGN cells are consistent with a delayed maturation of the LGN and suggest that REM sleep activity provides a source of endogenous neuronal activity necessary for normal LGN development. More recent works used various forms of selective REM s ...
... chiasm [47]. These morphological and functional changes in LGN cells are consistent with a delayed maturation of the LGN and suggest that REM sleep activity provides a source of endogenous neuronal activity necessary for normal LGN development. More recent works used various forms of selective REM s ...
Implication of novel neurotransmitter systems in the regulation of
... 2.1. Regulation of reproduction in mammals The adaptive regulation of the hypothalamo-pituitary-gonadal (HPG) axis is crucial in the successful reproduction among the vertebrates. The central unit of this axis is formed by the gonadotropin-releasing hormone (GnRH)-producing neurons which release the ...
... 2.1. Regulation of reproduction in mammals The adaptive regulation of the hypothalamo-pituitary-gonadal (HPG) axis is crucial in the successful reproduction among the vertebrates. The central unit of this axis is formed by the gonadotropin-releasing hormone (GnRH)-producing neurons which release the ...
Molecular and Cellular Mechanisms of Reelin Signaling in the Adult
... The study of Reelin signaling and its role in cortical development is responsible for the large preponderance of known signaling mechanism. For that reason, section one will consist of an overview of cortical development followed by a more specific discussion of major and aspiring players in the Re ...
... The study of Reelin signaling and its role in cortical development is responsible for the large preponderance of known signaling mechanism. For that reason, section one will consist of an overview of cortical development followed by a more specific discussion of major and aspiring players in the Re ...
Modulation of premotor circuits controlling locomotor activity by
... effortless to the point that many movements are almost executed unconsciously. Indeed, the generation of sophisticated motor behaviors relies on the complex interplay between supraspinal brain structures and circuits in the spinal cord. Understanding how the central nervous system generates a large ...
... effortless to the point that many movements are almost executed unconsciously. Indeed, the generation of sophisticated motor behaviors relies on the complex interplay between supraspinal brain structures and circuits in the spinal cord. Understanding how the central nervous system generates a large ...
Examination of Thyrotropin-Releasing Hormone (TRH)
... present in the anterior pituitary, intestine, placenta and thyroid gland [16, 20]. In rats, D1 is also present in the cerebral cortex with relatively low activity, but in humans, D1 is absent from the CNS [21, 22]. The main source of extra-thyroidal T3 is type 2 deiodinase (D2) that converts T4 to T ...
... present in the anterior pituitary, intestine, placenta and thyroid gland [16, 20]. In rats, D1 is also present in the cerebral cortex with relatively low activity, but in humans, D1 is absent from the CNS [21, 22]. The main source of extra-thyroidal T3 is type 2 deiodinase (D2) that converts T4 to T ...
The role of the basal ganglia in reinforcement learning
... in their firing rate when the situation is better than expected (positive surprise). This signal is in accordance with a reinforcement error signal. However, the low tonic discharge rate of the dopaminergic neurons suggests that their capability to encode negative events by suppressing firing rate i ...
... in their firing rate when the situation is better than expected (positive surprise). This signal is in accordance with a reinforcement error signal. However, the low tonic discharge rate of the dopaminergic neurons suggests that their capability to encode negative events by suppressing firing rate i ...
Mechanisms of gustatory coding in Spodoptera littoralis
... Taste is one of the fundamental senses by which animals can detect food sources (sugars, salts, lipids, amino acids) but also noxious compounds dissolved in aqueous solution or adsorbed on surfaces (leaf, cuticle). Unlike olfaction, where only cephalic organs are involved in the detection of volatil ...
... Taste is one of the fundamental senses by which animals can detect food sources (sugars, salts, lipids, amino acids) but also noxious compounds dissolved in aqueous solution or adsorbed on surfaces (leaf, cuticle). Unlike olfaction, where only cephalic organs are involved in the detection of volatil ...
Nonsynaptic plasticity
Nonsynaptic plasticity is a form of neuroplasticity that involves modification of ion channel function in the axon, dendrites, and cell body that results in specific changes in the integration of excitatory postsynaptic potentials (EPSPs) and inhibitory postsynaptic potentials (IPSPs). Nonsynaptic plasticity is a modification of the intrinsic excitability of the neuron. It interacts with synaptic plasticity, but it is considered a separate entity from synaptic plasticity. Intrinsic modification of the electrical properties of neurons plays a role in many aspects of plasticity from homeostatic plasticity to learning and memory itself. Nonsynaptic plasticity affects synaptic integration, subthreshold propagation, spike generation, and other fundamental mechanisms of neurons at the cellular level. These individual neuronal alterations can result in changes in higher brain function, especially learning and memory. However, as an emerging field in neuroscience, much of the knowledge about nonsynaptic plasticity is uncertain and still requires further investigation to better define its role in brain function and behavior.