Download Biol. Psychist. __, No.3, pp.243-246 (1972).

Biol. Psychist.
__
-
__, No.3,
pp.243-246
(1972).
Raferiert in: Psychopharmaoology Abstracts ii, No.l, p.l15 (1973).
14
VOLUME 11, NO. I
117135
116038 Griffiths, William 3.; Lester, Boyd K.;
Coulter, Joe D.; Williams,
Harold L. Dept.ol
Psychiatry,
University
of Oklahoma
Medical
Center, 800 Northeast 13th Street, Oklahoma City,
OK 73104 Tryptophan and sleep in young adults,
Psychophysiology.
9(3):345-356, 1972.
The effects of moderate (7.58) and larger (128)
doses of L-tryptophan on the EEG sleep patterns
of 21 normal young males were investigated.
Moderate
doses
produced
sedative
effects
(reports of extreme drowsiness and reduced time
awake)
accompanied
by increased
slow-wave
sleep. The only effects on REM parameters were
a trend (in some Ss) to early onset of stage REM,
a small decrease in the period of the REM cycle,
and decreased density of rapid eye movements.
With the high dose, Ss again reported extreme
drowsiness,
and time
to
sleep
onset
was
decreased. However, changes in slow wave sleep
and waking time appeared only as nonsignificant
trends. In the high dose group, percent of REM
sleep was markedly increased, due to early onset
of stage REM and to increased duration of REM
episodes during the second half of the night. EEG
sleep patterns on recovery nights following large
doses of tryptophan were not systematically
different from baseline nights. These results indicate
that the changes in sleep patterns produced by Ltryptophan, presumably acting through 5-hydroxyindole pathways,
are dependent on dose. The
findings
are consistent
with the idea that
serotonin, or one of its metabolites, is involved in
the mechanisms
controlling both SW and REM
the drug effect. MPT was the more discriminating
interindividual measure. MPT did not change in
the first monologue but was significantly different
in the second monologue for all three drug cornparisons. An increase of MPT without significant
change in MVT indicated slowing of speech.
Speech was slowed with LSD and increased with
DA. 8 references.
116937 Wender, Paul H. Laboratory o! Psychology, National Institute of Mental Health, Building
10, Room 2N222, Bethesda, MD 20014 The control
of children's behavior with medication. Bethesda,
Md.NIMH, 1972, 16 p.
The control
of minin_al brain dysfunction
(MBD) in children with medication is discussed.
The factual issues involved are considered:
the
types of psychological functioning that are altered
by drugs in children, and the types of alteration
which
are produced
by drugs. Philosophical
questions related to the field are sketched briefly,
with emphasis on the problems in the treatment of
MBD and the problems
associated
with the
problems.
Although treatment
with medication
clearly modifies the signs and symptoms of the
disorder on a short term basis, it is concluded that
whether chronic treatment modifies or prevents
the development of later problems, whether it has
any permanent effects on the life history of the
individual, remains to be determined.
117135 Hurst, Paul M.; Bagley, Sallyann K.;
Ross, Sherman. Institute for Research, 257 S.Pugh
methylphenidate
L,_
_ •
1168S5
J.;
sleep. 33_ references.
Dahlberg,
C.C.; modified)
Lurla,
J.;
(Author abstract
Psycholog-
icalReports.
31(1):59-67,
1972.Effects of alcohol and
St.,
State College,
PA 16801
son White
Institute,
New York,
NY Speech
Breskin,
J.; Lorick, E.
Alanrhythms S.;
in Chorosh,
patient monologues:
theWilliam
influence
of
LSD-2S
and
dextroamphetamine.
Biological
Psychiatry. 4(3):243-246, 1972.
The influence of d-lysergic acid diethylamide
(LSD-25) and dextroamphetamine
(DA) on speech
rhythms in patient monologues was investigated,
Seven patients received LSD, DA and a placebo
(P) over an average period of about one and one
half years. A patient by drug analysis of variance
was performed on mean pause time (MPT) and
mean vocalization time (MVT) of verbal behavior,
Monologues were recorded: 1) just prior to drug
ingestion; and 2) just prior to the test session
(2.5hours later). Speakers differed significantly on
both measures in the first monologttes,
prior to
with mood related influences,
methylphenidate
In a study of fl2mg/70kg
the interaction
cognitive effects
hydrochloride,
and of20mg/70kg),
ethyl
alcohol (60g/70kg), and a placebo (lactose) were
given to 50 college student volunteers.
Each S
received each treatment once during four separate
sessions,
and treatment
order was
counterbalanced.
Ss were experienced
bridge players,
who were given sets of bidding problems, which
varied in storage load, ambiguity
level, and
answer format (open ended vs multiple choice).
Performances
were
scored
according
to
1)
frequency of active bids vs passes, and 2) a figure
of merit assigned to each possible response, as
developed from expert consensus.
Ss wrote impromptu _editorials on assigned topics from which
word count measures of verbal production were
II$
,-
on complex judgments.
i