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Anatomy of the Nervous System I. Cells Four functions of neurons 1. Receive and integrate inputs dendrites, soma 2. Generate a nerve impulse (action potential) axon hillock 3. Conduct the action potential axon 4. Transmit information to target cell (neuron, muscle, gland) nerve terminals Dendrites and cell body Receive and integrate inputs Axon hillock and initial segment Generate action potentials Axon Conducts action potential Terminals Synaptic transmission receives and integrates inputs Axon hillock Generates action potential Conducts action potential Transmit to target cell Classifications of Neurons 1. Function 2. Structure 3. Shape 4. Effect 5. Axon length 6. Neurochemical identity Classifications of Neurons 1. Function a. sensory neurons b. motoneurons c. interneurons Classifications of Neurons 1. Function 2. Structure a. unipolar b. bipolar c. multipolar A B 100μm Classifications of Neurons 1. Function 2. Structure 3. Shape e.g., pyramidal, stellate, basket, granule, etc. Classifications of Neurons 1. Function 2. Structure 3. Shape 4. Effect a. excitatory neurons b. inhibitory neurons Classifications of Neurons 1. Function 2. Structure 3. Shape 4. Effect 5. Axon length a. projection neurons (Golgi Type I) b. local neurons (Golgi Type II) Classifications of Neurons 1. Function 2. Structure 3. Shape 4. Effect 5. Axon length 6. Neurochemical identity e.g., cholinergic, dopaminergic, GABAergic, etc. Classifications of Neurons 1. Function 2. Structure 3. Shape 4. Effect 5. Axon length 6. Neurochemical identity Types of glial cells 1. Astrocytes 2. Microglia 3. Oligodendroglia 4. Schwann cells Types of glial cells 1. Astrocytes a. mechanical support b. metabolic support transport nutrients and wastes c. encapsulate synapses d. regulate chemical and ionic environment e. form scar tissue f. act as phagocytes Types of glial cells 1. Astrocytes 2. Microglia a. act as phagocytes b. part of brain’s immune system Types of glial cells 1. Astrocytes 2. Microglia 3. Oligodendroglia myelinate axons of central nervous system Types of glial cells 1. Astrocytes 2. Microglia 3. Oligodendroglia 4. Schwann cells myelinate axons of peripheral nervous system II. Gross Anatomy Directional Terms Rostral toward the nose Caudal toward the tail Dorsal toward the back Ventral toward the belly Medial toward the midline Lateral away from the midline Proximal near a point of reference Distal distant from a point of reference Directional Terms Afferent projecting toward Efferent projecting away from Ipsilateral on the same side Contralateral on the opposite side Planes of Section Coronal or frontal perpendicular to the neuraxis perpendicular to ground apply only to brain Sagittal parallel to neuraxis perpendicular to ground midsagittal = axis of symmetry Horizontal parallel to ground parallel to neuraxis applies only to brain Transverse perpendicular to neuraxis applies to brain and spinal cord Oblique any section not in a standard plane (intermediate gray) A. Cervical spinal cord B. Thoracic spinal cord C. Lumbar spinal cord D. Lumbo-sacral spinal cord Autonomic Nervous System (ANS) Sympathetic division (arousal) Parasympathetic division (maintenance) Prosencephalon = diencephalon + telencephalon Mesencephalon = tegmentum + tectum Rhombencephalon = metencephalon (pons, + cerebellum) + myelencephalon (medulla) SYSTEM NERVORUM CENTRALE (Central nervous system) I. ENCEPHALON (brain) A. PROSENCEPHALON (forebrain) 1. TELENCEPHALON (endbrain; limbic system, basal ganglia & cerebral cortex) 2. DIENCEPHALON (between-brain, or interbrain; hypothalamus & thalamus) B. MESENCEPHALON (midbrain; tectum & tegmentum) C. RHOMBENCEPHALON (hindbrain) 1. METENCEPHALON (pons & cerebellum) 2. MYELENCEPHALON (medulla oblongata) II. MEDULLA SPINALIS (spinal cord) Notes: "BRAINSTEM" is an imprecisely defined term which usually refers to the rhombencephalon and mesencephalon together. It may or may not include the cerebellum, and sometimes the diencephalon is included. "CEREBRUM" or "CEREBRAL HEMISHPHERES" refer to the telencephalon.