Neurophysiology - American Physiological Society
... NEU 127. Draw the human audibility curve and explain the changes that occur with aging. NEU 128. Explain the frequency analysis performed by the cochlea on the basis of its physical ...
... NEU 127. Draw the human audibility curve and explain the changes that occur with aging. NEU 128. Explain the frequency analysis performed by the cochlea on the basis of its physical ...
A tale of two stories: astrocyte regulation of
... Activity-dependent modification of synaptic transmission critically moulds the properties of synaptic information transfer with important implications for computation performed by neuronal circuitry [1-4]. Multiple mechanisms could coexist in the same synapse, regulating the strength or the efficacy ...
... Activity-dependent modification of synaptic transmission critically moulds the properties of synaptic information transfer with important implications for computation performed by neuronal circuitry [1-4]. Multiple mechanisms could coexist in the same synapse, regulating the strength or the efficacy ...
The Role of Kv7 in Peripheral Neurons
... The Kv7 (KCNQ) channel is a family of voltage-gated potassium channels that is considered to be important in the regulation of cellular excitability and axonal conduction. Previous studies have shown that peripheral sensory neurons express Kv7.2, Kv7.3, and Kv7.5 subunits, and that suppression of Kv ...
... The Kv7 (KCNQ) channel is a family of voltage-gated potassium channels that is considered to be important in the regulation of cellular excitability and axonal conduction. Previous studies have shown that peripheral sensory neurons express Kv7.2, Kv7.3, and Kv7.5 subunits, and that suppression of Kv ...
THE SUBFORNICAL ORGAN AND AREA POSTREMA MEDIATE
... Chapter 3: RT-PCR was performed with the assistance of Christie Hopf. Immunohistochemistry and pSTAT3 signaling experiments were performed in the laboratory of Keith Sharkey by Adam Chambers and Winnie Ho. In vivo electrophysiology was performed by Dr. Christopher Price. Design, collection, and anal ...
... Chapter 3: RT-PCR was performed with the assistance of Christie Hopf. Immunohistochemistry and pSTAT3 signaling experiments were performed in the laboratory of Keith Sharkey by Adam Chambers and Winnie Ho. In vivo electrophysiology was performed by Dr. Christopher Price. Design, collection, and anal ...
What the young brain tells the spinal cord: top down modulation of
... of spinal sensory networks in young animals. In chapter 2, I demonstrate that cutaneous noxious stimulation activates neurons in regions of the brainstem which receive sensory inputs from the dorsal horn at P4; eight days before noxious-evoked neuronal activation in descending modulatory nuclei. In ...
... of spinal sensory networks in young animals. In chapter 2, I demonstrate that cutaneous noxious stimulation activates neurons in regions of the brainstem which receive sensory inputs from the dorsal horn at P4; eight days before noxious-evoked neuronal activation in descending modulatory nuclei. In ...
Neural Mechanisms of Extinction Learning and Retrieval
... Studies on the neurobiology of extinction have been driven by the well-documented circuitry of conditioned fear. The basolateral amygdala (BLA) associates sensory and shockrelated inputs and influences central nucleus output neurons, which drive fear expression through descending projections (Pare e ...
... Studies on the neurobiology of extinction have been driven by the well-documented circuitry of conditioned fear. The basolateral amygdala (BLA) associates sensory and shockrelated inputs and influences central nucleus output neurons, which drive fear expression through descending projections (Pare e ...
neuronal reward and decision signals: from theories to data
... tip of a microelectrode, one neuron at a time, thousands of them over the years, in rhesus’ brains with more than two billion neurons. I apologize to the authors whose work I have not been able to cite in full, as there is a large number of recent studies on the subject and I am selecting these stud ...
... tip of a microelectrode, one neuron at a time, thousands of them over the years, in rhesus’ brains with more than two billion neurons. I apologize to the authors whose work I have not been able to cite in full, as there is a large number of recent studies on the subject and I am selecting these stud ...
more information
... new tasks and causing a functional frontal lobotomy of those suffering toxicity. Cytochrome P450 Phase I enzyme induction depletes the brain of Glutathione Peroxidase Phase II enzymatic ability to clear hydroperoxynitate free radical. This is cotoxic with MSG, DU and organic acids in new GMO foods t ...
... new tasks and causing a functional frontal lobotomy of those suffering toxicity. Cytochrome P450 Phase I enzyme induction depletes the brain of Glutathione Peroxidase Phase II enzymatic ability to clear hydroperoxynitate free radical. This is cotoxic with MSG, DU and organic acids in new GMO foods t ...
Molecular and Cellular Mechanisms of Reelin Signaling in the Adult
... subset of GABAergic interneurons, we found that their expression was generally juxtaposed, with Dab1 being primarily expressed by principle neurons and a more widespread population of Reelin-negative GABAergic interneurons. While eKO mice exhibited normal forebrain lamination, dendritic architecture ...
... subset of GABAergic interneurons, we found that their expression was generally juxtaposed, with Dab1 being primarily expressed by principle neurons and a more widespread population of Reelin-negative GABAergic interneurons. While eKO mice exhibited normal forebrain lamination, dendritic architecture ...
Orexin/Hypocretin: A Neuropeptide at the Interface of Sleep, Energy
... II. Orexin and orexin receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . A. Identification of orexin (Hypocretin) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . B. Orex ...
... II. Orexin and orexin receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . A. Identification of orexin (Hypocretin) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . B. Orex ...
Histamine in the Nervous System
... bronchi. The presence of histamine in the brain, predominantly in the gray matter, was first shown by Kwiatkowski (1941 (378), and White (1959) (814) demonstrated its formation and catabolism in the brain. The sedative “side effects” of antihistamines (68) triggered early work and suggestions for hi ...
... bronchi. The presence of histamine in the brain, predominantly in the gray matter, was first shown by Kwiatkowski (1941 (378), and White (1959) (814) demonstrated its formation and catabolism in the brain. The sedative “side effects” of antihistamines (68) triggered early work and suggestions for hi ...
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... motor programs elicited in this manner are predominantly ingestive (Susswein et al., 1996) and are likely to be biting motor programs (Rosen et al., 1997). During carbachol-elicited programs we found that bursts of activity in B66 were out-of-phase with bursts of activity in B4/5 and out-of-phase wi ...
... motor programs elicited in this manner are predominantly ingestive (Susswein et al., 1996) and are likely to be biting motor programs (Rosen et al., 1997). During carbachol-elicited programs we found that bursts of activity in B66 were out-of-phase with bursts of activity in B4/5 and out-of-phase wi ...
thesis - ETDA
... excessive excitatory input, perhaps too little inhibitory input is given, or a combination of both. Balance between excitation and inhibition is a crucial role the basal ganglia exerts on the motor cortex through the thalamus, which itself influences the cortex in an excitatory manner. Inhibition of ...
... excessive excitatory input, perhaps too little inhibitory input is given, or a combination of both. Balance between excitation and inhibition is a crucial role the basal ganglia exerts on the motor cortex through the thalamus, which itself influences the cortex in an excitatory manner. Inhibition of ...
Anatomy & Physiology I
... the pen remains still, they will stop firing almost right away. The Merkel’s and Ruffini endings will continue to fire to let you know that something is still there. ...
... the pen remains still, they will stop firing almost right away. The Merkel’s and Ruffini endings will continue to fire to let you know that something is still there. ...
Rapid Translocation of Zn 2+ from Nerve Terminals
... and Christopher J. Frederickson. Rapid translocation of Zn2⫹ from presynaptic terminals into postsynaptic hippocampal neurons after physiological stimulation. J Neurophysiol 86: 2597–2604, 2001. Zn2⫹ is found in glutamatergic nerve terminals throughout the mammalian forebrain and has diverse extrace ...
... and Christopher J. Frederickson. Rapid translocation of Zn2⫹ from presynaptic terminals into postsynaptic hippocampal neurons after physiological stimulation. J Neurophysiol 86: 2597–2604, 2001. Zn2⫹ is found in glutamatergic nerve terminals throughout the mammalian forebrain and has diverse extrace ...
Structure and dynamics of the corticothalamic driver pathway in the
... environment, processing and analyzing those signals, store and retrieve memories, decide on appropriate behavior and finally coordinate the muscular contractions for an appropriate behavioral response. Accordingly, the brain is an equally complex structure and we therefore are still at the beginning ...
... environment, processing and analyzing those signals, store and retrieve memories, decide on appropriate behavior and finally coordinate the muscular contractions for an appropriate behavioral response. Accordingly, the brain is an equally complex structure and we therefore are still at the beginning ...
Previous results from our laboratory have shown that administration
... There are many people I want to thank for helping me through this process and making this dissertation possible. First I want to thank my advisor Dr. Jaime DiazGranados for his help and support throughout my graduate career. Without his willingness to indulge my drive to try new methods, and his fai ...
... There are many people I want to thank for helping me through this process and making this dissertation possible. First I want to thank my advisor Dr. Jaime DiazGranados for his help and support throughout my graduate career. Without his willingness to indulge my drive to try new methods, and his fai ...
MODELING THE MIRROR: GRASP LEARNING AND ACTION
... DEDICATION ........................................................................................................................... ii ACKNOWLEDGEMENTS .....................................................................................................iii ...
... DEDICATION ........................................................................................................................... ii ACKNOWLEDGEMENTS .....................................................................................................iii ...
Interaction of the Frontal Eye Field and Superior Colliculus for
... extent of SC neurons activated by FEF stimulation (Fig. 1A), which produces a horizontal 10° saccade, is represented by the dark gray circle on the SC movement map. The extent of a hypothetical lidocaine injection made at the same location on the SC map (Fig. 1B) is represented by the light gray cir ...
... extent of SC neurons activated by FEF stimulation (Fig. 1A), which produces a horizontal 10° saccade, is represented by the dark gray circle on the SC movement map. The extent of a hypothetical lidocaine injection made at the same location on the SC map (Fig. 1B) is represented by the light gray cir ...
Neural mechanism of rapid eye movement sleep generation
... seconds) and the total percentage of time spent in such a state is less as compared to mammalian REM sleep (about 5% of the total sleep time as compared to 15-30 % in mammals)19. Further, unlike mammalian REM sleep, there is no rebound increase in the REM sleep-like state in birds following its depr ...
... seconds) and the total percentage of time spent in such a state is less as compared to mammalian REM sleep (about 5% of the total sleep time as compared to 15-30 % in mammals)19. Further, unlike mammalian REM sleep, there is no rebound increase in the REM sleep-like state in birds following its depr ...
Implication of novel neurotransmitter systems in the regulation of
... the olfactory placodes (9) and migrate to their final location during the embryonic life. In addition to these data from mice, results of other experiments performed in chicks (10), rhesus macaques (11), rats (12) and humans (13) indicate that the olfactory origin of GnRH neurons is a general phenom ...
... the olfactory placodes (9) and migrate to their final location during the embryonic life. In addition to these data from mice, results of other experiments performed in chicks (10), rhesus macaques (11), rats (12) and humans (13) indicate that the olfactory origin of GnRH neurons is a general phenom ...
Might the olfactory bulb be an origin of olfactory auras in focal
... Synaptic glomeruli exhibit less synaptophysin expression at 16 weeks than at older gestational ages; all are reactive by term. Calretinin, by contrast, is not yet expressed in most of the synaptic glomeruli at mid-gestation, but is strong in the primary olfactory nerve axons forming layer 1 (Sarnat ...
... Synaptic glomeruli exhibit less synaptophysin expression at 16 weeks than at older gestational ages; all are reactive by term. Calretinin, by contrast, is not yet expressed in most of the synaptic glomeruli at mid-gestation, but is strong in the primary olfactory nerve axons forming layer 1 (Sarnat ...
Targeting of Monomer/Misfolded SOD1 as a Therapeutic Strategy for
... analyses using hindlimb stride length as an index of motor function was also performed. Mice vaccinated with SEDI peptide had significant improvements in walking patterns compared with controls (Fig. 1D,E). Mice were monitored for disease onset, as defined by a 20% reduction in rotarod performance. ...
... analyses using hindlimb stride length as an index of motor function was also performed. Mice vaccinated with SEDI peptide had significant improvements in walking patterns compared with controls (Fig. 1D,E). Mice were monitored for disease onset, as defined by a 20% reduction in rotarod performance. ...
Full-Text PDF
... The vast majority of prothrombin is produced in the liver and released into the plasma. It circulates within the bloodstream until it is converted into mature thrombin in the the coagulation cascade [10]. Thrombin is a large, spherical molecule, with a major groove around its equatorial axis, that i ...
... The vast majority of prothrombin is produced in the liver and released into the plasma. It circulates within the bloodstream until it is converted into mature thrombin in the the coagulation cascade [10]. Thrombin is a large, spherical molecule, with a major groove around its equatorial axis, that i ...
stimulant treatment history predicts frontal-striatal
... stimulant treatment has been intense, especially after the large-‐scale MTA consortium reported that, in the long term, stimulant treatment was not superior compared to behavioral treatment or even to community care (Jensen et al., 2007; M ...
... stimulant treatment has been intense, especially after the large-‐scale MTA consortium reported that, in the long term, stimulant treatment was not superior compared to behavioral treatment or even to community care (Jensen et al., 2007; M ...