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Transcript
What is CDNF? • Conserved Dopamine Neurotrophic Factor • Growth factor known as a trophic factor • Stimulates the growth of neurons Recent In Vivo Studies • Scientists need rats that exhibit Parkinson’slike symptoms – Administer 6-Hydroxydopamine (6-OHDA) • Kills off Dopaminergic neurons • Induces Parkinson’s-like symptoms L-Dopa Dopamine 6-hydroxydopamine Important Lab Findings • CDNF was injected into Striatum of rats before 6-OHDA – CDNF prevented PD symptoms from occurring • Rats were treated to express PD symptoms – Injected with 6-OHDA – 4 weeks later, treated with CDNF • Neuron function and viability was restored http://www.pharmacy.ac.uk/1638.html Screening Patients • Adequate patient response to L-Dopa – Indicates DA neurons are degraded but treatable • No effect of L-Dopa – Indicates that DA neurons have degraded completely http://www.physorg.com/news/2010-10-parkinson-disease-closer.html Benefits in human trials • CDNF has a “protective” effect – Prevents neuron degradation • CDNF can restore up to 98% function – Promoting DNA replication • Can be administered through lumbar puncture – Out-patient procedure – Anaesthetized for comfort – Use Mannitol to penetrate the Blood-Brain-Barrier
