Agilent Whole Human Genome Oligo Microarray Kit
... Designed to truly represent the known genes in the human genome and their resulting transcripts, Agilent’s Whole Human Genome Oligo microarray is comprised of approximately 41,000 (60-mer) oligonucleotide probes, which span conserved exons across the transcripts of the targeted full-length genes. Th ...
... Designed to truly represent the known genes in the human genome and their resulting transcripts, Agilent’s Whole Human Genome Oligo microarray is comprised of approximately 41,000 (60-mer) oligonucleotide probes, which span conserved exons across the transcripts of the targeted full-length genes. Th ...
A pair of Sox: distinct and overlapping functions of
... expression. The ovary provides sox9b as a maternal message that disappears during cleavage in zebrafish and Xenopus (Chiang et al., 2001; Li et al., 2002; Spokony et al., 2002). In 14 hpf embryos, the expression level of sox9a was high in the otic placode and somites (Fig. 1A). In contrast, the expr ...
... expression. The ovary provides sox9b as a maternal message that disappears during cleavage in zebrafish and Xenopus (Chiang et al., 2001; Li et al., 2002; Spokony et al., 2002). In 14 hpf embryos, the expression level of sox9a was high in the otic placode and somites (Fig. 1A). In contrast, the expr ...
A Novel CpG Island Set Identifies Tissue-Specific
... CpG islands (CGIs) are dense clusters of CpG sequences that punctuate the CpG-deficient human genome and associate with many gene promoters. As CGIs also differ from bulk chromosomal DNA by their frequent lack of cytosine methylation, we devised a CGI enrichment method based on nonmethylated CpG aff ...
... CpG islands (CGIs) are dense clusters of CpG sequences that punctuate the CpG-deficient human genome and associate with many gene promoters. As CGIs also differ from bulk chromosomal DNA by their frequent lack of cytosine methylation, we devised a CGI enrichment method based on nonmethylated CpG aff ...
Altered cellular proliferation and mesoderm
... In Drosophila, the complex pattern of homeotic gene (HOMC) expression is established early in development by the transiently expressed maternal and segmentation genes (Ingham, 1988). Late in development, two groups of genes are necessary to maintain the expression pattern of the homeotic genes. The ...
... In Drosophila, the complex pattern of homeotic gene (HOMC) expression is established early in development by the transiently expressed maternal and segmentation genes (Ingham, 1988). Late in development, two groups of genes are necessary to maintain the expression pattern of the homeotic genes. The ...
20656341304a5aa0f70818a
... forms of congenital hypothyroidism associated with a defect in organification. ...
... forms of congenital hypothyroidism associated with a defect in organification. ...
Dr Noor Lita Adam 260609
... forms of congenital hypothyroidism associated with a defect in organification. ...
... forms of congenital hypothyroidism associated with a defect in organification. ...
What is linkage disequilibrium
... - it can’t be removed unless it happens to undergo a back mutation to the normal wild type allele. - recombination acts to disentangle the deleterious mutation from its genetic background. - this allows selection to act on the specific deleterious mutation not the entire genome. - purifying selectio ...
... - it can’t be removed unless it happens to undergo a back mutation to the normal wild type allele. - recombination acts to disentangle the deleterious mutation from its genetic background. - this allows selection to act on the specific deleterious mutation not the entire genome. - purifying selectio ...
Why we have (only) five fingers per hand: Hox genes
... suggests that the paired fins evolved from a pair of ventrolateral skin folds extending along the length of the body axis (Fig. 5). Migration of mesenchymal cells from the body wall into these folds restricted the continuous fold into two separate domains to form the paired appendages. Consistent wi ...
... suggests that the paired fins evolved from a pair of ventrolateral skin folds extending along the length of the body axis (Fig. 5). Migration of mesenchymal cells from the body wall into these folds restricted the continuous fold into two separate domains to form the paired appendages. Consistent wi ...
Phytic Acid and Inorganic Phosphate Composition in Soybean Lines
... line Gm-lpa-ZC-2 contains a splice-site mutation in the chromosome 14 IPK1 gene, resulting in one nonfunctional IPK1 of the three IPK1 genes present (Yuan et al., 2012). Even though the chromosome 14 IPK1 gene was the highest expressed of the three genes in developing seeds, the null alleles of the ...
... line Gm-lpa-ZC-2 contains a splice-site mutation in the chromosome 14 IPK1 gene, resulting in one nonfunctional IPK1 of the three IPK1 genes present (Yuan et al., 2012). Even though the chromosome 14 IPK1 gene was the highest expressed of the three genes in developing seeds, the null alleles of the ...
Mol Biol Evol-2015-Lipinska-15
... where a high proportion of the genome may be differentially regulated in males and females during development. Malebiased genes tend to evolve more rapidly than female-biased genes, implying differences in the strength of the selective forces acting on the two sexes. Analyses of sex-biased gene expr ...
... where a high proportion of the genome may be differentially regulated in males and females during development. Malebiased genes tend to evolve more rapidly than female-biased genes, implying differences in the strength of the selective forces acting on the two sexes. Analyses of sex-biased gene expr ...
Aus dem Max-Planck-Institut für Psychiatrie
... The existence of a genetic component in the pathogenesis and maintenance of psychiatric disorders has long been recognized from twin and adoption studies. Nowadays, genetic linkage analysis even allows the precise identification of genetic loci involved in a pathology (Inoue and Lupski, 2003). In co ...
... The existence of a genetic component in the pathogenesis and maintenance of psychiatric disorders has long been recognized from twin and adoption studies. Nowadays, genetic linkage analysis even allows the precise identification of genetic loci involved in a pathology (Inoue and Lupski, 2003). In co ...
Gene Nomenclature System for Rice
... this gene. The locus designator consists of one to three digits and differentiates a gene at a particular locus from genes at other loci that confer a similar function or phenotype. The number used as the locus designator indicates the order in which a particular gene or gene family member was ident ...
... this gene. The locus designator consists of one to three digits and differentiates a gene at a particular locus from genes at other loci that confer a similar function or phenotype. The number used as the locus designator indicates the order in which a particular gene or gene family member was ident ...
Human mutations in glucose 6-phosphate dehydrogenase reflect
... are in fully conserved aa (where they might be lethal) or in poorly conserved aa, where presumably they simply would not cause G6PD deficiency. This is consistent with the notion that all human mutants have residual enzyme activity and that null mutations are lethal at some stage of development. Com ...
... are in fully conserved aa (where they might be lethal) or in poorly conserved aa, where presumably they simply would not cause G6PD deficiency. This is consistent with the notion that all human mutants have residual enzyme activity and that null mutations are lethal at some stage of development. Com ...
Obesity — a genetic disease of adipose tissue?
... Although the rapid increase in the prevalence of obesity in many countries suggests that environmental factors (mainly overeating and physical inactivity) play the most important role in the development of overweight, it is very likely that genetic factors also contribute. It appears that one major ...
... Although the rapid increase in the prevalence of obesity in many countries suggests that environmental factors (mainly overeating and physical inactivity) play the most important role in the development of overweight, it is very likely that genetic factors also contribute. It appears that one major ...
Progress in the Understanding of the Genetic Etiology of Vertebral
... Examples of vertebral malformation phenotypes are depicted in Fig. 1. Notably, this figure highlights that vertebral malformations may be categorically classified into defects of formation and proper segmentation. Studies in model organisms are consistent with a genetic contribution to CVM pathogene ...
... Examples of vertebral malformation phenotypes are depicted in Fig. 1. Notably, this figure highlights that vertebral malformations may be categorically classified into defects of formation and proper segmentation. Studies in model organisms are consistent with a genetic contribution to CVM pathogene ...
What is p53
... oncogenic forms of human papillomavirus (HPV E6). In cells, p53 can associate with a 90-kD protein, identified as the product of the mdm-2 oncogene, which is amplified in some types of tumors. When bound to mdm-2, p53 can no longer function as an activator of transcription. p53 plays multiple roles ...
... oncogenic forms of human papillomavirus (HPV E6). In cells, p53 can associate with a 90-kD protein, identified as the product of the mdm-2 oncogene, which is amplified in some types of tumors. When bound to mdm-2, p53 can no longer function as an activator of transcription. p53 plays multiple roles ...
Y chromosome azoospermia factor region microdeletions and
... demonstrated to be is testis-specific, so it is reasonable to hypothesize that RPS4Y2 may potentially play a role in posttranscriptional regulation of the spermatogenic program [33]. The CYORF15A and CYORF15B sequences belong to the taxilin family and are involved in transcriptional regulation in os ...
... demonstrated to be is testis-specific, so it is reasonable to hypothesize that RPS4Y2 may potentially play a role in posttranscriptional regulation of the spermatogenic program [33]. The CYORF15A and CYORF15B sequences belong to the taxilin family and are involved in transcriptional regulation in os ...
Identification of Genetic and Epigenetic Risk Factors for Psoriasis
... diseases, and seven additional regions that included chromosome 13q13 and 15q21. A follow-up study, aimed to identify potential functional SNPs in the PSORS1 region, implicated an allele-specific repressor role of SNP rs10456057 via binding to nuclear transcriptional factors. Further study with add ...
... diseases, and seven additional regions that included chromosome 13q13 and 15q21. A follow-up study, aimed to identify potential functional SNPs in the PSORS1 region, implicated an allele-specific repressor role of SNP rs10456057 via binding to nuclear transcriptional factors. Further study with add ...
CHAPTER 14 DNA applications in society
... produce sufficient growth hormone for use, very large numbers of pituitary glands from cadavers were required. Each batch of hGH was derived from a pool of pituitary glands from about 16 000 cadavers. During a year, patients received their hGH injections from two or three different batches. (A batc ...
... produce sufficient growth hormone for use, very large numbers of pituitary glands from cadavers were required. Each batch of hGH was derived from a pool of pituitary glands from about 16 000 cadavers. During a year, patients received their hGH injections from two or three different batches. (A batc ...
Gene Section USF1 (upstream transcription factor 1) Atlas of Genetics and Cytogenetics
... factors. The bHLH-ZIP domains are important for DNA binding and dimerization. USF homo- and heterodimers activate transcription of target genes through binding either at distal E-box elements or at pyrimidine-rich Inr elements in the core promoter (Roy et al., 1997). Whole genome ChIP-chip analysis ...
... factors. The bHLH-ZIP domains are important for DNA binding and dimerization. USF homo- and heterodimers activate transcription of target genes through binding either at distal E-box elements or at pyrimidine-rich Inr elements in the core promoter (Roy et al., 1997). Whole genome ChIP-chip analysis ...
Imprinting and Seed Development
... duce seeds asexually by apomixis, which exists in several different forms (Nogler, 1984; Koltunow, 1993; Bicknell and Koltunow, 2004). During gametophytic apomixis, the megagametophyte develops from an unreduced megaspore or from a somatic cell inside the ovule. The diploid embryo then develops from ...
... duce seeds asexually by apomixis, which exists in several different forms (Nogler, 1984; Koltunow, 1993; Bicknell and Koltunow, 2004). During gametophytic apomixis, the megagametophyte develops from an unreduced megaspore or from a somatic cell inside the ovule. The diploid embryo then develops from ...
Deletion of a conserved noncoding sequence in Plzf intron leads to
... Noncoding Sequences Because there is no solid evidence of presence of transcription activity other than the three above-mentioned genes in the 177-kb segment (Fig. 4A, see RefSeq and spliced expressed sequence tag tracks), and there is also no miRNA gene (data not shown), we set to find the potential ...
... Noncoding Sequences Because there is no solid evidence of presence of transcription activity other than the three above-mentioned genes in the 177-kb segment (Fig. 4A, see RefSeq and spliced expressed sequence tag tracks), and there is also no miRNA gene (data not shown), we set to find the potential ...
Fulltext - Jultika
... spectrum of the phenotypes caused by mutations in the COL2A1 gene coding for collagen II, the main cartilage collagen, is relatively well defined, but there is little data on the phenotypes caused by collagen IX and XI mutations. The structure of the human COL11A1 gene coding for the α1 chain of col ...
... spectrum of the phenotypes caused by mutations in the COL2A1 gene coding for collagen II, the main cartilage collagen, is relatively well defined, but there is little data on the phenotypes caused by collagen IX and XI mutations. The structure of the human COL11A1 gene coding for the α1 chain of col ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.