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Olfactory receptors influence the targeting of sensory axons to discrete glomeruli in the olfactory bulb. (Adapted, with permission, from Sanes and Yamagata 2009.) A. Each olfactory receptor neuron expresses one of approximately 1,000 possible odorant receptors. Neurons expressing the same receptor are distributed sparsely throughout the olfactory epithelium of the nose. The axons of these neurons form synapses with target neurons in a single glomerulus in the olfactory bulb. B. In mouseSource: mutantsFormation in which an odorant receptor gene has been deleted, the olfactory neurons that would have expressed the gene send their axons to and Elimination of Synapses, Principles of Neural Science, Fifth Editon other glomeruli, in part because these neurons now express other receptors. Citation: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, Mack S. Principles of Neural Science, Fifth Editon; 2012 Available C. When one odorant receptor gene replaces another May in a 10, set 2017 of olfactory sensory neurons, their axons project to a new glomerulus. Odorant receptor at: http://mhmedical.com/ Accessed: expression may set the overall activity level of the neuron, influencing the nature and level of expression of axonal guidance and recognition Copyright © 2017 McGraw-Hill Education. All rightsthus reserved molecules.)