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Download Text 4-Nervous system: Organization and Physiology
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4-Nervous system: Organization and Physiology ORGANIZATION AXON ION GRADIENTS ACTION POTENTIAL (axon conduction) GRADED POTENTIAL (cell-cell communication at synapse) Text SYNAPSE STRUCTURE & FUNCTION NEURAL INTEGRATION Q: What is the nervous system? A network of billions of nerve cells linked together in a highly organized fashion to form the rapid control center of the body In the brain, roughly 100 billion (1011) neurons and 100 trillion (1014) synapses (connections between nerve cells) 2 Q: What does the nervous system do? Functions include: –Integrating center for information coming into the body from the periphery or internally; sensation –Generation of movement –Regulation of many body functions –Locus of much of what makes us human – thought self-awareness, etc. 3 NERVOUS STRUCTURE ORGANIZATION Two major divisions: 1.Central Nervous System (CNS) -Brain & spinal cord 2.Peripheral Nervous System (PNS) -Nervous system outside of the brain and spinal cord -Carries information to and from the CNS 4 NERVOUS STRUCTURE ORGANIZATION Two divisions to PNS: i) Somatic; voluntary (afferent and efferent) -12 pairs of cranial nerves -31 pairs of spinal nerves ii) Autonomic; visceral; involuntary; (efferent) -Sympathetic component (“fight/ flight”; thoraco-lumbar) -Parasympathetic component (“rest/digest”; cranio-sacral) 5 MANY different types, shapes, and sizes Functional types 6 Among all types of neurons, myelinated neurons conduct action potentials most rapidly Schwann cells: axons of PNS Oligodendrocytes: axons of CNS 7 Neuroglia Neural Crest!!!! Q: What is function of neuroglia? Schwann cells: axons of PNS Oligodendrocytes: axons of CNS 8 “Spines” on dendrites: change shape and strength of connection with other nerve cells in response to learning Signal Signal 9 Brain Structure Major Landmarks: Forebrain -Cerebrum -Diencephalon Corpus callosum Brainstem -Midbrain -Pons -Medulla oblongata Cerebellum 10 Cranial nerves: 12 pairs 11 Spinal Nerves 12 Spinal Nerves Spinal nerve structure: (simple version) -“gray matter” = nerve cell bodies -“white matter” = nerve cell axons Anterior view of one vertebra and the nearby section of the spinal cord 13 CNS CNS = brain + spinal cord; all parts of interneurons are in the CNS PNS PNS: (1) afferent neurons (their activity “affects” what will happen next) into the CNS & (2) efferent neurons (“effecting” change: movement, secretion, etc.) projecting out of the CNS. 14 Contrast autonomic and somatic components of the nervous system 15 Contrast autonomic and somatic components of the nervous system Voluntary Command: MOVE! Involuntary Command: Rest/Digest Involuntary Command FIGHT! FLIGHT! Skeletal Muscle Contraction Heart, smooth muscle, glands, etc. Heart, smooth muscle, glands, etc. 16 Schematic diagram of the mammalian autonomic nervous system 17 Another schematic diagram of the mammalian autonomic nervous system 18 Spinal Nerves Q: What integrates the afferent and efferent signals? 19 Evolution of the spinal nerve pattern Not all vertebrates have the mammalian pattern Contrast autonomic and somatic components of the nervous system Voluntary Command: MOVE! Involuntary Command: Rest/Digest Involuntary Command FIGHT! FLIGHT! Skeletal Muscle Contraction Heart, smooth muscle, glands, etc. Heart, smooth muscle, glands, etc. 21 Physiology of the nervous system 22 Physiology of the nervous system Only a very thin shell of charge difference is needed to establish a membrane potential. 23 Membrane Channels K+ ion Shut Open From Above 24 Membrane Channels • Change conformation in response to voltage change in the surrounding membrane: “voltage gated” • Change conformation in response to binding by an ion or other compound: “ligand gated” • Are selective in which ions pass through the pore in the center • Amino acid charges around the pore can attract specific ions • May have 3 states: deactivated (closed), activated (open), inactivated (closed) 25 Sodium – Potassium Pump (Na+/K+-ATPase) • 3 Sodium ions moved out • 2 Potassium ions moved in • Uses ATP to power protein conformational change 26 The size of a graded potential is proportional to the size of the stimulus. Graded potentials decay as they move over distance. Membrane Potential (mV) Graded potentials can be excitatory (an action potential is more likely to occur), or inhibitory where an action potential is less likely. 27 Action potentials ~100mV An action potential is an “all-or-none” sequence of changes in membrane potential (and an example of positive feedback). Action potentials result from an all-or-none sequence of changes in ion permeability due to the operation of voltage-gated Na+ and K + channels. The rapid opening of voltage-gated Na+ channels allows rapid entry of Na+ The slower opening of voltage-gated K+ channels allows K + exit 28 Flash animations: 1.Voltage gated channels in the axon membrane “links” on site 29 Action potentials Four action potentials, each the result of a stimulus strong enough to cause depolarization, are shown. Note that all are the same height. 30 Action potential propagation down the axon The propagation of the action potential from the dendrites to the axon-terminal end is typically one-way because the absolute refractory period follows along in the “wake” of the moving action potential; the AP starts at the neuron initial segment. 31 Action potential propagation down the axon in myelinated axons Saltatory conduction: action potentials jump from one node to the next as they propagate along a myelinated axon. 32 Remember the synapse … when the action potential arrives at the axon terminals … The synapse is the point of communication between two neurons. Chemical synapses have a synaptic cleft (about 10 – 20 nm wide) and neurotransmitter diffuses across the cleft to bind to receptors on the postsynaptic neuron membrane. Chemical synapses are one-directional. 33 NOTE: 1. The role of voltage-gated calcium channels 2. Vesicles with neurotransmitter 3.Neurotransmitter binding to postsynaptic receptors (often ligand-gated ion channels) 4.Re-uptake and enzymatic breakdown of neurotransmitter 5. At an excitatory synapse nonselective ion channels open and ions, mostly Na+ move down the gradient 6. At an inhibitory synapse Cl- and K+ channels open 34 1.EPSP: excitatory postsynaptic potential Key point: An action potential in a presynaptic neuron results in a graded potential in the postsynaptic neuron. 2. IPSP: inhibitory postsynaptic potential 35 Neural integration •Real neurons receive as many as 200,000 synapses each •Ion flows from all inputs summate or average at the initial segment •An action potential in the postsynaptic neuron occurs if the membrane potential at the initial segment reaches threshold 36