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Schematic wiring diagram of the basal ganglia. The striatum is the principal input structure of the basal ganglia and receives excitatory glutamatergic input
from many areas of cerebral cortex. The striatum contains projection neurons expressing predominantly D1 or D2 dopamine receptors, as well as
interneurons that use ACh as a neurotransmitter. Outflow from the striatum proceeds along 2 routes. The direct pathway, from the striatum to the
substantia nigra pars reticulata (SNpr) and globus pallidus interna (GPi), uses the inhibitory transmitter GABA. The indirect pathway, from the striatum
through the globus pallidus externa (GPe) and the subthalamic nucleus (STN) to the SNpr and GPi, consists of 2 inhibitory GABA-ergic links and 1
excitatory glutamatergic projection (Glu). The substantia nigra pars compacta (SNpc) provides dopaminergic innervation to the striatal neurons, giving rise
Source: Treatment of Central Nervous System Degenerative Disorders, Goodman and Gilman's Manual of Pharmacology and Therapeutics, 2e
to both the direct and indirect pathways, and regulates the relative activity of these 2 paths. The SNpr and GPi are the output structures of the basal
Citation:feedback
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Gilman's Manual
of Pharmacology
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2e; 2016 Available at:
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