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Transcript
E:Med Martin Vingron’s group Jose M Muino Martin Vingron’s group • Sequence alignment • Microarray gene analysis • Gene regulation and evolution: – (combinatorial) TF DNA binding prediction – Histone modification gene expression – Factors affecting mutation rates My projects: • (RSE1): – Regulation of recombination initiation by epigenetic factors in response to stress • Environment => Epigenetics => DNA breaks • CancerEpisys: – Epigenetics in Chronic Lymphocytic Leukemia TFs => DNA methylation Motifs overrepresented in hypomethylated regions: […] Clustering of overrepresented motifs Hypomethylated regions Cis-regulatory module (ZNF423 + EBF1) Predicted affinity of EBF1 correlates with change in DNA methylation Objective: *To obtain pairs of TF and target regions that influence epigenetic status *Why the miss-regulation?: Miss-regulation TF complex Mutations Needed: *DNA met. & gene expression & SNPs *Experimental validation DNA methylation => TF binding • Objective: – To find pairs of TF target genes which coexpression is dependent of DNA methylation • Needed: – DNA met. & gene expression in same individuals Epigenetics=> genetic mut. • Objective: – Does epigenetics affect genetic mut.? – What happen first? – Environment=>epigenetics=>mut.(?) Hypo-methylated • Needed: – DNA met & mutations same individuals – Experimental validation Hyper-methylated Web-tool for ChIP-seq analysis • • • • User-friendly All public plant ChIP-seq (-chip) data available Compatible with Integrated Genome Browser Compatible with Galaxy
