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Edward L. Bartlett • Ph.D., University of Wisconsin – Auditory thalamus in vitro synaptic physiology and anatomy • Aud. Cortex Postdoctoral Research at Johns Hopkins University MGB – Auditory cortex and thalamus neuronal recordings in vivo • Assistant Professor, Departments of Biological Sciences and Biomedical Engineering – Functional organization of auditory cortex and thalamus in vivo and in vitro IC Adapted from Netter Current Research Areas • Neural representation of sound features in auditory thalamus and cortex – Sound sequences – Neural coding of temporal modulation – Neural coding of sound frequency, level Aud. Cortex Aud. Thalamus Perception, Decision, Action IC • Neuroanatomy – Calcium-binding proteins – Correlation with neurophysiology SOC/LL CN • Animal Models: – Marmoset monkey (at JHU) – Rodent (at Purdue) AN sound feature extraction Cochlea Sound Methodologies •Single-neuron extracellular recording -awake animals •Sound and electrical stimulation •Neuroanatomy •Intracellular recording in brain slices -synaptics, dynamic clamp •Modeling of neurons and circuits Recent Results Neural representation of temporal modulation - synchronized vs nonsynchronized - temporally vs spectrally specialized pathways Correlation with MGB subdivision 40 Hz click train Synchronized Temporal representation, MGV 250 Hz click train Non-Synchronized Rate representation, MGCD Future Directions • Auditory responses in thalamus and cortex: normal and aged animals • Corticothalamic feedback modulation • Representation of complex sounds (two sources, sounds in noise, behaviorally relevant sounds) • Cellular mechanisms of in vivo responses Auditory cortex Auditory thalamus Adapted from Castro-Alamancos, 2004 Single neuron response Cooling probe