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Different neural mechanisms underlie long-term potentiation at each of the three synapses in the trisynaptic pathway in the hippocampus. Long-term potentiation (LTP) is present at synapses throughout the hippocampus but depends to differing degrees on activation of NMDA-type glutamate receptors. A. Tetanic stimulation of the Schaffer collateral pathway (at arrow) induces LTP at the synapses between presynaptic terminals of CA3 pyramidal neurons and their postsynaptic CA1 pyramidal neurons. The graph plots the size of the extracellular field EPSP (fEPSP) expressed as a percent of the initial baseline fEPSP prior to induction of LTP. At these synapses LTP requires activation of the NMDA receptors in the CA1 neurons as it is completely blocked when the tetanus is delivered inCortex, the presence of the NMDA receptor antagonist (Reproduced, with permission, from MorganFifth andEditon Teyler 2001.) Source: Prefrontal Hippocampus, and the Biology of ExplicitAPV. Memory Storage, Principles of Neural Science, B. Tetanic stimulation of the ER, direct pathwayJH, from entorhinal cortex to CA1 neurons generates LTP the fEPSP that depends partially on activation of the Citation: Kandel Schwartz Jessell TM, Siegelbaum SA, Hudspeth AJ, Mack S. of Principles of Neural Science, Fifth Editon; 2012 Available 2+ channels. It is therefore only partially blocked by APV. Addition of APV and NMDA receptors and partially on activation of L type voltage-gated Ca at: http://mhmedical.com/ Accessed: April 30, 2017 nitrendipine, Copyright a dihydropyridine that blocks LEducation. - type channels, is needed © 2017 McGraw-Hill All rights reservedto fully inhibit LTP. (Reproduced, with permission, from Remondes and Schuman 2003.)