A SMN missense mutation complements SMN2 restoring snRNPs
... SMA mice containing two copies of SMN2 is not detrimental, but is beneficial with mice living on average 13 days (35). The mild SMA mutation, SMN(A2G) (36), when expressed in mice with SMN2 results in mild SMA, but SMN(A2G) by itself cannot rescue Smn2/2 mice (37). SMN has a well-characterized funct ...
... SMA mice containing two copies of SMN2 is not detrimental, but is beneficial with mice living on average 13 days (35). The mild SMA mutation, SMN(A2G) (36), when expressed in mice with SMN2 results in mild SMA, but SMN(A2G) by itself cannot rescue Smn2/2 mice (37). SMN has a well-characterized funct ...
1. Ackerman A 1943 (Experiments to increase the yield from spring
... chromosomal organization of DNA sequences coding for the ribosomal RNA's in cereals. Chromosoma 78: 293-311. Arbuzova VS 1989 Development of isogenic forms of wheat Saratovskaya 29 for introducing dominant gene-markers for separate chromosomes in monosomic lines. ...
... chromosomal organization of DNA sequences coding for the ribosomal RNA's in cereals. Chromosoma 78: 293-311. Arbuzova VS 1989 Development of isogenic forms of wheat Saratovskaya 29 for introducing dominant gene-markers for separate chromosomes in monosomic lines. ...
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... showed only weak expression at the basal pole of gnom, whereas the suspensor signal also seen in wild type is maintained (Fig. 1C,G). These data indicate that the root pole is not properly established in gnom. As cotyledon formation in gnom is also impaired, we next tested whether apical markers wer ...
... showed only weak expression at the basal pole of gnom, whereas the suspensor signal also seen in wild type is maintained (Fig. 1C,G). These data indicate that the root pole is not properly established in gnom. As cotyledon formation in gnom is also impaired, we next tested whether apical markers wer ...
Determining the Transcription Factor Genes Populating a Fruit Fly
... the instructions to make these traits are encoded in its DNA sequence. Since many organisms share a considerable amount of the same genetic sequences, the question arises as to how diverse traits are formed. One explanation is that diversity results from variation in how genes are expressed, which h ...
... the instructions to make these traits are encoded in its DNA sequence. Since many organisms share a considerable amount of the same genetic sequences, the question arises as to how diverse traits are formed. One explanation is that diversity results from variation in how genes are expressed, which h ...
The monogenic primary dystonias
... occurs as a paroxysmal sign in association with other movement anomalies and sometimes seizures. While gross neuropathological changes are absent in most primary dystonias, including the paroxysmal forms, striking morphological alterations are found in some, such as in the X-linked dystonia–parkinso ...
... occurs as a paroxysmal sign in association with other movement anomalies and sometimes seizures. While gross neuropathological changes are absent in most primary dystonias, including the paroxysmal forms, striking morphological alterations are found in some, such as in the X-linked dystonia–parkinso ...
ALLEN Developing Mouse Brain Atlas
... EXPERT ANNOTATION OF ISH DATA OVERVIEW The Allen Developing Mouse Brain Atlas is an extensive resource on gene expression over the course of brain development from embryonic through postnatal stages, providing both spatial and temporal information about gene expression. In situ hybridization (ISH) d ...
... EXPERT ANNOTATION OF ISH DATA OVERVIEW The Allen Developing Mouse Brain Atlas is an extensive resource on gene expression over the course of brain development from embryonic through postnatal stages, providing both spatial and temporal information about gene expression. In situ hybridization (ISH) d ...
A Theory of Conceptual Advance: Explaining Conceptual Change in
... One central object of study for philosophy is the human intellect. Philosophy attempts to understand rationality and objectivity as a characteristic of different forms of theoretical and practical reasoning. This is a study in philosophy of science, and thereby concerns a particular manifestation of ...
... One central object of study for philosophy is the human intellect. Philosophy attempts to understand rationality and objectivity as a characteristic of different forms of theoretical and practical reasoning. This is a study in philosophy of science, and thereby concerns a particular manifestation of ...
Wolbachia: master manipulators of invertebrate biology
... Ehrlichia and Rickettsia, typically have life cycles that include an invertebrate ‘vector’ and mammalian ‘host’, although strictly invertebrate-associated species are also found4. However, unlike members of these other genera, Wolbachia do not routinely infect vertebrates. Wolbachia have attracted c ...
... Ehrlichia and Rickettsia, typically have life cycles that include an invertebrate ‘vector’ and mammalian ‘host’, although strictly invertebrate-associated species are also found4. However, unlike members of these other genera, Wolbachia do not routinely infect vertebrates. Wolbachia have attracted c ...
A Second Mechanism for Aluminum Resistance in Wheat Relies on
... on acid soils. Wheat (Triticum aestivum) shows a large intraspecific variation in Al resistance (Polle et al., 1978; Garvin and Carver, 2003; Stodart et al., 2007; Raman et al., 2008), but establishing the genetic basis for this variation has proved controversial. Reports are generally divided into ...
... on acid soils. Wheat (Triticum aestivum) shows a large intraspecific variation in Al resistance (Polle et al., 1978; Garvin and Carver, 2003; Stodart et al., 2007; Raman et al., 2008), but establishing the genetic basis for this variation has proved controversial. Reports are generally divided into ...
VAAST 2 User`s Guide
... Provided with these inputs the VAAST analysis pipeline occurs in three basic steps: ...
... Provided with these inputs the VAAST analysis pipeline occurs in three basic steps: ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... symptoms.ARCL1A is caused by mutations in the FBLN5 gene. 3.1.2 ARCL 1B or FBLN4 (EFEMP2)-related cutis laxa is characterized by cutis laxa and the involvement of other body parts, namely the cardiovascular system (arterial problems such as tortuosity, aneurysms and stenosis), skeletal system (loose ...
... symptoms.ARCL1A is caused by mutations in the FBLN5 gene. 3.1.2 ARCL 1B or FBLN4 (EFEMP2)-related cutis laxa is characterized by cutis laxa and the involvement of other body parts, namely the cardiovascular system (arterial problems such as tortuosity, aneurysms and stenosis), skeletal system (loose ...
Identification of new components involved in shoot gravitropism in
... (WT) level. Most of the suppressors were isolated from different seed pools, and they show various degrees of gravitropic response as compared to WS (wild type) and scr1. Therefore, it is reasonable to predict that each suppressor represents a different mutation. Each mutation should point to a spe ...
... (WT) level. Most of the suppressors were isolated from different seed pools, and they show various degrees of gravitropic response as compared to WS (wild type) and scr1. Therefore, it is reasonable to predict that each suppressor represents a different mutation. Each mutation should point to a spe ...
anatomical skin dimples
... dominant pattern of inheritance. Dimples are one of the most dominant facial traits.Dimples are a dominant trait, which means that it only takes one gene to inherit dimples. If neither of your parents have dimples, you shouldn’t have them either, unless you experience a spontaneous mutation. If one ...
... dominant pattern of inheritance. Dimples are one of the most dominant facial traits.Dimples are a dominant trait, which means that it only takes one gene to inherit dimples. If neither of your parents have dimples, you shouldn’t have them either, unless you experience a spontaneous mutation. If one ...
Yersinia pestis Biofilm in the Flea Vector and Its Role
... For many years, bacterial aggregation in the flea midgut and proventricular blockage was attributed to a coagulase activity of the pPla-encoded Y. pestis plasminogen activator (Pla). Although Pla acts to rapidly degrade fibrin clots at 37°C by activating plasminogen, at lower temperatures typical of ...
... For many years, bacterial aggregation in the flea midgut and proventricular blockage was attributed to a coagulase activity of the pPla-encoded Y. pestis plasminogen activator (Pla). Although Pla acts to rapidly degrade fibrin clots at 37°C by activating plasminogen, at lower temperatures typical of ...
4. Rh Phenotyping
... In this procedure, commonly tested antigens of the Rh system will be studied. Normally the only Rh antigen identified in routine pretransfusion testing is the D antigen. Four additional Rh antigens are: C, E, –c, and . Information obtained through the identification of these antigens may be used in ...
... In this procedure, commonly tested antigens of the Rh system will be studied. Normally the only Rh antigen identified in routine pretransfusion testing is the D antigen. Four additional Rh antigens are: C, E, –c, and . Information obtained through the identification of these antigens may be used in ...
Environmental Microbiology Reports
... consortium is responsible for sugarcane-associated BNF. In an effort to get more insight into the natural N-fixing bacterial community present in sugarcane plants, Ando and colleagues (2005) evaluated nifH gene diversity in sugarcane tissues and found phylotypes similar to the genera Serratia, Klebs ...
... consortium is responsible for sugarcane-associated BNF. In an effort to get more insight into the natural N-fixing bacterial community present in sugarcane plants, Ando and colleagues (2005) evaluated nifH gene diversity in sugarcane tissues and found phylotypes similar to the genera Serratia, Klebs ...
TaqMan® SNP Genotyping Assays User Guide
... particular level of observation or actions as described below: Note: Provides information that may be of interest or help but is not critical to the use of the product. ...
... particular level of observation or actions as described below: Note: Provides information that may be of interest or help but is not critical to the use of the product. ...
An N-terminally truncated envelope protein encoded
... Homburg, Germany Full list of author information is available at the end of the article ...
... Homburg, Germany Full list of author information is available at the end of the article ...
Haemophilia (2013) - Haemophilia Foundation Australia
... Because females have two copies of these genes, one inherited from each parent, women with an altered factor VIII or IX gene usually have another copy that is not altered. This helps factor VIII and IX to work properly in the blood clotting process and is often enough to control bleeding. However, t ...
... Because females have two copies of these genes, one inherited from each parent, women with an altered factor VIII or IX gene usually have another copy that is not altered. This helps factor VIII and IX to work properly in the blood clotting process and is often enough to control bleeding. However, t ...
Nectary formation is ABC independent - Development
... UNUSUAL FLORAL ORGANS. Even though nectary glands arise from cells previously expressing the B class ...
... UNUSUAL FLORAL ORGANS. Even though nectary glands arise from cells previously expressing the B class ...
Interactions between the otitis media gene, Fbxo11, and p53 in the
... Our previous studies of the Jeff mutant indicate that FBXO11 is involved in controlling TGFβ signalling by regulating the levels of pSMAD2 in embryonic epithelial cells (Tateossian et al., 2009). While Jeff heterozygous mice develop deafness due to chronic proliferative otitis media (Hardisty et al ...
... Our previous studies of the Jeff mutant indicate that FBXO11 is involved in controlling TGFβ signalling by regulating the levels of pSMAD2 in embryonic epithelial cells (Tateossian et al., 2009). While Jeff heterozygous mice develop deafness due to chronic proliferative otitis media (Hardisty et al ...
MINI - REVIEW Turner. B.C., D.D. Perkins
... r(Sk-2)-l in its map location and effect on recombination. The existence of neutral strains that are resistant only to Sk-2^K or only to Sk-3^K provides one basis for treating the two Spore killers as distinct entities. r-(Sk-2)-l and r(Sk-3)-l confer complete resistance, but different neutral strai ...
... r(Sk-2)-l in its map location and effect on recombination. The existence of neutral strains that are resistant only to Sk-2^K or only to Sk-3^K provides one basis for treating the two Spore killers as distinct entities. r-(Sk-2)-l and r(Sk-3)-l confer complete resistance, but different neutral strai ...
Genes Involved in the Uptake and Catabolism of
... z to 3 days at 37 "C. These colonies were picked and purified by repeated isolation of single colonies. They were found to be still devoid of PEP-carboxylase activity, and would therefore not grow on any hexose or other substrate which requires this anaplerotic enzyme for catabolism, until theppc+ a ...
... z to 3 days at 37 "C. These colonies were picked and purified by repeated isolation of single colonies. They were found to be still devoid of PEP-carboxylase activity, and would therefore not grow on any hexose or other substrate which requires this anaplerotic enzyme for catabolism, until theppc+ a ...
Genes Involved in the Uptake and Catabolism of
... z to 3 days at 37 "C. These colonies were picked and purified by repeated isolation of single colonies. They were found to be still devoid of PEP-carboxylase activity, and would therefore not grow on any hexose or other substrate which requires this anaplerotic enzyme for catabolism, until theppc+ a ...
... z to 3 days at 37 "C. These colonies were picked and purified by repeated isolation of single colonies. They were found to be still devoid of PEP-carboxylase activity, and would therefore not grow on any hexose or other substrate which requires this anaplerotic enzyme for catabolism, until theppc+ a ...
X-Chromosome inactivation ratios affect wild-type
... methyl-CpG-binding protein 2 (MeCP2). The onset of symptoms in RTT is delayed until 6 – 18 months and 4 –6 months in the Mecp2 2/1 mouse model, corresponding to a dynamic and gradual accumulation of MeCP2 expression in individual neurons of the postnatal brain. Because of X chromosome inactivation ( ...
... methyl-CpG-binding protein 2 (MeCP2). The onset of symptoms in RTT is delayed until 6 – 18 months and 4 –6 months in the Mecp2 2/1 mouse model, corresponding to a dynamic and gradual accumulation of MeCP2 expression in individual neurons of the postnatal brain. Because of X chromosome inactivation ( ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse