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BASICS OF NEUROBIOLOGY CYTOARCHITECTURE OF CEREBRAL CORTEX ZSOLT LIPOSITS 2016. 11. 24. 1 Basics of Neurobiology: Cytoarchitecture of cerebral cortex CELLULAR COMPOSITION OF THE CEREBRAL CORTEX THE CEREBRAL CORTEX CONSISTS OF THE ARCHICORTEX (HIPPOCAMPAL FORMATION), PALEOCORTEX (OLFACTORY AREAS) AND NEOCORTEX THE NEOCORTEX IS COMPRISED OF SIX SUPERIMPOSED LAYERS. THERE ARE ABOUT 1010 NEURONS IN THE CEREBRAL CORTEX THE CORTEX IS BUILT UP BY PRINCIPAL, PYRAMIDAL NEURONS, INHIBITORY INTERNEURONS AND GLIA CELLS THERE ARE VARIATIONS IN THE CYTOARCHITECTURE OF THE CORTEX. THE PRIMARY SENSORY CORTEX IS GRANULAR, THE PRIMARY MOTOR CORTEX IS RATHER AGRANULAR IN NATURE THE INCOMING SUBCORTICAL AND CORTICAL AFFERENTS HAVE SPECIAL TERMINATION PATTERNS. THEY TRANSFER THE INFORMATION TO INTERNEURONS, THAT RELAY IT FURTHER TO PRINCIPAL CELLS NEURONS INTERACTING LOCALLY ARE ORGANIZED IN COLUMNS CALLED CORTICAL MODULES 2016. 11. 24. 2 Basics of Neurobiology: Cytoarchitecture of cerebral cortex F ORGANIZATION OF NEURONS IN CORTICAL LAYERS 1. MOLECULAR LAYER 2. EXTERNAL GRANULAR LAYER 3. EXTERNAL PYRAMIDAL LAYER 4. INTERNAL GRANULE LAYER 5. INTERNAL PYRAMIDAL LAYER 6. MULTIFORM LAYER NEURONS 2016. 11. 24. FIBERS 3 Basics of Neurobiology: Cytoarchitecture of cerebral cortex LAYERS OF THE CEREBRAL CORTEX 2016. 11. 24. 4 Basics of Neurobiology: Cytoarchitecture of cerebral cortex HISTOLOGY OF CEREBRAL CORTEX I. II. III. IV. V. VI. A B C CORTICAL SECTIONS STAINED BY CONVENTIONAL HEMATOXYLIN-EOSIN (A) AND TOLUIDINE BLUE (B). NOTE, THE THICK LAYER IV IN THE VISUAL CORTEX (C) 2016. 11. 24. 5 Basics of Neurobiology: Cytoarchitecture of cerebral cortex CELL TYPES OF THE CEREBRAL CORTEX 2016. 11. 24. 6 Basics of Neurobiology: Cytoarchitecture of cerebral cortex THE PYRAMIDAL NEURON C DENDRITIC TREE APICAL DENDRITE CELL BODY BASAL DENDRITES AXON A B AXON COLLATERAL AS IT IS SHOWN IN PICTURE A DRAWN BY RAMON Y CAJAL, THE CEREBRAL CORTEX IS RICH IN PYRAMIDAL NEURONS OF DIFFERENT SIZES. FIGURE B DEPICTS A GOLGI-IMPREGNATED PYRAMIDAL NEURON. NOTE, THE RAMIFICATION OF THE BASAL AND APICAL DENDRITES. FIGURE C ILLUSTRATES THE MAIN STRUCTURAL DOMAINS OF THE SPINY, PYRAMIDAL NEURON 2016. 11. 24.. 7 Basics of Neurobiology: Cytoarchitecture of cerebral cortex FEATURES OF INTERNEURONS A B THERE ARE SEVERAL KINDS OF INHIBITORY INTERNEURONS CLASSIFIED BASED ON THEIR STRUCTURAL, ELECTROPHYSIOLOGICAL AND CHEMICAL PROPERTIES. THE RICH PHENOTYPE OF THEM IS DEPICTED IN FIG A. THE MOST KNOWN REPRESENTATIVES OF INTERNEURONS ARE THE BASKET, CHANDELIER, STELLATE, RETZIUS-CAJAL AND MARTINOTTI CELLS. FOR A DEEPER INSIGHT SEE NATURE REVIEWS NEUROSCIENCE , VOLUME 9, 2008, 565. INTERNEURONS ESTABLISH SOPHISTICATED CIRCUITS WITH PRINCIPAL NEURONS (B) AND RELAY THE INFORMATION BROUGHT IN BY SPECIFIC AND NON-SPECIFIC AFFERENTS TO PYRAMIDAL CELLS 2016. 11. 24. 8 Basics of Neurobiology: Cytoarchitecture of cerebral cortex PROPERTIES OF CORTICAL INTERNEURONS Summary of the the Petilla Interneuron Nomenclature Group Morphological features • Soma: shape; size; orientation; other • Dendrite: arborization polarity; branch metrics; fine structure; postsynaptic element; other • Axon: initial segment; arbor trajectory; terminal shape; branch metrics; boutons; synaptic targets; other • Connections: chemical and electrical; source; location and distribution; other Molecular features •Transcription factors • Neurotransmitters or their synthesizing enzymes • Neuropeptides • Calcium-binding proteins • Receptors: ionotropic; metabotropic • Structural proteins • Cell-surface markers • Ion-channels • Connexins • Transporters: plasma membrane; vesicular • Others 2016. 11. 24. Physiological features • Passive or subthreshold parameters: resting membrane potential; membrane time constants; input resistance; oscillation and resonance; rheobase and chronaxie; rectification • Action potential (AP) measurements: amplitude; threshold; halfwidth; afterhyperpolarization; afterdepolarization; changes in AP waveform during train. • Dendritic back-propagation • Depolarizing plateaus • Firing pattern: oscillatory and resonant behaviour; onset response to depolarizing step; steadystate response to depolarizing step • Response to hyperpolarizing step: rectification; rebound • Spiking recorded extracellularly: phase relationship to oscillations; functional response specificity; cross-correlation and other dynamics • Postsynaptic responses: spontaneous and evoked; ratio of receptor subtypes; spatial and temporal summation; short- and long-term plasticity; gap junctions 9 Basics of Neurobiology: Cytoarchitecture of cerebral cortex CORTICAL COLUMNS 2016. 11. 24. 10 Basics of Neurobiology: Cytoarchitecture of cerebral cortex NEURONAL ASSEMBLY OF A CORTICAL MODULE 300 MICROMETER THE CORTICAL COLUMN IS ABOUT 300 MICROMETER WIDE AND HAS THE HEIGHT OF THE CORTEX (2.5-3 mm). EACH HOSTS ABOUT FIVE THOUSAND NEURONS. THERE ARE APPROXIMATELY 2x106 CORTICAL MODULES IN HUMANS. THE SYSTEM SPECIFIC AFFERENTS AND THE CORTICOCORTICAL AFFERENTS FEED THE CORTICAL COLUMNS. THE FORMER FIBERS TERMINATE IN THE MIDDLE AREA, THE LATTER ONES IN THE SUPERFICIAL ZONE OF THE COLUMN. A FEW KINDS OF INTERNEURONS ARE SHOWN IN SOLID BLACK IN THE ORIGINAL FIGURE OF J. SZENTÁGOTHAI. A CHANDELIER CELL IS ENFRAMED. THEIR AXONS FORM AXO-AXONIC CONNECTIONS WITH PYRAMIDAL NEURONS. AT THE TOP AND THE BASE OF THE COLUMN THE EXCITATION SPREADS LATERALLY, WHILE IN THE MIDDLE PART THE LATERAL INFORMATION FLOW IS LIMI-TED. THE OUTFLOW FROM THE COLUMN IS EXECUTED BY AXONS OF PYRAMID CELLS. LAYER III CELLS PROJECT TO CORTICAL REGIONS AS ASSOCIATIVE AND COMMISSURAL FIBERS, WHILE THE LARGE BETZ PYRAMIDAL NEURONS OF LAYER V ESTABLISH THE DESCENDING CONNECTIONS CORTICO-CORTICAL SPECIFIC AFFERENT AFFERENT 2016. 11. 24. 11 Basics of Neurobiology: Cytoarchitecture of cerebral cortex COMMUNICATION AMONG CORTICAL MODULES A B F MIDLINE OF THE BRAIN FIGURE A SHOWS THE IPSI- AND CONTRALATERAL CONNECTIONS OF MODULES ESTABLISHING CORTICO-CORTICAL NETWORKS. INHIBITORY NEURONS OF ACTIVE CORTICAL COLUMNS (HIGHLIGHTED IN YELLOW) ARE SURROUNDED BY INACTIVE ONES (RED HIGHLIGHT). THE COLLATERAL INHIBITION IS DUE TO BASKET CELLS. FIGURE B DEPICTS THE PROPOSED FUNCTIONAL SHAPE (DASHED LINE) OF THE MODULE 2016. 11. 24. 12 Basics of Neurobiology: Cytoarchitecture of cerebral cortex CORTICAL ASSOCIATION PATHWAYS 2016. 11. 24. 13 Basics of Neurobiology: Cytoarchitecture of cerebral cortex ASSOCIATIVE PATHWAYS WITHIN THE CEREBRAL CORTEX 2016. 11. 24. 14 Basics of Neurobiology: Cytoarchitecture of cerebral cortex EFFERENT NEURONS OF THE CORTEX 2016. 11. 24. 15 Basics of Neurobiology: Cytoarchitecture of cerebral cortex EFFERENT PATHWAYS OF THE CORTEX 2016. 11. 24. 16 Basics of Neurobiology: Cytoarchitecture of cerebral cortex DIFFERENT FUNCTIONAL OUTPUTS OF CORTICAL MODULES OF DIFFERENT BRAIN REGIONS CORTICAL AREA FUNCTION PREFRONTAL CORTEX PROBLEM SOLVING, EMOTION, COMPLEX THOUGHT MOTOR ASSOCIATION CORTEX COORDINATION OF COMPLEX MOVEMENT PRIMARY MOTOR CORTEX INITIATION OF VOLUNTARY MOVEMENT PRIMARY SOMATOSENSORY CORTEX RECEIVES TACTILE INFORMATION FROM THE BODY SENSORY ASSOCIATION AREA PROCESSING OF MULTISENSORY INFORMATION VISUAL ASSOCIATION AREA COMPLEX PROCESSING OF VISUAL INFORMATION VISUAL CORTEX DETECTION OF SIMPLE VISUAL STIMULI WERNICKE'S AREA LANGUAGE COMPREHENSION AUDITORY ASSOCIATION AREA COMPLEX PROCESSING OF AUDITORY INFORMATION AUDITORY CORTEX DETECTION OF SOUND QUALITY (LOUDNESS, TONE) MOTOR SPEECH CENTER (BROCA'S AREA) SPEECH PRODUCTION AND ARTICULATION 2016. 11. 24. 17 Basics of Neurobiology: Cytoarchitecture of cerebral cortex LOCALIZATION OF CORTICAL FUNCTIONS B A C NON-INVASIVE, RADIOLOGICAL IMAGING TECHNIQUES (PET, FMRI) ALLOW THE LOCALIZATION OF SPECIFIC BRAIN FUNCTIONS IN WELL-DEFINED REGIONS. THE SCANS SHOW BRAIN ACTIVITIES UNDER NORMAL (A), THINKING (B) AND SOMATIC MOTOR (C) CONDITIONS 2016. 11. 24. 18 Basics of Neurobiology: Cytoarchitecture of cerebral cortex Blood supply of the cerebral cortex ATRERIA CEREBRI ANTERIOR ARTERIA CEREBRI MEDIA ARTERIA CEREBRI POSTERIOR 2016. 11. 24. 19