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CLM Manuel Mameli, PhD Nicolas Gervasi, PhD Corentin Le Magueresse, PhD UMR-S 839 INSERM/UPMC Institut du Fer a Moulin 17 rue du Fer a Moulin 75005 Paris UFR de biologie, UPMC Subject: Proposal for a scientific colloquium entitled “Novel approaches to study neuronal signal integration, computation and transduction”. We are three young investigators supported by INSERM and working at the Institut du Fer à Moulin (INSERM/UPMC) and the Ecole des Neurosciences de Paris. With this letter, we are delighted to present you a proposal for a one-day scientific colloquium that we plan to organize in Paris on October 10th 2014. This event aims to cover the most recent advances and tool development for understanding the processes governing synaptic integration in complex neuronal circuits and how they affect specific behaviors. We have assembled a line-up of internationally recognized speakers at the forefront of their respective fields covering synaptic and dendritic integration in neural circuits during development and adulthood, both in simple models and in the intact brain during animal behaviors. They have all agreed to participate to the colloquium. Given the outstanding list of speakers we wish to give to all students and postdoctoral fellows the opportunity to attend this event. To this end, the policy of the IFM colloquium includes free registration, which facilitates the involvement of young scientists in their early career. We believe that this proposal has the potential to represent a key event for the Neuroscience community in the Ile de France. We hope that you will share our excitement and provide us with the support necessary to make this event a scientific breakthrough. Best regards, Nicolas Gervasi, Corentin Le Magueresse and Manuel Mameli 5th IFM Colloquium Novel approaches to study neuronal signal integration, computation and transduction – Friday October 10th 2014 – Communication among interconnected neurons creates functional neural circuits and underlies nearly every aspect of nervous system function. Recent advances in molecular, electrophysiological, in vivo imaging techniques, as wells as circuit interrogation in behaving animals have led to a rapid enhancement in our understanding of the mechanisms that causally link structure, function and connectivity to animal behavior. It has become increasingly clear that such multifaceted approaches have further demonstrated the extent to which neuronal structure and function may undergo plastic changes that contribute to development, learning and diseases. The 5th IFM colloquium aims to explore the integration, computational and signal transduction properties in neural circuits, and causally linked them to animal behavior. Two sessions will examine the recent technological advances in a wide range of topics spanning from synaptic integration, and transduction mechanisms implicated in the plasticity of synaptic signaling, to the probing of neural circuits during sensory modalities, action and development. This single day event will tie together a diversity of investigators who are at the forefront of their field making use of multidisciplinary approach and cutting-edge techniques. In addition, two outstanding scientists, whose work on the function of cortical activity and the role of individual neurons in complex ensembles provide major scientific breakthroughs, will be giving keynote lectures. An exciting aspect of this meeting is its highly international nature bringing together European and American experts in different areas, and fostering future developments by promoting interaction between investigators. In the spirit of the IFM colloquium, the meeting will be highly interactive. Concise cutting-edge presentations will be followed by intense discussion both during the sessions and ensuing free time. ● The organizers Nicolas Gervasi, PhD UMR-S 839 INSERM/UPMC Institut du Fer a Moulin 17 rue du Fer a Moulin – 75005 Paris –France Email : [email protected] Phone : +33 (0)1.45.87.61.51 N. Gervasi is a very talented INSERM researcher at the Institut du Fer a Moulin working in the team « Neurotransmission and signalling » led by Jean-Antoine Girault and Denis Hervé. After obtaining his PhD in the laboratory of P. Vincent (UMR7102 UPMC) he joined the laboratory of T. Preat (ESPCI) as a postdoctoral fellow. He is an expert in electrophysiology, intracellular signaling and cellular imaging techniques. His main interest at the IFM is to focus on the analysis of intracellular signaling networks and information flow from dendritic spines to nucleus. Corentin Le Magueresse, PhD UMR-S 839 INSERM/UPMC Institut du Fer a Moulin 17 rue du Fer a Moulin – 75005 Paris –France Email : [email protected] Phone : +33 (0)1.45.87.61.17 C. Le Magueresse is a junior INSERM investigator at the Institut du Fer à Moulin. He completed his PhD work in the laboratories of Jean-Pierre Changeux at the Pasteur Institute in Paris and Enrico Cherubini at the International School for Advanced Studies in Trieste. Prior to joining IFM in 2013, he was a postdoctoral fellow in the team led by Hannah Monyer at the German Cancer Research Center in Heidelberg. His research focusses on cortical development and the physiology of neurodevelopmental disorders. Manuel Mameli, PhD UMR-S 839 INSERM/UPMC Institut du Fer a Moulin 17 rue du Fer a Moulin – 75005 Paris –France Email : [email protected] Phone : +33 (0)1.45.87.61.17 M. Mameli is a Junior Inserm PI, recipient of the 2010 ENP Chair of excellence and ERC Starting Grant 2013 and affiliated to the Institut du Fer à Moulin since September 2010. He was trained in the laboratories of C.F. Valenzuela (University of New Mexico) and C. Lüscher (University of Geneva). He is an expert of electrophysiology in vitro that he now combines with fluorescent tract-tracing, optogenetics and behavior modeling reward and aversive encoding. His main objective is the understanding and dissection of the synaptic circuits implicated in saliency-related learning. ● Scientific committee Corentin Le Magueresse, PhD Nicolas Gervasi, PhD Manuel Mameli, PhD Jean Antoine Girault, MD Jean-Christophe Poncer, PhD ● Confirmed Speakers The 9 following scientists at the forefront of the field of the neurobiology accepted to be part of the symposium. Keynote lecture (45 minutes): Eve Marder, PhD Volen Center for Complex Systems Brandeis University 415 South Street Waltham, MA 02454 - USA Principal publications : - SnapShot: Neuromodulation. Bucher D, Marder E. Cell. 2013 Oct 10;155(2):482-482.e1. doi: 10.1016/j.cell.2013.09.047. - Multiple mechanisms switch an electrically coupled, synaptically inhibited neuron between competing rhythmic oscillators. Gutierrez GJ, O'Leary T, Marder E. Neuron. 2013 Mar 6;77(5):84558 - Multiple models to capture the variability in biological neurons and networks. Marder E, Taylor AL. Nat Neurosci. 2011 Feb;14(2):133-8 Massimo Scanziani, PhD Center for Neural Circuits and Behavior, La Jolla CA - USA Principal publications : - Tuned thalamic excitation is amplified by visual cortical circuits. Lien AD, Scanziani M. Nat Neurosci. 2013 Sep;16(9):1315-23 - Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons. Pfeffer CK, Xue M, He M, Huang ZJ, Scanziani M. Nat Neurosci. 2013 Aug;16(8):1068-76 - A neural circuit for spatial summation in visual cortex. Adesnik H, Bruns W, Taniguchi H, Huang ZJ, Scanziani M. Nature. 2012 Oct 11;490(7419):226-31. Short lecture (30 minutes): Nelson Spruston, PhD Janelia Farm Research Campus Ashburn, VA 20147 Principal publications : - Hippocampal pyramidal neurons comprise two distinct cell types that are countermodulated by metabotropic receptors. Graves AR, Moore SJ, Bloss EB, Mensh BD, Kath WL, Spruston N. Neuron. 2012 Nov 21;76(4):776-89 - Synapse distribution suggests a two-stage model of dendritic integration in CA1 pyramidal neurons. Katz Y, Menon V, Nicholson DA, Geinisman Y, Kath WL, Spruston N. Neuron. 2009 Jul 30;63(2):171-7. - Plasticity of burst firing induced by synergistic activation of metabotropic glutamate and acetylcholine receptors. Moore SJ, Cooper DC, Spruston N. Neuron. 2009 Jan 29;61(2):287-300. Ryohei Yasuda, PhD Max Planck Florida Insitute for Neuroscience Jupiter, FL 33458 – USA Principal publications : - Long-distance integration of nuclear ERK signaling triggered by activation of a few dendritic spines. Zhai S, Ark ED, Parra-Bueno P, Yasuda R. Science. 2013 Nov 29;342(6162):1107-11. doi: 10.1126/science.1245622. - Centaurin-α1-Ras-Elk-1 signaling at mitochondria mediates β-amyloid-induced synaptic dysfunction. Szatmari EM, Oliveira AF, Sumner EJ, Yasuda R. J Neurosci. 2013 Mar 20;33(12):5367-74 Local, persistent activation of Rho GTPases during plasticity of single dendritic spines. Murakoshi H, Wang H, Yasuda R. Nature. 2011 Apr 7;472(7341):100-4. Graham Ellis-Davies, Professor Mont Sinai hospital, New York – USA Principal publications : - Compartmentalization of GABAergic inhibition by dendritic spines. Chiu CQ, Lur G, Morse TM, Carnevale NT, Ellis-Davies GC, Higley MJ. Science. 2013 May 10;340(6133):759-62. doi: 10.1126/science.1234274. - Two-photon uncaging of gamma-aminobutyric acid in intact brain tissue. Matsuzaki M, Hayama T, Kasai H, Ellis-Davies GC. Nat Chem Biol. 2010 Apr;6(4):255-7. doi: 10.1038/nchembio.321. Epub 2010 Feb 21. - Two-color, two-photon uncaging of glutamate and GABA. Kantevari S, Matsuzaki M, Kanemoto Y, Kasai H, Ellis-Davies GC. Nat Methods. 2010 Feb;7(2):123-5. doi: 10.1038/nmeth.1413. Epub 2009 Dec 27 Thomas Mrsic-Flogel, PhD University College of London 21 University Street, London. Principal publications : - Cortical connectivity and sensory coding. Harris KD, Mrsic-Flogel TD. Nature. 2013 Nov 7;503(7474):51-8. - The emergence of functional microcircuits in visual cortex. Ko H, Cossell L, Baragli C, Antolik J, Clopath C, Hofer SB, Mrsic-Flogel TD. Nature. 2013 Apr 4;496(7443):96-100. - Differential connectivity and response dynamics of excitatory and inhibitory neurons in visual cortex. Hofer SB, Ko H, Pichler B, Vogelstein J, Ros H, Zeng H, Lein E, Lesica NA, Mrsic-Flogel TD. Nat Neurosci. 2011 Jul 17;14(8):1045-52 SongHai Shi, PhD Sloan Kettering Institute 1275 York Ave New York – USA Principal publications : - Lineage-dependent circuit assembly in the neocortex. Gao P, Sultan KT, Zhang XJ, Shi SH. Development. 2013 Jul;140(13):2645-55. - Preferential electrical coupling regulates neocortical lineage-dependent microcircuit assembly. Yu YC, He S, Chen S, Fu Y, Brown KN, Yao XH, Ma J, Gao KP, Sosinsky GE, Huang K, Shi SH. Nature. 2012 May 2;486(7401):113-7. - Clonal production and organization of inhibitory interneurons in the neocortex. Brown KN, Chen S, Han Z, Lu CH, Tan X, Zhang XJ, Ding L, Lopez-Cruz A, Saur D, Anderson SA, Huang K, Shi SH. Science. 2011 Oct 28;334(6055):480-6. Rui Costa, PhD Champalimaud Neuroscience Institute Lisbon – Portugal. Principal publications : - Orbitofrontal and striatal circuits dynamically encode the shift between goal-directed and habitual actions. Gremel CM, Costa RM. Nat Commun. 2013;4:2264. - Concurrent activation of striatal direct and indirect pathways during action initiation. Cui G, Jun SB, Jin X, Pham MD, Vogel SS, Lovinger DM, Costa RM. Nature. 2013 Feb 14;494(7436):23842. - Start/stop signals emerge in nigrostriatal circuits during sequence learning. Jin X, Costa RM. Nature. 2010 Jul 22;466(7305):457-62. Sidney Wiener, PhD Principal publications : - Optic flow stimuli update anterodorsal thalamus head direction neuronal activity in rats. Arleo A, Déjean C, Allegraud P, Khamassi M, Zugaro MB, Wiener SI. J Neurosci.;33(42):16790-5. -Dynamics of decision-related activity in hippocampus. Catanese J, Cerasti E, Zugaro M, Viggiano A, Wiener SI. Hippocampus. 2012;22(9):1901-11. -Coherent theta oscillations and reorganization of spike timing in the hippocampal- prefrontal network upon learning. Benchenane K, Peyrache A, Khamassi M, Tierney PL, Gioanni Y, Battaglia FP, Wiener SI. Neuron. 2010; 66(6):921-36. Nicolas Gervasi, PhD UMR-S 839 INSERM/UPMC Institut du Fer a Moulin 17 rue du Fer a Moulin – 75005 Paris –France Principal publications : - Type 4 phosphodiesterase plays different integrating roles in different cellular domains in pyramidal cortical neurons. Castro LR, Gervasi N, Guiot E, Cavellini L, Nikolaev VO, Paupardin-Tritsch D, Vincent P. J Neurosci. 2010 Apr 28;30(17):6143-51. doi: 10.1523/JNEUROSCI.5851-09.2010. - PKA dynamics in a Drosophila learning center: coincidence detection by rutabaga adenylyl cyclase and spatial regulation by dunce phosphodiesterase. Gervasi N, Tchénio P, Preat T. Neuron. 2010 Feb 25;65(4):516-29. doi: 10.1016/j.neuron.2010.01.014. Principal publications : ● Institutional support and potential audience The 2014 Institut du Fer a Moulin (IFM) colloquium follows a successful yearly series started in 2010. Past editions covered topics spanning from cortical development, synaptic circuits on health and disease, neuropsychiatric disorders, and connectomics. All editions resulted in a large attendance making this an attractive scientific event in the Paris area for french and foreign scientists. The IFM directed by Jean-Antoine Girault is a research center affiliated to INSERM and University Pierre and Marie Curie (UPMC) devoted to the study of the development and plasticity of the nervous system. The IFM is constituted by 10 research group representing around 100 scientists. It gives an opportunity to young investigators to organize scientific events of a great scientific impact in the “Ile de France” region providing dynamism, support and experience necessary to realize such events. Research in basic neuroscience in “Ile de France” spans from channel function, to pathophysiology of neural networks and cellular basis of behavior, in more than a hundred laboratories. In addition many clinical neuroscience groups have complementary interests. Considering that synaptic basis of disease and dissecting neural circuits are two hot-topics in the neuroscience field, our symposium sounds very attractive for basic and clinical neuroscientists coming from Paris regions and other areas. Free open access to the event will be facilitating the participation of students and scientists of all levels. Based on the past events we expect about 150-200 participants. ● A program outline. 8.45 – Introductory remarks – Jean Antoine Girault, Director IFM 9.00 – Keynote Lecture: E Marder: Variability, robustness and modulation of neurons and circuits 10.00 – 10.15 Coffee break 10.15 – Session 1: Integration of transduction of neuronal singals N Spruston: Dendritic Integration, Plasticity, and Diversity in Hippocampal Pyramidal Neurons R Yasuda: To be announced G. Ellis-Davis: Two color uncaging N Gervasi: Imaging and modeling signaling pathway integration in neurons 12.00 – 14.00 Lunch 14.15 – Session 2: From Neural circuits dynamics to behavior S Shi To be announced T Mrsic-Flogel: To be announced R Costa: Generating and shaping novel action repertoires S Wiener: Set-shifting behaviors and hippocampal-prefrontal striatal pathway activity 16.15 – 16.30 – Coffee break 16.30 – Keynote Lecture M Scanziani : Cortical Circuits of Vision 17.30 – 19.00 Session 3: Cocktail ● Tentative budget Expenses Requested Support (Euros) Sponsor DIM Cerveau Pensée (to request) Sub-total - 10,000.00 Ecole de Neuroscience de Paris (To request) 5,000.00 Institut du Fer a Moulin (Confirmed) 3,000.00 Nature Methods 2000 Leica Microsystems 4000 Coherent 1000 Coffee Breaks and Catering Café 2,500.00 2500.00 Auditorium renting Institut du Globe Amphiteater 5,000.00 5,000.00 Accomodation XXXXXX 3,500.00 3,500.00 Speakers Travel Expenses 1 X Train ticket London-Paris-London 1 X Airfare ticket Waltham-Paris-Waltham 1 X Airfare ticket Lisbon-Paris-Lisbon 9,400.00 600.00 1,700.00 600.00 1 X Airfare ticket San Diego-Paris-San Diego 1,400.00 1 X Airfare ticket New York-Paris-New York 1,400.00 1 X Airfare tickets Miami - Paris- Miami 1,700.00 Food 6,800.00 Final banquet 2,000.00 Lunch Friday 2,800.00 Dinner Friday 2,000.00 Total (HT) 27,200.00 - Curriculum Vitae Manuel Mameli Date and place of birth: Citizenship: Marital status: Children: Personal address: Work address: Phone: E-mail address: Languages : French: oral August 3rd, 1978; Cagliari, Italy Italian Married 2 7 rue Parmentier 92130 Issy les Moulineaux (FRA). Institut du Fer à Moulin (INSERM/UPMC) 17 Rue du Fer à Moulin, 75005 Paris (FRA) +33 (0)1.45.87.61.17 [email protected] Italian: mother tongue; English: oral and written; I - Current position: September 2010 - present CR1 Inserm ENP “Chair of Excellence 2010” Junior Group Leader Institution: Institut du Fer a Moulin (INSERM/UPMC), Director: Dr. Jean-Antoine Girault, MD, PhD. II - Education: September 1992 – July 1997 Bachelor training Maturita’ Scientifica (High School, Scientific Area), Liceo Scientifico “Alberti LB” Cagliari, Italy Final Grade: 50/60 October 1997 - July 2002 Undergraduate training Laurea in Biological Sciences (Doctor in Biology), University of Cagliari, Italy Thesis title:“Gamma-Hydroxybutirate (GHB) action on the spontaneous activity of rat hippocampal pyramidal neurons in primary culture”. Advisor: Enrico Sanna, Ph.D. University of Cagliari, Italy. Final Grade: 110/110 summa cum laude January 2006 – February 2009 Graduate training Ph.D. student of the International Lemanic Doctoral School Thesis entitled: Controlling the persistence of cocaine-evoked plasticity in the mesolimbic dopamine system Institution: University of Geneva, Department of Basic Neuroscience, Advisor: Prof. C. Lüscher MD, PhD.. III - Working experience July 2002 – September 2002: Research Fellow, Dept. of Experimental Biology, Division of Neuroscience, Laboratory of Electrophysiology, University of Cagliari, Italy. Advisor: Enrico Sanna, Ph.D.. October 2002 – December 2005: Research Fellow, Dept. of Neurosciences, University of New Mexico, Albuquerque, NM (USA). Advisor: C. Fernando Valenzuela, M.D., Ph.D.. January 2006 – August 2010 Research Fellow University of Geneva, Department of Basic Neuroscience, Advisor: Prof. C. Lüscher MD, PhD.. IV – Selected Publications Maroteaux M., Mameli M.. Cocaine-evokes projection-specific synaptic plasticity in the lateral habenula. JNeurosci. 2012 5;32(36):12641-6. Mameli M., Bellone C., Brown T.C., Lüscher C. Cocaine inverts rules for synaptic plasticity of glutamate transmission in the VTA. Accepted. Nature Neuroscience. Brown T.C., Mameli M., Bellone C., Balland B., Dahan L., Lujan R., Deisseroth K., Lüscher C. Drug-driven AMPA receptor redistribution mimicked by selective dopamine neuron stimulation. PLoSOne 2011. In press. Mameli M., Halbout B., Creton C., Engblom D., Parkitna J. R., Spanagel R., Lüscher C.. Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. Nat Neurosci. 2009 Aug;12(8):1036-41. Epub 2009 Jul 13. Engblom D., Bilbao A., Sanchis-Segura C., Dahan L., Pereau-lenz S., Balland B., Parkitna J.R., Lujan R., Halbout B., Mameli M., Parlato R., Sprengel R., Lüscher C., Schütz G., Spanagel R.. Glutamate receptors on dopamine neurons control the persistence of cocaine-seeking. Neuron 2008 Aug 14; 59(3):497-508. Mameli M., Balland B., Lujan R., Lüscher C.. Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental area. Science. 2007 July; 317(5837):530-3. Mameli M. and Valenzuela C.F.. Alcohol increases efficacy of immature synapses in a neurosteroid- dependent manner. Eur. J. Neurosci. 2006 Feb; 23(3):835-9. Carta M., Mameli M.* and Valenzuela C.F.. Alcohol potently modulates climbing fibers-to-purkinje neuron synapses: role of metabotropic glutamate receptors. J. Neurosci. 2006 Feb 15; 26(7):1906-12. Mameli M., Zamudio P.A., Carta M., Valenzuela C.F.. Developmentally regulated actions of alcohol on hippocampal glutamatergic transmission. J. Neurosci. 2005 Aug 31; 25(35):8027-36. Mameli M., Carta M., Partridge L.D., Valenzuela C.F.. Neurosteroid-induced plasticity of immature synapses via retrograde modulation of presynaptic NMDA receptors. J. Neurosci. 2005, 25 (9), 2285-94. Carta M., Mameli M., Valenzuela C.F.. Alcohol enhances GABAergic transmission to cerebellar granule cells via an increase in golgi cell excitability. J. Neurosci. 2004, 24 (15), 3746-51. *Equally contributed Curriculum Vitae Nicolas Gervasi Date and place of birth: Citizenship: Marital status: Children: Personal address: Work address: Phone: E-mail address: Languages : July 5st, 1979; Maison-Alfort, France French Married 2 120 Avenue Daumesnil 75012 Paris (FRA). Institut du Fer à Moulin (INSERM/UPMC) 17 Rue du Fer à Moulin, 75005 Paris (FRA) +33 (0)1.45.87.61.53 [email protected] French: mother tongue; English: oral and written I - Current position: September 2010 - present Post-doctorant Team Neurotransmission and signaling Institution: Institut du Fer a Moulin (INSERM/UPMC), Director: Dr. Jean-Antoine Girault, MD, PhD. II - Education: September 1994 – July 1997 Bachelor training Baccalauréat Scientifique spécialité Mathématiques. Lycée Edouard Branly, Nogentsur-marne, France. September 2002 Undergraduate training D.E.A. de Neurosciences, Université Pierre et Marie Curie (UMPC), Paris, France. Advisor: Nathalie Leresche, Ph.D. UPMC, Paris, France. Mention : Très Bien. Octobre 2002 – February 2006 Graduate training Ph.D. student of the Cerveau, cognition, comportement doctoral school (ED3C). Thesis entitled: Dynamique spatio-temporelle et régulation de l’activité de la PKA dans des préparations de neurones de souris en tranche et mécanisme cellulaire d’action du GHB dans le thalamus ventrobasal. Institution: UMPC, UMR7102 Neurobiologie des Processus Adaptatifs, Advisor: Dr. P. Vincent PhD.. III - Working experience February 2001 – June 2001: Research Fellow, UMR7102 Neurobiologie des Processus Adaptatifs, Team of Cellular Neurobiology Cellulaire, UPMC, France. Advisor: Nathalie Leresche, Ph.D.. September 2001 – February 2006: Research Fellow, UMR7102 Neurobiologie des Processus Adaptatifs, Team of Neuromodulator and second messengers dynamics, UPMC, France. Advisor: P. Vincent Ph.D.. February 2006 – April 2010 Research Fellow UMR 7637 Neurobiologie Team Genes and dynamics of memory systems. Ecole Supérieure de Physique et Chimie Industrielle (ESPCI), Paris, France. Advisor: T. Préat PhD.. IV - Publications Castro, L.R.V., Gervasi, N. et al. Type 4 phosphodiesterase plays different integrating roles in different cellular domains in pyramidal cortical neurons. J. Neurosci. 30, 6143-6151 (2010). Gervasi, N., Tchénio, P. & Preat, T. PKA dynamics in a Drosophila learning center: coincidence detection by rutabaga adenylyl cyclase and spatial regulation by dunce phosphodiesterase. Neuron. 65, 516-529 (2010). Vincent, P., Gervasi, N. & Zhang, J. Real-time monitoring of cyclic nucleotide signaling in neurons using genetically encoded FRET probes. Brain Cell Biol. 36, 317 (2008). Hepp, R. Tricoire, L., Hu, E., Gervasi, N., Paupardin-Tritsch, D., Lambolez, B., Vincent P. Phosphodiesterase type 2 and the homeostasis of cyclic GMP in living thalamic neurons. J. Neurochem. 102, 1875-1886 (2007). Gervasi, N. et al. Dynamics of protein kinase A signaling at the membrane, in the cytosol, and in the nucleus of neurons in mouse brain slices. J. Neurosci. 27, 27442750 (2007). Gervasi, N. et al. Pathway-specific action of gamma-hydroxybutyric acid in sensory thalamus and its relevance to absence seizures. J. Neurosci. 23, 11469-11478 (2003). Curriculum Vitae Corentin Le Magueresse Date and place of birth: Citizenship: Personal address: Work address: Phone: E-mail address: Languages : September 27th, 1977; Machecoul, France French 3 rue de Sévigné 75004 Paris (FRA). Institut du Fer à Moulin (INSERM/UPMC) 17 Rue du Fer à Moulin, 75005 Paris (FRA) +33 (0)1.45.87.61.49 [email protected] French: mother tongue; English: oral and written I - Current position: February 2013 - present INSERM Investigator (“chargé de recherche”), Team Institution: Institut du Fer a Moulin (INSERM/UPMC), Director: Dr. Jean-Antoine Girault, MD, PhD. II - Education: October 1995 – September 2001: Undergraduate training Diplôme d’ingénieur (MSc) in Chemical Engineering, Ecole Nationale Supérieure de Chimie, Montpellier, France D.E.A. (MPhil) in Neuropharmacology, Université Paris 7 - Diderot, Paris, France. Advisor: Jean-Pierre Changeux, Ph.D. Institut Pasteur, Paris, France. October 2001 – September 2006 Graduate training Ph.D. student of the Cerveau, cognition, comportement doctoral school (ED3C). Thesis entitled: contribution des récepteurs nicotiniques de l'acétylcholine à la modulation de l'activité synaptique et des synchronisations de neurones dans le cortex hippocampique immature Advisors : Jean-Pierre Changeux, Ph.D (Paris). and Enrico Cherubini, Ph.D (Trieste). III - Working experience October 2001 – September 2006: Research Fellow, Récepteurs et Cognition team, Institut Pasteur, France and Department of Neurobiology, International School for Advanced Studies, Italy Advisors : Jean-Pierre Changeux, Ph.D. and Enrico Cherubini, Ph.D. November 2006 – January 2013: Research Fellow, Department of Clinical Neurobiology, German Cancer Research Center, Germany Advisor: H. Monyer, M.D. IV - Publications Le Magueresse C, Monyer H. GABAergic interneurons shape the functional maturation of the cortex. Neuron 77(3):388-405 (2013). Review article. Khodosevich K, Zuccotti A, Kreuzberg MM, Le Magueresse C, Frank M, Willecke K, Monyer H. Connexin45 modulates the proliferation of transit-amplifying precursor cells in the mouse subventricular zone. PNAS 109(49):20107-12 (2012). Caputi A, Fuchs EC, Allen K, Le Magueresse C, Monyer H.Selective reduction of AMPA currents onto hippocampal interneurons impairs network oscillatory activity. PLoS One. 7(6):e37318 (2012) Alfonso J#, Le Magueresse C#, Khodosevich K, Monyer H. Diazepam Binding Inhibitor promotes proliferation of neural progenitors in the SVZ by reducing GABA signaling. Cell Stem Cell, 10(1):76-87 (2012) # equal contribution Le Magueresse C#, Alfonso J#, Bark C, Eliava M, Khrulev S, Monyer H. Subventricular zone-derived neuroblasts use vasculature as a scaffold to migrate radially to the cortex. Cerebral Cortex. 22(10):2285-96 (2012) # equal contribution Le Magueresse C#, Alfonso J#, Khodosevich K, Bark C, Monyer H. “Small axonless neurons”: postnatally generated neocortical interneurons with delayed functional maturation. Journal of Neuroscience. 31(46):16731-47 (2011). # equal contribution Le Magueresse C, Cherubini E. Presynaptic calcium stores contribute to nicotineelicited potentiation of evoked synaptic transmission at CA3-CA1 connections in the neonatal rat hippocampus. Hippocampus 17(4):316-25 (2007) Le Magueresse C, Safiulina V, Changeux JP, Cherubini E. Nicotinic modulation of network and synaptic transmission in the immature hippocampus investigated with genetically modified mice. Journal of Physiology 576(2):533-46 (2006) Maggi L, Sola E, Minneci F, Le Magueresse C, Changeux JP, Cherubini E. Persistent decrease in synaptic efficacy induced by nicotine at Schaffer collateral-CA1 synapses in the immature rat hippocampus. Journal of Physiology 559(3):863-74 (2004) Maggi L, Le Magueresse C, Changeux JP, Cherubini E. Nicotine activates immature "silent" connections in the developing hippocampus. PNAS 100(4):2059-64 (2003)