The P53 pathway and metabolism: implications in tissue
... WHY DO WE AGE AND GET CANCER? ARE THESE 2 PROCESSES INTRINSICALLY LINKED? p53 ...
... WHY DO WE AGE AND GET CANCER? ARE THESE 2 PROCESSES INTRINSICALLY LINKED? p53 ...
Evidence Suggesting that Pif1 Helicase Functions in DNA
... viable and repair proficient. Both yeast proteins have 5⬘to-3⬘ DNA helicase activity (21, 30, 31). The region of similarity between Pif1 and Rrm3 is limited to the seven helicase motifs, which exhibit 40% identity and 60% similarity (3). This may indicate that the two helicases have structurally sim ...
... viable and repair proficient. Both yeast proteins have 5⬘to-3⬘ DNA helicase activity (21, 30, 31). The region of similarity between Pif1 and Rrm3 is limited to the seven helicase motifs, which exhibit 40% identity and 60% similarity (3). This may indicate that the two helicases have structurally sim ...
NO sensing by FNR: regulation of the Escherichia coli NO
... the ¯avohaemoglobin-encoding gene of E.coli, hmp, is upregulated by NO and RNS; this appears not to involve SoxRS (Poole et al., 1996). We have reported (MembrilloHernaÂndez et al., 1998) a mechanism of hmp gene regulation that involves interaction between S-nitrosothiols and Hcy. Intracellular Hcy ...
... the ¯avohaemoglobin-encoding gene of E.coli, hmp, is upregulated by NO and RNS; this appears not to involve SoxRS (Poole et al., 1996). We have reported (MembrilloHernaÂndez et al., 1998) a mechanism of hmp gene regulation that involves interaction between S-nitrosothiols and Hcy. Intracellular Hcy ...
Decreased energy metabolism extends lifespan in
... worms and likely contribute to the physiology and lifespan of these worms. Evidence supporting a role for altered ROS levels in determining the clk-1 phenotype comes from the demonstration that increasing the levels of ROS through decreasing superoxide dismutase expression has been shown to modulate ...
... worms and likely contribute to the physiology and lifespan of these worms. Evidence supporting a role for altered ROS levels in determining the clk-1 phenotype comes from the demonstration that increasing the levels of ROS through decreasing superoxide dismutase expression has been shown to modulate ...
BT314 Virology
... regulation — the processes that control the expression of genetic information. The focus in molecular genetics is the gene — its structure, organization, and function. Population genetics explores the genetic composition of groups of individual members of the same species (populations) and how that ...
... regulation — the processes that control the expression of genetic information. The focus in molecular genetics is the gene — its structure, organization, and function. Population genetics explores the genetic composition of groups of individual members of the same species (populations) and how that ...
Introduction to Genetics
... regulation — the processes that control the expression of genetic information. The focus in molecular genetics is the gene — its structure, organization, and function. Population genetics explores the genetic composition of groups of individual members of the same species (populations) and how that ...
... regulation — the processes that control the expression of genetic information. The focus in molecular genetics is the gene — its structure, organization, and function. Population genetics explores the genetic composition of groups of individual members of the same species (populations) and how that ...
Selective Disruption of Aurora C Kinase Reveals Distinct Functions
... CPC. Separation of AURKB and AURKC function during meiosis in oocytes by conventional approaches has not been successful. Therefore, the meiotic function of AURKC is still not fully understood. Here, we describe an ATP-binding-pocketAURKC mutant, that when expressed in mouse oocytes specifically per ...
... CPC. Separation of AURKB and AURKC function during meiosis in oocytes by conventional approaches has not been successful. Therefore, the meiotic function of AURKC is still not fully understood. Here, we describe an ATP-binding-pocketAURKC mutant, that when expressed in mouse oocytes specifically per ...
Human mitochondrial transfer RNAs: Role of pathogenic
... the mutant tRNA result in increased degradation and ultimately lead to decreased steady-state levels of a mitochondrial tRNA. In addition, the efficiency of the aminoacylation process will be particularly sensitive to point mutations because the enzymes involved recognize a specific structure of a tRN ...
... the mutant tRNA result in increased degradation and ultimately lead to decreased steady-state levels of a mitochondrial tRNA. In addition, the efficiency of the aminoacylation process will be particularly sensitive to point mutations because the enzymes involved recognize a specific structure of a tRN ...
Product description P003-D1 MLH1-MSH2-v01 - MRC
... containing MLH1 or MSH2 exon deletions or amplifications: http://www.nibsc.org/documents/ifu/11-218xxx.pdf. As an alternative, an artificial positive duplication DNA sample for MLH1 and MSH2 (product name SD027) can be ordered from MRC-Holland. This FOR RESEARCH USE ONLY SD027 DNA will show a duplic ...
... containing MLH1 or MSH2 exon deletions or amplifications: http://www.nibsc.org/documents/ifu/11-218xxx.pdf. As an alternative, an artificial positive duplication DNA sample for MLH1 and MSH2 (product name SD027) can be ordered from MRC-Holland. This FOR RESEARCH USE ONLY SD027 DNA will show a duplic ...
Document
... Base your answers to questions 27 - 28 on the information and data table below and on your knowledge of biology. When a culture of cells is exposed to gamma rays, chromosome damage results. This damage is very evident when the cells are stained and observed with a compound light microscope. The chro ...
... Base your answers to questions 27 - 28 on the information and data table below and on your knowledge of biology. When a culture of cells is exposed to gamma rays, chromosome damage results. This damage is very evident when the cells are stained and observed with a compound light microscope. The chro ...
Biology II Final Exam Practice
... Indicate whether the statement is true or false. If false, change the identified word or phrase to make the statement true. ____ 26. The following sequence could be a tRNA anticodon: GTG. _________________________ ____ 27. A mutation is a random change in genetic material. _________________________ ...
... Indicate whether the statement is true or false. If false, change the identified word or phrase to make the statement true. ____ 26. The following sequence could be a tRNA anticodon: GTG. _________________________ ____ 27. A mutation is a random change in genetic material. _________________________ ...
Control of DNA excision efficiency in Paramecium
... transcriptionally silent and provide genetic continuity between sexual generations. In the course of sexual reproduction the micronuclei undergo meiosis, whereas the macronuclei degenerate. The fusion of two gametic nuclei produces a zygotic nucleus. This nucleus divides twice and the daughter nucle ...
... transcriptionally silent and provide genetic continuity between sexual generations. In the course of sexual reproduction the micronuclei undergo meiosis, whereas the macronuclei degenerate. The fusion of two gametic nuclei produces a zygotic nucleus. This nucleus divides twice and the daughter nucle ...
to view
... Ans. Monozygotic twins develop from a single zygote. In rest of the individuals, the zygote develops directly into an individual 2) A plant was introduced in India because of its beautiful flowers & shape of Leaves. It propagates vegetatively at a phenomenal rate and spread all over the water bodies ...
... Ans. Monozygotic twins develop from a single zygote. In rest of the individuals, the zygote develops directly into an individual 2) A plant was introduced in India because of its beautiful flowers & shape of Leaves. It propagates vegetatively at a phenomenal rate and spread all over the water bodies ...
Properties of Mitotic and Meiotic Recombination in the
... (Liang et al., 1998). Saccharomyces cerevisiae strains that lack HR are very sensitive to DNA damaging agents such as X-rays (Resnick and Martin, 1976), and have a high rate of spontaneous chromosome loss (Song and Petes, 2012). HR is essential for cell survival of mammalian cells (Helleday, 2003). ...
... (Liang et al., 1998). Saccharomyces cerevisiae strains that lack HR are very sensitive to DNA damaging agents such as X-rays (Resnick and Martin, 1976), and have a high rate of spontaneous chromosome loss (Song and Petes, 2012). HR is essential for cell survival of mammalian cells (Helleday, 2003). ...
A Physical Gene Map of the Bacteriophage P22 Late
... DNA (5.22 kb; Fiers et al., 1978) or pBR322 form II dimer (8.72 kb; Sutcliffe, 1978) DNA was present in all samples as -an internal length standard. Recombination and complementation of P22 mutants with cloned fragments of P22 DNA. Plasmid DNA containing cloned P22 fragments was isolated from E. col ...
... DNA (5.22 kb; Fiers et al., 1978) or pBR322 form II dimer (8.72 kb; Sutcliffe, 1978) DNA was present in all samples as -an internal length standard. Recombination and complementation of P22 mutants with cloned fragments of P22 DNA. Plasmid DNA containing cloned P22 fragments was isolated from E. col ...
What is p53
... the p53 pathway (picture summarizing the cellular functions of p53, 996, by Hall PA et al.) ...
... the p53 pathway (picture summarizing the cellular functions of p53, 996, by Hall PA et al.) ...
Selection for TnlO Tet Repressor Binding to tet Operator
... We have constructed a genetic assay which selects positively for a functional interaction between Tet repressor and its cognate operator in Escherichia coli. In this strain Tet repressor blocks expression of lacl and lacZ. This leads to derepression of a lacPO controlled galK gene. The strain can be ...
... We have constructed a genetic assay which selects positively for a functional interaction between Tet repressor and its cognate operator in Escherichia coli. In this strain Tet repressor blocks expression of lacl and lacZ. This leads to derepression of a lacPO controlled galK gene. The strain can be ...
Optimal estimation of diffusion coefficients from single
... paramount for the precise understanding of these processes. Recent developments in fluorescent labels have made it possible to track diffusion of single molecules, e.g., proteins on biopolymers such as DNA [1–3] or microtubules [4–6], on surfaces [7], in lipid membranes [8–10], and inside cells [11– ...
... paramount for the precise understanding of these processes. Recent developments in fluorescent labels have made it possible to track diffusion of single molecules, e.g., proteins on biopolymers such as DNA [1–3] or microtubules [4–6], on surfaces [7], in lipid membranes [8–10], and inside cells [11– ...
Simple identification of dominant p53 mutants by
... transactivate its target genes. While this abortive activation/ impaired degradation model provides a satisfactory explanation for the high level p53 expression seen in tumours (5,6), it does not rule out the possibility that a selective growth advantage may be conferred by mutated p53 proteins, eit ...
... transactivate its target genes. While this abortive activation/ impaired degradation model provides a satisfactory explanation for the high level p53 expression seen in tumours (5,6), it does not rule out the possibility that a selective growth advantage may be conferred by mutated p53 proteins, eit ...