Download Neurobiology 204: Neurophysiology of Central Circuits, Spring 2006

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NB204
Spring 2010
Week #3 (Feb. 10) Cortical Microcircuits
Clay Reid ([email protected])
Due to the holiday on Monday February 15 (President's Day), there will be no discussion section and no
homework this week.
The lecture will cover the nature of microcircuits within the cerebral cortex. I've assigned a review
article to give our point of view about cortical circuits: to understand circuits, one needs to know both
the in vivo function of neurons as well as the wiring diagram. The Petersen paper is to show an
"exhaustive" characterization of the excitatory connections in the cortex. Why is this characterization of
the network—which is devoid of function or of "higher-order dependencies"—not enough? Try to think
of concrete examples of other things you would like to know about the circuit.
Prior to Monday’s lecture, please read:
Ohki, K & Reid RC (2007) "Specificity and randomness in the visual cortex." Curr. Opin. Neurobiol.
17:401-407.
Lefort S, Tomm C, Sarria JCF, Petersen CCH (2009) "The excitatory neuronal network of the C2 barrel
column in mouse primary somatosensory cortex." Neuron. 61:301-16.
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