Serotonin synthesis, release and reuptake in terminals: a
... Traditionally, serotonin (5-HT) has been associated to a wide variety of behaviors including feeding and body-weight regulation, social hierarchies, aggression and suicidality, obsessive compulsive disorder, alcoholism, anxiety, and affective disorders[1]. In addition, 5-HT has been linked to motor ...
... Traditionally, serotonin (5-HT) has been associated to a wide variety of behaviors including feeding and body-weight regulation, social hierarchies, aggression and suicidality, obsessive compulsive disorder, alcoholism, anxiety, and affective disorders[1]. In addition, 5-HT has been linked to motor ...
to the Proceedings
... synapses, and mCherry-PSD-95 to label excitatory synapses. We simultaneously tracked the daily dynamics of both synapse types using spectrally resolved two-photon microscopy. We found that aside from the lower magnitude of excitatory synaptic changes in the adult, as compared to inhibitory ones, exc ...
... synapses, and mCherry-PSD-95 to label excitatory synapses. We simultaneously tracked the daily dynamics of both synapse types using spectrally resolved two-photon microscopy. We found that aside from the lower magnitude of excitatory synaptic changes in the adult, as compared to inhibitory ones, exc ...
Structure and Function of the Brain Serotonin System
... around and within the caudal and lateral aspects of the interpeduncular nucleus. Caudally, the ventral border of this group is the trapezoid body, and the dorsal border fuses with the ventromedial (interfascicular) component of the DRN. In cats the MRN begins as a single cluster of cells at the leve ...
... around and within the caudal and lateral aspects of the interpeduncular nucleus. Caudally, the ventral border of this group is the trapezoid body, and the dorsal border fuses with the ventromedial (interfascicular) component of the DRN. In cats the MRN begins as a single cluster of cells at the leve ...
Corticotropin-Releasing Hormone Directly Activates Noradrenergic
... Data analysis. The membrane potential was defined as the change in the electrode potential after withdrawal of the electrode from the membrane. Action potential threshold was defined as the potential at which the greatest change in slope of the membrane potential occurred, which was determined from ...
... Data analysis. The membrane potential was defined as the change in the electrode potential after withdrawal of the electrode from the membrane. Action potential threshold was defined as the potential at which the greatest change in slope of the membrane potential occurred, which was determined from ...
Shape Selectivity in Primate Frontal Eye Field
... decades of research within different disciplines, including neuropsychology, animal lesion studies, neuroanatomy, neurophysiology, and computational modeling, a consensus has emerged suggesting that shape and other aspects of object processing are largely segregated in the brain from spatial process ...
... decades of research within different disciplines, including neuropsychology, animal lesion studies, neuroanatomy, neurophysiology, and computational modeling, a consensus has emerged suggesting that shape and other aspects of object processing are largely segregated in the brain from spatial process ...
Insula function in anorexia nervosa
... analyze different regions of the brain for connectivity in humans in vivo. fMRI measures the changes in blood flow which is related to neuronal activity in the brain or spinal cord. Since then fMRI has become the most used method for brain mapping due to its low invasiveness, no radiation exposure a ...
... analyze different regions of the brain for connectivity in humans in vivo. fMRI measures the changes in blood flow which is related to neuronal activity in the brain or spinal cord. Since then fMRI has become the most used method for brain mapping due to its low invasiveness, no radiation exposure a ...
Topographical organization of the pedunculopontine nucleus
... pars dissipata (rostral) and pars compacta (caudal) on the basis of the density of cholinergic neurons (Olszewski and Baxter, 1982), which were believed to be the most representative, if not the only, neuronal type in the PPN (Rye et al., 1987). Other subdivisions included rostral, middle, and cauda ...
... pars dissipata (rostral) and pars compacta (caudal) on the basis of the density of cholinergic neurons (Olszewski and Baxter, 1982), which were believed to be the most representative, if not the only, neuronal type in the PPN (Rye et al., 1987). Other subdivisions included rostral, middle, and cauda ...
Distinct Roles for Somatically and Dendritically Synthesized Brain
... whereas long 3⬘ UTR Bdnf mRNA is also trafficked to dendrites for local translation. Mutant mice lacking long 3⬘ UTR Bdnf mRNA display normal spines at 3 weeks of age, but thinner and denser spines in adults compared to wild-type littermates. These observations suggest that BDNF translated from long ...
... whereas long 3⬘ UTR Bdnf mRNA is also trafficked to dendrites for local translation. Mutant mice lacking long 3⬘ UTR Bdnf mRNA display normal spines at 3 weeks of age, but thinner and denser spines in adults compared to wild-type littermates. These observations suggest that BDNF translated from long ...
Word - Review of Disability Studies: An International Journal
... educational and public welfare practices. Understanding the social and cultural contingency of autism permits a more experimental approach toward institutions that can accommodate and be shaped by the diversity of modes of mental processing, communication and socialization that autism presents. Key ...
... educational and public welfare practices. Understanding the social and cultural contingency of autism permits a more experimental approach toward institutions that can accommodate and be shaped by the diversity of modes of mental processing, communication and socialization that autism presents. Key ...
Five Sources of a Dorsal Root Potential: Their Interactions and
... the response of interneurons during evoked DRPs or tonic DRPs (Wall 1995) or spontaneous variations of the DRP (Lidierth and Wall 1996). This paper supplements the previous work of many others in three ways: it compares DRPs produced from five sources, it examines their interactions, and it defines ...
... the response of interneurons during evoked DRPs or tonic DRPs (Wall 1995) or spontaneous variations of the DRP (Lidierth and Wall 1996). This paper supplements the previous work of many others in three ways: it compares DRPs produced from five sources, it examines their interactions, and it defines ...
Vestibular Signals in the Parasolitary Nucleus
... the vestibular complex. Vestibular primary afferents also project to the uvula-nodulus of the cerebellum where they terminate on granule cells. In this report we describe the physiological properties of neurons in a “new” vestibular nucleus, the parasolitary nucleus (Psol). This nucleus consists of ...
... the vestibular complex. Vestibular primary afferents also project to the uvula-nodulus of the cerebellum where they terminate on granule cells. In this report we describe the physiological properties of neurons in a “new” vestibular nucleus, the parasolitary nucleus (Psol). This nucleus consists of ...
The natural hallucinogen 5-MeO-DMT, component of Ayahuasca
... 5-MeO-DMT, respectively, with significant post-hoc differences between 5-MeO-DMT and saline in all posttreatment periods (Fig. 2). Since hallucinogenic drugs are known to have clear effects on the autonomic nervous system and blood pressure (McCall et al., 1987; McCall and Harris, 1988). In order to ...
... 5-MeO-DMT, respectively, with significant post-hoc differences between 5-MeO-DMT and saline in all posttreatment periods (Fig. 2). Since hallucinogenic drugs are known to have clear effects on the autonomic nervous system and blood pressure (McCall et al., 1987; McCall and Harris, 1988). In order to ...
Proopiomelanocortin Neurons in Nucleus Tractus Solitarius Are
... integral to the regulation of feeding, such as the hypothalamus, amygdala, and nucleus accumbens (Schwartz, 2000; Broberger and Hokfelt, 2001). The medial NTS, in which NTS POMC neurons are concentrated, contains highly fenestrated endothelial cells providing a permeant blood– brain barrier (Gross e ...
... integral to the regulation of feeding, such as the hypothalamus, amygdala, and nucleus accumbens (Schwartz, 2000; Broberger and Hokfelt, 2001). The medial NTS, in which NTS POMC neurons are concentrated, contains highly fenestrated endothelial cells providing a permeant blood– brain barrier (Gross e ...
Glycine Binding Sites of Presynaptic NMDA Receptors May
... Whole cell mEPSCs recordings were performed on 58 pyramidal neurons in layer II/III of the visual cortical slices. Spontaneous mEPSCs in the presence of TTX (0.5 M), strychnine (1 M), and picrotoxin (100 M) were abolished by application of D-APV (50 M) and CNQX (10 M) in the Mg-free ACSF (data ...
... Whole cell mEPSCs recordings were performed on 58 pyramidal neurons in layer II/III of the visual cortical slices. Spontaneous mEPSCs in the presence of TTX (0.5 M), strychnine (1 M), and picrotoxin (100 M) were abolished by application of D-APV (50 M) and CNQX (10 M) in the Mg-free ACSF (data ...
Blood-Spinal Cord Barrier Alterations in Subacute and Chronic
... model (28). Recently, we showed BBB alterations not only in the ipsilateral hemisphere, but also in contralateral brain areas, 7 and 30 days after tMCAO in rats, indicating subacute and chronic ischemic diaschisis (29, 30). Damaged ECs containing numerous autophagosomes and vascular leakage were ide ...
... model (28). Recently, we showed BBB alterations not only in the ipsilateral hemisphere, but also in contralateral brain areas, 7 and 30 days after tMCAO in rats, indicating subacute and chronic ischemic diaschisis (29, 30). Damaged ECs containing numerous autophagosomes and vascular leakage were ide ...
Resonance properties of different neuronal populations in the
... sinks in region CA1 and dentate gyrus. Current source density analysis from the local field potential supports the model of phases of encoding and retrieval. The phasic changes in current sinks result from the synaptic transmissions. In vitro studies revealed that stimulation on the peak of theta wa ...
... sinks in region CA1 and dentate gyrus. Current source density analysis from the local field potential supports the model of phases of encoding and retrieval. The phasic changes in current sinks result from the synaptic transmissions. In vitro studies revealed that stimulation on the peak of theta wa ...
Frontal Eye Field Sends Delay Activity Related to Movement
... sent from the FEF to the SC contributes to several different functions during saccade generation. Moreover, these results provide the first detailed description of delay activity identified as leaving any part of the prefrontal cortex. We hypothesize that a major, general way in which prefrontal cor ...
... sent from the FEF to the SC contributes to several different functions during saccade generation. Moreover, these results provide the first detailed description of delay activity identified as leaving any part of the prefrontal cortex. We hypothesize that a major, general way in which prefrontal cor ...
Understanding Circuit Dynamics Using the Stomatogastric Nervous
... of easily identifiable neurons allowed the establishment of connectivity diagrams among the neurons of the stomatogastric ganglion. We now know that (a) neuromodulatory substances reconfigure circuit dynamics by altering synaptic strength and voltage-dependent conductances and (b) individual neurons c ...
... of easily identifiable neurons allowed the establishment of connectivity diagrams among the neurons of the stomatogastric ganglion. We now know that (a) neuromodulatory substances reconfigure circuit dynamics by altering synaptic strength and voltage-dependent conductances and (b) individual neurons c ...
Gamma Oscillations in the Hippocampus
... lesioned animals than in control animals, and the maximal gamma power shifted to CA1 with large excitatory currents appearing in stratum radiatum, a layer that receives CA3 projections. Additional support for an entorhinal generator of hippocampal gamma oscillations was provided by CSD studies in pa ...
... lesioned animals than in control animals, and the maximal gamma power shifted to CA1 with large excitatory currents appearing in stratum radiatum, a layer that receives CA3 projections. Additional support for an entorhinal generator of hippocampal gamma oscillations was provided by CSD studies in pa ...
A role for subplate neurons in the patterning of
... Subplate neurons can be deleted by injections of kainic acid into the subplate at E43. The vast majority of later-generated neurons of the cortical plate remain intact (Chun and Shatz, 1988b), presumably because at these early ages they are sufficiently immature to be insensitive to kainate neurotox ...
... Subplate neurons can be deleted by injections of kainic acid into the subplate at E43. The vast majority of later-generated neurons of the cortical plate remain intact (Chun and Shatz, 1988b), presumably because at these early ages they are sufficiently immature to be insensitive to kainate neurotox ...
Supplementary Information (doc 1146K)
... selection (t-test) and leave-one-out cross validation was used. During each iteration of leaveone-out cross validation (primary sample), one subject was withheld from the dataset and 1) a 2-sample t-test was performed over the remaining training data 2) the features were ranked by absolute t-score a ...
... selection (t-test) and leave-one-out cross validation was used. During each iteration of leaveone-out cross validation (primary sample), one subject was withheld from the dataset and 1) a 2-sample t-test was performed over the remaining training data 2) the features were ranked by absolute t-score a ...
Graziano's CV
... Graziano MSA and Aflalo TN (2007) Rethinking cortical organization: Moving away from discrete areas arranged in hierarchies. The Neuroscientist, 13: 138-147. Aflalo TN and Graziano MSA (2007) Relationship between unconstrained arm movement and single neuron firing in the macaque motor cortex. Journ ...
... Graziano MSA and Aflalo TN (2007) Rethinking cortical organization: Moving away from discrete areas arranged in hierarchies. The Neuroscientist, 13: 138-147. Aflalo TN and Graziano MSA (2007) Relationship between unconstrained arm movement and single neuron firing in the macaque motor cortex. Journ ...
Prefrontal Projections to the Thalamic Reticular Nucleus
... TRN connection zones of nearby cortical or thalamic sites overlap, allowing indirect modulation of TRN inhibition. The activity of TRN changes dramatically during the sleep– wake cycle, shifting from spindle oscillations during slow-wave sleep that inhibit thalamocortical activity, to single-spike a ...
... TRN connection zones of nearby cortical or thalamic sites overlap, allowing indirect modulation of TRN inhibition. The activity of TRN changes dramatically during the sleep– wake cycle, shifting from spindle oscillations during slow-wave sleep that inhibit thalamocortical activity, to single-spike a ...
$doc.title
... preparatory activity of neuronal ensembles within the FEF while a monkey played an oculomotor version of the mixed-‐strategy game ‘matching-‐pennies’. Each trial began with fixation on a central visual stimulu ...
... preparatory activity of neuronal ensembles within the FEF while a monkey played an oculomotor version of the mixed-‐strategy game ‘matching-‐pennies’. Each trial began with fixation on a central visual stimulu ...
Multimodal Integration in Rostral Fastigial Nucleus Provides an
... from each other. Note that only data for which the firing rate was ⬎20 sp/s were included in the optimization. To determine whether each individual cell was better fit with the vestibular or summation model linear regression analyses were used to fit both models. To evaluate how well these models fi ...
... from each other. Note that only data for which the firing rate was ⬎20 sp/s were included in the optimization. To determine whether each individual cell was better fit with the vestibular or summation model linear regression analyses were used to fit both models. To evaluate how well these models fi ...