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Transcript
The medium spiny neurons in the striatum have extrinsic and intrinsic inputs. Glutamatergic inputs from the cerebral cortex and dopaminergic inputs from the substantia nigra pars compacta terminate on dendritic spines of medium spiny neurons. The reward-related dopaminergic inputs are thought to modulate the strength of cortical inputs and to play a role in synaptic changes and reinforcement learning in the striatum. Glutamatergic inputs from the thalamus end on the spines and shafts of dendrites of medium spiny neurons. Medium spiny neurons also receive cholinergic and GABAergic input from interneurons in the striatum. Source: The Basal Ganglia, Principles of Neural Science, Fifth Editon Citation: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, Mack S. Principles of Neural Science, Fifth Editon; 2012 Available at: http://mhmedical.com/ Accessed: April 30, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved
