American Thoracic Society Documents
... 10% of parents of children with CCHS (3, 6); and (6) improved understanding of the specific mechanisms whereby PHOX2B results in the CCHS phenotype (6, 18–21). The purpose of a new ATS statement on CCHS is to aid the clinician in optimizing patient care that will be specifically tailored to knowledg ...
... 10% of parents of children with CCHS (3, 6); and (6) improved understanding of the specific mechanisms whereby PHOX2B results in the CCHS phenotype (6, 18–21). The purpose of a new ATS statement on CCHS is to aid the clinician in optimizing patient care that will be specifically tailored to knowledg ...
Fulltext PDF - Indian Academy of Sciences
... 38ºC (table 2). For wild-type (Canton-S) males maintained in our laboratory, it takes 32 minutes for paralysis at 38ºC. The paralytic behaviours of wild-type, stmA / stmA and stmA / + flies differ greatly. Homozygous stmA adults show a gradual slowing down of physical activity within 30–45 seconds o ...
... 38ºC (table 2). For wild-type (Canton-S) males maintained in our laboratory, it takes 32 minutes for paralysis at 38ºC. The paralytic behaviours of wild-type, stmA / stmA and stmA / + flies differ greatly. Homozygous stmA adults show a gradual slowing down of physical activity within 30–45 seconds o ...
PROGRAM PROGRAM
... • Novel candidates for host response to BLV infection in Holstein cattle based on genome-wide association study (P. Brym) – 12 min • Comparing gene expression profiles in the mammary glands of high- and low-milkyield Holstein Friesian cows (M. Miller) – 12 min • Association between polymorphisms ...
... • Novel candidates for host response to BLV infection in Holstein cattle based on genome-wide association study (P. Brym) – 12 min • Comparing gene expression profiles in the mammary glands of high- and low-milkyield Holstein Friesian cows (M. Miller) – 12 min • Association between polymorphisms ...
Specificity of Insertion by the Translocatable Tetracycline Resistance Element Tn10.
... different insertions within a cluster. Different insertions within a cluster usually have the same reversion frequency; however, heterogeneity in reversion frequency has been detected in at least two clusters. For most clusters, the available data are consistent with the simple possibility that all ...
... different insertions within a cluster. Different insertions within a cluster usually have the same reversion frequency; however, heterogeneity in reversion frequency has been detected in at least two clusters. For most clusters, the available data are consistent with the simple possibility that all ...
About Neurofibromatosis 1 - Children`s Tumor Foundation
... This brochure is intended to provide an introductory overview of neurofibromatosis type 1 (NF1) for patients, families, and healthcare providers with the hope that readers will seek additional information about the disorder according to their own individual needs. Physicians knowledgeable about ...
... This brochure is intended to provide an introductory overview of neurofibromatosis type 1 (NF1) for patients, families, and healthcare providers with the hope that readers will seek additional information about the disorder according to their own individual needs. Physicians knowledgeable about ...
Effete, a Drosophila chromatin-associated ubiquitin
... TPE suppressors has been a difficult task due the widespread presence of TAS deficiencies among Drosophila stocks and the allele specific differences among the mutations that suppress TPE (Boivin et al. 2003; Mason et al. 2004; Doheny et al. 2008). So far, only a few bona fide TPE suppressors have b ...
... TPE suppressors has been a difficult task due the widespread presence of TAS deficiencies among Drosophila stocks and the allele specific differences among the mutations that suppress TPE (Boivin et al. 2003; Mason et al. 2004; Doheny et al. 2008). So far, only a few bona fide TPE suppressors have b ...
genetics and cytogenetics
... gametopbyte, any departure from these ideal conditions representt-: an aberration. The varIOUS types of aberrations are described in this §ection, and their bearing on problems of evolution is discussed. This material is often called "cytogenetics," although apy correlation at all between genetic da ...
... gametopbyte, any departure from these ideal conditions representt-: an aberration. The varIOUS types of aberrations are described in this §ection, and their bearing on problems of evolution is discussed. This material is often called "cytogenetics," although apy correlation at all between genetic da ...
BT314 Virology
... life has a common origin (see Chapter 2); so this diversity has developed during Earth’s 4-billion-year history. Life is also characterized by adaptation: many organisms are exquisitely suited to the environment in which they are found. The history of life is a chronicle of new forms of life emergin ...
... life has a common origin (see Chapter 2); so this diversity has developed during Earth’s 4-billion-year history. Life is also characterized by adaptation: many organisms are exquisitely suited to the environment in which they are found. The history of life is a chronicle of new forms of life emergin ...
Chance and Necessity in Arthur Peacocke`s Scientific Work
... studies on effects of gamma-radiation on DNA structure. Around this time it had just been determined that DNA was the hereditary (genetic) material, and the fact that DNA is the molecular bases of heredity peaked Peacocke’s interest in this molecule (Drysdale and Peacocke 1961), although exactly how ...
... studies on effects of gamma-radiation on DNA structure. Around this time it had just been determined that DNA was the hereditary (genetic) material, and the fact that DNA is the molecular bases of heredity peaked Peacocke’s interest in this molecule (Drysdale and Peacocke 1961), although exactly how ...
Gene Section ATF4 (activating transcription factor 4 (tax responsive enhancer element B67)) -
... (ASNS). In addition to regulating the expression of ASNS during lack of nutrition, ATF4 also regulates several aspects of mammalian metabolism, such as fat storage, energy expenditure, and glycemic control. The TOR pathway regulates invertebrate and vertebrate metabolism, and ATF4 mutant mice have r ...
... (ASNS). In addition to regulating the expression of ASNS during lack of nutrition, ATF4 also regulates several aspects of mammalian metabolism, such as fat storage, energy expenditure, and glycemic control. The TOR pathway regulates invertebrate and vertebrate metabolism, and ATF4 mutant mice have r ...
Induced Adrenocortical Tumorigenesis in Mice
... adrenal glands of ovariectomized B6AF1 mice contained type A cells that expressed GATA4 antigen (Supplemental Fig. 2C) and type B cells that expressed both GATA4 (Supplemental Fig. 2C) and gremlin (Supplemental Fig. 2E). As in B6D2F1 mice, Gata4 haploinsufficiency mitigated ovariectomy-induced adren ...
... adrenal glands of ovariectomized B6AF1 mice contained type A cells that expressed GATA4 antigen (Supplemental Fig. 2C) and type B cells that expressed both GATA4 (Supplemental Fig. 2C) and gremlin (Supplemental Fig. 2E). As in B6D2F1 mice, Gata4 haploinsufficiency mitigated ovariectomy-induced adren ...
oto`s role in head and trunk development
... To characterize the forebrain defects in more detail, we examined embryos from mid-gestation and earlier stages. At 9.5 dpc, forebrain phenotypes in oto embryos ranged from apparently normal to severely affected. To better understand the defects, we categorized embryos as mildly, moderately or sever ...
... To characterize the forebrain defects in more detail, we examined embryos from mid-gestation and earlier stages. At 9.5 dpc, forebrain phenotypes in oto embryos ranged from apparently normal to severely affected. To better understand the defects, we categorized embryos as mildly, moderately or sever ...
Full Text
... Histological analysis of the Otx2+/-;HNF3β +/- phenotype To characterize the Otx2+/-;HNF3β +/- phenotype in more detail, E12.5 and E9.5 double heterozygous embryos showing a mutant phenotype were sectioned for histological analysis (Fig. 3, 6 and data not shown). In wild-type or singly heterozygous ...
... Histological analysis of the Otx2+/-;HNF3β +/- phenotype To characterize the Otx2+/-;HNF3β +/- phenotype in more detail, E12.5 and E9.5 double heterozygous embryos showing a mutant phenotype were sectioned for histological analysis (Fig. 3, 6 and data not shown). In wild-type or singly heterozygous ...
Abstracts - Parthenon Management Group
... even within the brain. Progress has been made in the study of a few particular genes, such as BDNF in a stress model of depression, and RELN in schizophrenia. There is some evidence in both of these cases that medications that can reverse the epigenetic changes observed. Other intriguing findings ha ...
... even within the brain. Progress has been made in the study of a few particular genes, such as BDNF in a stress model of depression, and RELN in schizophrenia. There is some evidence in both of these cases that medications that can reverse the epigenetic changes observed. Other intriguing findings ha ...
Pax1, Pax9, Vertebral column, Chondrogenesis, Proliferation
... Iδ/ε functions necessary for survival. Since the amino acid sequences and three-dimensional structures of Casein kinase Iδ/ε enzymes are highly conserved, the results suggest that these proteins may also function in controlling cell growth and survival in other organisms. ...
... Iδ/ε functions necessary for survival. Since the amino acid sequences and three-dimensional structures of Casein kinase Iδ/ε enzymes are highly conserved, the results suggest that these proteins may also function in controlling cell growth and survival in other organisms. ...
Leukaemia Section 3q rearrangements in myeloid malignancies Atlas of Genetics and Cytogenetics
... Often associated with young age at diagnosis, trilineage dysplasia, dysmegakaryopoiesis and prior treatment with alkylating agents. ...
... Often associated with young age at diagnosis, trilineage dysplasia, dysmegakaryopoiesis and prior treatment with alkylating agents. ...
The Complex Inheritance of Maize Domestication Traits and Gene
... Multiple factors contribute to culm diameter and kernel row number 45 ...
... Multiple factors contribute to culm diameter and kernel row number 45 ...
hermann joseph muller 1890—1967
... Edgar Altenburg to share the teaching while they carried out research on mutation rates and the mutation process. Muller also continued with Altenburg a long-term project started in 1912 that was not published until 1920: a study of what Muller called the gene-character problem. On theoretical groun ...
... Edgar Altenburg to share the teaching while they carried out research on mutation rates and the mutation process. Muller also continued with Altenburg a long-term project started in 1912 that was not published until 1920: a study of what Muller called the gene-character problem. On theoretical groun ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.