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Transcript
Chapter 7
THE STRUCTURE OF
THE NERVOUS SYSTEM
INTRODUCTION
 Nervous System
 The structure of the nervous system
will tell us about brain function
 Brain organization
 General organization and terms used to describe it
 Examine how the 3D structure of the brain
arises through development
 Cerebral neocortex
GROSS ORGANIZATION OF
THE MAMMALIAN NERVOUS SYSTEM
 Nervous System of all mammals has two divisions
 CNS (central nervous system)
 PNS (peripheral nervous system)
 Anatomical References
GROSS ORGANIZATION OF
THE MAMMALIAN NERVOUS SYSTEM
 The Central Nervous System
 The parts of the nervous system that are encased in bone
 Brain : Cerebrum, cerebellum, brain stem
 Spinal cord
Relayas
information
among
Cerebral
hemispheres,
Contains
many neurons
cerebrum,
spinal
cord
bycerebellum,
the
deep sagittal
fissure
asseparated
both
cerebral
hemispheres
combined
The sitewith
where
vital functions are regulated
Sensations
andmovements
movements
Concerned
Breathing,
consciousness,
temperature
the contralateral
of the body
of on
ipsilateral
side of theside
body
GROSS ORGANIZATION OF
THE MAMMALIAN NERVOUS SYSTEM
 The Central Nervous System
 Spinal cord
 Surrounded by bony vertebral column, attached to the brain stem
 Conduit of information (brain body)
 Skin, joints, muscles
 Communication with body via the spinal nerves
 Dorsal root : into the spinal cord
 Ventral root : away from the spinal cord
GROSS ORGANIZATION OF
THE MAMMALIAN NERVOUS SYSTEM
 The Peripheral Nervous System
 Nervous system outside of the brain and spinal cord
 Somatic PNS
 Innervates skin, joints, muscles that are under voluntary control
 Visceral PNS = autonomic nervous system (ANS)
 Innervates internal organs, blood vessels, glands
 Afferent and Efferent Axons
 afferent : sensory axons bringing information into the CNS
 efferent : axons that emerge from the CNS
GROSS ORGANIZATION OF
THE MAMMALIAN NERVOUS SYSTEM
 The Cranial Nerves
 12 nerves from brain stem
 Mostly innervate the head
 Axons from CNS, somatic PNS, visceral PNS
 The Meninges
 Three membranes that surround the brain
 Dura mater
 Arachnoid membrane
 Pia mater
 Brain floats in cerebrospinal fluid
(CSF)
GROSS ORGANIZATION OF
THE MAMMALIAN NERVOUS SYSTEM
 The Ventricular System
 CSF-filled caverns and canals inside brain
 Choroid plexus
: specialized tissue in ventricles that secretes CSF
 Path
: Cerebrum  brain stem core  subarachnoid space
 special structures called arachnoid villi absorb CSF
 Imaging the Living Brain
 Computed Tomography (CT)
 Magnetic Resonance Imaging (MRI)
 Functional Brain Imaging
 Positron emission tomography (PET)
 Functional MRI (fMRI)
UNDERSTANDING CNS
STRUCTURE THROUGH DEVELOPMENT
 Ventricular System and the CNS
 The entire CNS forms from the walls of a fluid-filled tube
 The tube ultimately becomes ventricular system
 Formation of the Neural Tube
 The embryo begins as a flat disk with 3 distinct layers
 Endoderm : the lining of many of the internal organs
 Mesoderm : the bones of the skeleton and the muscles
 Ectoderm : the nervous system – the neural plate
UNDERSTANDING CNS
STRUCTURE THROUGH DEVELOPMENT
 Formation of the Neural Tube
 Neural plate  neural groove
 Fusion of neural folds
 Neural tube (forms CNS neurons)
 Neural crest (forms PNS neurons)
 Somites
: vertebrae
: skeletal muscle
 Somatic motor nerves
 Neurulation
: the process which the
neural plate becomes
the neural tube
UNDERSTANDING CNS
STRUCTURE THROUGH DEVELOPMENT
 Three Primary Brain Vesicles
 Differentiation
: the process by which structures become more complex
and functionally specialized during development
 Primary vesicles
: the entire brain derives from the three primary vesicles
UNDERSTANDING CNS
STRUCTURE THROUGH DEVELOPMENT
 Differentiation of the Forebrain
 The secondary brain vesicles of the forebrain
UNDERSTANDING CNS
STRUCTURE THROUGH DEVELOPMENT
 Differentiation of the Forebrain
 Differential of the Telencephalon and Diencephalon
 Telencephalon
: cerebral hemispheres, olfactory bulbs, basal telencephalon
 Diencephalon : thalamus, hypothalamus
 Ventricles : lateral ventricles, third ventricle
 Major white matter systems
: Axons extend from developing forebrain to other parts of the NS
 Cortical white matter : cerebral cortex
 Corpus callosum : two cerebral hemispheres
 Internal capsule : brain stem, particularly the thalamus
UNDERSTANDING CNS
STRUCTURE THROUGH DEVELOPMENT
 Differentiation of the Forebrain
 Forebrain Structure-Function Relationships
 Cerebral cortex
: Analyze sensory input and command motor output
 Thalamus
: Gateway of the cortex
: Carry information from contralateral side of the body
 Hypothalamus
: Control of visceral (autonomic) nervous system
UNDERSTANDING CNS
STRUCTURE THROUGH DEVELOPMENT
 Differentiation of the Midbrain
UNDERSTANDING CNS
STRUCTURE THROUGH DEVELOPMENT
 Differentiation of the Midbrain
 Midbrain Structure-Function Relationships
 Information conduit from spinal cord to forebrain and vice versa
: Sensory systems, the control of movements… contralateral side
 Tectum
 Superior colliculus (216p)
: receives direct input from the eye, controls eye movements
 Inferior colliculus : the ear instead of the eye
 Tegmentum
: Substantia nigra (black substance), red nucleus
: Control of voluntary movement
UNDERSTANDING CNS
STRUCTURE THROUGH DEVELOPMENT
 Differentiation of the Hindbrain
 Three structures
 Cerebellum : Movement control
: Sensory systems, the control of movements
 Pons : Switchboard connecting cerebral cortex to cerebellum
 Medulla
 Decussation : Crossing of axons from one side to the other
 Neurons that perform many different sensory and motor function
UNDERSTANDING CNS
STRUCTURE THROUGH DEVELOPMENT
 Differentiation of the Spinal Cord
UNDERSTANDING CNS
STRUCTURE THROUGH DEVELOPMENT
 Putting the Pieces Together
UNDERSTANDING CNS
STRUCTURE THROUGH DEVELOPMENT
 Special Features of the Human CNS
 Many convolutions on the surface : Sulcus / Gyrus
 The lobes of the human cerebrum
A GUIDE TO THE CEREBRAL CORTEX
 Common Features of Cerebral Cortex
 Cell bodies in layers of sheets
 Surface layer separated from pia mater
 Apical dendrites form multiple branches
A GUIDE TO THE CEREBRAL CORTEX
 Areas of Neocortex
 Brodmann construted a cytoarchitectural map
: Cortical areas that look different perform different functions
A GUIDE TO THE CEREBRAL CORTEX
 Areas of Neocortex
 Neocortical Evolution and S-F Relationship
 Cortex amount has changed, but not structure
 Leah Krubitzer
: Primary sensory areas, secondary sensory areas, motor areas
 Jon Kaas : Expansion of secondary sensory areas
 Association areas
: ex) ability to interpret behavior in terms of mental state