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Sleep Helps the Brain! A Lesson on the Importance of Sleep After a TBI Created For You By: No Limits Eastern Shore www.nolimiteasternshore.com Please feel free to download, print, or share this PowerPoint with credit given to No Limits Eastern Shore. “A senior National Football League official acknowledged for the first time the link between head injuries in football and a degenerative brain disease called chronic traumatic encephalopathy.” This admission has been compared with Big Tobacco’s 1997 disclosure that smoking causes cancer! Effective TBI Treatments • Remains undecided – some doctors prescribed to rest for several weeks while others claim too much rest is actually negative and urge their patients to stay active. University Hospital Zurich (UHZ) • A team of researchers at UHZ have found that forcing the “slow-wave” cycle of sleep in patients recovering from TBI may increase cognitive function and recovery overall. – Slow-wave sleeps lessens damage to the axons of the brain or the long projections of your neurons that communicate with other brain cells. – Axon damage has been proven to cause buildup of neurotoxic molecular waste products (proteins) – which may be able to be reversed by inducing the “slowwave” sleep state. What is Slow-Wave Sleep? The deepest stage of sleep that is characterized by low-frequency, high-amplitude waves that helps the brain clear out protein build up often caused by axonal damage. (Axonal damage is very common after a TBI!) The Experiment • 25 rats with prefrontal cortex injuries were divided into 3 groups: 1. The 1st was treated with sodium oxybate which is a drug used to produce slow-wave brain function. 2. The 2nd was forced to stay awake for prolonged periods of time – studies have shown that sleep deprivation leads to slow-wave sleep naturally during a process called “rebound sleep.” 3. The 3rd group was given placebo drugs. Experiment (continued) • Using electroencephalography researchers were able to prove that the first 2 groups of rats had indeed been induced into a slow-wave sleep state. • They then tested the cognitive abilities of all 3 groups. • The rats that had received enhanced sleep treatments performed better on various cognitive tests such as object recognition and memory recall. Further experimentation needs to be done before sleep treatments will be implemented on humans to treat TBI – but this is one of the first times that enhanced sleep therapy has been proven to reverse certain symptoms of TBI and other brain diseases noninvasively. Citations • Photographs on all pages - © ClipArt • Cepelewicz, Jordana. "Inducing Deep Sleep after Head Injury May Protect the Brain." Scientific American. Springer Nature, 23 Mar. 2016. Web. 24 Mar. 2016.