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Unit 2 overheads: Biological psychology 1 Biological Bases of Behaviour Neuron: cell specialized to receive, process, and transmit information to other cells: Soma, Dendrites, Axon ● myelin sheath: insulating material, speeds up transmission of signals ● terminal buttons secrete neurotransmitters: chemical messengers ● synapses: the junction where information is transmitted from one neuron to another neural impulse: a complex electrochemical event positively charged sodium and potassium ions, and negatively charged chloride ions, flow across the cell membrane at different rates neuron’s resting potential is about -70 millivolts when stimulated, channels in cell membrane open and positively charged sodium ions rush in. creates an action potential: a very brief shift in the neuron’s electrical charge that travels down the axon the channel closes back up very quickly for a brief time the neuron cannot “fire” again: the absolute refractory period is the minimum length of time after an action potential during which another action potential cannot begin (1 or 2 milliseconds) firing is “all-or-none” stronger stimuli make a cell fire more rapidly Unit 2 overheads: Biological psychology ● neurons 2 communicate here they meet: the synapse ● separated by the synaptic cleft: a microscopic gap ● presynaptic neuron and postsynaptic neuron ● neurotransmitters: stored in terminal button’s vesicles ● neurotransmitters diffuse across the cleft to the membrane of the receiving neuron ● bind with special molecules at receptor sites on the receiving neuron ● causes a postsynaptic potential (PSP) ●PSPs are graded potentials: increase/decrease the probability of that neuron firing in proportion to the amount of voltage change ● excitatory PSP: positive voltage shift, increases likelihood that the neuron will fire ● inhibitory PSP: negative voltage shift, decreases likelihood that the postsynaptic neuron will fire ● neurotransmitter is either reabsorbed via reuptake or broken down by enzymes ● 15 to 20 neurotransmitters have been identified so far ● lock and key system: neurotransmitter has to fit to bind to a site Neurotransmitters Acetylcholine (ACh) ●found throughout the nervous system ● motor movements ● attention, arousal, and memory ●nicotine is an Ach agonist ● curare is an antagonist for ACh Unit 2 overheads: Biological psychology 3 Monoamines dopamine (DA), norepinephrine (NE), serotonin (5-HT) ●dopamine: voluntary movements degeneration of DA pathways causes Parkinsonism ●serotonin: sleep & waking, eating, aggression, impulsive behavior depression: low NE, low 5-HT schizophrenia: high DA ● amphetamines increase release of DA and NE from presynaptic neurons & slow reuptake Endorphins ●endogenous morphines: internally produced opiates ●widely distributed throughout the body ● contribute to modulation of pain, experiences of euphoria Nervous System CNS PNS Somatic N.S. Brain Spinal Cord - skeletal muscles - afferent and efferent pathways Autonomic N.S. - basic life processes Sympathetic Parasympathetic Unit 2 overheads: Biological psychology PNS: nerves outside the brain and spinal cord. ● Nerves: bundles of neuron fibers (axons) routed together in the PNS ● PNS divides into somatic n.s. and autonomic n.s. Somatic N.S. ●nerves connecting to voluntary skeletal muscles and sensory receptors ● info from receptors in skin, muscles, joints to the CNS ● commands from CNS to the muscles ●needs 2 pathways to do this 1) afferent nerve fibers: axons carrying information inward to the CNS from the periphery of the body 2) efferent nerve fibers: axons carrying info outward from the CNS to the periphery of the body Autonomic N.S. ● nerves connecting to heart, blood vessels, glands, smooth muscles ● involuntary functions (heart rate, digestion, perspiration) ●physiological arousal (fight or flight response) ● chronic autonomic arousal stress, disease ● 2 branches: sympathetic and parasympathetic divisions ● sympathetic division: fight-or-flight response (slows digestion, drains blood from the periphery, signals adrenal glands to release hormones like adrenaline ● parasympathetic division: conserves bodily resources (slows heart rate, lowers b.p., promotes digestion) 4 Unit 2 overheads: Biological psychology 5 CNS: brain and spinal cord ● encased in sheaths called meninges ● cerebrospinal fluid (CSF)nourishes & protects Spinal cord: connects the brain to rest of body through the PNS bundles of axons carrying brain’s commands to peripheral nerves & receiving information from peripheral nerves to take back to brain Brain: weighs 3 lbs, containing billions of cells integrates information from outside and inside the body, coordinates the body’s actions, enables us to talk, think, remember, plan, create, dream 4 techniques to Study the Living Brain 1) Electrical Recordings EEG (electroencephalogram): electrodes on surface of head record patterns of electrical activity line tracings called brain waves different patterns associated with different states of mental activity patterns of brain activity for specific behaviors and specific emotions (e.g. anxiety) studying stages of sleep Unit 2 overheads: Biological psychology 6 2) Lesioning: selectively disable specific brain areas in animals high-frequency electric current through an electrode to burnt tissue stereotaxic instrument: used to implant electrodes at precise locations 3. Electrical Stimulation of the Brain (ESB) weak electric current stimulates (activates) brain areas 4. Brain Imaging Procedures CT scan (computerized tomography): X-rays at different angles, provides an image of a brain “slice”; can also visualize the whole brain by assembling a series of images representing successive slices of the brain ● permits us to examine brain structure PET scan (positron emission tomography): uses radioactive substances to portray brain function ● can map brain activity ● radioactively tagged chemicals serve as markers for blood flow or metabolic activity ● indicates what parts are more active than others when performing specific tasks or feel specific emotions MRI (magnetic resonance imaging): magnetic fields & radio waves to map brain structure. ● better images that CT scans can give ● 3-D pictures of the brain with very high resolution Unit 2 overheads: Biological psychology 7 functional MRI (fMRI): both functional and structural information in the same image Brain Structures and Their Functions 3 major regions: the hindbrain, the midbrain, and the forebrain. Hindbrain ● cerebellum, medulla, pons medulla: attaches to the spinal cord, in charge of largely unconscious vital functions like circulation, breathing, maintaining muscle tone, reflexes like sneezing, coughing, salivating pons: a bridge of fibers that connects the brain stem to the cerebellum; also clusters of cell bodies (called nuclei) involved in sleep and arousal cerebellum (“little brain”): coordination of movement, equilibrium, physical balance; also coordinates sensory information that guides movements Midbrain ● lies between the forebrain and the hindbrain ●sensory processes (e.g. turning head in direction of a noise) ● voluntary movements (dopamine pathways).Parkinsonism is due to degeneration in this area ● reticular formation runs through the hindbrain and the midbrain: contributes to muscle reflexes, breathing, pain perception, and regulation of sleep and arousal Unit 2 overheads: Biological psychology Forebrain ● largest and most complex region ● includes thalamus, hypothalamus, and limbic system at its core, and above them, the cerebrum and its outer layer, the cerebral cortex Thalamus: a way-station ● a number of clusters of cell bodies, or somas, each concerned with relaying sensory info to a particular part of the cortex Hypothalamus: a regulator of biological needs ● near base of the forebrain, under the thalamus ● controls the ANS, the endocrine system via the pituitary gland ● “Four Fs”: fighting, fleeing, feeding, fornicating Limbic System: the seat of emotion ● includes parts of the thalamus, hypothalamus, hippocampus, amygdala ● hippocampus: memory processes: spatial memory, consolidation of new info into long term memory ● amygdala: fear response, rage response ●pleasure centers: e.g. where the medial forebrain bundle passes through the hypothalamus ● opiates and stimulants work by exciting this dopamine system 8 Unit 2 overheads: Biological psychology 9 Cerebrum: the seat of complex thought ●largest and most complex part of the human brain ●learning, remembering, thinking, consciousness ●cerebral cortex: the thin outer layer ● 2 hemispheres connected by the corpus callosum ● each hemisphere has 4 lobes 1) occipital lobe: includes the primary visual cortex, where visual information gets processed 2) parietal lobe: registers the sense of touch, called the primary somatosensory cortex 3) temporal lobe: includes the primary auditory cortex 4) Frontal lobe: includes the primary motor cortex amount of cortex for each body area reflects its complexity, not its actual size prefrontal cortex: portion in front of the motor cortex, contributes to higher-order functions: memory, reasoning, executive control (planning, paying attention, organization) Left Hemisphere ● frontal lobe: Broca’s area (language generation) ● temporal lobe: Wernicke’s area (language comprehension) Right Hemisphere ● visuo-spatial tasks, recognizing faces Unit 2 overheads: Biological psychology 10 Split Brain Research ● corpus callosum is cut to reduce epileptic seizures ● each hemisphere controls the motor & sensory functions to and from the opposite side of the body ● visual system: stimuli in the right half of the visual field in both eyes goes to the LH; stimuli in the left half of the visual field in both eyes goes to the RH ● auditory system: inputs to each ear go to both hemisphere, but connections to the opposite hemisphere are stronger or more immediate Gazzaniga, Bogen, & Sperry (1965) ●presented visual stimuli in a single visual field ● stimuli only lasted a fraction of a second ● pictures flashed to the right visual field: subjects were able to name what they were seeing ● pictures flashed to the left visual field: not able to name what they were seeing ● but RH did process information - People could point out a picture of an object they had held in their left hand - people could point out pictures of things flashed to their left visual field ● RH is superior for assembling puzzles & copying drawings, even when the person is right handed Unit 2 overheads: Biological psychology 11 Specialization of the Hemispheres in an Intact Brain ● perceptual asymmetries: left/right imbalances in the speed of visual or auditory processing - in normal people the input sent to one hemisphere is quickly shared with the other - but subtle differences can be detected by measuring how long it takes subjects to recognize different kinds of stimuli ● findings: the 2 hemispheres are specialized (LH- language, logical thinking; RH – visual-spatial, recognizing emotions, expressing emotions, classical conditioning.) the endocrine system a system of glands that secrete chemicals called hormones into the blood stream to help control body functioning. Hormones: chemicals released by endocrine glands ● long-term regulation of basic bodily processes ● glands are like synapses but with distant receptors ● some chemicals act as neurotransmitters in CNS and as hormones in the endocrine system ● 30 different hormones; some have specific targets and some have targets all over the body hypothalamus pituitary gland stimulates other endocrine glands ●pituitary gonadotropins, affecting the gonads (prebirth formation of external sex organs; increased levels of sexual hormones at puberty to develop secondary sex characteristics (female breasts, male facial hair, etc.) Unit 2 overheads: Biological psychology 12 Genetics and Behavior Behavioural genetics: studies the influence of genetic factors on behavioural traits. Principles of genetics chromosomes: strands of DNA molecules carrying genetic information ●every cell (except sperm & egg) contains 46 chromosomes genes: DNA segments, the key functional units in hereditary transmission - homozygous condition: 2 genes in a pair are the same - heterozygous condition: the 2 genes in a pair are different single gene inheritance: a single pair of genes determines a trait (e.g. attached versus detached earlobes) dominant gene: expressed when paired genes differ recessive gene: masked when paired genes differ genetic relatedness with each parent, 50% with siblings, 50% with identical twin, 100% Genotype: a person’s genetic makeup Phenotype: genotype’s manifestation in observable characteristics Unit 2 overheads: Biological psychology 13 Polygenic Inheritance: influenced by more than one pair of genes. Studies to Assess Genes versus Environment Family Studies: examining blood relatives to see how much they resemble one another on a specific trait. Problem: doesn’t tease out the impact of a shared environment Twin Studies: comparing the resemblance of identical twins and fraternal twins on a specific trait. ● identical (Monozygotic) twins are 100% identical ●fraternal (Dizygotic) twins are no more similar than any 2 siblings (50%) ● if identical twins exhibit more similarity on a trait than fraternal twins, this is likely due to heredity Adoption studies: examining the resemblance between adopted kids and both their biological and adoptive parents. ● adopted in infancy, raised without contact with biological parents ●if adopted kids resemble their biological parents on a trait more than they resemble their adoptive parents, then this suggests a genetic influence on that trait ● if adopted kids resemble their adoptive parents more, this show it was more influenced by environment than genes “We inherit dispositions, not destinies.” Unit 2 overheads: Biological psychology 14 Parental Investment and Mating Systems ● parental investment what each sex has to invest to produce and nurture offspring. ● in most mammalian species, males don’t have to invest much more than their sperm to pass their genes on to the next generation. So, males’ reproductive potential is maximized by mating with as many as possible. Males will compete with each other for mating opportunities. ● females typically have to invest a lot more: time carrying the developing fetus, danger in giving birth, nourishing and caring for the offspring once born. They have a limited number of offspring they can produce, regardless of how many males they mate with. So, females don’t have an incentive to mate with many males. They optimize their reproductive potential by being picky in terms of good genes and/or access to material resources. ● polygyny: where each male seeks to mate with multiple females, who in turn only mate with him. o natural selection favors males who compete aggressively for copulation opportunities o females mate with the winners who presumably have “better genes” Unit 2 overheads: Biological psychology 15 ● polyandry: each female seeks to mate with as many males as possible, whereas each male mates with only one female o emerges when parental investment is high for males and low for females (e.g. female spotted sandpipers) o relatively rare ● monogamy: where one male and one female mate exclusively, or almost exclusively, with each other o when male and female investment is about even, and both parents raise the young (many bird species, some mammals, like wolves and foxes) o sometimes even here they mate outside their pair bond (cheating!) Hemispheric Specialization and Handedness ● the superiority of one hemisphere over another for tasks like recognizing letters, words, faces, and melodies, is only modest. ● in normal people, the hemispheres never work alone ● some people display very little specialization ● others reverse the usual specialization ● especially common in left-handed people ● Rasmussen & Milner (1977): bilateral representation of speech for 15% of left-handers (versus 0% of right-handers); reversal of specialization in another 15% of left-handers (versus about 5% of right-handers)