... access, devoted to genes, cytogenetics, and clinical entities in cancer, and cancer-prone diseases. It presents structured review articles (“cards”) on genes, leukaemias, solid tumours, cancer-prone diseases, and also more traditional review articles (“deep insights”) on the above subjects and on su ...
equine sarcoids - part 1 - Vlaams Diergeneeskundig Tijdschrift
... A more recent approach in diagnosing equine sarcoids is the detection of BPV DNA in lesions by meansof polymerase chain reaction (PCR). This can be performed on histopathological samples of tissue suspected of equine sarcoid but not displaying the typical histological features (Angelos et al., 1991 ...
... A more recent approach in diagnosing equine sarcoids is the detection of BPV DNA in lesions by meansof polymerase chain reaction (PCR). This can be performed on histopathological samples of tissue suspected of equine sarcoid but not displaying the typical histological features (Angelos et al., 1991 ...
Slide 1
... Individual II-1 is affected. Assuming that no recombination has occurred, what is the status of the individuals in generation III with respect to hemophilia A? a. III-1 and III-3 are affected, III-2 is normal, and III-4 is a carrier. • b. III-1 and III-3 are affected, III-2 is normal, and III-4 is n ...
... Individual II-1 is affected. Assuming that no recombination has occurred, what is the status of the individuals in generation III with respect to hemophilia A? a. III-1 and III-3 are affected, III-2 is normal, and III-4 is a carrier. • b. III-1 and III-3 are affected, III-2 is normal, and III-4 is n ...
FEMS Microbiology Letters
... were characterised from A. variabilis and Anabaena 7119, respectively. Now an 1.1 kb nifJ probe, containing part of the earlier characterised 267 bp segment, was generated by inverse PCR from Anabaena 7119 and used in hybridisation experiments of EcoRV/HindIII-digested genomic DNA from A. variabilis ...
... were characterised from A. variabilis and Anabaena 7119, respectively. Now an 1.1 kb nifJ probe, containing part of the earlier characterised 267 bp segment, was generated by inverse PCR from Anabaena 7119 and used in hybridisation experiments of EcoRV/HindIII-digested genomic DNA from A. variabilis ...
Access Presentation
... - Mdm2 is a proto-oncogene, encodes E3 ubiquitin ligase that negatively regulates p53 protein stability and transcriptional activity - Mdm2 gene has two promoters. P1 controls “basal” expression and P2 is regulated by many TFs including p53. - Single Nucleotide Polymorphism (T-to-G) in P2 (SNP309G) ...
... - Mdm2 is a proto-oncogene, encodes E3 ubiquitin ligase that negatively regulates p53 protein stability and transcriptional activity - Mdm2 gene has two promoters. P1 controls “basal” expression and P2 is regulated by many TFs including p53. - Single Nucleotide Polymorphism (T-to-G) in P2 (SNP309G) ...
Hox Genes: Let`s Work Together
... showed Ubx binding on the promoters of all anterior Hox genes and not posterior Hox genes (Slattery et al., 2011). This observation provides an evidence for direct Ubx-mediated transcriptional regulation of anterior Hox genes. Suppression through Non-coding RNAs Sense and anti-sense long non-coding ...
... showed Ubx binding on the promoters of all anterior Hox genes and not posterior Hox genes (Slattery et al., 2011). This observation provides an evidence for direct Ubx-mediated transcriptional regulation of anterior Hox genes. Suppression through Non-coding RNAs Sense and anti-sense long non-coding ...
Agrobacterium: nature`s genetic engineer
... Once a restriction map of an octopine Ti plasmid was generated (Chilton et al., 1978), studies on the Ti plasmid were aimed at identifying the various functions encoded on the plasmid. An early study was carried out by Holsters et al. (1980) on a nopaline plasmid and Ooms et al. (1981) on an octopin ...
... Once a restriction map of an octopine Ti plasmid was generated (Chilton et al., 1978), studies on the Ti plasmid were aimed at identifying the various functions encoded on the plasmid. An early study was carried out by Holsters et al. (1980) on a nopaline plasmid and Ooms et al. (1981) on an octopin ...
080201 Clinical and Molecular Genetic Features of Pulmonary
... pulmonary hypertension have defects in the gene for bone morphogenetic protein receptor II (BMPR2), a member of the transforming growth factor b (TGF-b) superfamily of receptors. Because patients with hereditary hemorrhagic telangiectasia may have lung disease that is indistinguishable from primary ...
... pulmonary hypertension have defects in the gene for bone morphogenetic protein receptor II (BMPR2), a member of the transforming growth factor b (TGF-b) superfamily of receptors. Because patients with hereditary hemorrhagic telangiectasia may have lung disease that is indistinguishable from primary ...
Comparative Analysis Using DNA Microarrays: Sensitivity
... sensitivity of gene arrays is not nearly so simple as specificity With same-vs.-same, we had a large set of equivalently expressed genes whose SLRTRUE was, by definition, equal to zero But what to do for differentially expressed genes? ...
... sensitivity of gene arrays is not nearly so simple as specificity With same-vs.-same, we had a large set of equivalently expressed genes whose SLRTRUE was, by definition, equal to zero But what to do for differentially expressed genes? ...
Transcriptome analysis of Drosophila CNS midline cells reveals
... unc.edu) (Wheeler et al., 2009b). Thus, each midline cell type can be identified at all stages of development, aiding in genetic analyses of midline cell development. Nevertheless, there has been relatively little characterization of the unique differentiated properties of each midline neuronal cell ...
... unc.edu) (Wheeler et al., 2009b). Thus, each midline cell type can be identified at all stages of development, aiding in genetic analyses of midline cell development. Nevertheless, there has been relatively little characterization of the unique differentiated properties of each midline neuronal cell ...
Conserved syntenic clusters of protein coding genes are missing in
... Functional enrichment analysis combined with orthogroup analysis and paralog searches revealed enrichments that were shared by non-avian species, present only in birds, or shared between all species. Conclusions: Together these results provide a clearer definition of the genetic background of extant ...
... Functional enrichment analysis combined with orthogroup analysis and paralog searches revealed enrichments that were shared by non-avian species, present only in birds, or shared between all species. Conclusions: Together these results provide a clearer definition of the genetic background of extant ...
Isolation, Characterization and Complementation
... Growth conditions,preparation qf'extracts and enzyme assays. These were as described by Cole et a/. (1974) and by Newman & Cole (1978) but with the following modifications. The concentration of nitrite during growth of mutants in 2 litre conical flasks was decreased from 5 mM to 2.5 mM, and 0.4% (w/ ...
... Growth conditions,preparation qf'extracts and enzyme assays. These were as described by Cole et a/. (1974) and by Newman & Cole (1978) but with the following modifications. The concentration of nitrite during growth of mutants in 2 litre conical flasks was decreased from 5 mM to 2.5 mM, and 0.4% (w/ ...
Tandem Genetic Duplications in Phage and Bacteria
... tion method should yield duplications that are the best indicators of the sizes and frequencies of spontaneous duplications. COINHERITANCE OF ALLELIC MARKERS A variety of detection schemes in volve genetic crosses that select for simultaneous inheritance of two alleles of a single locus. These alle ...
... tion method should yield duplications that are the best indicators of the sizes and frequencies of spontaneous duplications. COINHERITANCE OF ALLELIC MARKERS A variety of detection schemes in volve genetic crosses that select for simultaneous inheritance of two alleles of a single locus. These alle ...
Tandem duplications and the limits of natural
... Tandem duplications are an essential source of genetic novelty, and their variation in natural populations is expected to influence adaptive walks. Here, we describe evolutionary impacts of recently-derived, segregating tandem duplications in Drosophila yakuba and Drosophila simulans. We observe an ...
... Tandem duplications are an essential source of genetic novelty, and their variation in natural populations is expected to influence adaptive walks. Here, we describe evolutionary impacts of recently-derived, segregating tandem duplications in Drosophila yakuba and Drosophila simulans. We observe an ...
Conserved syntenic clusters of protein coding genes are missing in birds
... Functional enrichment analysis combined with orthogroup analysis and paralog searches revealed enrichments that were shared by non-avian species, present only in birds, or shared between all species. Conclusions: Together these results provide a clearer definition of the genetic background of extant ...
... Functional enrichment analysis combined with orthogroup analysis and paralog searches revealed enrichments that were shared by non-avian species, present only in birds, or shared between all species. Conclusions: Together these results provide a clearer definition of the genetic background of extant ...
Prediction and investigation of novel proteins in DNA double
... DNA double stranded breaks (DSBs) are the most genotoxic forms of DNA lesions, causing fragmentation of the DNA strands. Mis-repaired and unrepaired DSBs lead to chromosomal rearrangement and genomic instability promoting tumorigenesis or cell death. DSBs are primarily repaired by two independent an ...
... DNA double stranded breaks (DSBs) are the most genotoxic forms of DNA lesions, causing fragmentation of the DNA strands. Mis-repaired and unrepaired DSBs lead to chromosomal rearrangement and genomic instability promoting tumorigenesis or cell death. DSBs are primarily repaired by two independent an ...
Vegetative incompatibility in filamentous fungi: Podospora and
... by a high degree of divergence. This is particularly striking for the het-6 gene. The products of the two het-6 alleles are only 68% identical, which is extremely low for two allelic forms of the same locus [14•]. This is also true to a lesser extent for the products of the three het-C alleles of N. ...
... by a high degree of divergence. This is particularly striking for the het-6 gene. The products of the two het-6 alleles are only 68% identical, which is extremely low for two allelic forms of the same locus [14•]. This is also true to a lesser extent for the products of the three het-C alleles of N. ...
Synthetic Chemical Inducers and Genetic
... required for controlled expression of these genes (rhaSR) are found in two divergent operons.24,29,30 The gene encoding the rhamnose-proton symporter (rhaT) is found at another locus. Expression of rhaBAD and rhaT both result from a regulatory cascade.31 Transcription of rhaS and rhaR is driven by t ...
... required for controlled expression of these genes (rhaSR) are found in two divergent operons.24,29,30 The gene encoding the rhamnose-proton symporter (rhaT) is found at another locus. Expression of rhaBAD and rhaT both result from a regulatory cascade.31 Transcription of rhaS and rhaR is driven by t ...
Review of the p53 Tumor Suppressor Gene and its Role in Gliomas
... only one of the factors needed to complete the process of tumorigenesis, as anti-oncogenes (tumor suppressor genes) must also be deleted or mutated. Tumor suppressor genes have not been studied to the extent that oncogenes have, but their importance in the scheme of tumor formation is equally appare ...
... only one of the factors needed to complete the process of tumorigenesis, as anti-oncogenes (tumor suppressor genes) must also be deleted or mutated. Tumor suppressor genes have not been studied to the extent that oncogenes have, but their importance in the scheme of tumor formation is equally appare ...
Genomic Databases for Tomato
... this library were used to generate fingerprints at the Arizona Genome Institute (Mueller et al. 2005b; http://www.sgn.cornell.edu/cview/map.pl?map_id9& physical1). The fingerprints are used in selecting subsequent BACs for BAC-by-BAC sequencing. To anchor BACs to the linkage map “Tomato-EXPEN 2000 ...
... this library were used to generate fingerprints at the Arizona Genome Institute (Mueller et al. 2005b; http://www.sgn.cornell.edu/cview/map.pl?map_id9& physical1). The fingerprints are used in selecting subsequent BACs for BAC-by-BAC sequencing. To anchor BACs to the linkage map “Tomato-EXPEN 2000 ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.