Hermann Joseph Muller - National Academy of Sciences
... Edgar Altenburg to share the teaching while they carried out research on mutation rates and the mutation process. Muller also continued with Altenburg a long-term project started in 1912 that was not published until 1920: a study of what Muller called the gene-character problem. On theoretical groun ...
... Edgar Altenburg to share the teaching while they carried out research on mutation rates and the mutation process. Muller also continued with Altenburg a long-term project started in 1912 that was not published until 1920: a study of what Muller called the gene-character problem. On theoretical groun ...
Analysis of large and small colony L5178Y tk−/− mouse lymphoma
... cytogenetic studies showed that a subset of small colony mutants has cytogenetically detectable aberrations of chromosome 11, including translocations (usually non-reciprocal) in which non-11 chromosomal material is fused to a break point in the distal end of chromosome 11, presumably at or near the ...
... cytogenetic studies showed that a subset of small colony mutants has cytogenetically detectable aberrations of chromosome 11, including translocations (usually non-reciprocal) in which non-11 chromosomal material is fused to a break point in the distal end of chromosome 11, presumably at or near the ...
Genetics Principles And Analysis
... Genetics: Principles and analysis / Daniel L. Hartl, Elizabeth W. Jones.—4th ed. p. cm. Includes bibliographical references (p.). ISBN 0-7637-0489-X 1. Genetics. I. Jones, Elizabeth W. II. Title. QH430.H3733 1998 576.5—dc21 ...
... Genetics: Principles and analysis / Daniel L. Hartl, Elizabeth W. Jones.—4th ed. p. cm. Includes bibliographical references (p.). ISBN 0-7637-0489-X 1. Genetics. I. Jones, Elizabeth W. II. Title. QH430.H3733 1998 576.5—dc21 ...
The Deletion Stocks of Common Wheat
... The aneuploid stocks developed in a common wheat cultivar Chinese Spring are a powerful tool for genetic and breeding studies of wheat (Sears 1954, 1966; Sears and Sears 1978). These stocks are immensely useful for localization of genes on chromosomes and chromosomes arms (Mclntosh 1988). Endo (1988 ...
... The aneuploid stocks developed in a common wheat cultivar Chinese Spring are a powerful tool for genetic and breeding studies of wheat (Sears 1954, 1966; Sears and Sears 1978). These stocks are immensely useful for localization of genes on chromosomes and chromosomes arms (Mclntosh 1988). Endo (1988 ...
org.Mm.eg.db
... assigned in the literature, users are cautioned that this map may produce multiple matching results for a single gene symbol. Users should map back from the entrez gene IDs produced to determine which result is the one they want when this happens. Because of this problem with redundant assigment of ...
... assigned in the literature, users are cautioned that this map may produce multiple matching results for a single gene symbol. Users should map back from the entrez gene IDs produced to determine which result is the one they want when this happens. Because of this problem with redundant assigment of ...
Saccharomyces cerevisiae
... libraries of enzyme variants. Bacteria and yeast are preferred, but eukaryotic proteins often fail to express in active form in these cells. We have attempted to resolve this problem by identifying mutations in the target gene that facilitate its functional expression in a given recombinant host. He ...
... libraries of enzyme variants. Bacteria and yeast are preferred, but eukaryotic proteins often fail to express in active form in these cells. We have attempted to resolve this problem by identifying mutations in the target gene that facilitate its functional expression in a given recombinant host. He ...
Diagnosis of Helicobacter pylori
... VacAm region-specific antigen was not able to predict the risk of gastric cancer development [41]. In the past, ELISA performed with antigens obtained from local strains led to better results than when kits were used. In a study carried out in Vietnam, Pyloriset EIA-GIII (Orion Diagnostics, Espoo, F ...
... VacAm region-specific antigen was not able to predict the risk of gastric cancer development [41]. In the past, ELISA performed with antigens obtained from local strains led to better results than when kits were used. In a study carried out in Vietnam, Pyloriset EIA-GIII (Orion Diagnostics, Espoo, F ...
factor involved in dorsal-ventral axis formation and neurogenesis
... that fragment. MNR31, MNR62, cl-7, and MNR73 all contain exon 5 from the 1.3-kb EcoRI fragment and, thus, differ only in the 5'-most exon. MNR22 begins at the same site as MNR73 but reads through the splice signals utilized by MNR73. The final cDNA examined, c3-0, appears to be a partial unprocessed ...
... that fragment. MNR31, MNR62, cl-7, and MNR73 all contain exon 5 from the 1.3-kb EcoRI fragment and, thus, differ only in the 5'-most exon. MNR22 begins at the same site as MNR73 but reads through the splice signals utilized by MNR73. The final cDNA examined, c3-0, appears to be a partial unprocessed ...
A novel role for the floral homeotic gene APETALA2
... valves and replum, respectively. In ful rpl double mutants, the valve margin identity genes become ectopically expressed, and, as a result, the entire outer surface of the ovary takes on valve margin identity. We carried out a genetic screen in this sensitized genetic background and identified a sup ...
... valves and replum, respectively. In ful rpl double mutants, the valve margin identity genes become ectopically expressed, and, as a result, the entire outer surface of the ovary takes on valve margin identity. We carried out a genetic screen in this sensitized genetic background and identified a sup ...
Maintenance of genomic integrity by p53: complementary
... preventing ®xation of DNA damage as mutations. This function of p53 led to the now famous coining of p53 as the `guardian of the genome' by Lane (1992). Although the main features of p53's role in maintaining the integrity of the genome seem to be outlined, there is still a lot to be learned as to h ...
... preventing ®xation of DNA damage as mutations. This function of p53 led to the now famous coining of p53 as the `guardian of the genome' by Lane (1992). Although the main features of p53's role in maintaining the integrity of the genome seem to be outlined, there is still a lot to be learned as to h ...
Coffee B, Ikeda M, Budimirovic DB, Hjelm LN, Kaufmann WE and Warren ST: Mosaic FMR1 Deletion Causes Fragile X Syndrome and Can Lead to Molecular Misdiagnosis: A Case Report and Review of the Literature. American J of Medical Genetics Part A 146A:1358-1367 (2008).
... of a CGG trinucleotide repeat in the 50 UTR of FMR1. This expansion leads to transcriptional silencing of the gene. However, other mutational mechanisms, such as deletions of FMR1, also cause fragile X syndrome. The result is the same for both the expansion mediated silencing and deletion, absence o ...
... of a CGG trinucleotide repeat in the 50 UTR of FMR1. This expansion leads to transcriptional silencing of the gene. However, other mutational mechanisms, such as deletions of FMR1, also cause fragile X syndrome. The result is the same for both the expansion mediated silencing and deletion, absence o ...
Primary amenorrhea
... Genetic causes of primary amenorrhea 1 – X chromosome alterations: - X chromosome monosomy - X deletion, translocation (POF1, POF-1B, POF-2, POF-3) - BMP-15 mutation - premutation of the FMR1 gene (FraX Syndrome) 2 – autosomal genes ...
... Genetic causes of primary amenorrhea 1 – X chromosome alterations: - X chromosome monosomy - X deletion, translocation (POF1, POF-1B, POF-2, POF-3) - BMP-15 mutation - premutation of the FMR1 gene (FraX Syndrome) 2 – autosomal genes ...
org.Dr.eg.db
... assigned in the literature, users are cautioned that this map may produce multiple matching results for a single gene symbol. Users should map back from the entrez gene IDs produced to determine which result is the one they want when this happens. Because of this problem with redundant assigment of ...
... assigned in the literature, users are cautioned that this map may produce multiple matching results for a single gene symbol. Users should map back from the entrez gene IDs produced to determine which result is the one they want when this happens. Because of this problem with redundant assigment of ...
Tracing the Thread of Plastid Diversity through the Tapestry of Life
... The Glaucocystophyta are a small group of relatively uncommon freshwater, unicellular algae that are of little economic importance, and they are often neglected even by specialists. It has become apparent, however, that this group occupies a key position in the evolution of plastids. Unlike other pl ...
... The Glaucocystophyta are a small group of relatively uncommon freshwater, unicellular algae that are of little economic importance, and they are often neglected even by specialists. It has become apparent, however, that this group occupies a key position in the evolution of plastids. Unlike other pl ...
Gene Section ATF2 (activating transcription factor 2) Atlas of Genetics and Cytogenetics
... SMAD3 and ATF2 activate IL-23 p19 promoter (AlSalleeh and Petro, 2008). IL-23 consists of a p40 subunit IL12B coupled to the p19 subunit IL23A, and has an essential role in the development of T cell-mediated autoimmune diseases (Inoue, 2010). ...
... SMAD3 and ATF2 activate IL-23 p19 promoter (AlSalleeh and Petro, 2008). IL-23 consists of a p40 subunit IL12B coupled to the p19 subunit IL23A, and has an essential role in the development of T cell-mediated autoimmune diseases (Inoue, 2010). ...
MATRILINEAL, a sperm-specific phospholipase, triggers maize
... and signalling (Table 2 and Extended Data Table 6). Given the intensive communication between the two gametophytes and the dynamic membrane reshuffling involved in fertilization28, we speculate that some of these differentially expressed genes may mediate one or more of the pleiotropic phenotypes tr ...
... and signalling (Table 2 and Extended Data Table 6). Given the intensive communication between the two gametophytes and the dynamic membrane reshuffling involved in fertilization28, we speculate that some of these differentially expressed genes may mediate one or more of the pleiotropic phenotypes tr ...
SPA1: A New Genetic Locus Involved in Phytochrome A
... long hypocotyls, whereas the wild type has short hypocotyls (Xu et al., 1995). We screened the M2 seedlings for individuals that showed suppression of the phyA-105 mutant phenotype and thereby appeared to be like wild-type seedlings. Thus, seedlings were sought that displayed a short hypocotyl and/o ...
... long hypocotyls, whereas the wild type has short hypocotyls (Xu et al., 1995). We screened the M2 seedlings for individuals that showed suppression of the phyA-105 mutant phenotype and thereby appeared to be like wild-type seedlings. Thus, seedlings were sought that displayed a short hypocotyl and/o ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.