* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download The Brain (Handout)
Neuroesthetics wikipedia , lookup
Optogenetics wikipedia , lookup
Biochemistry of Alzheimer's disease wikipedia , lookup
Donald O. Hebb wikipedia , lookup
Evolution of human intelligence wikipedia , lookup
History of anthropometry wikipedia , lookup
Functional magnetic resonance imaging wikipedia , lookup
Development of the nervous system wikipedia , lookup
Human multitasking wikipedia , lookup
Molecular neuroscience wikipedia , lookup
Artificial general intelligence wikipedia , lookup
Stimulus (physiology) wikipedia , lookup
Activity-dependent plasticity wikipedia , lookup
Neurogenomics wikipedia , lookup
Single-unit recording wikipedia , lookup
Blood–brain barrier wikipedia , lookup
Neurophilosophy wikipedia , lookup
Neuroinformatics wikipedia , lookup
Neural engineering wikipedia , lookup
Neuroeconomics wikipedia , lookup
Neurolinguistics wikipedia , lookup
Microneurography wikipedia , lookup
Neuroregeneration wikipedia , lookup
Human brain wikipedia , lookup
Nervous system network models wikipedia , lookup
Neural correlates of consciousness wikipedia , lookup
Aging brain wikipedia , lookup
Cognitive neuroscience wikipedia , lookup
Clinical neurochemistry wikipedia , lookup
Brain morphometry wikipedia , lookup
Haemodynamic response wikipedia , lookup
Neuroplasticity wikipedia , lookup
Selfish brain theory wikipedia , lookup
Brain Rules wikipedia , lookup
Holonomic brain theory wikipedia , lookup
Neuropsychology wikipedia , lookup
History of neuroimaging wikipedia , lookup
Circumventricular organs wikipedia , lookup
Neuropsychopharmacology wikipedia , lookup
The Brain (Handout) prof. aza prof.aza 1 Brains exist because the distribution of resources necessary for survival and the hazards that threaten survival vary in space and time. There would be little need for a nervous system in an immobile organism or an organism that lived in regular and predictable environment. Brains are informed by the senses about the presence of resources and hazards; they evaluate and store this input and generate adaptive responses executed by the muscles. prof.aza 2 Figure 03a E. coli's Response to Chemical Gradient prof.aza 3 Some of the most basic features of brains can be found in bacteria because even the simplest motile organisms must solve the problem of locating resources and avoiding toxins. prof.aza 4 They sense their environment through a large number of receptors, which are protein molecules embedded in the cell wall. The action taken in response to the inputs usually depends on the gradient of the chemicals (see Figure 03a). Thus memory is required to compare the inputs from different locations. The strength of the signal is modulated by immediate past experience. prof.aza 5 This in turn regulates the strength of the signal sent by chemical messengers from the receptor to the flagellar motors. Thus even at the unicellular level, the bacteria have already possessed the ability to integrate numerous analog inputs and generate a binary (digital) output of stop or go. prof.aza 6 In multicellar organism, cells specialized for receptor function are located on the surface. Other cells specialized for the transmission and analysis of information are located in the protected interior and are linked to effector cells, usually muscles, which produce adaptive responses. As do unicellular organisms, neurons integrate the diverse array of incoming information from the receptors, which in neurons may result in the firing of an action potential (when the summation is above a threshold level) rather than swimming toward a nutrient source as in the unicellular organisms prof.aza 7 Once the threshold for generating an action potential is reached, the signal is always the same, both in amplitude and shape (a nerve consists of many neurons, it does not obey the all-or-none law). Action potentials and voltage-gated sodium channels are present in jellyfish, which are the simplest organisms to possess nervous systems. The development of this basic neuronal mechanism set the stage for the proliferation of animal life that occurred during the Cambrian period. Among these Cambrian animals were the early chordates, which possessed very simple brains. prof.aza 8 Some of these early fish developed a unique way to insulate their axons by wrapping them with a fatty material called myelin, which greatly facilitated axonal transmission and evolution of larger brains. Some of their descendants, which also were small predators, crawled up on the muddy shores and eventually took up permanent residence on dry land. Challenged by the severe temperature changes in the terrestrial environment, some experimented with becoming warm-blooded, and the most successful became the ancestors of birds and mammals. Changes in the brain and parental care were a crucial part of the set of mechanisms that enabled these animals to maintain a constant body temperature. prof.aza 9 Animals with large brains are rare -- there are tremendous costs associated with large brains (the active human brain consumes about 20 watts). The brain must compete with other organs in the body for the limited amount of energy available, which is a powerful constraint on the evolution of large brains. Large brains also require a long time to mature, which greatly reduces the rate at which their possessors can reproduce. Because large-brained infants are slow to develop and are dependent on their parents for such a long time, the parents must invest a great deal of effort in raising their infants. prof.aza 10 Figure 03b Maternal Care prof.aza 11 Young reptiles function as miniature versions of adults, but baby mammals and birds are dependent because of their poor capacity to thermo-regulate, the consequence of their need to devote most their energy to growth. Most mammals solve the problem with maternal care (Figure 03b), shelter, warmth, and milk. In most birds, both parents cooperate to provide food and shelter to their young. The expanded forebrain and parental care provide mechanisms for the extra-genetic transmission of information from one generation to the next. prof.aza 12 This transmission results from the close contact with parents during infancy, which provides the young with opportunity to observe and learn from their behavior; the expanded forebrain provides an enhanced capacity to store these memories. The expanded forebrain and the observation of parents are probably necessary for the establishment of successful care giving behavior itself, as the young mature into adults that will in their turn have to serve dependent young. During the period of infant dependency, baby mammals and birds play, prof.aza 13 During the period of infant dependency, baby mammals and birds play behavior that may be essential for the development of the forebrain. The baby's playful interaction with its environment may serve to provide the initial training of the forebrain networks that ultimately will enable the animal to localize, identify, and capture resources in its environment. prof.aza 14 prof.aza 15 The human brain can be divided into three parts: the hindbrain, which has been inherited from the reptiles; the limbic system, which was first emerged in mammals; and the forebrain, which has its full development in human. Different views of the human brain are shown in Figure 03c and 04d. Tables 01 lists the functions of the different parts of the human brain. The brain is separated into two hemispheres. prof.aza 16 Apart from a single little organ -- the pineal gland in the centre base of the brain -- every brain module is duplicated in each hemisphere. The left brain is calculating, communicative and capable of conceiving and executing complicated plans -- the reductionistic brain; while the right one is considered as gentle, emotional and more at one with the natural world -- the holistic brain. prof.aza 17 prof.aza 18 The cerebral cortex is covered in a thin skin of deeply wrinkled grey tissue called the grey matter (densely packed neurons for information processing). Each infold on the surface is known as a sulcus, and each bulge is know as a gyrus. While the white tissue inside are axons -tentacles which reach out to other cells (to relay information). The cortex can be broken down into many functional regions, each containing thousands of cortical columns (oriented perpendicular to the cortical surface). prof.aza 19 Columns are typically about half a millimeter in diameter and contain about one hundred thousand neurons. They are the units of cognition (the mental process of acquiring knowledge by the use of reasoning, intuition or perception). Table 02 below lists the location and functions of the major components in the human brain. prof.aza 20 Figure 03e Brain Waves The third, or parietal, eye is a light-sensitive spot thought to sense changing light conditions. Opsin proteins sensitive to blue and green light has been identified in the cell prof.aza 21 It is well known that the brain is an electrochemical organ; a fully functioning brain can generate as much as 20 watts of electrical power. Even though this electrical power is very limited, it does occur in very specific ways that are characteristic of the human brain. Electrical activity emanating from the brain can be displayed in the form of brainwaves. There are four categories of these brainwaves, ranging from the most active to the least active. Figure 03e is produced by an EEG (ElectroEncephaloGraph) chart prof.aza 22 Figure 03e is produced by an EEG (ElectroEncephaloGraph) chart recorder to show the different kind of brainwave according to the different state of the brain. These are all oscillating electrical voltages in the brain, but they are very tiny voltages, just a few millionths of a volt. Electrodes are placed on the outer surface of the head to detect electrical changes in the extracellular fluid of the brain in response to changes in potential among large groups of neurons. The resulting signals from the electrodes are amplified and recorded. prof.aza 23 Autonomic Nervous System One division of the autonomic nervous system, called the sympathetic nervous system, dominates in times of stress. It controls the "fight or flight" reaction, increasing blood pressure, heart rate, breathing rate, and blood flow to the muscles. Another division, called the parasympathetic nervous system, has the opposite effect. It conserves energy by slowing the heartbeat and breathing rate, and by promoting digestion and elimination (of waste). prof.aza 24 Most glands, smooth muscles, and cardiac muscles constantly get inputs from both the sympathetic and parasympathetic systems. The CNS controls the activity by varying the ratio of the signals. Depending on which motor neurons are selected by the CNS, the net effect of the arriving signals will either stimulate or inhibit the organ. Figure 07 shows the various organs and actions, which are related to the two different divisions. prof.aza 25 Figure 07 ANS Side View prof.aza 26 prof.aza 27 Brain waves originate from the cerebral cortex, but also reflect activities in other parts of the brain that influence the cortex, such as the reticular formation. Because the intensity of electrical changes is directly related to the degree of neuronal activity, brain waves vary markedly in amplitude and frequency between sleep and wakefulness. Beta wave rhythms appear to be involved in higher mental activity, including perception and consciousness. It seems to be associated with consciousness, e.g., it disappears with general anesthesia. prof.aza 28 Other waves that can be detected are Alpha, Theta, and Delta. When the hemispheres or regions of the brain are producing a wave synchronously, they are said to be coherent. Alpha waves are generated in the Thalamus (the brain within the brain), while Theta waves occur mainly in the parietal and temporal regions of the cerebrum. prof.aza 29 The Alpha and Theta waves seem to be associated with creative, insightful thought. When an artist or scientist has the "aha" experience, there's a good chance he or she is in Alpha or Theta. These two kinds of brain waves are also associated with relaxation and, stronger immune systems. Therefore, many people try to train themselves to enter such states through various biofeedback7 techniques (with varying degree of success). Delta Waves occur during sleep. They originate from the cerebral cortex when it is not being activated by the reticular formation. In slow-wave sleep, the entire brain oscillates in a gentle rhythm quite unlike the fragmented oscillations of normal consciousness. prof.aza 30 Peripheral Nervous System prof.aza Figure 05 Cranial Nerves 31 Figure 05 Cranial Nerves prof.aza 32 Figure 06 Spinal Nerves prof.aza 33 The peripheral nervous system The peripheral nervous system is outside the CNS. It consists of the various nerves that connect particular parts of the CNS with particular organs. Humans have 12 pairs of cranial nerves and 31 pairs of spinal nerves. Cranial nerves (Figure 05) are either sensory nerves, motor nerves, or mixed nerves. All of them, except the vagus nerve, control the head, the face, the neck, and the shoulders. The vagus nerve controls the internal organs. Table 03 lists the functions of the various cranial nerves. All spinal nerves (Figure 06) are mixed nerves that take impulses to and from the spinal cord. Table 04 describes the symptom of spinal cord injury (SCI) with the particular spinal nerve(s). prof.aza 34 Autonomic Nervous System One division of the autonomic nervous system, called the sympathetic nervous system, dominates in times of stress. It controls the "fight or flight" reaction, increasing blood pressure, heart rate, breathing rate, and blood flow to the muscles. Another division, called the parasympathetic nervous system, has the opposite effect. It conserves energy by slowing the heartbeat and breathing rate, and by promoting digestion and elimination (of waste). prof.aza 35 Most glands, smooth muscles, and cardiac muscles constantly get inputs from both the sympathetic and parasympathetic systems. The CNS controls the activity by varying the ratio of the signals. Depending on which motor neurons are selected by the CNS, the net effect of the arriving signals will either stimulate or inhibit the organ. Figure 07 shows the various organs and actions, which are related to the two different divisions. prof.aza 36 Figure 08 ANS Front View prof.aza 37 Figure 07 ANS Side View prof.aza 38 Motor fibers that govern involuntary responses, do not lead directly to the organs they innervate. Instead, they make their trips in two stages. The first set of fibers leads from the CNS to ganglia (which are collections of nerve cell bodies) that lie outside the CNS (the preganglionic fibers). At the ganglia the fibers form synaptic junctions with the dendrites of as many as twenty different cell bodies. The axons of these cell bodies form a second set of fibers, the postganglionic fibers. It is these postganglionic fibers that lead to the organs. The chief ganglia involved in the autonomic nervous system form two lines running down either side of the spinal column. They are outside the bony vertebrae. prof.aza 39 These two lines of ganglia outside the column resemble a pair of long beaded cords. At the lower end, the two cords join and finish in a single central stretch. These lines of ganglia are sometimes called the sympathetic trunks (used by the sympathetic nervous system). Not all ganglia are located in the sympathetic trunks. Some are not; and it is possible for a preganglionic fiber to go right through, making no synaptic junction there at all, joining instead with ganglia located in front of the vertebrae. For the parasympathetic nervous system, some of the ganglia separating the preganglionic fibers from the postganglionic fibers are actually located within the organ the nerve is servicing. prof.aza 40 In that case, the preganglionic fiber runs almost the full length of the total track, whereas the postganglionic fiber is at most just a few millimeters long. The splanchnic nerves, which originate from some of the thoracic nerves, have their preganglionic fibers ending in a mass of ganglia lying just behind the stomach. It represents the largest mass of nerve cells that is not within the CNS and is sometimes called the "abdominal brain". It is a vital spot to be protected during boxing. prof.aza 41 prof.aza 42