Myelin and White Matter
... On the same axon, adjacent myelin segments belong to different oligodendrocytes. A single oligodendrocyte provides the myelin for many internodal segments of different axons simultaneously. One oligodendrocyte can be responsible for the production and maintenance of up to 40 nerve fibers (Fig. 1.9). ...
... On the same axon, adjacent myelin segments belong to different oligodendrocytes. A single oligodendrocyte provides the myelin for many internodal segments of different axons simultaneously. One oligodendrocyte can be responsible for the production and maintenance of up to 40 nerve fibers (Fig. 1.9). ...
Thomas C. Südhof - Nobel Lecture Slides
... 1. Why does the Syt1 KO have a phenotype if Syt2 and Syt9 can compensate? 2. Why doesn’t Syt7 function in release if it is so similar to other ‘blue’ synaptotagmins? ...
... 1. Why does the Syt1 KO have a phenotype if Syt2 and Syt9 can compensate? 2. Why doesn’t Syt7 function in release if it is so similar to other ‘blue’ synaptotagmins? ...
Genetic analysis of the Complexin trans-clamping model Please share
... (26). A second aspect of the trans Cpx/SNARE array clamping model is that the Cpx helix forms a rigid bridge between two SNARE complexes (26). To test whether this rigidity is required in vivo, we expressed mCpx mutants with three glycine residues between the central helix and the accessory helix (H ...
... (26). A second aspect of the trans Cpx/SNARE array clamping model is that the Cpx helix forms a rigid bridge between two SNARE complexes (26). To test whether this rigidity is required in vivo, we expressed mCpx mutants with three glycine residues between the central helix and the accessory helix (H ...
Ethanol Potentiation of Glycine-Induced Responses in Dissociated
... NJ). It was diluted in the pipette solution to a final concentration of 50 to 100 g/ml just before the experiment. The pipette tip was filled with gramicidin-free solution by brief immersion before back filling. After establishing the giga-seal in the cell-attached configuration by gentle suction, ...
... NJ). It was diluted in the pipette solution to a final concentration of 50 to 100 g/ml just before the experiment. The pipette tip was filled with gramicidin-free solution by brief immersion before back filling. After establishing the giga-seal in the cell-attached configuration by gentle suction, ...
Targeting membrane proteins to inner segments of vertebrate
... like to thank all of my friends especially Suifang Mao and Xu Liu. I treasure the time we spent together and support each other towards our goals in this journey. ...
... like to thank all of my friends especially Suifang Mao and Xu Liu. I treasure the time we spent together and support each other towards our goals in this journey. ...
Axon Physiology - Physiological Reviews
... (394), but it is also found in the AIS of retinal ganglion cells (542) and in spinal cord motoneurons (169; see Table 2 for details). With a few exceptions, its expression in interneurons is restricted to the proximal part of the AIS and displays little overlap with Nav1.6 that occupies the distal p ...
... (394), but it is also found in the AIS of retinal ganglion cells (542) and in spinal cord motoneurons (169; see Table 2 for details). With a few exceptions, its expression in interneurons is restricted to the proximal part of the AIS and displays little overlap with Nav1.6 that occupies the distal p ...
CHAPTER 21 ELECTROCHEMISTRY: CHEMICAL CHANGE AND
... No, add spectator ions to the balanced ionic equation to obtain the balanced molecular equation. ...
... No, add spectator ions to the balanced ionic equation to obtain the balanced molecular equation. ...
THE ELECTRODE-TISSUE INTERFACE DURING RECORDING
... There are two people who were instrumental in my graduate career and I definitely would not been able to do this work without them. Svjetalana Miocinovic is one of the smartest and most generous people I know. She did a lot of the dirty work and I just happened to come along at the right time and ta ...
... There are two people who were instrumental in my graduate career and I definitely would not been able to do this work without them. Svjetalana Miocinovic is one of the smartest and most generous people I know. She did a lot of the dirty work and I just happened to come along at the right time and ta ...
concentration-dependent effects of neostigmine on the endplate
... were recorded from individual twitch fiber endplates with a two-microelectrode voltage clamp circuit similar to that described by Dionne and Stevens (1975) with two modifications: (1) the high voltage current stages were replaced with low voltage (f15 V) equivalents, and (2) the membrane voltage was ...
... were recorded from individual twitch fiber endplates with a two-microelectrode voltage clamp circuit similar to that described by Dionne and Stevens (1975) with two modifications: (1) the high voltage current stages were replaced with low voltage (f15 V) equivalents, and (2) the membrane voltage was ...
Novel Methods and Materials in Development of Liquid Carrier
... who would take over the supervision of my work. I led quite long e-mail correspondence with Prof. Melin whom I knew from Bayer AG, where I did my first industrial working experience in summer 1996. Meanwhile, I got a position in a big pharmaceutical company in Slovenia. But then Prof. Melin suggeste ...
... who would take over the supervision of my work. I led quite long e-mail correspondence with Prof. Melin whom I knew from Bayer AG, where I did my first industrial working experience in summer 1996. Meanwhile, I got a position in a big pharmaceutical company in Slovenia. But then Prof. Melin suggeste ...
Biophysics of Extracellular Action Potentials
... The goal of this thesis is to analyze the generation of single unit extracellular action potentials (EAPs), and to explore pertinent issues in the interpretation of EAP recordings. I use the line source approximation to model the EAP produced by individual neurons. I compare simultaneous intracellul ...
... The goal of this thesis is to analyze the generation of single unit extracellular action potentials (EAPs), and to explore pertinent issues in the interpretation of EAP recordings. I use the line source approximation to model the EAP produced by individual neurons. I compare simultaneous intracellul ...
Excitatory Postsynaptic Potentials Trigger a Plateau Potential in Rat
... (Nakanishi et al. 1987; Overton and Greenfield 1995). But it is not known whether plateau potentials can be triggered by synaptic potentials. In the present study, we therefore tested whether activation of excitatory synaptic inputs to STN neurons can trigger a plateau potential and if so, how the p ...
... (Nakanishi et al. 1987; Overton and Greenfield 1995). But it is not known whether plateau potentials can be triggered by synaptic potentials. In the present study, we therefore tested whether activation of excitatory synaptic inputs to STN neurons can trigger a plateau potential and if so, how the p ...
Impairment of a parabolic bursting rhythm by the ectopic expression
... We also expressed a GFP-fused rSK2 channel mutant (T387W), in which a threonine residue within the channel conduction pore was replaced by a hydrophobic residue, tryptophan. Although the mutant channels are known to target the cell surfaces when expressed in either Xenopus oocytes or mammalian cells ...
... We also expressed a GFP-fused rSK2 channel mutant (T387W), in which a threonine residue within the channel conduction pore was replaced by a hydrophobic residue, tryptophan. Although the mutant channels are known to target the cell surfaces when expressed in either Xenopus oocytes or mammalian cells ...
Information on measuring ammonia in water
... into a completely gas-tight fitting. The gas-tight fitting can, for instance, be an Erlenmeyer flask with a bored-out stopper. The ammonia sensor is pushed into the borehole, so that it is above the surface of the liquid in the Erlenmeyer flask. A head space measurement is also advisable if oil or g ...
... into a completely gas-tight fitting. The gas-tight fitting can, for instance, be an Erlenmeyer flask with a bored-out stopper. The ammonia sensor is pushed into the borehole, so that it is above the surface of the liquid in the Erlenmeyer flask. A head space measurement is also advisable if oil or g ...
Neuronal polarity: establishing and maintaining the axon initial
... somatodendritic region after synapse stimulation is called a postsynaptic potential (PSP). Axons also require a fast electric signal transfer, however since axons can be much longer than dendrites this transfer must be more faithful and stronger. Therefore axons have a system that boots the electric ...
... somatodendritic region after synapse stimulation is called a postsynaptic potential (PSP). Axons also require a fast electric signal transfer, however since axons can be much longer than dendrites this transfer must be more faithful and stronger. Therefore axons have a system that boots the electric ...
Spike train propagation in the axon of a visual interneuron,... Locusta migratoria
... during its propagation down the length of the axonal transmission line. Action potentials require that an electrochemical gradient be established across the membrane of a neuron. The Na+/K+ ATPase contributes to maintaining the Na+/K+ gradient across the membrane by pumping three Na+ ions out for ev ...
... during its propagation down the length of the axonal transmission line. Action potentials require that an electrochemical gradient be established across the membrane of a neuron. The Na+/K+ ATPase contributes to maintaining the Na+/K+ gradient across the membrane by pumping three Na+ ions out for ev ...
A Biosensor Based on Immobilization of Horseradish Peroxidase in Chitosan Matrix Cross-linked with Glyoxal for Amperometric Determination of Hydrogen Peroxide
... in a porous matrix, covalent binding and electrochemical copolymerization. Immobilization of enzyme may lead to changes in enzyme structure and hence causes the kinetics, stability and specificity differing from that of the enzyme in homogeneous solution [1]. Therefore, great interest is devoted to ...
... in a porous matrix, covalent binding and electrochemical copolymerization. Immobilization of enzyme may lead to changes in enzyme structure and hence causes the kinetics, stability and specificity differing from that of the enzyme in homogeneous solution [1]. Therefore, great interest is devoted to ...
Individual olfactory sensory neurons project into more than one
... in the present study does not allow any conclusion as to how many glomeruli are innervated by OSNs expressing the same OR. On the basis of the light microscopic observation of an avidin-stained fiber in the olfactory nerve layer, it is often impossible to distinguish whether this fiber consists of one ...
... in the present study does not allow any conclusion as to how many glomeruli are innervated by OSNs expressing the same OR. On the basis of the light microscopic observation of an avidin-stained fiber in the olfactory nerve layer, it is often impossible to distinguish whether this fiber consists of one ...
Article Full Text PDF
... Fig. 1B). The M-cells are bilateral, located in the medulla under the cerebellum (C) and behind the optic tectum (OT) near the point of entry of the VIIIth nerve. They have two principal dendrites, one lateral and one ventral. As in other teleosts (Zottoli, 1978) their axon crosses the midline, turn ...
... Fig. 1B). The M-cells are bilateral, located in the medulla under the cerebellum (C) and behind the optic tectum (OT) near the point of entry of the VIIIth nerve. They have two principal dendrites, one lateral and one ventral. As in other teleosts (Zottoli, 1978) their axon crosses the midline, turn ...
REGENERATION OF AN IDENTIFIED CENTRAL NEURON IN THE
... cell body, the normally stable, characteristic dendritic arborization is induced to sprout supernumerary neurites. The origin of the induced dendritic sprouts is not random; they emerge preferentially from the dendritic tips and branches close to the exit of the axon from the terminal ganglion. If a ...
... cell body, the normally stable, characteristic dendritic arborization is induced to sprout supernumerary neurites. The origin of the induced dendritic sprouts is not random; they emerge preferentially from the dendritic tips and branches close to the exit of the axon from the terminal ganglion. If a ...
Patch clamp
The patch clamp technique is a laboratory technique in electrophysiology that allows the study of single or multiple ion channels in cells. The technique can be applied to a wide variety of cells, but is especially useful in the study of excitable cells such as neurons, cardiomyocytes, muscle fibers, and pancreatic beta cells. It can also be applied to the study of bacterial ion channels in specially prepared giant spheroplasts.The patch clamp technique is a refinement of the voltage clamp. Erwin Neher and Bert Sakmann developed the patch clamp in the late 1970s and early 1980s. This discovery made it possible to record the currents of single ion channel molecules for the first time, which improved understanding of the involvement of channels in fundamental cell processes such as action potentials and nerve activity. Neher and Sakmann received the Nobel Prize in Physiology or Medicine in 1991 for this work.