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Playdoh Brains/Brain Surgery Name________________________ AP Psychology Surgeon Follow the procedures outlined below. Make sure to execute these procedures exactly as stated to ensure the health of your patient (and your class participation) grade. Use the diagrams provided and the model I will simultaneously be constructing to assist you. You may feel the need to consult textbooks for additional information on the structures (location and respective functions). 1. Gather your materials. You will need adequate supplies for the initial construction of your brain (i.e., 4 containers of Playdoh – all different colors). 2. Prepare yourself and your area. Sanitize your hands, glove up and don your surgical mask (gloves and masks optional). Clear one desk of all objects except for Playdoh and this instruction/activity sheet. 3. Prepare your Cerebrum – make two large, flat pancake-like structures, at least as big as your hand with extended fingers. Then, wrinkle it down to resemble the furrows of the cerebrum. You must make an indentation where the lateral fissure runs (the “thumb” of the “boxing glove” or “mitten” – think state of Michigan). Set aside the two hemispheres of the cerebrum. Note: The outer ¼” of the cerebrum is the cerebral cortex, the center of intellectual (higher) thought. What is the primary function of the Cerebrum?__________________________________ ________________________________________________________________________ 4. Prepare the Brainstem with Thalamus “bulb” – Make a slightly lopsided “chicken leg” or “brontosaurus head and neck.” Then make a Medulla Oblongata in the shape of a small football (about 1.5” long). The Medulla should be a different color from your brainstem/thalamus bulb. After that, make the RAS (Reticular Activating System) – aka Reticular Formation - from yet another different color – about ½ diameter of medulla and about 1” long. Make a furrow (or “canoe”) in the medulla and insert the RAS. Close it up by folding over the Playdoh and re-shaping. Then make another furrow (or “canoe”) in the brain stem and enclose the medulla/RAS. Again, fold over Playdoh and re-shape. Then make a thalamus (ball about 1” diameter) and hypothalamus (pea-sized) from two different colors and enclose them in the thalamus bulb, with the thalamus on top and slightly behind (i.e., hypothalamus should be in front of thalamus and below = “hypo”). What are the respective functions of each of these structures (RAS, Medulla, Thalamus and Hypothalamus)? ________________________________________________________________________ ________________________________________________________________________ ________________________________________________________________________ ________________________________________________________________________ 5. Prepare the Pons – Make a 5-6” thin snake from a different color than the brainstem and flatten it out. Wrap it around the back of the brainstem (like a scarf), just below the thalamus bulb and pinch it together in the front (creating a waddle or turkey “gobbler”). What is the function of the Pons?_____________________________________________ ________________________________________________________________________ 6. Prepare the Cerebellum – Make 2 small balls (each slightly smaller than thalamus) from a color different than the brainstem or pons. Flatten into a yo-yo shape and make gyri and sulci (ridges and valleys). Attach on the back of the pons. What is the function of the Cerebellum? ______________________________________ ________________________________________________________________________ 7. Prepare the Optic Chiasm – Take 2 small pieces and roll into 1” long snakes/worms. Make an “X” with these snakes/worms. Connect to the brainstem/thalamus bulb right above the pons on the front (rostral) side. What is the primary function of the optic chiasm? _______________________________ ________________________________________________________________________ 8. Prepare the Hippocampus and Amygdala – Make a 6” snake, ¼ - ½” in diameter. Looking from the back of your brain, place the middle of the snake in the back middle of the thalamus (creating a “U” just above the cerebellum) and curl the ends of the snake around the sides of the thalamus bulb, creating 2 structures in the shape of ram’s horns. Place a small (pea-sized) lump at the tip of each horn for the amygdalae (almond-shaped structures on the tips of hippocampus). What are the respective functions of the Hippocampus and Amygdala? ________________________________________________________________________ ________________________________________________________________________ ________________________________________________________________________ 9. Prepare the Pituitary and Pineal Glands – Make 2 small balls, 1 twice the size of the other. Pituitary is the larger of these structures (pinto bean shape). Pineal gland is smaller, about the size of a pea. These structures will be attached later (step 11). What are the respective functions of the Pituitary and the Pineal glands?_________________________________________________________________ _______________________________________________________________________ 10. Prepare the Corpus Callosum – Make a crescent moon shape, about twice as long as the thalamus bulb from front to back. The corpus callosum will be attached in the next step. What is the function of the Corpus Callosum? __________________________________ ________________________________________________________________________ 11. Final assembly – Lay out one hemisphere of the cerebrum (set aside in step 3) with the ridges down. Carefully place the completed brainstem and midbrain structures on it, with the cerebellum sticking out the back and the pons out the front. Position the corpus callosum above the hippocampus and thalamus bulb, leaving space between for the ventricles. Place the pituitary in front of the optic chiasm. Place the pineal in back, above the cerebellum. Finally place the other hemisphere of the cerebrum over the top (smooth side down) and seal around the edges, molding into the shape of a brain. The second hemisphere needs to “mirror” the first. What are the respective functions of the Left and Right hemispheres? ________________________________________________________________________ ________________________________________________________________________ ________________________________________________________________________ 12. Visually identify the four Lobes of each hemisphere. Use a pencil to gently deepen the sulci (valleys) between them (lateral, central and parietal-occipital). What is the respective specialized function of each of the four lobes? Frontal__________________________________________________________________ Parietal_________________________________________________________________ Temporal________________________________________________________________ Occipital________________________________________________________________ 13. Once you have completed your brain, you will need to consult a specialist for a final consultation. Please notify me and I will offer my expertise and an overall evaluation. Upon receiving your evaluation, you should clean your surgical area and wrap your brains in plastic “cling” wrap to preserve them for further analysis and eventual deconstruction. When a brain goes bad… AP Psychology Directions: Read, highlight, and annotate the following summaries of brain diseases/abnormalities. Multiple Sclerosis: Multiple (attacks many sites simultaneously) and sclerosis (hardening); MS attacks the myelin sheaths of axon bundles in the brain, spinal cord, and optic nerves; lesions develop around the axon bundles, leading to muscular weakness, lack of coordination, and impairments of vision and speech; disease typically begins in early adult life, and is often characterized by remissions and relapses that occur over a period of years; environmental (cool climate) and genetic (rare among gypsies and Asians) factors have been isolated. Guillain-Barre Syndrome: a more common demyelinating disease that attacks the myelin of peripheral nerves that innervate (stimulate or supply with nerves) muscle and skin; often develops from minor infectious illnesses or even inoculations – seems to result from a faulty immune reaction in which the body attacks its own myelin as if it were a foreign substance; symptoms include fever, malaise, and nausea (early on) and ultimately muscular weakness and eventually paralysis – all of which stem from the slowing of action potential conduction in the axons that innervate the muscles. Parkinson’s Disease (PD): A neurological disorder named after James Parkinson, the English physician who first described its “involuntary tremulous motion” in 1817. The primary symptoms are a rapid, coarse tremor, a mask-like facial expression, loss of sensorymotor (pertaining to or characterizing that which involves muscles, muscular movements and, by extension, glandular secretions – anything that gives rise to or results in stimulation of effector organs) coordination, loss of the ability to initiate action and a general tendency towards exhaustion. May also notice some cognitive impairments (general slowing of learning and memory) and speech difficulties (imprecise articulation or oddly accelerated speech rate in which words run together). Damage to structures in the basal ganglia can affect posture and muscle tone or cause abnormal movements. In 1960’s, scientists discovered that tremors resulted from death of nerve cells that produce dopamine – first illness attributed to a neurotransmitter deficiency. The dopamine-rich neurons of the substantia nigra (layer of cells in the pons) normally project to the basal ganglia and die off in PD patients. L-dopa can be used to treat PD because it crosses blood-brain barrier and then converted into dopamine by brain. Encephalitis: refers to an inflammation of the membranes covering the brain or the brain itself, typically resulting from infection. Encephalitis Lethargica: severe Parkinsonian-like condition caused by encephalitis; outbreak between 1916 and 1927 affected 5 million people, killing around 1 million of them; symptoms included rigidity of posture, sleepiness, manic behavior, compulsiveness, and occasionally aggressiveness. Rasmussen’s Encephalitis: seizures due to inflammation of brain and central nervous system; hemispherectomy is common treatment to control seizures. Stroke: the rupture or blockage of a blood vessel in the brain; this can lead to speaking/writing difficulties, loss of coordination, paralysis, or absence of sensation. Lesion: tissue damage/destruction, a circumscribed area of impairment to organic tissue caused by injury, disease, or surgical intervention. Aneurysm: a blood-filled dilation of a blood vessel. Aphasia: a general term covering any partial or complete loss of language abilities. The origins are always organic, namely a lesion in the brain. There are literally dozens of varieties of aphasia (Broca’s, Wernicke’s, auditory, global, traumatic, etc.). Aphagia: lack of eating resulting from damage to the lateral hypothalamus. Visual Agnosia: inability to recognize or interpret objects in the visual field.; person can sense objects and forms, but is unable to recognize or interpret their meaning. Hydrocephalus: an abnormal accumulation of cerebrospinal fluid within the ventricles. Epilepsy: an umbrella term for a number of disorders characterized by various combinations of the following: periodic motor or sensory seizures accompanied by an abnormal EEG, with or without actual convulsions, clouding or loss of consciousness, and motor, sensory, or cognitive malfunctions. Hemispherectomy: surgical removal of one hemisphere. Alzheimer’s Disease: a progressive form of dementia characterized by the gradual deterioration of intellectual abilities such as memory, judgment, the capacity of abstract thought, and other higher-level cortical functions as well as by changes in personality and behavior. Brain matter begins to deteriorate, especially neurons that produce Acetylcholine (muscle action, learning and memory). The causes are unclear, yet cumulative (no single cause, but a combination of causes). Age and genetics are factors. Tumor: any uncontrolled, abnormal proliferation of cells, often leading to formation a lump (benign or malignant). Brain and Behavior AP Psychology Directions: Come up with a mnemonic to remember each of the following parts of the brain. Key Brain Structures: Brain Structure Amygdala Angular Gyrus Basal Ganglia Brainstem Respective Function An almond-shaped neural structure on tips of hippocampus; play a significant role in emotional behavior and motivation, particularly aggressive and fear-based behaviors Area in the parietal lobe close to the temporal lobe; visual processing, mathematics, cognition, high-language functions like understanding metaphors, and vestibular (balance) sensations; transforms visual representation into auditory code; Subjects of researchers in Switzerland recently reported “out of body” experiences when their a.g. was stimulated A cluster of neurons (nuclei) at the base of the forebrain which connect to the cerebral cortex and that thalamus. Involved in “action selection” (which action to do first). Acts as an inhibitor in motor movement; when inhibition released, certain motor systems are freed. The part of the brain that is left when both the cerebrum and cerebellum are removed; the “primitive” brain; helps brain communicate with rest of the body (connecting spinal cord to brain); responsible for automatic survival functions Broca’s Area Cerebellum Cerebral Cortex Cerebrum Corpus Callosum Frontal Lobes Hippocampus Hypothalamus Limbic System Medulla Oblongata Motor Strip/Cortex Occipital Lobes A cortical area involved in the processing of language functions; located in frontal lobe of left hemisphere; damage to area can result in Broca’s aphasia (little or poor speech production); named after scientist who discovered area, Paul Broca (1861); BS in WC A large structure at the back of the brain involved in movement (muscle coordination, balance, posture) as well as other involuntary functions (implicit memories, conditioning) The surface covering of grey matter (unmyelinated) that forms the outermost layer of the cerebrum (1/4”); allows flexible construction of sequences of voluntary movements, permits subtle discriminations among complex sensory patterns, and makes possible symbolic thinking, enabling people to have conversations about things that do not exist or are not presently in view – foundation of human thought and language Largest and most prominent structure of brain; inner core made of white matter (myelinated axons) and basal ganglia, outer core is cerebral cortex (grey matter); involved in processing and interpretation of sensory inputs, consciousness, planning, and execution of action, thinking, ideating, language, reasoning, judging, and control over voluntary motor activity A band of 80 million axons that connect left and right hemispheres; located at the floor of the longitudinal fissure; transfers information from one hemisphere to the other; if severed (e.g., to control seizures), will result in “split brain” Region (lobe) of cerebral cortex in front of brain, near forehead; our executive decision-maker, responsible for rational thought, prioritizing information, speaking, working (STM) memories, solving problems, and thoughts/plans of the future Mid-brain structure, part of limbic system; responsible for consolidating new explicit memories (STM – LTM) A neural structure lying below (hypo) the thalamus; “master” of endocrine system (via pituitary gland), triggering fight-or-flight response; directs several maintenance activities (eating, drinking, body temperature), linked to emotion and motivation; maintains homeostasis Evolutionarily primitive system under the cortex which includes structures like the hippocampus, amygdala, and hypothalamus. Supports a variety of functions including emotion, long term memory, and olfaction. At the base of the brainstem; controls heartbeat and breathing At the rear of the frontal lobes (adjacent to sensory strip); controls voluntary movements The portion of the cerebral cortex lying at the back of the head (just above the cerebellum); includes the visual areas, integrates visual information (from opposite visual field) Parietal Lobes The portion of the cerebral cortex lying at the top of the head and toward the rear (in between occipital and frontal lobes); includes the sensory strip (touch), taste, and visuospatial organization Pineal Gland Gland at rear of brain that secretes melatonin, which regulates sleep Pituitary Gland “Master” gland of endocrine system; secretes growth hormone and regulates other endocrine glands Pons A part of the hindbrain that, with other structures, controls respiration and regulates heart rhythms. The pons is a major route by which the forebrain sends information to and receives information from the spinal cord and PNS; connects medulla and cerebellum; involved in sleep Reticular A nerve network in the brainstem that plays an important role in Formation/R.A.S. controlling arousal; our “alarm clock,” alerting us to incoming messages Sensory The area at the front of the parietal lobes (adjacent to motor strip) Strip/Cortex that registers and processes body sensations – touch Temporal Lobes Primary auditory lobe, includes Wernicke’s Area; the portion of the cerebral cortex lying roughly above the ears; hearing and smell Thalamus The brain’s sensory switchboard (“operator”); located on top of brainstem; directs and prioritizes messages to the appropriate areas of cortex; also transmits information from cortex to cerebellum and medulla; a relay station for sensory information coming from nervous system Ventricles Fluid-filled (cerebrospinal fluid) areas deep in brain; implicated in schizophrenia (larger than normal); excessive fluid in hydrocephalic patients, could lead to larger than normal ventricles; could provide hydration and cushioning for brain Wernicke’s Area A cortical area involved in language comprehension and expression; located in left temporal lobe (BS in WC) Association Areas AP Psychology Neurotransmitter Chart AP Psychology Directions: Complete the following chart using your textbook and the Internet. Neurotransmitter Effects of Chemical (on Brain/ Behavior) Serotonin Norepinephrine Epinephrine (not to be confused with its hormone cousin, adrenaline) pg. 56 Myers GABA Acetylcholine Dopamine Endorphins This whole packet is due on Test Day! Diseases, abnormalities, other phenomena associated with neurotransmitter (if any)