Determining the Transcription Factor Genes Populating a Fruit Fly
... All animals possess a specific set of morphological traits that defines them, and the instructions to make these traits are encoded in its DNA sequence. Since many organisms share a considerable amount of the same genetic sequences, the question arises as to how diverse traits are formed. One explan ...
... All animals possess a specific set of morphological traits that defines them, and the instructions to make these traits are encoded in its DNA sequence. Since many organisms share a considerable amount of the same genetic sequences, the question arises as to how diverse traits are formed. One explan ...
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... wild-type heart-stage embryos is expressed throughout the cotyledon primordia (Long and Barton, 1998; Schoof et al., 2000), was detected around the whole apical circumference of gnom embryos (Fig. 1D,H), and was mainly restricted to the epidermis. This aberrant marker expression reflects the failure ...
... wild-type heart-stage embryos is expressed throughout the cotyledon primordia (Long and Barton, 1998; Schoof et al., 2000), was detected around the whole apical circumference of gnom embryos (Fig. 1D,H), and was mainly restricted to the epidermis. This aberrant marker expression reflects the failure ...
gemini Documentation
... As version 0.12.2 of GEMINI it is required that your input VCF file undergo additional preprocessing such that multiallelic variants are decomposed and normalized using the vt toolset from the Abecasis lab. Note that we have also decomposed and normalized all of the VCF-based annotation files (e.g., ...
... As version 0.12.2 of GEMINI it is required that your input VCF file undergo additional preprocessing such that multiallelic variants are decomposed and normalized using the vt toolset from the Abecasis lab. Note that we have also decomposed and normalized all of the VCF-based annotation files (e.g., ...
How to Model Microevolution How to Model Microevolution
... D, “linkage disequilibrium” • It measures the degree of association at the population level between the two sites/loci • D is created by many evolutionary forces and historical events, including the very act of mutation because the new mutant variant initially exists on only one chromosomal backgrou ...
... D, “linkage disequilibrium” • It measures the degree of association at the population level between the two sites/loci • D is created by many evolutionary forces and historical events, including the very act of mutation because the new mutant variant initially exists on only one chromosomal backgrou ...
Haemophilia (2013) - Haemophilia Foundation Australia
... Because females have two copies of these genes, one inherited from each parent, women with an altered factor VIII or IX gene usually have another copy that is not altered. This helps factor VIII and IX to work properly in the blood clotting process and is often enough to control bleeding. However, t ...
... Because females have two copies of these genes, one inherited from each parent, women with an altered factor VIII or IX gene usually have another copy that is not altered. This helps factor VIII and IX to work properly in the blood clotting process and is often enough to control bleeding. However, t ...
Product description P018-G1 SHOX-v03 - MRC
... - Complete or partial duplications found within SHOX or its surrounding regulatory regions have been found in LWD and ISS patients (Benito-Sanz et al. 2011b). - Deletion of the SHOX intron 6 probes, which are located downstream of the stop codon, may not affect SHOX gene function. - Please note that ...
... - Complete or partial duplications found within SHOX or its surrounding regulatory regions have been found in LWD and ISS patients (Benito-Sanz et al. 2011b). - Deletion of the SHOX intron 6 probes, which are located downstream of the stop codon, may not affect SHOX gene function. - Please note that ...
The Genetics of Migraine
... CACNA1A) and a genome-wide linkage analysis has mapped a susceptibility locus on chromosome 4. Another locus for migraine may be on the X chromosome. Finally, many positive association studies have been published, but few have been replicated. Lancet Neurology 2002; 1: 285–93 ...
... CACNA1A) and a genome-wide linkage analysis has mapped a susceptibility locus on chromosome 4. Another locus for migraine may be on the X chromosome. Finally, many positive association studies have been published, but few have been replicated. Lancet Neurology 2002; 1: 285–93 ...
Attachment 2.2 Sequencing results
... tumour initiation and progression. [19-22] The TCDD-dependant release from contact inhibition seems to be a common phenomenon as it is observed in several cell lines. [23] In the human breast cancer epithelial cell line MCF-7 a down regulation of E-cadherin (a transmembrane protein playing an import ...
... tumour initiation and progression. [19-22] The TCDD-dependant release from contact inhibition seems to be a common phenomenon as it is observed in several cell lines. [23] In the human breast cancer epithelial cell line MCF-7 a down regulation of E-cadherin (a transmembrane protein playing an import ...
Visceral endoderm-restricted translation of Otx1
... In particular Otx1 null mice are viable and show spontaneous epileptic seizures and abnormalities affecting the dorsal telencephalic cortex. Otx2 null mice die early in development and fail in specification of the rostral neuroectoderm and proper gastrulation. In order to determine whether Otx1−/− a ...
... In particular Otx1 null mice are viable and show spontaneous epileptic seizures and abnormalities affecting the dorsal telencephalic cortex. Otx2 null mice die early in development and fail in specification of the rostral neuroectoderm and proper gastrulation. In order to determine whether Otx1−/− a ...
NF1 Gene Test Review - The Friedman Lab at UBC
... Headaches occur frequently among individuals with NF1, and hydrocephalus or seizures are seen occasionally. People with NF1 have larger brains, on an average, than people without NF1, but gray matter volume is not correlated with intelligence quotient in NF1.78,79 Most individuals with NF1 have norm ...
... Headaches occur frequently among individuals with NF1, and hydrocephalus or seizures are seen occasionally. People with NF1 have larger brains, on an average, than people without NF1, but gray matter volume is not correlated with intelligence quotient in NF1.78,79 Most individuals with NF1 have norm ...
Leptin regulation of lipid homeostasis: dietary and metabolic
... Leptin receptor and signalling Leptin is synthesized as an 18 kDa protein with a signal sequence that is cleaved to yield the mature 16 kDa hormone. Leptin circulates bound to proteins in serum and is a four-helix bundle cytokine (for reviews, see Houseknecht & Portocarrero, 1998; Ahima & Flier, 200 ...
... Leptin receptor and signalling Leptin is synthesized as an 18 kDa protein with a signal sequence that is cleaved to yield the mature 16 kDa hormone. Leptin circulates bound to proteins in serum and is a four-helix bundle cytokine (for reviews, see Houseknecht & Portocarrero, 1998; Ahima & Flier, 200 ...
Standard PDF - Wiley Online Library
... mercial rat colonies, and found four distinct karyotype forms. Further analysis raised the number of distinct karyotype forms in rats to eight [15]. Karyotype forms of P. carinii f.sp. carinii have been shown to be stable for at least a year [8]. A particular karyotype form can occur in multiple col ...
... mercial rat colonies, and found four distinct karyotype forms. Further analysis raised the number of distinct karyotype forms in rats to eight [15]. Karyotype forms of P. carinii f.sp. carinii have been shown to be stable for at least a year [8]. A particular karyotype form can occur in multiple col ...
Periplasmic adaptor protein AcrA has a distinct
... interact with both AcrB and TolC17 – 20 as well as being bound to the inner membrane by an N-terminal lipid moiety.21 Suggested roles for AcrA include assembly and maintenance of a stable complex in vivo,19,22 and transmitting conformational changes in AcrB to TolC, facilitating the opening of the o ...
... interact with both AcrB and TolC17 – 20 as well as being bound to the inner membrane by an N-terminal lipid moiety.21 Suggested roles for AcrA include assembly and maintenance of a stable complex in vivo,19,22 and transmitting conformational changes in AcrB to TolC, facilitating the opening of the o ...
The Plasmodium 6-cysteine protein family in sexual and sporozoite
... regions with high transmission, intermittent preventive treatment (IPT) with antimalarial drugs is being used for protection of pregnant women because an increased risk to malaria during pregnancy results in a substantial number of maternal and infant deaths [4,5]. For first-line treatment of uncomp ...
... regions with high transmission, intermittent preventive treatment (IPT) with antimalarial drugs is being used for protection of pregnant women because an increased risk to malaria during pregnancy results in a substantial number of maternal and infant deaths [4,5]. For first-line treatment of uncomp ...
Neurospora Spore Killers Sk-2 and Sk
... be silenced. The resulting ascus is devoid of microtubules and will be arrested before metaphase I. Evidently, the presence of an unpaired copy of a gene is a red flag for mischief, which will alert the silencing system to destroy all transcripts similar to it (Shiu et al. 2001). The MSUD mechanism ...
... be silenced. The resulting ascus is devoid of microtubules and will be arrested before metaphase I. Evidently, the presence of an unpaired copy of a gene is a red flag for mischief, which will alert the silencing system to destroy all transcripts similar to it (Shiu et al. 2001). The MSUD mechanism ...
Endonucleolytic processing of CCAless tRNA precursors by RNase
... In the archaea, the maturation of the 3¢ end of tRNAs occurs by endonucleolytic cleavage 3¢ to the discriminator base (Schierling et al., 2002), the unpaired base immediately preceding the CCA motif and used as an identity element by many aminoacyl-tRNA synthetases. In yeast and higher eukaryota, tw ...
... In the archaea, the maturation of the 3¢ end of tRNAs occurs by endonucleolytic cleavage 3¢ to the discriminator base (Schierling et al., 2002), the unpaired base immediately preceding the CCA motif and used as an identity element by many aminoacyl-tRNA synthetases. In yeast and higher eukaryota, tw ...
The one-eyed pinhead gene functions in mesoderm and endoderm
... site (STS) marker for the 15AH.500 locus was generated by cloning and sequencing the RAPD fragment and synthesizing primers specific for that sequence (primer WTZ97, 5′-ACTTGCAGGAGTGGATCTGAC, and primer WTZ106, 5′-CACAAAAACACCATCTGACC). In the oep mapping crosses, all of the animals display an allel ...
... site (STS) marker for the 15AH.500 locus was generated by cloning and sequencing the RAPD fragment and synthesizing primers specific for that sequence (primer WTZ97, 5′-ACTTGCAGGAGTGGATCTGAC, and primer WTZ106, 5′-CACAAAAACACCATCTGACC). In the oep mapping crosses, all of the animals display an allel ...
Effete, a Drosophila chromatin-associated ubiquitin
... Many studies have shown that telomeres modulate the expression of genes located in their proximity, a phenomenon known as telomere position effect (TPE). This form of transcriptional regulation is conserved from yeast to humans, and has been implicated in numerous human pathologies (reviewed in (Ott ...
... Many studies have shown that telomeres modulate the expression of genes located in their proximity, a phenomenon known as telomere position effect (TPE). This form of transcriptional regulation is conserved from yeast to humans, and has been implicated in numerous human pathologies (reviewed in (Ott ...
The Homothorax homeoprotein activates the nuclear localization of
... exd has other roles in addition to its homeotic cofactor function. exd mutant clones caused ectopic eye formation in the ventral head, ventral to dorsal transformation in the imaginal abdomen, affected bristle patterning in the thorax and wing, and affected the proximal leg development (Gonzalez-Cre ...
... exd has other roles in addition to its homeotic cofactor function. exd mutant clones caused ectopic eye formation in the ventral head, ventral to dorsal transformation in the imaginal abdomen, affected bristle patterning in the thorax and wing, and affected the proximal leg development (Gonzalez-Cre ...
Expression and characterization of von Willebrand
... subtypes IIA, IIC, IID, IIE, IIF, IIG, and IIH, have been combined to form a common type, vWD type 2A, which comprises all variants lacking HMWM in plasma.11 The single exception is type 2B, in which the absence of plasma HMWM ...
... subtypes IIA, IIC, IID, IIE, IIF, IIG, and IIH, have been combined to form a common type, vWD type 2A, which comprises all variants lacking HMWM in plasma.11 The single exception is type 2B, in which the absence of plasma HMWM ...
NO sensing by FNR: regulation of the Escherichia coli NO
... the ¯avohaemoglobin-encoding gene of E.coli, hmp, is upregulated by NO and RNS; this appears not to involve SoxRS (Poole et al., 1996). We have reported (MembrilloHernaÂndez et al., 1998) a mechanism of hmp gene regulation that involves interaction between S-nitrosothiols and Hcy. Intracellular Hcy ...
... the ¯avohaemoglobin-encoding gene of E.coli, hmp, is upregulated by NO and RNS; this appears not to involve SoxRS (Poole et al., 1996). We have reported (MembrilloHernaÂndez et al., 1998) a mechanism of hmp gene regulation that involves interaction between S-nitrosothiols and Hcy. Intracellular Hcy ...
A survey on computational methods for enhancer and
... targets. First, there is no simple rule governing the relative location of an enhancer from a gene that it targets. It can be positioned either upstream or downstream of the transcription start site (TSS) of its target gene. It can reside in an intergenic region, an intron, or even an exon of anothe ...
... targets. First, there is no simple rule governing the relative location of an enhancer from a gene that it targets. It can be positioned either upstream or downstream of the transcription start site (TSS) of its target gene. It can reside in an intergenic region, an intron, or even an exon of anothe ...
Current Trends of Emergence and Spread of Vancomycin
... 3.4 Resistance to macrolides, lincosamides and streptogramin B (MLSB) Resistance to MLSB antibiotics is encoded by the widespread erm(B) gene and only occasionally via erm(A) or erm(C)(Roberts et al., 1999). Erm (“erythromycin resistance methylases”) confer resistance by modifying nucleotide A2058 o ...
... 3.4 Resistance to macrolides, lincosamides and streptogramin B (MLSB) Resistance to MLSB antibiotics is encoded by the widespread erm(B) gene and only occasionally via erm(A) or erm(C)(Roberts et al., 1999). Erm (“erythromycin resistance methylases”) confer resistance by modifying nucleotide A2058 o ...
Establishing neuroblast-specific gene expression in the Drosophila
... To understand fully how neuronal diversity is generated in the Drosophila CNS, we need to know how neuroectoderm position translates into neuroblast-specific gene expression, and how gene expression in a neuroblast leads to its characteristic cell lineage. In this paper we address the first question ...
... To understand fully how neuronal diversity is generated in the Drosophila CNS, we need to know how neuroectoderm position translates into neuroblast-specific gene expression, and how gene expression in a neuroblast leads to its characteristic cell lineage. In this paper we address the first question ...