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The neurotransmitter phenotype of central neurons is controlled by basic helix-loop-helix transcription factors. A. In the cerebral cortex GABAergic and glutamatergic neurons derive from different proliferative zones and are specified by different basic helix-loop-helix (bHLH) transcription factors. Glutamatergic pyramidal neurons derive from the cortical ventricular zone, and their differentiation depends on the activities of neurogenin-1 and -2. The differentiation of GABAergic interneurons in the ganglionic eminences of the ventral telencephalon depends on the bHLH protein Mash1. These neurons migrate dorsally to supply the cerebral cortex with most of its inhibitory interneurons (see Figure 53–8). B. In the developing cerebellum and GABAergic glutamatergic neurons also derive fromFifth different Source: Differentiation Survival and of Nerve Cells, Principles of Neural Science, Editon proliferative zones and are specified by bHLH transcription factors. Glutamatergic granule cells migrate into the cerebellum from the rhombic lip, settle in the inner granular layer (IGL), and are specified Citation: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, Mack S. Principles of Neural Science, Fifth Editon; 2012 Available by the bHLH protein Math-1. GABAergic Purkinje neurons migrate from the deep cerebellar proliferative zone, settle in the Purkinje cell layer (PCL), and at: http://mhmedical.com/ Accessed: May 10, 2017 are specified by the bHLH protein Ptf1a. Copyright © 2017 McGraw-Hill Education. All rights reserved