ADAPTATION AND MALADAPTATION IN SELFING AND
... where U is the genomic mutation rate toward strongly deleterious mutations, C is the genomic recombination rate, S the mean selection coefficient against strongly deleterious mutations, and H is their dominance coefficients (e.g., Glémin 2007). When there is no background selection (U = 0), α tends ...
... where U is the genomic mutation rate toward strongly deleterious mutations, C is the genomic recombination rate, S the mean selection coefficient against strongly deleterious mutations, and H is their dominance coefficients (e.g., Glémin 2007). When there is no background selection (U = 0), α tends ...
factor occupancy and gene expression Effects of sequence variation
... with homozygous exons but heterozygous introns (Knight et al. 2003), revealing many additional otherwise undetectable instances of differential allelic expression. Together, the results provide many insights into how genome sequence impacts TF occupancy, and the extent to which that occupancy impact ...
... with homozygous exons but heterozygous introns (Knight et al. 2003), revealing many additional otherwise undetectable instances of differential allelic expression. Together, the results provide many insights into how genome sequence impacts TF occupancy, and the extent to which that occupancy impact ...
factor occupancy and gene expression Effects of
... with homozygous exons but heterozygous introns (Knight et al. 2003), revealing many additional otherwise undetectable instances of differential allelic expression. Together, the results provide many insights into how genome sequence impacts TF occupancy, and the extent to which that occupancy impact ...
... with homozygous exons but heterozygous introns (Knight et al. 2003), revealing many additional otherwise undetectable instances of differential allelic expression. Together, the results provide many insights into how genome sequence impacts TF occupancy, and the extent to which that occupancy impact ...
factor occupancy and gene expression Effects of sequence variation
... with homozygous exons but heterozygous introns (Knight et al. 2003), revealing many additional otherwise undetectable instances of differential allelic expression. Together, the results provide many insights into how genome sequence impacts TF occupancy, and the extent to which that occupancy impact ...
... with homozygous exons but heterozygous introns (Knight et al. 2003), revealing many additional otherwise undetectable instances of differential allelic expression. Together, the results provide many insights into how genome sequence impacts TF occupancy, and the extent to which that occupancy impact ...
Genome-wide analysis of the distribution of AP2/ERF transcription
... © 2014 Thamilarasan et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the ...
... © 2014 Thamilarasan et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the ...
Microbiology
... 2003, 2005). MutS is involved in the methyl-directed recognition of DNA mismatches related to replication, which include base mismatches and small insertion and deletion mispairs (Modrich, 1991). The expression of mismatch repair systems can be negatively influenced by stress or growth-limiting cond ...
... 2003, 2005). MutS is involved in the methyl-directed recognition of DNA mismatches related to replication, which include base mismatches and small insertion and deletion mispairs (Modrich, 1991). The expression of mismatch repair systems can be negatively influenced by stress or growth-limiting cond ...
The-NOS-problem
... o They isolated 32 lethal mutations falling into 5 complementation groups. They further supported that one of these mutants, which they called NOSC (actually dNOSC), had a homozygous lethal allele of NOS (and thus that NOS is essential) by doing the following: o They backcrossed 5 times and found th ...
... o They isolated 32 lethal mutations falling into 5 complementation groups. They further supported that one of these mutants, which they called NOSC (actually dNOSC), had a homozygous lethal allele of NOS (and thus that NOS is essential) by doing the following: o They backcrossed 5 times and found th ...
RNA interference pathways display high rates of adaptive protein
... model of neutrality and constraint—that can be attributed to positive selection. We first used an explicit population-genetic model to estimate the number of adaptive nonsynonymous substitutions per site (DFEalpha) (Eyre-Walker & Keightley, 2009). This approach has the advantage that it provides dir ...
... model of neutrality and constraint—that can be attributed to positive selection. We first used an explicit population-genetic model to estimate the number of adaptive nonsynonymous substitutions per site (DFEalpha) (Eyre-Walker & Keightley, 2009). This approach has the advantage that it provides dir ...
jsm2003 - University of Wisconsin–Madison
... additive effects may be most important (Wright/Fisher debate) statistical goal: maximize number of correctly identified QTL ...
... additive effects may be most important (Wright/Fisher debate) statistical goal: maximize number of correctly identified QTL ...
Multiple genetic loci modify risk for retinoblastoma in
... We have reported the generation and phenotypic characterization associated with expression of the HPV-16 E6 and E7 oncogenes in the mouse lens.35 In that study, three independent lines of aAcry-HPVl6E6/E7 mice, lines 4, 18, and 19, were created on the FVB inbred genetic background. In these mice, ex ...
... We have reported the generation and phenotypic characterization associated with expression of the HPV-16 E6 and E7 oncogenes in the mouse lens.35 In that study, three independent lines of aAcry-HPVl6E6/E7 mice, lines 4, 18, and 19, were created on the FVB inbred genetic background. In these mice, ex ...
Epigenetic Regulation ofbdnfGene Transcription in the
... changes when using the “unmethylated” primers and vice versa. We also evaluated -tubulin-4 DNA after context exposure or contextual fear conditioning and found no significant alterations in unmethylated -tubulin-4 DNA. Thus, we used unmethylated -tubulin-4 levels for normalization of bdnf DNA met ...
... changes when using the “unmethylated” primers and vice versa. We also evaluated -tubulin-4 DNA after context exposure or contextual fear conditioning and found no significant alterations in unmethylated -tubulin-4 DNA. Thus, we used unmethylated -tubulin-4 levels for normalization of bdnf DNA met ...
Plant Functional Genomics Plant Functional Genomics
... community for genomics research ([http://www.genome.arizona.edu] and [http://www.genome.clemson.edu]). The construction of a BAC library is quite different from that of a general plasmid or h DNA library used to isolate genes or promoter sequences by positive screening. Megabase high molecular weigh ...
... community for genomics research ([http://www.genome.arizona.edu] and [http://www.genome.clemson.edu]). The construction of a BAC library is quite different from that of a general plasmid or h DNA library used to isolate genes or promoter sequences by positive screening. Megabase high molecular weigh ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... appreciate by Humphrey Davy from the time that nitrous oxide was first used for analgesia by Horace wells in 1844 until 1956, nitrous oxide was considered to be completely benign. The first clear association of nitrous oxide and hematologic disease came in a report by Lassen, et al in the Lancet in ...
... appreciate by Humphrey Davy from the time that nitrous oxide was first used for analgesia by Horace wells in 1844 until 1956, nitrous oxide was considered to be completely benign. The first clear association of nitrous oxide and hematologic disease came in a report by Lassen, et al in the Lancet in ...
Molecular basis of the clinical variability of Rett syndrome
... Syndrome and five distinct categories of variant forms of Rett Syndrome. Thereafter, the author summarises the molecular knowledge on Rett Syndrome, noting that MECP2 mutations are responsible for about 90 % of the classic cases of Rett Syndrome but for a significantly lower percentage of the varian ...
... Syndrome and five distinct categories of variant forms of Rett Syndrome. Thereafter, the author summarises the molecular knowledge on Rett Syndrome, noting that MECP2 mutations are responsible for about 90 % of the classic cases of Rett Syndrome but for a significantly lower percentage of the varian ...
Clinical Features, and Nucleotide Changes in Three Families with
... muscle palsy was based on the presence of hypertropia (upward deviation of the eye) on the affected paralyzed side, which became greatest in the gaze toward the nasal field of the involved eye. The additional diagnostic feature was a positive Bielschowsky head tilt test, showing an upward deviation of ...
... muscle palsy was based on the presence of hypertropia (upward deviation of the eye) on the affected paralyzed side, which became greatest in the gaze toward the nasal field of the involved eye. The additional diagnostic feature was a positive Bielschowsky head tilt test, showing an upward deviation of ...
Modeling Trabecular Microstructure Evolution via Genetic Algorithm by Samuel W. L. Shames
... the evolution via cumulative selection of highly specialized structures. Beyond biomaterials, cumulative selection o↵ers a generalizable model for materials optimization via accumulative of beneficial mutations in a material’s genome that improve the properties for a given function. A genetic algori ...
... the evolution via cumulative selection of highly specialized structures. Beyond biomaterials, cumulative selection o↵ers a generalizable model for materials optimization via accumulative of beneficial mutations in a material’s genome that improve the properties for a given function. A genetic algori ...
Depolarization of the actin cytoskeleton is a specific phenotype in
... al., 1989). Again, it is unclear whether the depolarization phenotype indicates that the actin cytoskeleton has a role in adapting to these stresses or is simply a non-specific response to stress in general. Third, mutations in certain genes cause actin cytoskeleton depolarization but those genes ha ...
... al., 1989). Again, it is unclear whether the depolarization phenotype indicates that the actin cytoskeleton has a role in adapting to these stresses or is simply a non-specific response to stress in general. Third, mutations in certain genes cause actin cytoskeleton depolarization but those genes ha ...
Multiple Routes to Subfunctionalization and Gene Duplicate
... framework again assumes that during the preduplication phase, evolution is frozen and no genetic variation is possible. In effect, it argues that duplications diverge because of multifunctional proteins but kicks back the question of how multifunctional genes arise. The problem with this view is tha ...
... framework again assumes that during the preduplication phase, evolution is frozen and no genetic variation is possible. In effect, it argues that duplications diverge because of multifunctional proteins but kicks back the question of how multifunctional genes arise. The problem with this view is tha ...
Molecular Evolution of Overlapping Genes
... overlap on either the same strand or on the opposite strand. The sequence interdependence between two overlapping coding regions adds complexity to almost all molecular evolution analyses. Here, I use a comparative-genomic approach aimed at resolving several open questions concerning the evolution o ...
... overlap on either the same strand or on the opposite strand. The sequence interdependence between two overlapping coding regions adds complexity to almost all molecular evolution analyses. Here, I use a comparative-genomic approach aimed at resolving several open questions concerning the evolution o ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.