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PROGRAM ŁÓDŹ • 19-22 września 2016 POLSKIE TOWARZYSTWO ŁÓDŹ • 19-22 września 2016 GENETYKI CZŁOWIEKA PROGRAM Poniedziałek, 19 września 2016 – Monday, September 19, 2016 9.00 9.00 Początek rejestracji uczestników Kongresu 9.30 9.30 10.00 10.00 10.30 10.30 11.00 11.00 Posiedzenia Zarządów PTGC i PTG; inne oficjalne posiedzenia i spotkania zgłoszone do Komitetu Organizacyjnego Kongresu (nie później niż do 15 września 2016) 11.30 12.00 12.30 13.00 SESJA DYSMORFOLOGICZNA Dysmorphology; Pre-Congress session and workshop Przewodniczą (Chairs): R. Śmigiel, E. Obersztyn Część I: • What can we learn from old dysmorphic syndromes using next-generation sequencing screening? (M. Krajewska-Walasek, A. Jezela-Stanek) – 25 min • Diagnostics and genetic counseling in split-hand/foot malformation syndrome (A. Jamsheer) – 25 min • Mowat-Wilson syndrome in Polish patients (R. Śmigiel) – 20 min • Expanding the clinical phenotype of a novel overgrowth syndrome due to a unique recurrent PDGFRB mutation (M. Pelc) – 20 min • Laminopathies – clinical variability of diseases associated with mutations in LMNA gene (A. Madej‑Pilarczyk) – 20 min 11.30 12.00 12.30 13.00 Przerwa kawowa z przekąskami (Coffee break with snacks) 13.30 13.30 Część II: • Unknown cases (4 przypadki) 14.00 14.00 14.30 14.30 1 PROGRAM ŁÓDŹ • 19-22 września 2016 Poniedziałek, 19 września 2016 – Monday, September 19, 2016 15.00 15.00 15.30 UROCZYTOŚĆ OTWARCIA KONGRESU Opening Ceremony 15.30 Prowadzą: B. Naganowska, A. K. Kononowicz, L. Jakubowski 16.00 Powitanie honorowych gości; Przemówienia; Wręczanie odznaczeń i/lub nagród 16.00 Krótki koncert inaugurujący Kongres 16.30 17.00 Wykłady plenarne Plenary Lectures Przewodniczą (Chairs): Adam Jaworski, Andrzej K. Kononowicz, Malcolm Ferguson-Smith 16.30 17.00 Wykładowcy (Speakers): Sir David Baulcombe: RNA and epigenetics in plants 17.30 Jerzy Paszkowski: Epigenetics contribution to the plant breeding strategies 17.30 Robert D. Wells: DNA Structure Matters (3 x 30 min) 18.00 18.00 20.00 20.00 Koktajl powitalny w Pałacu Poznańskiego Gala Dinner at Poznanski Palace 2 PROGRAM ŁÓDŹ • 19-22 września 2016 Wtorek, 20 września 2016 – Tuesday, September 20, 2016 8.45 8.45 Ogłoszenia organizacyjne Organisational Remarks/Informations (5 min) Wykłady plenarne Plenary Lectures 9.00 9.00 Przewodniczą (Chairs): Jan Lubiński, Grzegorz Węgrzyn Wykładowcy (Speakers): Carole Charlier: High-throughput sequencing to identify disease-causing mutations in livestock 9.30 9.30 Terje Raudsepp: Mammalian sex chromosomes: cytogenetics, sequencing and phenotypes Rodney J. Scott: Panel testing for familial breast cancer: calibrating the tension between research and clinical care Grzegorz Węgrzyn: 100 years of bacteriophage genetics: light and dark sides of the (phage) force 10.00 10.00 Richard G. F. Visser – Possibilities and limitations of breeding in polyploid crops (5 x 20 min) 10.30 10.30 Przerwa kawowa (Coffee break) 11.00 G -1 Choroby Rzadkie i Ultrarzadkie 1 Rare and Ultra-Rare Diseases 1 Sesja pod Patronatem Polskiego Towarzystwa Wrodzonych Wad Metabolizmu (PTWWM) 11.30 12.00 12.30 13.00 Przewodniczą (Chairs): J. Sykut-Cegielska, M. Borowiec • Heterogeneity of molecular background of mitochondrial diseases in children (D. Piekutowska-Abramczuk) – 25 min • The role of genotyping in patients with phenylketonuria (M. Bik-Multanowski) – 25 min • Role of DNA analysis in the newborn screening by tandem mass spectrometry (J. Sykut‑Cegielska) – 25 min • Dysmorphic features and congenital defects in inborn errors of metabolism (R. Śmigiel) – 25 min • High resolution CNV detection using exonfocused aCGH microarray designs (A. Allen) wykład sponsorowany przez firmę OGT – 10 min G -2 Genetyka kliniczna zespołów dziedzicznej predyspozycji do nowotworów Clinical Genetics of susceptibility to the hereditary cancers G -3 Genetyczne Podłoże Chorób Cywilizacyjnych Genetics of the common diseases Przewodniczą (Chairs): J. Lubiński, R. Scott • New genes associated with a high risk of breast cancer (C. Cybulski) – 15 min • A population screening – detection of BRCA1 and other genes founder mutations (J. Gronwald) – 15 min • Hereditary Ovarian Cancer – a multipanel analysis in a group of 200 patients (M. Ratajska) – 15 min • Implementation of NGS for the molecular diagnostics of mutations in BRCA1/2 (A. Kowalik) – 15 min • The impact of oophorectomy on survival after breast cancer in BRCA1-positive breast cancer patients (T. Huzarski) – 15 min • Diagnostyka zespołów predyspozycji do nowotworów układu trawiennego (D. Nowakowska) – 15 min • Effectiveness of detection of mutations within genes predisposing to Lynch Syndrome (T. Dębniak) – 15 min • Omicology – contribution to cardiovascular diseases (Z. Gaciong) – 25 min • Genetic and epigenetic aspects of mental disorders (B. Misiak) – 20 min • Genetic and epigenetic determinants of obesity (T. Ferenc) – 20 min • The Polish National Centre of Diagnostics and Treatment of Familial Hypercholesterolemia – molecular diagnostics of familial hypercholesterolemia in Poland (B. Wasąg) – 25 min • Multi-national network of excellence for research on genetic predisposition to cardio-metabolic disorders due to UCP1 gene polymorphisms (A. Kowalska) – 10 min • Gender-Dependent Genetic Association with Body Mass Index in Poles (M. Sobalska-Kwapis) – 10 min • Expression and immunoexpression of Pentraxin 3 in stable patients with chronic obstructive pulmonary disease (M. Poznański) – 10 min Przewodniczą (Chairs): Z. Gaciong, M. Sanak, T. Ferenc Z -1 Genetyka cech ilościowych u zwierząt Genetics of quantitative traits in animals Przewodniczą (Chairs): W. Jagusiak, T. Strabel • Quantitative genetics in genomic era (T. Strabel) – 25 min • Effect of GHSR and LEPR genes polymorphisms on production results and meat quality of broiler chickens (U. Kaczor) – 15 min • Detection of genome regions determining semen quality in holstein bulls using entropy analysis (A. Borowska) – 15 min • Detection of SNP effects on performance traits in pigs based on entropy approach (A. Borowska) – 15 min • Study on the bta-miR-29b-2 polymorphism in association with fatty acid composition in milk of Jersey cows (Bos taurus) (A. Konieczna) – 15 min • Genetic analyses of methane emissions from dairy cattle (M. Pszczoła) – 15 min R -1 Genomika roślin Plant genomics Przewodniczą (Chairs): J. Sadowski, B. Naganowska, R. Hasterok • New insights into crucifer genome evolution: genome stasis, polyploidy and dysploidy (M. Lysak) – 20 min • Dissecting grass genome organisation at the cytomolecular level using the model genus Brachypodium (H. Hasterok) – 20 min • Genomics of natural tolerance of maize to glyphosate (W. Karłowski) – 15 min • Genetic factors shaping the spatial distribution of meiotic crossover in the plant genome (P. Ziółkowski) – 15 min • A core set of Polish oat landraces based on ISSR markers and agro-morphological traits (M. Boczkowska) – 15 min • Molecular analysis of nuclear and organellar genomes of Solanum × michoacanum (+) S. tuberosum somatic hybrids and autofused 4x S. x michoacanum (P. Smyda‑Dajmund) – 10 min • Identification of coding sequences seed storage proteins of yellow lupine (Lupinus luteus) (N. Klajn) – 10 min • The use of GBS method for mapping the male RF genes in triticale with sterilityinducing cytoplasm of T. timopheevi (M.Sobczyk) – 10 min • Development of molecular probes enriched for sequence repeats as a tool for Festuca pratensis and Lolium perenne chromosome mapping (T. Książczyk) – 10 min M -1 Molekularne podstawy patogenezy mikroorganizmów Molecular basis of microbial pathogenesis Przewodniczą (Chairs): A.Skorupska, G. Węgrzyn • Molecular adaptation of Staphylococcus aureus for intracellular survival (J. Kozieł) – 20 min • Functional small RNA molecule identified in Escherichia coli after induction of Shiga toxin-converting bacteriophage Φ24 (B.Nejman-Faleńczyk) – 20 min • Allergenic proteins of Leptosphaeria maculans – the ascomycete fungus pathogenic to oilseed rape (Brassica napus L.) (M.Jędryczka) – 20 min • The exo-xis region – important part of genome of Shiga toxin-converting phages in oxidative stress-mediated induction (K. Licznerska) – 12 min • Species diversity of Trichoderma isolated from various habitats in Poland and their antagonistic activities towards toxigenic Fusarium (A. Basińska) – 12 min • The role of genes and open reading frames from the exo-xis region of lambdoid phages in the development of these phages (A. Dydecka) – 12 min • Mgl2 as a hypothetical methyltransferase essential for EPS synthesis and symbiosis in Rhizobium leguminosarum (M. Marczak) – 12 min Sesje tematyczne (Concurrent Invited Sessions): G – genetyka człowieka (human genetics); Z – genetyka zwierząt (animal genetics); R – genetyka roślin (plant genetics); M – genetyka w mikrobiologii (microbial genetics) 11.00 11.30 12.00 12.30 13.00 3 PROGRAM ŁÓDŹ • 19-22 września 2016 Wtorek, 20 września 2016 – Tuesday, September 20, 2016 13.00 13.00 Lunch 13.30 14.00 14.30 15.00 15.30 G -4 Medycyna Personalizowana Personalized medicine G -5 Podłoże genetyczne guzów litych Genetics of the solid cancers G -6 Biobanki Biobanking Przewodniczą (Chairs): Z. Gaciong, M.M. Sąsiadek Przewodniczą (Chairs): M. Dębiec-Rychter, M. Iliszko Przewodniczą (Chairs): Ł. Kozera, D. Strapagiel • Personalized medicine in oncology (M.M. Sąsiadek) – 20 min • Personalized therapeutic approach to cystic fibrosis (M. Witt) – 15 min • Targeted therapy in hemato-oncology (T. Sacha) – 15 min • Enzyme replacement therapy in lysosomal storage diseases (M. Bik-Multanowski) – 20 min • Medycyna personalizowana w hematologii – spojrzenie z pozycji AOTMiT (W. Matusewicz) – 20 min • Liquid Biopsy and Next Generation Sequencing as a tools for multiplexed molecular analysis of CTCs, cfDNA, and germline DNA in a single workflow (M. Swoboda, M. Orsztynowicz) – wykład sponsorowany przez Thermo Fisher Scientific – 20 min • Roche Sequencing Story Driving toward personalized medicine – wykład sponsorowany przez Roche Diagnostics Polska – 10 min • Pediatric solid tumors: the molecular profile and new insight in clinical approach (J. Trubicka) – 30 min • The putative oncogene, CRNDE, as a Negative Prognostic Factor in Ovarian Cancer Patients (Ł. Szafron) – 30 min • CpG island methylator phenotype in gastrointestinal tumors (P. Karpiński) – 25 min • Standards of molecular research: guidelines for genetic laboratories of solid tumors (B. Pieńkowska-Grela) – 25 min • Biobanking and Genetic Studies in Africa: Opportunities and Challenges (M. Mendy) – 30 min • Biobanking in Poland and Europe – where do we go? Technical, legal aspects and ethical issues (Ł. Kozera) – 30 min • From research project, through biorepository to biobank – Biobank Lab at the University of Lodz – case study (D. Strapagiel) – 30 min • Biobanking in clinical laboratory – experiences of the Holycross Cancer Center (A. Kowalik) – 15 min • Relationships between biobanks and cell and tissue banks for transplantation purposes - do they really exist? (Z. Pojda) – 15 min 13.30 Z -2 Choroby genetyczne i zwierzęta transgeniczne Genetic diseases and transgenic animals R -2 Epigenomika roślin Plant epigenomics Przewodniczą (Chairs): R. Słomski, Ł. Huminiecki • Histone modifiers control cell fate determinacy and growth phase transition during plant development (Wen-Hui Shen) – 30 min • Genome-wide analyses of Arabidopsis chromatin remodeler BRM reveal its functions in transcription regulation and plant growth control (R. Archacki) – 30 min • HD2C histone deacetylase and a SWI/SNF complex are both involved in mediating the heat stress response in Arabidopsis (D. Buszewicz) – 15 min • The evolutionarily conserved histone acetylatransferase complex NuA4 is crucial for plant development (T. Bieluszewski) – 15 min • Histone variant H2A.Z is removed from nucleosomes in genes activated upon stress (W. Sura) – 15 min • Chromatin-level gene expression regulation during early development of first maize leaf (A. Sobkowiak) – 15 min • New possibilities for diagnosis of chromosome abnormalities in domestic animals (I. Szczerbal) – 25 min • Polymorphisms of selected genes in horse genome and their association with the occurrence of osteochondrosis (M. Wypchło) – 12 min • Analysis of candidate genes (MC4R, FTO, POMC) for dog obesity (M. Mańkowska) – 12 min • Molecular background of testes or ovotestes development in dogs and pigs with female karyotype and lack of the SRY gene (M. Świtoński) – 12 min • Primary cultures of Sertoli cells (S. Tabor‑Osińska) – 12 min • Expression analysis of equine sarcoids – viral origin skin tumors (W. Witarski) – 12 min • Precancerous molecular features committing development of colonic polyps – studies with APC1311-targeted pigs (M. Dragan-Stachowiak) – 12 min Przewodniczą (Chairs): M. Koblowska, A. Jerzmanowski M -2 Genomika, transkryptomika, proteomika i ewolucja molekularna Genomics, transcriptomics, proteomics and molecular evolution Przewodniczą (Chairs): I. Sitkiewicz, J. Dziadek • How next-generation sequencing can make microbiologist’s life easier (I. Sitkiewicz) – 20 min • Mobilome of psychrotolerant bacteria from the polar regions (Ł.Dziewit) – 20 min • ABC transporters in dermatophytes (M.Gadzalski) – 12 min • Insight into virome of Alphaproteobacteria (P. Decewicz) – 12 min • Comparative genomics approach to understanding diversity of cellulose biofilms produced by species from Gluconacetobacter genus (M. Ryngajłło) – 12 min • Application of metagenomic methods for microbial biodiversity analyses in archeology and conservation (M. Dyda) – 12 min • Genomic and proteomics reveal bacterial stress responses in the sea of gradients - the Baltic Sea (J. Karczewska-Golec) – 12 min • Small genome sequencing – evaluation of different protocols of DNA library preparation (S. Czarnomska) – 12 min 16.00 14.00 14.30 15.00 15.30 16.00 Przerwa kawowa (Coffee break) 16.15 16.15 16.30 Sesja Plakatowa PTGC Walny Zjazd Członków PTG 16.30 17.00 Poster viewing (Members’ general meetings) 17.00 17.30 17.30 18.00 Walne Zgromadzenie Członków PTGC (I termin – 17.15) Sesja Plakatowa PTG 18.00 18.30 (Members’ general meetings) Poster viewing 18.30 18.45 18.45 Poznajmy Łódź zgodnie z propozycjami przygotowanymi przez organizatorów lub w ramach czasu wolnego Sesje tematyczne (Concurrent Invited Sessions): G – genetyka człowieka (human genetics); Z – genetyka zwierząt (animal genetics); R – genetyka roślin (plant genetics); M – genetyka w mikrobiologii (microbial genetics) 4 PROGRAM ŁÓDŹ • 19-22 września 2016 Środa, 21 września 2016 – Wednesday, September 21, 2016 8.45 8.45 Ogłoszenia organizacyjne Organisational Remarks/Informations (5 min) Wykłady plenarne Plenary Lectures 9.00 9.00 Przewodniczą (Chairs): Wojciech Wiszniewski, Jarosław Dziadek 9.30 9.30 Wykładowcy (Speakers): Andrzej Jerzmanowski: Chromatin and plant adaptation to stress Wojciech Wiszniewski: Whole-exome Sequencing in the Clinic: Where Are We Now and Where Are We Going? 10.00 10.00 Allan Schulman: We are the 80%! Transposable elements and genome dynamics in barley Joris R. Vermeesch – Zygotes cleave parental genomes in different lineages: on the origin of chimaerism, mixoploidy and molar pregnancies (4 x 25 min) 10.30 10.30 Przerwa kawowa (Coffee break) 11.00 11.30 12.00 12.30 13.00 G -7 Terapie i interwencje genowe Gene therapies and interventions G -8 Neurogenetyka Neurogenetics G -9 Wykłady sponsorowane Sponsored lectures Z -3 Genomika i epigenomika zwierząt Animal genomics and epigenomics Przewodniczą (Chairs): M. Kurpisz, Ł. Huminiecki Przewodniczą (Chairs): J. Zaremba, M. Jędrzejowska Przewodniczą (Chairs): M. Borowiec, L. Jakubowski Przewodniczą (Chairs): M. Świtoński, K. Flisikowski • Clinical trials and pre-clinical studies with application of genetically modified myogenic stem cells (M. Kurpisz) – 30 min • A simple metric of promoter architecture robustly predicts expression breadth of human genes (Ł. Huminiecki) – 30 min • Posttranscriptional regulation of genes expression in human seminoma (B. Ginter‑Matuszewska) – 20 min • Genistein-dependent stimulation of mutant huntingtin degradation as a potential new therapy for Huntington’s disease (K. Pierzynowska) – 10 min Sesja organizowana wspólnie z Komisją Neurogenetyki Komitetu Nauk Neurologicznych PAN • Analiza i integracja danych NGS w badaniach multiomicznych (B. Wojciechowicz, Perlan Technologies Polska) – 20 min • Extracellular flux analysis – novel approach in functional studies (S. Vikström, Agilent Technologies) – 20 min • Zastosowanie technik spektrometrii mas w biologii systemowej (Ł. Nowicki, Perlan Technologies Polska) – 20 min • Postnatal “Optima” Experience by Affymetrix Platform in a Single Center (A. Koc, eBioscience) – 10 min • Towards Data-Driven Medicine (C. Miganeh, Sophia Genetics) – 10 min • Functional molecular validation of DNA mutations in livestock. (K. Flisikowski) – 25 min • Novel candidates for host response to BLV infection in Holstein cattle based on genome-wide association study (P. Brym) – 12 min • Comparing gene expression profiles in the mammary glands of high- and low-milkyield Holstein Friesian cows (M. Miller) – 12 min • Association between polymorphisms of genes encoding mare’s milk whey proteins (LALBA, LGB1, LGB2) and their expression level (Ł. Wodas) – 12 min • Novel sequence of pregnancy-associated glycoprotein genes (within exon 4) identified in the eurasian beaver genome (A. Lipka) – 12 min • DNA methylation pattern and transcriptome analysis of horse sarcoids (E. Semik) – 12 min • Genetic factors regulating cell lineage specification and pluripotency maintenance at the early stage of bovine embryonic development (Z. Madeja) – 12 min • Characteristics of microRNA expression profile of horse sarcoids (K. Pawlina) – 12 min • Dystrofie obręczowo-kończynowe – nowe fenotypy, geny, mutacje (A. Macias) – 20 min • Prenatal and early diagnosis of tuberous sclerosis complex (S. Jóżwiak) – 20 min • Genetic causes of stroke (J. Pera) – 15 min • Ekspansja powtórzeń G4C2 w genie C9orf72 – jako jedna z przyczyn stwardnienia zanikowego bocznego i otępienia czołowo-skroniowego (A. Sułek) – 15 min • Very rare exon 48 deletion in the dystrophin gene and its’ clinical specificity; observations on occurrence of the new mutations in DMD and BMD (J. Zimowski) – 15 min • When is a mutation not a mutation – problems of the point mutations’ pathogenicity interpretation in diagnostics of the epileptic encephalopathies (D. Hoffman-Zacharska) – 15 min • Neurofibromatosis, type I – characteristics of spectrum mutation in Polish patients – four years experience (E. Witkowska) – 8 min • Can you be scared too much? Hyperekplexia due to mutations in CTNNB1 and GLRA1 genes (M. Badura‑Stronka) – 8 min Sesje tematyczne (Concurrent Invited Sessions): G – genetyka człowieka (human genetics); R -3 Genetyczne podłoże regulacji rozwoju i odpowiedzi na stres u roślin Genetic foudation of plant development and response to stress regulation Przewodniczą (Chairs): P. Masojć, J. Sadowski • A new genetic model for analyzing genes interaction in controlling variation of quantitative traits (P. Masojć) – 30 min • Light and Circadian Clock Regulation of Growth and Acclimation to Low Temperature (T. Rorat) – 30 min • Functional analysis of genes involved in ABA-related response to abiotic stresses using TILLING mutants in barley (A. Daszkowska-Golec) – 30 min • Uncovering abiotic stress responses in crops (J. Gracz, A. Tyczewska) – 30 min M -3 Metabolizm DNA, replikacja i podziały komórkowe, rekombinacja, naprawy DNA – część 1. DNA metabolism, replication and cell division, recombination, DNA repair – part 1. 11.00 11.30 Przewodniczą (Chairs): I. Fijałkowska, P. Stączek • Mechanisms controlling fidelity of DNA replication in Escherichia coli cells (I. Fijałkowska) – 30 min • Single cell studies of the bacterial cell cycle (J. Zakrzewska-Czerwińska) – 30 min • Mechanisms of ribonucleotides incorporation and repair in E.coli cells (K. Makiela-Dzbenska) ) – 15 min • RecA-independent DNA repair in M. tuberculosis induced mitomycin C. (A. M. Brzostek) – 15 min • Bacteriophage polymerase as a tool for replication fidelity studies (A. Bębenek) – 15 min • The 4-subunit Polymerase zeta participates in the DNA replication. (C. Suski) – 15 min 12.00 12.30 13.00 Z – genetyka zwierząt (animal genetics); R – genetyka roślin (plant genetics); M – genetyka w mikrobiologii (microbial genetics) 5 PROGRAM ŁÓDŹ • 19-22 września 2016 Środa, 21 września 2016 – Wednesday, September 21, 2016 13.00 13.00 Lunch 13.30 14.00 14.30 15.00 G -10 Sekwencjonowanie kliniczne i bioinformatyka Clinical sequencing and Bioinformatics Przewodniczą (Chairs): R. Płoski, T. Żemojtel • Whole exome sequencing in Polish population for broadening of knowledge on monogenic diseases (R. Płoski) – 30 min • Next-generation diagnostics in medical genetics (T. Żemojtel) – 30 min • Analysis of large NGS datasets using big data tools (T. Gambin) – 25 min • Machine learning methods for multiplatform genetic signatures with applications to The Cancer Genome Atlas data (T. Biecek) – 25 min G -11 Diagnostyka Prenatalna Prenatal Diagnosis G -12 Genetyka sądowa Forensic genetics Przewodniczą (Chairs): P. Węgrzyn, M.M. Sąsiadek, B. Nowakowska Przewodniczą (Chairs): N. Morling, W. Branicki, R. Jacewicz • Preimplantation and prenatal diagnosis: • New directions in forensic medicine novel developments (J. Vermeesch) (N. Morling) – 40 min – 40 min • The Polish Genetic Database of Victims of • Postępy w diagnostyce prenatalnej Totalitarianisms (A. Ossowski) – 40 min z punktu widzenia klinicysty (P. Węgrzyn) • Predictive DNA analysis in forensic genetics – 30 min (W. Branicki) – 40 min • Najnowsze metody z zakresu laboratoryjnej genetyki medycznej w diagnostyce prenatalnej (B. Nowakowska) – 30 min • 2 cases of de novo deletion 6q27 detected in arrayCGH studies of fetuses affected with congenital defects (P. Własienko) – 10 min 15.30 16.00 13.30 Z -4 Genetyka populacji i bioróżnorodność zwierząt Genetics of population and animal diversity Przewodniczą (Chairs): K. Charon, E. Juszczuk-Kubiak • Identification of the biomarkers of the selenium metabolic pathway in terms of nutrigenomics (E. Juszczuk-Kubiak) – 25 min • Genome-wide analysis of the diversity in European bison (Bison bonasus) living in the Białowieża Forest (K. Oleński) – 12 min • Uneven distribution of complementary sex determiner (csd) alleles in western honey bee population (M. Cebrat) – 12 min • Characterization of Polish Primitive Horse maternal lines using mitochondrial D-loop sequence polymorphism (J. Cieślak) – 12 min • Single nucleotide polymorphisms in salmonid cross-species and populations studies (A. Drywa) – 12 min • Genetic monitoring of reintroduction - an example of the capercaillie populations in Lower Silesian Forest (K. Pusz-Bocheńska) – 12 min • Urban environment and genetic diversity of invertebrates - an example of harlequin ladybird (Harmonia axyridis) (R. Rutkowski) – 12 min • On the origin of Polish domestic cats based on results of mitochondrial DNA analysis (I. Głażewska) – 12 min R -4 Nowe strategie inżynierii genetycznej New strategies of genetic engineering Przewodniczą (Chairs): A. Nadolska-Orczyk, J. Szopa-Skórkowski • Molecular farming of innovative therapeutics (A. Depicker) – 30 min • CRISPR – gene editing [Leszek Łyżnik (Alex Lyznik)] – 30 min • Crop improvement, epigenetic approach (W. Wojtasik, J. Szopa-Skórkowski) – 20 min • Development of genomics resources in a large-genome non-model species Secale cereale L. (H. Bolibok-Brągowszewska) – 20 min • Differences in expression of cytochrome P450 genes during cucumber flower morphogenesis (M. Pawełkowicz) – 20 min M -4 Metabolizm DNA, replikacja i podziały komórkowe, rekombinacja, naprawy DNA – część 2. DNA metabolism, replication and cell division, recombination, DNA repair – part 2. 14.00 14.30 Przewodniczą (Chairs): J. Zakrzewska-Czerwińska, A. Szalewska-Pałasz • Coordination of DNA replication by metabolic fluctuations in Escherichia coli (A. Szalewska-Pałasz) – 30 min • DNA repair systems of tubercle bacilli – new perspective (P. Płociński) – 30 min • AlkB dioxygenases and their new functions (E. Grzesiuk) – 15 min • Structural resemblance of partition proteins RepB of Rhizobium leguminosarum and P1 ParB of E. coli (P. Koper) – 15 min • Two component signal transduction systems in mycobacteria (R. Płocińska) – 15 min • rDNA status inferred from DNA cloud assays and mass spectrometry identification of agarose squeezed DNAbound proteins (A. Skoneczna) – 15 min 15.00 15.30 16.00 Przerwa kawowa (Coffee break) 16.30 16.30 Sesje tematyczne (Concurrent Invited Sessions): G – genetyka człowieka (human genetics); Z – genetyka zwierząt (animal genetics); R – genetyka roślin (plant genetics); M – genetyka w mikrobiologii (microbial genetics) 6 PROGRAM ŁÓDŹ • 19-22 września 2016 Środa, 21 września 2016 – Wednesday, September 21, 2016 16.30 G -13 Choroby Rzadkie i Ultrarzadkie 2 Rare and Ultra-Rare Diseases 2 Przewodniczą (Chairs): K. Chrzanowska, J. Bal 17.00 17.30 • Diagnostics of selected genodermatoses – a summary of 10 years of research (K. Wertheim-Tysarowska) – 15 min • RASopathies – the diagnostic opportunities and functional models (M. Gos) – 15 min • Advances in genetic diagnosis of chronic kidney disease in children (B. Lipska‑Ziętkiewicz) – 15 min • Searching for markers of disease progression and causal treatment in patients with Wolfram syndrome (A. Zmysłowska) – 15 min • Monogenic diabetes in polish population (M. Borowiec) – 15 min • Genetic basis of ichthyosis - suitability of selected molecular tools for the development of diagnostic algorithm (D. Śniegórska) – 10 min • Relation of LELP1 polymorphisms with atopic disease (M. Wesserling) – 10 min G -14 Nabyte zmiany genetyczne jako podłoże nowotworów układu krwiotwórczego Somatic rearrangements as a cause of hematopoietic system cancers Przewodniczą (Chairs): B. Pieńkowska-Grela, A. Filip, T. Sacha • New molecular factors important for prognosis and treatment decisions in chronic lymphocytic leukemia (CLL) (A. Filip) – 20 min • Genetic basis of lymphoma pathogenesis – new facts in the light of known mechanisms (R. Woroniecka) – 20 min • Genetic investigations in myeloproliferative neoplasms - what can be and what should be tested (O. Haus) – 20 min • Applycation of novel genetic technologies in hematooncology (A. Kowalik) – 20 min • In search for novel genetic prognostic markers in pediatric T-cell acute lymphoblastic leukemia (T-ALL) (M. Dawidowska) – 10 min G -15 Zagadnienia etyczne i prawne związane z rozwojem nauk biologicznych i medycznych Development of Biological Sciences and Biomedicine – legal issues and ethical dilemmas Przewodniczą (Chairs): Z. Szawarski, T. Mazurczak, M. Witt • ELSI challenges of genetic testing (M. Witt) – 30 min • Normative principles, goals and practice of genetic counseling (W. Chańska) – 20 min • Genetic, ethical and legal aspects of prenatal diagnosis and perinatology (A. Stembalska) – 30 min G -16 Genetyka w antropologii Anthropological Genetics Przewodniczą (Chairs): R. Pinhasi, E. Żądzińska • New perspectives on human evolution and demographic history during the last 15,000 years based on ancient DNA genomics (R. Pinhasi) – 30 min • Y-STR haplogroup prediction – genetic reflection of anthropological changes (M. Szargut) – 15 min • Validation of candidate DNA variants for human hair morphology using massively parallel sequencing technology (E. Pośpiech) – 15 min • Non-destructive isolation of DNA from human teeth and bones (D. Pluta, T. Dobosz) – 15 min • A contribution to the history of human populations from the area of Central Poland (P. Borówka) – 15 min 18.00 R -5 Genetyczne mechanizmy odporności roślin na patogeny Genetic mechanisms of plant resistance to pathogenes R -6 Biogospodarka w UE bez GMO Bioeconomy in EU without GMO Przewodniczą (Chairs): E. Zimnoch-Guzowska, V. K. Macioszek • Genetics, a strong pillar for a sustainable Bioeconomy in Europe (A. Aquilar) – 30 min • Genomic variability in Cucurbitaceae and its application in Breeding (P. Puigdomènech) – 30 min • New Plant Breeding Techniques – innovations for sustainable agriculture in EU (A. Linkiewicz) – 15 min • Recent developments in patenting plants: between GMOs and conventional breeding (T. Zimny) – 15 min • Combining genomic and metabolomic analysis to elucidate plant immunity related metabolic pathways (P. Bednarek) – 20 min • Introgression of resistance to late blight from 1 EBN Solanum x michoacanum into potato breeding genepool (E. Zimnoch‑Guzowska) – 20 min • Secret(ed) life of type three effectorsagents, double agents and re-doubeld agents (M. Krzymowska) – 20 min • Phytopathological and cytogenetic analysis of Brassica plants with known resistance to clubroot. (M. Jędryczka) – 10 min • TaWAK is an important component of wheat resistance to leaf rust (Puccinia triticina) (M. Dmochowska-Boguta) – 10 min • Plasmodiophora brassicae exploits phloem transport in order to usurp host nutrient distribution (R. Malinowski) – 10 min 16.30 Przewodniczą (Chairs): T. Twardowski, A. Aquilar 20.00 17.00 17.30 18.00 20.00 Wieczór towarzyski przy muzyce Sesje tematyczne (Concurrent Invited Sessions): G – genetyka człowieka (human genetics); Z – genetyka zwierząt (animal genetics); R – genetyka roślin (plant genetics); M – genetyka w mikrobiologii (microbial genetics) 7 PROGRAM ŁÓDŹ • 19-22 września 2016 Czwartek, 22 września 2016 – Thursday, September 22, 2016 8.45 8.45 Ogłoszenia organizacyjne Organisational Remarks/Informations (5 min) Wykłady plenarne Plenary Lectures 9.00 9.00 Przewodniczą (Chairs): Maria Dębiec-Rychter, Paweł Stączek, Maria M. Sąsiadek Wykładowcy (Speakers): 9.30 9.30 Richard P. Bowater: Using Synthetic Biology to Promote Advances in Genetics Maria Dębiec-Rychter: Integrated molecular profiling in undifferentiated uterine sarcomas for identification of novel therapeutic targets Anna Płuciennik: Triplet repeat expansion diseases: mutational mechanisms and cellular dysfunction 10.00 10.00 Wojciech Niedźwiedź: Homologous recombination and human health (4 x 25 min) 10.30 10.30 Przerwa kawowa (Coffee break) 11.00 11.30 12.00 12.30 G -17 Choroby Rzadkie i Ultrarzadkie 3: Ciliopatie Rare and Ultra-Rare Diseases 3: Ciliopathies Przewodniczą (Chairs): E. Ziętkiewicz, M. Witt • From biology to clinics: ciliopathies, diagnostics and therapy (M. Witt) – 25 min • Genetic basis of primary ciliary dyskinesia (E. Ziętkiewicz) – 25 min • Identification of new ciliary proteins – from gene to ultrastructure (D. Urbańska) – 20 min • Respiratory epithelium cultures in diagnostics and therapy of primary ciliary dyskinesia (Z. Bukowy-Bieryłło) – 20 min • From the cilium to the nucleus – Gli protein regulation in Hedgehog signaling (P. Niewiadomski) – 20 min G -18 Mikromacierze i NGS w diagnostyce wad rozwojowych i chorób rzadkich Microarrays and NGS as a diagnostic tool for birth defects and rare diseases detection G -19 Dzieje Genetyki – stąd do przeszłości History of Genetics – from the here and now to the past Przewodniczą (Chairs): A. Latos-Bieleńska, M.M. Sąsiadek, J. Wierzba • Chromosome over the centuries (B. Pieńkowska-Grela) – 30 min • DNA: the aims and hopes of yesterday and today (M. Borowiec) – 30 min • When Adam meets Eve – a turbulent story of male chromosome (M. Woźniak) – 30 min • Cilinical genetics – patients and professionals in belles-lettres (O. Haus) – 30 min • Applications of High-Throughput Sequencing Technologies in Medical Genetics – a Canadian Perspective (J. Majewski) – 20 min • Genetic counseling in genomic era (K. Chrzanowska) – 20 min • Next-generation sequencing in rare diseases (A. Wójcicka) – 20 min • CRSPR-Cas9 – an innovative technology for genome editing and regulation: mechanisms and applications (A. Sowińska‑Seidler) – 20 min • Microarrays and Next Generation Sequencing in practical ophthalmogenetic diagnostics (M. Krawczyński) – 20 min • Zespół Sensenbrenner (Cranioectodermal dysplasia) - ultrarzadki zespół o charakterystycznym fenotypie i heterogennym podłożu molekularnym (J. Walczak-Sztulpa) – 15 min M -5 Inżynieria genetyczna w biotechnologii i ochronie środowiska Genetic engineering in biotechnology and environment protection Przewodniczą (Chairs): O. Haus, B. Pieńkowska-Grela Przewodniczą (Chairs): M. Koziołkiewicz, K. Pyrć • CRISPR/Cas: adaptive immunity and molecular biology (K. Pyrć) – 30 min • Competitive phage display combined with affinity chromatography as a novel technique for isolation of bacteriophages (K. Dąbrowska) – 30 min • Phenotypic characterization of mutants of Gluconacetobacter genus with different cellulose synthesis ability (M. Jędrzejczak‑Krzepkowska) – 15 min • Morphological and biological diversity of a large group of bacteriophages isolated from urban sewage (A. Jurczak-Kurek) – 15 min • Genetically engineered bacteria produce uniquely structured bionanocellulose tailored for different applications (K. Kubiak) – 15 min 13.00 11.00 11.30 12.00 12.30 13.00 Przerwa kawowa z przekąskami (Coffee break with snacks) 13.30 Sesje tematyczne (Concurrent Invited Sessions): G – genetyka człowieka (human genetics); 13.30 Z – genetyka zwierząt (animal genetics); R – genetyka roślin (plant genetics); M – genetyka w mikrobiologii (microbial genetics) 8 PROGRAM ŁÓDŹ • 19-22 września 2016 Czwartek, 22 września 2016 – Thursday, September 22, 2016 13.30 14.00 14.30 15.00 G -20 Choroby Rzadkie i Ultrarzadkie 4: Genetycznie uwarunkowane chroby tkanki łącznej Rare and Ultra-Rare Diseases 4: Connective tissue genetic disorders G -21 Zaburzenia rozwoju i funkcji układu płciowego Genetics of developmental and functional disorders of the reproductive tract (Disorders of Sex Development) Przewodniczą (Chairs): O. Haus, E. Jakubowska-Pietkiewicz, A.L. Sieroń Przewodniczą (Chairs): J. Jaruzelska, M. Niedziela • Osteogenesis imperfecta: its today’s state and therapeutic perspectives (A.L. Sieroń) – 20 min • Clinical manifestation of COL1A1/COL1A2 genes mutation – osteogenesis imperfecta (E. Jakubowska-Pietkiewicz) – 20 min • Hypophosphatasia – clinical features and new methods of treatment (I. Michałus) – 15 min • Cardiovascular system status in children and adults with Marfan syndrome (L. Woźniak) – 15 min • Results of molecular investigations among 400 Polish patients with Ehlers-Danlos syndrome (A. Junkiert-Czarnecka) – 15 min • Zaburzenia różnicowania płci człowieka (M. Niedziela) – 20 min • Molecular characteristic of patients with complete androgen insensitivity syndrome (CAIS) (A. Malcher) – 15 min • Challenges in searching for genes responsible for human sex determination (K. Kusz‑Zamelczyk) – 15 min • Molecular diagnostics for the presence of Y chromosome in girls with Turner syndrome (A. Rojek) – 10 min • Gonadal tumors in complete gonadal dysgenesis with 46,XY karyotype (Z. Kolesińska) – 15 min • Heterogeneous phenotype and genotype of patients with Mayer-Rokitansky-KüsterHauser (MRKH) syndrome (K. Kapczuk) – 15 min G -22 Genetyka w medycynie sportowej Genetics in sports medicine M -6 Diagnostyka i epidemiologia molekularna Molecular diagnostics and epidemiology Przewodniczą (Chairs): A. Zambroń-Łacny, E. Brzeziańska-Lasota Przewodniczą (Chairs): B. Krawczyk, E. Paradowska • Genetyka w medycynie sportowej (A. Zambroń-Łacny) – 30 min • Diagnostyka genetyczna a prewencja urazów w sporcie (P. Cięszczyk) – 30 min • Analiza polimorfizmów genów kodujących czynniki transkrypcyjne a predyspozycje zawodników do różnych typów wysiłku fizycznego (A. Maciejewska-Skrendo) – 30 min • Identification and genotyping of Acinetobacter species by molecular methods – old problems and new developments (B. Krawczyk) – 30 min • Cytomegalovirus infection: molecular epidemiology and association with congenital malformations (E. Paradowska) – 30 min • Molecular epidemiology of multidrugresistant Enterobacteriaceae (R. Izdebski) – 30 min 13.30 14.00 14.30 15.00 15.10 15.10 Podsumowanie i oficjalne zakończenie Kongresu (Conluding remarks and closing ceremony) 15.30 Sesje tematyczne (Concurrent Invited Sessions): G – genetyka człowieka (human genetics); 15.30 Z – genetyka zwierząt (animal genetics); R – genetyka roślin (plant genetics); M – genetyka w mikrobiologii (microbial genetics) 9