Laalami S., Zig L. and H. Putzer - Institut de Biologie Physico
... the 3′ end on a large scale (see below). Indeed, this would be a biologically inefficient and wasteful process that accumulates incomplete polypeptides from truncated mRNAs. The mechanisms by which transcripts are degraded obviously depend on the enzymes available in a given organism. Interestingly, ...
... the 3′ end on a large scale (see below). Indeed, this would be a biologically inefficient and wasteful process that accumulates incomplete polypeptides from truncated mRNAs. The mechanisms by which transcripts are degraded obviously depend on the enzymes available in a given organism. Interestingly, ...
Calcium at Fertilization and in Early Development
... phosphoinositide/calcium signaling during resumption of meiosis. Changes to the calcium signaling machinery occur during meiosis to enable the production of a calcium wave in the mature oocyte when it is fertilized; evidence that the shape and structure of the endoplasmic reticulum alters dynamicall ...
... phosphoinositide/calcium signaling during resumption of meiosis. Changes to the calcium signaling machinery occur during meiosis to enable the production of a calcium wave in the mature oocyte when it is fertilized; evidence that the shape and structure of the endoplasmic reticulum alters dynamicall ...
The cell biology of major histocompatibility complex class
... with MHC I molecules and facilitates peptide loading (30). Interaction of ERp57 with both tapasin and calreticulin may strengthen the individually weak interactions that exist between these chaperones and MHC I molecules. However, all might not be quite so simple: Zhang et al. showed that ERp57 requ ...
... with MHC I molecules and facilitates peptide loading (30). Interaction of ERp57 with both tapasin and calreticulin may strengthen the individually weak interactions that exist between these chaperones and MHC I molecules. However, all might not be quite so simple: Zhang et al. showed that ERp57 requ ...
two types of titin interactions lead to an asymmetrical sorting of actinin
... spectrin-like repeats (slrs) and a single site on titin. We also demonstrate that the central Z-repeats of titin can interact equally with the C-terminal domain of α-actinin, similarly to the flanking repeats. These interactions control the assembly of ternary complexes of titin, α-actinin and actin ...
... spectrin-like repeats (slrs) and a single site on titin. We also demonstrate that the central Z-repeats of titin can interact equally with the C-terminal domain of α-actinin, similarly to the flanking repeats. These interactions control the assembly of ternary complexes of titin, α-actinin and actin ...
Sample pages 1 PDF
... The investigation of plant myosin had begun from attempting to elucidate the molecular mechanism of characean cytoplasmic streaming [82]. In 1970–1990, several proteins with ATPase activities had been isolated biochemically and reported as plant myosins (cited in [84]). However, none of these result ...
... The investigation of plant myosin had begun from attempting to elucidate the molecular mechanism of characean cytoplasmic streaming [82]. In 1970–1990, several proteins with ATPase activities had been isolated biochemically and reported as plant myosins (cited in [84]). However, none of these result ...
Cooperative and independent functions of FGF and Wnt signaling
... increases in size in Spry1 and Spry2 compound mutant embryos, the size of the Wnt-reporter-positive domain does not increase to the same extent as the Wnt-reporter-negative domain. Conclusions: This study provides genetic evidence that FGF and Wnt signaling cooperate during early inner ear developme ...
... increases in size in Spry1 and Spry2 compound mutant embryos, the size of the Wnt-reporter-positive domain does not increase to the same extent as the Wnt-reporter-negative domain. Conclusions: This study provides genetic evidence that FGF and Wnt signaling cooperate during early inner ear developme ...
Ferritin and ferritin isoforms I: Structure–function relationships, synthesis, degradation and secretion
... subunit interactions. There are a large number of inter-subunit interactions that form regions of marked hydrophobicity and other regions where polar interactions predominate (Ford et al., 1984). If these hydrophobic residues are to be partially buried from solvent then further assembly of dimers mu ...
... subunit interactions. There are a large number of inter-subunit interactions that form regions of marked hydrophobicity and other regions where polar interactions predominate (Ford et al., 1984). If these hydrophobic residues are to be partially buried from solvent then further assembly of dimers mu ...
Aqua-BioSci. Monogr. (ABSM), Vol. 1, No. 2, pp. 1–57 (2008)
... medium contains 11 mM glucose, 20 kinds of amino acids, some kinds of vitamins and inorganic salts. Isolated hepatocytes are necessary to attach the surface of culture dishes for culture. However, eel hepatocytes are difficult to attach and the dishes precoated with fibronectin or poly L-lysine must ...
... medium contains 11 mM glucose, 20 kinds of amino acids, some kinds of vitamins and inorganic salts. Isolated hepatocytes are necessary to attach the surface of culture dishes for culture. However, eel hepatocytes are difficult to attach and the dishes precoated with fibronectin or poly L-lysine must ...
Comparison of induction during development between Xenopus
... into specific tissues via the expression of tissue-specific genes in a tightly controlled temporal and dose-dependent manner (Ariizumi et al., 1991, Green et al., 1992, Gurdon et al., 1999, Smith, 1993, Smith et al., 1991). There have been many developmental studies of morphogen gradients and axes p ...
... into specific tissues via the expression of tissue-specific genes in a tightly controlled temporal and dose-dependent manner (Ariizumi et al., 1991, Green et al., 1992, Gurdon et al., 1999, Smith, 1993, Smith et al., 1991). There have been many developmental studies of morphogen gradients and axes p ...
2014 Novel Therapeutic Targets in the Management of Atrial
... NH2-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK).[25] In a mouse model, an increase in the production of Ang II by rapid electrical stimulation was found to be associated with increased expression of connexin 43 (Cx43). This effect was also associated with upregulation of MA ...
... NH2-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK).[25] In a mouse model, an increase in the production of Ang II by rapid electrical stimulation was found to be associated with increased expression of connexin 43 (Cx43). This effect was also associated with upregulation of MA ...
375 Na+/Ca2+ ANTIPORT IN THE MAMMALIAN HEART
... striking similarity to the canine heart antiporter (>90 % amino acid identity). Cardiac-type antiporters have also been cloned from brain, kidney and smooth muscle (see Nakasaki et al. 1993; Kofuji et al. 1994). They each show extensive homology with the canine antiporter and differ primarily within ...
... striking similarity to the canine heart antiporter (>90 % amino acid identity). Cardiac-type antiporters have also been cloned from brain, kidney and smooth muscle (see Nakasaki et al. 1993; Kofuji et al. 1994). They each show extensive homology with the canine antiporter and differ primarily within ...
Human Eosinophils from Transport-Mediated Release of Preformed
... in allergen-induced cutaneous late-phase reactions in atopic subjects (15, 19), human blood-derived eosinophils are a major potential source of IL-4. Because eosinophils contain preformed IL-4, the mechanisms to mobilize IL-4 from specific granule storage sites for its extracellular release need to ...
... in allergen-induced cutaneous late-phase reactions in atopic subjects (15, 19), human blood-derived eosinophils are a major potential source of IL-4. Because eosinophils contain preformed IL-4, the mechanisms to mobilize IL-4 from specific granule storage sites for its extracellular release need to ...
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... Tie1 is an endothelial receptor tyrosine kinase that is essential for development and maintenance of the vascular system; however, the role of Tie1 in development of the lymphatic vasculature is unknown. To address this question, we first documented that Tie1 is expressed at the earliest stages of l ...
... Tie1 is an endothelial receptor tyrosine kinase that is essential for development and maintenance of the vascular system; however, the role of Tie1 in development of the lymphatic vasculature is unknown. To address this question, we first documented that Tie1 is expressed at the earliest stages of l ...
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... the absence of PTHrP signaling, upregulation of Ihh signaling accelerates chondrocyte hypertrophy at an early stage of long bone development in vivo. Next, we tested whether Ihh signals directly to the chondrocytes in a PTHrP-independent manner to regulate chondrocyte hypertrophy. We have previously ...
... the absence of PTHrP signaling, upregulation of Ihh signaling accelerates chondrocyte hypertrophy at an early stage of long bone development in vivo. Next, we tested whether Ihh signals directly to the chondrocytes in a PTHrP-independent manner to regulate chondrocyte hypertrophy. We have previously ...
store-operated calcium channels
... (129) made it possible to detect Ca2⫹ release in response to TG added in the absence of extracellular Ca2⫹ followed by Ca2⫹ entry through SOCs after subsequent readdition of Ca2⫹. These kinds of experiments led to an avalanche of reports of SOCE in diverse cell types, primarily nonexcitable cells (o ...
... (129) made it possible to detect Ca2⫹ release in response to TG added in the absence of extracellular Ca2⫹ followed by Ca2⫹ entry through SOCs after subsequent readdition of Ca2⫹. These kinds of experiments led to an avalanche of reports of SOCE in diverse cell types, primarily nonexcitable cells (o ...
Development of in vitro procedures that can predict the safety of
... pre-clinical safety tests that can better predict the toxicity of immunomodulatory mAbs, such as TGN1412, are required. The aim of this study was to investigate the hypothesis that cytokinedriven adverse effects of therapeutic monoclonal antibodies and the mechanisms involved can be better predicted ...
... pre-clinical safety tests that can better predict the toxicity of immunomodulatory mAbs, such as TGN1412, are required. The aim of this study was to investigate the hypothesis that cytokinedriven adverse effects of therapeutic monoclonal antibodies and the mechanisms involved can be better predicted ...
Plant hormones and growth regulators
... and/or leaf fall; and many other conditions (Table 5). Very small concentrations of these substances produce major growth changes. Hormones are produced naturally by plants, while plant growth regulators are applied to plants by humans. Plant growth regulators may be synthetic compounds (e.g., IBA a ...
... and/or leaf fall; and many other conditions (Table 5). Very small concentrations of these substances produce major growth changes. Hormones are produced naturally by plants, while plant growth regulators are applied to plants by humans. Plant growth regulators may be synthetic compounds (e.g., IBA a ...
... lence of H. pylori infection in Africa and South Asia, the incidence of gastric cancer in those areas is much lower than in other regions. Such geographic differences in pathology can be explained in part by the presence of different types of H. pylori virulence factors[4,10-13]. Many studies have b ...
The COOH-terminal domain of agrin signals via a synaptic receptor
... receptor that mediates agrin-induced clustering of AChRs in muscle is a complex consisting of a muscle-specific kinase (MuSK) and an as yet to be identified myotube-associated specificity component (MASC; Glass et al., 1996). Thus, structural elements sufficient to bind and activate the MuSK–MASC re ...
... receptor that mediates agrin-induced clustering of AChRs in muscle is a complex consisting of a muscle-specific kinase (MuSK) and an as yet to be identified myotube-associated specificity component (MASC; Glass et al., 1996). Thus, structural elements sufficient to bind and activate the MuSK–MASC re ...
Activation of the Arabidopsis B Class Homeotic
... Later in development, its expression is downregulated in the central dome and is restricted to the outer two whorls. In contrast, AP3 and PI start to be expressed during floral stage 3 in a subset of AP1-expressing cells (Jack et al., 1992; Weigel and Meyerowitz, 1993; Goto and Meyerowitz, 1994). Al ...
... Later in development, its expression is downregulated in the central dome and is restricted to the outer two whorls. In contrast, AP3 and PI start to be expressed during floral stage 3 in a subset of AP1-expressing cells (Jack et al., 1992; Weigel and Meyerowitz, 1993; Goto and Meyerowitz, 1994). Al ...
Week 5 Day 2
... Some members of the pumpkin family produce roots capable of storing large amounts of water. Some of these roots have a mass of about 30 kg. In which type of environment are these plants most likely found? F Aquatic G Dry H Cold J Humid ...
... Some members of the pumpkin family produce roots capable of storing large amounts of water. Some of these roots have a mass of about 30 kg. In which type of environment are these plants most likely found? F Aquatic G Dry H Cold J Humid ...
PATELLIN1/2 interact with CVL1 and CVP2 to regulate vascular
... The structure and function of vascular tissue In order for terrestrial plants to grow more than a few centimeters from the ground, evolution of specialized vascular tissue was required (Raven, 1993). The veins formed by the vascular tissue provide mechanical support and carry water from the parts of ...
... The structure and function of vascular tissue In order for terrestrial plants to grow more than a few centimeters from the ground, evolution of specialized vascular tissue was required (Raven, 1993). The veins formed by the vascular tissue provide mechanical support and carry water from the parts of ...
Opposite and redundant roles of the two Drosophila perilipins in
... controls, plin138 mutant and plin1 overexpression larvae under fed conditions. Compared to controls, the circulating lipid levels are significantly reduced in plin138 mutants (Fig. 2F). In addition, we found that the circulating lipid levels were dramatically increased in plin1 overexpression larvae ...
... controls, plin138 mutant and plin1 overexpression larvae under fed conditions. Compared to controls, the circulating lipid levels are significantly reduced in plin138 mutants (Fig. 2F). In addition, we found that the circulating lipid levels were dramatically increased in plin1 overexpression larvae ...
Collagen Diversity, Synthesis and Assembly
... due to the use of alternative transcriptional start sites. Collagen IX is covalently cross-linked to both collagens II and XI in the cartilage fibril, through lysine-derived cross-links; recent studies have shown how flexibility within the non-collagenous domains allows these cross-links to form (Ey ...
... due to the use of alternative transcriptional start sites. Collagen IX is covalently cross-linked to both collagens II and XI in the cartilage fibril, through lysine-derived cross-links; recent studies have shown how flexibility within the non-collagenous domains allows these cross-links to form (Ey ...
Three Molecular Structures Cause Rhesus D Category VI
... their RhD protein. Initially, these individuals have been classified into six distinct categories (DII to DVII, DI being obsolete) based on the mutual reactivity with polyclonal anti-D sera from immunized partial D carriers.11 Today, characterization of partial D is performed by differential reactiv ...
... their RhD protein. Initially, these individuals have been classified into six distinct categories (DII to DVII, DI being obsolete) based on the mutual reactivity with polyclonal anti-D sera from immunized partial D carriers.11 Today, characterization of partial D is performed by differential reactiv ...