Fig. 1 - Repositorio Académico
... In the early Drosophila melanogaster embryo, Dpp, a secreted molecule that belongs to the TGF-β superfamily of growth factors, activates a set of downstream genes to subdivide the dorsal region into amnioserosa and dorsal epidermis. Here, we examined the expression pattern and transcriptional regula ...
... In the early Drosophila melanogaster embryo, Dpp, a secreted molecule that belongs to the TGF-β superfamily of growth factors, activates a set of downstream genes to subdivide the dorsal region into amnioserosa and dorsal epidermis. Here, we examined the expression pattern and transcriptional regula ...
Natural Selection, Infectious Transfer and the Existence Conditions
... Gerdes et al. 1986; Luria and Suit 1987; Nordström and Austin 1989; Mongold 1992; Paulsson and Ehrenberg 1998), the rates of loss due to vegetative segregation remain strictly positive. In the absence of some mechanism countering their intrinsic costs and segregation loss rates, plasmids would even ...
... Gerdes et al. 1986; Luria and Suit 1987; Nordström and Austin 1989; Mongold 1992; Paulsson and Ehrenberg 1998), the rates of loss due to vegetative segregation remain strictly positive. In the absence of some mechanism countering their intrinsic costs and segregation loss rates, plasmids would even ...
Biology 30 January 2000 Diploma Examination and Key
... Use the following information to answer the next five questions. The spermicide nonoxynol-9, which is applied to contraceptive devices such as diaphragms and condoms, has been linked to increased urinary tract infections in women. Although nonoxynol-9 is helpful in fighting the herpes virus and HIV ...
... Use the following information to answer the next five questions. The spermicide nonoxynol-9, which is applied to contraceptive devices such as diaphragms and condoms, has been linked to increased urinary tract infections in women. Although nonoxynol-9 is helpful in fighting the herpes virus and HIV ...
pdf
... Diversity of the functional genes encoding dissimilatory nitrite reductase was investigated for the first time in denitrifying halobenzoate degrading bacteria and in two 4-chlorobenzoate degrading denitrifying consortia. Nitrite reductase genes were PCR-amplified with degenerate primers (specific to ...
... Diversity of the functional genes encoding dissimilatory nitrite reductase was investigated for the first time in denitrifying halobenzoate degrading bacteria and in two 4-chlorobenzoate degrading denitrifying consortia. Nitrite reductase genes were PCR-amplified with degenerate primers (specific to ...
BROWSING GENES AND GENOMES WITH ENSEMBL
... 8 Expand the ‘ORTHOLOGS’ section by clicking on the + box. 8 Select ‘Mouse Ensembl Gene ID’ and ‘Homology Type’. 8 Click the [Results] button on the toolbar. 8 Select ‘View All rows as HTML’ or export all results to a file. Tick the box ‘Unique results only’. Your results should show that for mo ...
... 8 Expand the ‘ORTHOLOGS’ section by clicking on the + box. 8 Select ‘Mouse Ensembl Gene ID’ and ‘Homology Type’. 8 Click the [Results] button on the toolbar. 8 Select ‘View All rows as HTML’ or export all results to a file. Tick the box ‘Unique results only’. Your results should show that for mo ...
Genetics of mammalian meiosis: regulation, dynamics and impact
... (SMC1B)) and synaptonemal complex (SC)-specific proteins, such as SYCP3 and SYCP2. The chromatids experience genetically programmed double-strand DNA breaks (induced by SPO11), which provide the substrate for recombination (the two chromatids of the upper homologue are depicted by a turquoise line, ...
... (SMC1B)) and synaptonemal complex (SC)-specific proteins, such as SYCP3 and SYCP2. The chromatids experience genetically programmed double-strand DNA breaks (induced by SPO11), which provide the substrate for recombination (the two chromatids of the upper homologue are depicted by a turquoise line, ...
Assaying … promoter activity
... …the plasmid integrated into the genome by homologous recombination with the nimB and ORF5468 gene. We tested the stability of the integrated plasmid via a true breeding experiment. In this experiment, recombinant cells were grown at the non-permissive temperature in the absence of antibiotic select ...
... …the plasmid integrated into the genome by homologous recombination with the nimB and ORF5468 gene. We tested the stability of the integrated plasmid via a true breeding experiment. In this experiment, recombinant cells were grown at the non-permissive temperature in the absence of antibiotic select ...
Is myeloma an inherited cancer?
... the systematic scanning of the entire genetic material (genome) to search for specific genetic differences between different groups of people. In a GWAS funded by Myeloma UK, researchers at The Institute of Cancer Research have been able to identify certain inherited genetic variations that only occu ...
... the systematic scanning of the entire genetic material (genome) to search for specific genetic differences between different groups of people. In a GWAS funded by Myeloma UK, researchers at The Institute of Cancer Research have been able to identify certain inherited genetic variations that only occu ...
PDF-729K - ScienceCentral
... The first genome-wide linkage study of stuttering in Pakistani inbred family was performed by Riaz et al. [13] at NIDCD/NIH. In this study, forty-four families with multiple individuals affected by stuttering were ascertained from the city of Lahore and nearby areas in Pakistan. The status of stutte ...
... The first genome-wide linkage study of stuttering in Pakistani inbred family was performed by Riaz et al. [13] at NIDCD/NIH. In this study, forty-four families with multiple individuals affected by stuttering were ascertained from the city of Lahore and nearby areas in Pakistan. The status of stutte ...
No more than 14: the end of the amphioxus Hox cluster
... Since Edward Lewis discovery of the Bithorax complex of Drosophila [1], the Hox gene cluster has captivated the imagination of developmental and evolutionary biologists. Hox genes are a subclass of homeobox transcription factors deeply involved in the regulation of body patterning in metazoans [2]. ...
... Since Edward Lewis discovery of the Bithorax complex of Drosophila [1], the Hox gene cluster has captivated the imagination of developmental and evolutionary biologists. Hox genes are a subclass of homeobox transcription factors deeply involved in the regulation of body patterning in metazoans [2]. ...
Interaction of nonsense suppressor tRNAs and codon nonsense
... gene SUP53 (a tRNALeu3 allele) encodes a pre-tRNA which contains a 32-base intron and its mature tRNASUP53 contains a 5-methylcytosine modification of the anticodon wobble base. The SUP53 intron was mutated and the suppressor function of these mutant tRNA genes was assayed after their integration in ...
... gene SUP53 (a tRNALeu3 allele) encodes a pre-tRNA which contains a 32-base intron and its mature tRNASUP53 contains a 5-methylcytosine modification of the anticodon wobble base. The SUP53 intron was mutated and the suppressor function of these mutant tRNA genes was assayed after their integration in ...
Genome-Wide Analysis of In Vivo Binding of the Master Regulator
... TGGTCTAGACCA(G/C)T. These target sequences are primarily associated with genes related ...
... TGGTCTAGACCA(G/C)T. These target sequences are primarily associated with genes related ...
Familial Adenomatous Polyposis (FAP)
... Scientists are working on ways to put a correct copy of the FAP gene into the bowel wall. This is called “gene therapy”. Doctors are also looking at non-surgical ways to stop polyps growing, such as drug treatment. These may offer a way to treat FAP without surgery in the future. At the moment, the ...
... Scientists are working on ways to put a correct copy of the FAP gene into the bowel wall. This is called “gene therapy”. Doctors are also looking at non-surgical ways to stop polyps growing, such as drug treatment. These may offer a way to treat FAP without surgery in the future. At the moment, the ...
Chapter 3
... Therefore, we decided to compare genes known to be involved in mesoderm formation in deuterostomes and ecdysozoans with orthologs of those genes in lophotrochozoans, in particular in molluscs. An obvious candidate gene for a comparison of the molecular genetic basis of mesoderm formation is twist si ...
... Therefore, we decided to compare genes known to be involved in mesoderm formation in deuterostomes and ecdysozoans with orthologs of those genes in lophotrochozoans, in particular in molluscs. An obvious candidate gene for a comparison of the molecular genetic basis of mesoderm formation is twist si ...
Gene Section CTSH (cathepsin H) Atlas of Genetics and Cytogenetics
... Cathepsin H is one of the lysosomal cysteine proteinases, which are involved in intracellular protein degradation. It is one of the few noncomplement proteases that cleave native C5 to generate the potent chemotaxin C5a. Cathepsin H was detected in extracellular compartments of atherosclerotic plaqu ...
... Cathepsin H is one of the lysosomal cysteine proteinases, which are involved in intracellular protein degradation. It is one of the few noncomplement proteases that cleave native C5 to generate the potent chemotaxin C5a. Cathepsin H was detected in extracellular compartments of atherosclerotic plaqu ...
Alu - Environmental
... Alu elements • Alu elements are only found in the primate branch • Each Alu insertion is a unique event and is inherited from each parent • Most occurred millions of years ago and are often on both pairs of chromosomes • There are Alu elements that have occurred since humans branched from other pri ...
... Alu elements • Alu elements are only found in the primate branch • Each Alu insertion is a unique event and is inherited from each parent • Most occurred millions of years ago and are often on both pairs of chromosomes • There are Alu elements that have occurred since humans branched from other pri ...
Atlas of Genetics and Cytogenetics in Oncology and Haematology Scope
... karyotypic abnormalities of the hereditary multiple exostoses chromosomal loci 8q24.1 (EXT1) and 11p11-12 (EXT2) in patients with sporadic and hereditary osteochondromas. Cancer. 1998 May 1;82(9):1657-63 ...
... karyotypic abnormalities of the hereditary multiple exostoses chromosomal loci 8q24.1 (EXT1) and 11p11-12 (EXT2) in patients with sporadic and hereditary osteochondromas. Cancer. 1998 May 1;82(9):1657-63 ...
7nQ Jj I f NO "7^07 - UNT Digital Library
... During the course of my thesis work, I was required to read a genetics textbook, with which I had not previously read. As I read this book, I realized that there was still much information to which I had not previously been exposed. My thesis work offered a new way for me obtain knowledge that I di ...
... During the course of my thesis work, I was required to read a genetics textbook, with which I had not previously read. As I read this book, I realized that there was still much information to which I had not previously been exposed. My thesis work offered a new way for me obtain knowledge that I di ...
SHY2/IAA3 regulates root development
... demonstrated to be IAA17 (Rouse et al., 1998). shy2 and axr3 mutants share several phenotypes, such as short hypocotyls, curled-up leaves and leaf formation in darkness. However, unlike shy2 mutants, axr3 mutants have few shoot branches and highly agravitropic roots that lack root hairs (Leyser et a ...
... demonstrated to be IAA17 (Rouse et al., 1998). shy2 and axr3 mutants share several phenotypes, such as short hypocotyls, curled-up leaves and leaf formation in darkness. However, unlike shy2 mutants, axr3 mutants have few shoot branches and highly agravitropic roots that lack root hairs (Leyser et a ...
Curt Stern on Somatic Crossing Over
... Stern had accidentally discovered the first example of somatic crossing over and segregation. Typically, heterozygotes exhibit the dominant form throughout their somatic cells. Calvin Bridges, however, had found dominant mutations that he thought were causing the loss of the chromosome on which they ...
... Stern had accidentally discovered the first example of somatic crossing over and segregation. Typically, heterozygotes exhibit the dominant form throughout their somatic cells. Calvin Bridges, however, had found dominant mutations that he thought were causing the loss of the chromosome on which they ...
Bridging the transgenerational gap with epigenetic memory
... offspring of fathers fed a high-fat diet uncovered genes involved in a range of pathways, including insulin and glucose metabolism as well as mitogen-activated protein ...
... offspring of fathers fed a high-fat diet uncovered genes involved in a range of pathways, including insulin and glucose metabolism as well as mitogen-activated protein ...
NEW EVIDENCE FOR THE HOMOLOGY OF THE SHORT
... D. busckii males of a wild strain from the population of Columbia, MO. (8-1 0, 1949). Phenotypically characteristic of the mutant males is a fusion of the medial (L-3) and cubital (L-4) veins of the wings in their basal parts up to the region of the I-st crossvein, although this is occasionally not ...
... D. busckii males of a wild strain from the population of Columbia, MO. (8-1 0, 1949). Phenotypically characteristic of the mutant males is a fusion of the medial (L-3) and cubital (L-4) veins of the wings in their basal parts up to the region of the I-st crossvein, although this is occasionally not ...
"Tooth Agenesis". - Thimios Mitsiadis
... cases of tooth agenesis can help to elucidate mechanisms involved in human odontogenesis, when phenotypes are carefully evaluated and correlated with associated genotypes. Phenotypes can be restricted to the dentition or include also defects in other tissues or organs, most frequently clefts of the ...
... cases of tooth agenesis can help to elucidate mechanisms involved in human odontogenesis, when phenotypes are carefully evaluated and correlated with associated genotypes. Phenotypes can be restricted to the dentition or include also defects in other tissues or organs, most frequently clefts of the ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.