An investigation of sympatric speciation in diploid organisms by
... genetic mechanisms of reproduction. In this methodology there is no direct comparison with biological data but the simulation follows, as closely as possible, natural genetic mechanisms of reproduction. The selected modelling method uses a framework derived from Penna [1995] which represents individ ...
... genetic mechanisms of reproduction. In this methodology there is no direct comparison with biological data but the simulation follows, as closely as possible, natural genetic mechanisms of reproduction. The selected modelling method uses a framework derived from Penna [1995] which represents individ ...
Inherited epidermolysis bullosa - zum EB
... summarized as: major EB type / phenotype (severity and distribution) / mode of transmission / ultrastructural site of cleavage and associated findings / protein involved (with or without specific IFM findings listed) / gene involved and mutational type / specific mutation present. A contracted versi ...
... summarized as: major EB type / phenotype (severity and distribution) / mode of transmission / ultrastructural site of cleavage and associated findings / protein involved (with or without specific IFM findings listed) / gene involved and mutational type / specific mutation present. A contracted versi ...
The monogenic primary dystonias
... periaqueductal grey matter. These inclusions were immunoreactive for ubiquitin, torsinA and nuclear envelope (NE) protein lamin A/C. In brains from patients with adult-onset dystonia thought to be dystonia 1, Holton et al. (2008) did not find such inclusions. These findings suggest that the underlyi ...
... periaqueductal grey matter. These inclusions were immunoreactive for ubiquitin, torsinA and nuclear envelope (NE) protein lamin A/C. In brains from patients with adult-onset dystonia thought to be dystonia 1, Holton et al. (2008) did not find such inclusions. These findings suggest that the underlyi ...
Here - Orrery Software
... The PSoup Analogy---------------------------------------------------------------------------------------------------19 Speed Controls in PSoup ---------------------------------------------------------------------------------------------21 Background To Scenarios ------------------------------------- ...
... The PSoup Analogy---------------------------------------------------------------------------------------------------19 Speed Controls in PSoup ---------------------------------------------------------------------------------------------21 Background To Scenarios ------------------------------------- ...
The KetelD Dominant-Negative Mutations Identify
... intriguing biological phenomena and raises questions about the origin and function of factors required for the initiation of a new life. What are those factors? Where and how are they made? What are their functions? It has long been known that most of the factors that are required during early embry ...
... intriguing biological phenomena and raises questions about the origin and function of factors required for the initiation of a new life. What are those factors? Where and how are they made? What are their functions? It has long been known that most of the factors that are required during early embry ...
Creating order from chaos: epigenome dynamics in
... Finally, it is worth considering variation in selection against TE proliferation at the level ...
... Finally, it is worth considering variation in selection against TE proliferation at the level ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... Hyper extensible skin should also be distinguished from that observed in the cutis laxa syndromes and in De Barsy syndrome, in which the redundant skin hangs in loose folds and only returns very slowly to its former position. In these syndromes, the skin is not fragile, and wound healing is normal. ...
... Hyper extensible skin should also be distinguished from that observed in the cutis laxa syndromes and in De Barsy syndrome, in which the redundant skin hangs in loose folds and only returns very slowly to its former position. In these syndromes, the skin is not fragile, and wound healing is normal. ...
Engrailed cooperates with extradenticle and homothorax to repress
... Fig. 1F-H, complete removal of both maternal and zygotic exd function caused a dramatic drop in En repression activity on the slp gene. However, as with hth, there appeared to be residual activity even in the absence of exd function. Thus, although En retains a residual repression activity in vivo w ...
... Fig. 1F-H, complete removal of both maternal and zygotic exd function caused a dramatic drop in En repression activity on the slp gene. However, as with hth, there appeared to be residual activity even in the absence of exd function. Thus, although En retains a residual repression activity in vivo w ...
hhmi resource for new ap bio curriculum
... wild-type and mutant rock pocket mouse Mc1r genes and compare sequences to identify the locations and types of mutations responsible for the coat color variation described in the film. ...
... wild-type and mutant rock pocket mouse Mc1r genes and compare sequences to identify the locations and types of mutations responsible for the coat color variation described in the film. ...
The Genetics of Migraine
... among individuals belonging to different families but also within the same family.13,15,16 Besides familial cases, some sporadic cases of hemiplegic migraine with cerebellar symptoms have also been reported.16,27 Whether FHM has the same pathophysiological mechanisms as other types of migraine with ...
... among individuals belonging to different families but also within the same family.13,15,16 Besides familial cases, some sporadic cases of hemiplegic migraine with cerebellar symptoms have also been reported.16,27 Whether FHM has the same pathophysiological mechanisms as other types of migraine with ...
Unequal Crossing-over in Unique PABP2 Mutations in Japanese
... repeats are responsible for a number of hereditary neuromuscular diseases.7,14,15 These pathologic repeat expansions can be explained by the slippage model. However, it has been proposed that tracts of approximately 25 to 35 perfect trinucleotide repeats are required for instability and expansion vi ...
... repeats are responsible for a number of hereditary neuromuscular diseases.7,14,15 These pathologic repeat expansions can be explained by the slippage model. However, it has been proposed that tracts of approximately 25 to 35 perfect trinucleotide repeats are required for instability and expansion vi ...
Standard PDF - Wiley Online Library
... The best understood special form of P. carinii, P. carinii formae specialis (f.sp.) carinii, appears to be haploid and contains about 8 million base pairs of DNA (8.5 fg) per nucleus. The genome of P. carinii f.sp. carinii is divided into 13^15 linear chromosomes that range from 300 to 700 kb in siz ...
... The best understood special form of P. carinii, P. carinii formae specialis (f.sp.) carinii, appears to be haploid and contains about 8 million base pairs of DNA (8.5 fg) per nucleus. The genome of P. carinii f.sp. carinii is divided into 13^15 linear chromosomes that range from 300 to 700 kb in siz ...
gsea user guide
... dataset. This prevents flat genes from driving the clustering result and improves processing time by focusing on a smaller number of interesting genes. The GSEA algorithm does not filter the expression dataset and does not benefit from your filtering of the expression dataset. During the analysis, g ...
... dataset. This prevents flat genes from driving the clustering result and improves processing time by focusing on a smaller number of interesting genes. The GSEA algorithm does not filter the expression dataset and does not benefit from your filtering of the expression dataset. During the analysis, g ...
Expression and function of decapentaplegic and thick veins during
... and GAL4-1348. Clones of Dpp- and Tkv*expressing cells were generated by FLPmediated excision of a lacZ flip-out casette in flies of genotype FLP1.22/+; Ubx>lacZ>dpp/+ and FLP1.22/+; Ubx>lacZ>tkv*/+ as described by Lecuit et al. (1996). Two reporter lines were also used: a construct in which an 8.5 ...
... and GAL4-1348. Clones of Dpp- and Tkv*expressing cells were generated by FLPmediated excision of a lacZ flip-out casette in flies of genotype FLP1.22/+; Ubx>lacZ>dpp/+ and FLP1.22/+; Ubx>lacZ>tkv*/+ as described by Lecuit et al. (1996). Two reporter lines were also used: a construct in which an 8.5 ...
A survey on computational methods for enhancer and
... conformation capture (Hi-C) (Lieberman-Aiden et al. 2009) and chromatin interaction analysis with paired-end tag sequencing (ChIA-PET) (Fullwood et al. 2009). Hi-C and ChIA-PET have facilitated whole-genome identification of DNA regions that are in close proximity in the three-dimensional genome str ...
... conformation capture (Hi-C) (Lieberman-Aiden et al. 2009) and chromatin interaction analysis with paired-end tag sequencing (ChIA-PET) (Fullwood et al. 2009). Hi-C and ChIA-PET have facilitated whole-genome identification of DNA regions that are in close proximity in the three-dimensional genome str ...
Mesenchymal Dysplasia: A Recessive Mutation
... human conditions (Winter 1988). With the rapidly expanding mouse genetic map, the structural genes for many mutations causing such syndromes are now being identified. Thus, each new mouse mutation that causes congenital malformations provides the potential of identifying the gene affected in compara ...
... human conditions (Winter 1988). With the rapidly expanding mouse genetic map, the structural genes for many mutations causing such syndromes are now being identified. Thus, each new mouse mutation that causes congenital malformations provides the potential of identifying the gene affected in compara ...
Product description P018-G1 SHOX-v03 - MRC
... SHOX gene function. - Please note that single exon deletions have a considerable chance of being a false positive result, either due to non-pathogenic copy number variants (Benito-Sanz et al. 2011a), mutations within the probe binding site (Barca-Tierno et al. 2011) or due to impurities in the DNA. ...
... SHOX gene function. - Please note that single exon deletions have a considerable chance of being a false positive result, either due to non-pathogenic copy number variants (Benito-Sanz et al. 2011a), mutations within the probe binding site (Barca-Tierno et al. 2011) or due to impurities in the DNA. ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.