Download Mutations

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Where do mutations occur?
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Which mutations are significant for future
generations?
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How are mutations connected to the theory
of Evolution?
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Where do mutations occur?
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Read LE 4 (page 41-42) Traits & Fates;
Do TASK #1-3 using the Pink Sheet with
mRNA sequences of
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 Normal Hemoglobin (A)
 Sickle Hemoglobin (S)
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Use the decoding / codon sheet or p.42 chart
to determine the amin0 acid sequence
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Answer the analysis questions #1 -5 in
notebook
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Share your answer with table partner
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Volunteer(s) to share your answers…
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Change in DNA involving
 A single nucleotide
 A few nucleotides (sequences) within a gene or
chromosome
 Large sections of a chromosome

Hemoglobin Molecule involves a single
nucleotide change
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DNA
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Protein
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Trait
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Read page 43 and complete TASK in pairs
Each pair will be assigned a group number[1- 7]
Each pair uses a white board to show your error
in the DNA sequence
ALL start with TACCGTCTGAAAGGT

Write this DNA sense strand code in
notebook OR on back of pink sheet!
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Transcribe and then Translate to the resulting
protein

Use the Doc Camera to show your work

Describe what your group did…
How it altered the amino acid sequence…
What implications this may have…
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Where do these changes occur?

What is the difference between a change in a
sex cell and a body cell mutation?
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Which is needed for the variations within a
population for natural selection?

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During DNA Replication
Environmental Causes:
 Radiation
 Chemicals
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Most mutations are random and occur in
regions of DNA that do NOT code for
proteins --- Called SILENT MUTATIONS

Harmless
 Does not affect the production of a ____________
because it does not change its DNA sequence

Harmful
 Changes the production of a ______________ which
causes harm (illness or lethal)
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Helpful
 Changes the production of a _____________ which
makes the organism more fitted to its environment
 Harmless
&/or “silent”

Where does a mutation have to be in order to
be passed on to the next generation?
Sex and Gamete cells
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Do questions #1-4 (p43-44)
Read the “Living with Gaucher’s Disease”
article and Sandy’s Story and answer
questions #1-5 p46