PDF - Retrovirology
... primarily by interfering with Vif ’s ability to induce degradation of the A3 proteins [4, 5, 9]. HIV-1 Vif associates with CBFβ in human cells and recombinant CBFβ
enhances Vif ’s solubility, stability, and association with an
E3 ubiquitin ligase complex [9, 10, 12–14]. Initially, the
interaction in ...