Hemoglobinopathies 2002 Ware
... genes are deleted on the same chromosome, in cis (--/ ), or when they are
deleted on opposite chromosomes, in trans ( -/ -). The Southeast-Asian couple
likely both carry the deletions in cis (--/ ), so their risk of an offspring with 4gene deletion -thalassemia would be 25%. In contrast, -thalassemi ...