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Transcript
Seminar Abstract Christen Simon Graduate Student in the Laboratory of Dr. Edgar Garcia-Rill Department of Neurobiology and Developmental Sciences Center for Translational Neuroscience Tuesday, April 28, 2009 at Noon BioMed-II Building, Rayford Auditorium Glutamatergic Modulation of the Pedunculopontine Nucleus and its Potential Effects on Waking and REM Sleep Abstract: The Pedunculopontine Nucleus (PPN) is the cholinergic arm of the Reticular Activating System and is involved in cortical arousal. More specifically, the PPN is active during waking and REM sleep. The PPN receives input from many areas of the brain, including glutamatergic input from other mesopontine nuclei and the thalamus. Studies involving microinjections into the PPN in the freely moving rat have demonstrated that glutamate increases waking and REM sleep. These studies showed that glutamate induced wakefulness may be mediated through NMDA receptors in the PPN and that glutamate induced REM sleep may be mediated through KA receptors in the PPN. Furthermore, there is a developmental change in the responsiveness of PPN neurons to NMDA and KA. This developmental change could underlie the developmental decrease in REM sleep observed in rats and possibly humans. Further studies are required to determine the responses of different PPN cell types to glutamate receptor agonists and the roles of these cell types in waking and REM sleep. These studies will add to the understanding of the mechanisms behind sleep and waking.
