Complete genome sequence of the thermophilic Thermus sp
... scotoductus SA-01) were selected for the comparison. The genome of strain HB27 consists of a chromosome (1.89 Mb) and a megaplasmid (0.23 Mb). On the other hand, strain HB8 has a chromosome of 1.85 Mb, a megaplasmid (0.26 Mb) and a plasmid (9.3 kb) [5]. The genome of T. scotoductus includes a 2.3 Mb ...
... scotoductus SA-01) were selected for the comparison. The genome of strain HB27 consists of a chromosome (1.89 Mb) and a megaplasmid (0.23 Mb). On the other hand, strain HB8 has a chromosome of 1.85 Mb, a megaplasmid (0.26 Mb) and a plasmid (9.3 kb) [5]. The genome of T. scotoductus includes a 2.3 Mb ...
fulltext - DiVA portal
... addition, upon screening of several different Salmonella enterica serovars, functional homologues to the clyA gene were identified in the typhoid Salmonella serovars Typhi and Paratyphi A [9]. The presence of the clyA gene in wild-type isolates of Salmonella suggests a conserved function of the gene ...
... addition, upon screening of several different Salmonella enterica serovars, functional homologues to the clyA gene were identified in the typhoid Salmonella serovars Typhi and Paratyphi A [9]. The presence of the clyA gene in wild-type isolates of Salmonella suggests a conserved function of the gene ...
Requirement for chitin biosynthesis in epithelial tube morphogenesis. Proc. Natl. Acad. Sci. USA 102: 17014-17019. pdf
... any organs, including the lungs, kidney, liver, and vascular system, are composed of branched networks of epithelial (or endothelial) tubes that transport vital fluids or gases, and the proper size and shape of the tubes are crucial for their transport function. Although there has been progress rece ...
... any organs, including the lungs, kidney, liver, and vascular system, are composed of branched networks of epithelial (or endothelial) tubes that transport vital fluids or gases, and the proper size and shape of the tubes are crucial for their transport function. Although there has been progress rece ...
Leukaemia Section Classification of acute myeloid leukemias Atlas of Genetics and Cytogenetics
... Although the term "de novo" is not fully appropriate (see below "secondary AML"), this category of patients is usually referred as such in the literature since MDS or chemo/radiotherapy does not usually precede them either. The most commonly identified abnormalities are reciprocal translocations: t( ...
... Although the term "de novo" is not fully appropriate (see below "secondary AML"), this category of patients is usually referred as such in the literature since MDS or chemo/radiotherapy does not usually precede them either. The most commonly identified abnormalities are reciprocal translocations: t( ...
The Ehlers–Danlos syndrome, a disorder with many faces
... new EDS variants has called for an expansion of the classification. From these new data it has become clear that, besides the collagens, genetic defects affecting the biosynthesis of other ECM components and processes as diverse as signaling pathways or intracellular trafficking can contribute to ED ...
... new EDS variants has called for an expansion of the classification. From these new data it has become clear that, besides the collagens, genetic defects affecting the biosynthesis of other ECM components and processes as diverse as signaling pathways or intracellular trafficking can contribute to ED ...
Alu repeat analysis in the complete human genome: trends and
... cases, particularly chromosomes 7, 12, 17 and 19. In case of random distribution, one would have expected a continuous decline in Alu numbers with decreasing chromosome sizes in Figure 1, but that is not the case. The analysis showed that there is a clear difference between Alu densities across diff ...
... cases, particularly chromosomes 7, 12, 17 and 19. In case of random distribution, one would have expected a continuous decline in Alu numbers with decreasing chromosome sizes in Figure 1, but that is not the case. The analysis showed that there is a clear difference between Alu densities across diff ...
Translational control of regA, a key gene controlling
... with which the control construct (pVcRegA1, shortend A1) restored the WT phenotype equal to 100%. Mutational ablation of AUG1, AUG2 or ORF2 causes a marked reduction of regA expression Here, we use RNA nomenclature (AUG, etc) when it concerns translation control, and DNA nomenclature (ATG, etc) when ...
... with which the control construct (pVcRegA1, shortend A1) restored the WT phenotype equal to 100%. Mutational ablation of AUG1, AUG2 or ORF2 causes a marked reduction of regA expression Here, we use RNA nomenclature (AUG, etc) when it concerns translation control, and DNA nomenclature (ATG, etc) when ...
The universal reagent for genome tailoring
... control that the remaining loxP site does not create a disturbance in the gene function after the selectable marker is removed. Interestingly, this allele without the marker removal (Fig. 3B) can provide a useful tool for learning more about the function of the gene of interest. If the marker was de ...
... control that the remaining loxP site does not create a disturbance in the gene function after the selectable marker is removed. Interestingly, this allele without the marker removal (Fig. 3B) can provide a useful tool for learning more about the function of the gene of interest. If the marker was de ...
Copy Number Analysis in Partek® Genomics Suite™ 6.6
... Figure 8: Viewing the Unpaired Copy Number dialog. Three kinds of baseline references are possible: using a baseline file distributed by Partek® (Option 1), using a previously created (cnmodel) reference file (Option 2), or using some or all of the samples in the current experiment as the reference ...
... Figure 8: Viewing the Unpaired Copy Number dialog. Three kinds of baseline references are possible: using a baseline file distributed by Partek® (Option 1), using a previously created (cnmodel) reference file (Option 2), or using some or all of the samples in the current experiment as the reference ...
Sex-specific Trans-regulatory Variation on the Drosophila melanogaster X Chromosome
... SNP for one gene can still act as a trans-acting SNP for other genes. To estimate the X chromosome’s general contribution to trans-regulation, and to test for differences between SNPs with sexually concordant and sexually discordant effects, we calculated the proportions of X-linked SNPs associated ...
... SNP for one gene can still act as a trans-acting SNP for other genes. To estimate the X chromosome’s general contribution to trans-regulation, and to test for differences between SNPs with sexually concordant and sexually discordant effects, we calculated the proportions of X-linked SNPs associated ...
Transcript Isoform Differences Across Human Tissues Are
... transcription start and stop sites to isoform diversity, as compared to alternative splicing, have been reported in an analysis of transcript databases 25 and in an analysis of mouse cerebellar development 26 . However, the extent to which each of these isoform generating processes result in isoform ...
... transcription start and stop sites to isoform diversity, as compared to alternative splicing, have been reported in an analysis of transcript databases 25 and in an analysis of mouse cerebellar development 26 . However, the extent to which each of these isoform generating processes result in isoform ...
SLOs - 3.3 Genetics small - Miss Jan`s Science Wikispace
... regulator gene and repressor molecule Explain how structural genes are switched on Explain how metabolic pathways are regulated in prokaryotes through gene induction Explain what a repressor is Explain how the end-product of a metabolic pathway can activate a repressor and switch genes off ( ...
... regulator gene and repressor molecule Explain how structural genes are switched on Explain how metabolic pathways are regulated in prokaryotes through gene induction Explain what a repressor is Explain how the end-product of a metabolic pathway can activate a repressor and switch genes off ( ...
Liver Effects of Clinical Drugs Differentiated in Human Liver
... (500 µM) increased ATP levels by 10% above control levels at 24 and 48 h in two of three livers, then decreased ATP levels significantly by 14%–33% at 72 h. ETM (100 µM) caused fluctuations in ATP production in all three livers. At 24 h ATP levels were significantly decreased by 35% in one liver, wh ...
... (500 µM) increased ATP levels by 10% above control levels at 24 and 48 h in two of three livers, then decreased ATP levels significantly by 14%–33% at 72 h. ETM (100 µM) caused fluctuations in ATP production in all three livers. At 24 h ATP levels were significantly decreased by 35% in one liver, wh ...
Visualizations of Microarray Data in Partek Genomics Suite 6.6
... PGS’s function Sort rows by prototype enables you to identify genes with similar expression profiles. For instance, if a gene with an interesting expression pattern has been detected, using Sort by prototype makes it possible to find other genes that have a similar pattern of intensity values. Altho ...
... PGS’s function Sort rows by prototype enables you to identify genes with similar expression profiles. For instance, if a gene with an interesting expression pattern has been detected, using Sort by prototype makes it possible to find other genes that have a similar pattern of intensity values. Altho ...
French 2003 - University of Washington
... anterior corner of the oocyte. The majority of follicle cells forms a columnar layer over the oocyte, while a few follicle cells are stretched out over the nurse cells. During stage 10B, those follicle cells closest to the nurse cell/oocyte boundary begin to migrate centripetally, between nurse cell ...
... anterior corner of the oocyte. The majority of follicle cells forms a columnar layer over the oocyte, while a few follicle cells are stretched out over the nurse cells. During stage 10B, those follicle cells closest to the nurse cell/oocyte boundary begin to migrate centripetally, between nurse cell ...
Lymphedema Patient Information Comments,
... The lymphatic system is one of the first places where cancer cells may spread. For this reason, cancer surgery often includes the removal and examination of lymph nodes. Lymph nodes act like little nets and are able to remove cancer cells from the body. However, sometimes the cancer will enter the l ...
... The lymphatic system is one of the first places where cancer cells may spread. For this reason, cancer surgery often includes the removal and examination of lymph nodes. Lymph nodes act like little nets and are able to remove cancer cells from the body. However, sometimes the cancer will enter the l ...
Specialized Transduction by Bacteriophage P22 in Salmonella typhimurium: Genetic and Physical Structure of the Transducing Genomes and the Prophage Attachment Site.
... phages resemble P22Tc-10, another specialized transducing phage with an oversize, intracellular replicated genome which carries a tetracycline-resistance determinant from an R-factor.--Unlike P22Tc-10, however, P22pro-2 and P22pro-3 fail to integrate normally during lysogenizing infections, even whe ...
... phages resemble P22Tc-10, another specialized transducing phage with an oversize, intracellular replicated genome which carries a tetracycline-resistance determinant from an R-factor.--Unlike P22Tc-10, however, P22pro-2 and P22pro-3 fail to integrate normally during lysogenizing infections, even whe ...
PDF
... for the genitalia; sources of descriptions of thoracic structures are as previously cited (Ingham, ...
... for the genitalia; sources of descriptions of thoracic structures are as previously cited (Ingham, ...
Article (Published version)
... develop diabetes and die after birth42. NEUROD1 also functions as an activator of both GCK and insulin (INS)43. In humans, a homozygous mutation leads to permanent neonatal diabetes associated with cerebellar hypoplasia, learning difficulties, profound sensorineural deafness, and visual impairment as ...
... develop diabetes and die after birth42. NEUROD1 also functions as an activator of both GCK and insulin (INS)43. In humans, a homozygous mutation leads to permanent neonatal diabetes associated with cerebellar hypoplasia, learning difficulties, profound sensorineural deafness, and visual impairment as ...
genomebiology.com
... revealed that TEs are less likely to be fixed within transcribed regions relative to orthologous regions in human and mouse [16]. In G. gallus, D. rerio and C. intestinalis, 33.2%, 47.3% and 39.4% of TEs reside within introns, respectively, whereas in the human genome, approximately 60% of TEs resid ...
... revealed that TEs are less likely to be fixed within transcribed regions relative to orthologous regions in human and mouse [16]. In G. gallus, D. rerio and C. intestinalis, 33.2%, 47.3% and 39.4% of TEs reside within introns, respectively, whereas in the human genome, approximately 60% of TEs resid ...
Probable presence of an ubiquitous cryptic mitochondrial gene on
... potentially functional gau regions have been found in nuclear genomes. However, a recent bioinformatics study showed that several hypothetical overlapping mt genes could be predicted, including gau; this involves the possible import of the cytosolic AGR tRNA into the mitochondria and/or the expressi ...
... potentially functional gau regions have been found in nuclear genomes. However, a recent bioinformatics study showed that several hypothetical overlapping mt genes could be predicted, including gau; this involves the possible import of the cytosolic AGR tRNA into the mitochondria and/or the expressi ...
Hox Targets and Cellular Functions
... and 5 for proteins of the extracellular ligand/receptor class. Therefore, many of the genes identified in these two studies [54, 61] code for transcription factors or for proteins involved in signaling pathways, but some of the genes are more directly involved in cellular functions. Other microarray ...
... and 5 for proteins of the extracellular ligand/receptor class. Therefore, many of the genes identified in these two studies [54, 61] code for transcription factors or for proteins involved in signaling pathways, but some of the genes are more directly involved in cellular functions. Other microarray ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.