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IDMIT Symposium 2016 Infectious diseases models for innovative therapies Friday, June 10th, 2016 Institut Pasteur - Auditorium - Centre François Jacob 28 rue du Docteur Roux - 75015 Paris - France PROGRAM Infectious Diseases Models for Innovative Therapies OPENING 9:00-9:15 WELCOME & INTRODUCTION Pr. Christian Bréchot Director of Institut Pasteur, Paris, France. Pr. Jean-François Delfraissy Director of ANRS and Institute of Microbiology and infectious diseases of Aviesan, Paris, France. Pr. Yves Lévy Director of Inserm, Paris France. SESSION 1 9:15-10:35 PRECLINICAL MODELS FOR HIV PREVENTION Chairs: Drs. Jeffrey Lifson and Roger Le Grand 9:15-9:40 Maturation of protective immunity induced by live attenuated SIV Pr. R. Paul Johnson Yerkes National Primate Research Center, Emory University, Atlanta, USA. 9:40-10:05 Superior efficacy of an HIV vaccine combined with ARV prevention in SHIV challenged non-human primates Pr. Robin Shattock Chair in Mucosal Infection and Immunity, Department of Medicine, Imperial College, London, UK. 10:05-10:20 Origin of AIDS virus in semen Dr. Laurent Houzet Inserm U 1085-IRSET, Rennes, France. 10:20-10:35 HIV-1 seminal plasma exposures increase the mucosal immune responses in the female reproductive tract of MVA-HIV vaccinated macaques Dr. Romain Marlin Immunology of viral infections and autoimmune diseases/IDMIT, Fontenay-Aux-Roses, France. COFFEE BREAK 10:35-11:00 SESSION 2 11:00-12:45 NEW STRATEGIES FOR HUMAN VACCINES Chairs: Drs. Cristian Apetrei and Françoise Bachelerie 11:00-11:25 Antiviral Properties of Broadly Neutralizing HIV-1 Antibodies Dr. Hugo Mouquet Laboratory of Humoral Response to Pathogens Department of Immunology, INSERM U1222, Institut Pasteur, Paris, France. 11:25-11:50 Dendritic cells targeting vaccines for infectious diseases Dr. Sylvain Cardinaud Institut Mondor de recherche biomédicale, INSERM U955, Labex VRI, Créteil, France. 11:50-12:15 The baboon model for the study of pertussis vaccines Dr. Camille Locht Institut Pasteur, Lille, France. 12:15-12:30 Single cell analysis of innate and specific adaptive immune responses in vaccinated macaques using mass cytometry Dr. Anne Sophie Beignon Immunology of viral infections and autoimmune diseases/IDMIT, Fontenay-Aux-Roses, France. 12:30-12:45 Modulation of innate immune responses by single stranded oligonucleotides Dr. Anna Lena Spetz Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Sweden. LUNCH AND POSTER SESSION 12:45-14:15 SESSION 3 14:15-15:35 SESSION 4 16:00-17:20 PRECLINICAL MODELS FOR PATHOGENESIS OF HUMAN DISEASES PRECLINICAL MODELS FOR CHALLENGES IN INFECTIOUS DISEASES Chairs: Drs. Guido Silvestri and Michaela Müller-Trutwin Chairs: Drs. Jan Langerman and Rémi Cheynier 14:15-14:40 The predictive value of different animal species to model human diseases caused by high consequence pathogens Dr. Gary Kobinger Département de Microbiologie et Infectiologie, Université Laval, Québec, Canada. 14:40-15:05 Imaging Lymphoid Tissues to Understand Viral Persistence and Impaired Architecture and Function Dr. Jacob D. Estes Frederick National Laboratory for Cancer Research, Frederick, USA. 15:05-15:20 Peculiar NK cell distribution in lymph nodes in response to non-pathogenic SIV infection Dr. Nicolas Huot Unité HIV, Inflammation et Persistance, Département de Virologie, Institut Pasteur, Paris, France. 15:20-15:35 Epigenetic regulation in Plasmodium relapsing species Dr. Gigliola Zanghi Centre d’Immunologie et des Maladies Infectieuses, Paris, France. COFFEE BREAK 15:35-16:00 16:00-16:25 PET/CT Imaging Provides New Insights into Tuberculosis Dr. Charles A. Scanga Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, USA. 16:25-16:50 Preclinical Models for Emerging Infectious Diseases in Humans Pr. Albert Osterhaus Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine, Hannover, Germany. 16:50-17:05 Development of a cynomolgus macaque model of infection with hRSV to evaluate therapeutic approaches Dr. Stéphanie Blanc Cynbiose, Marcy l’Etoile, France. 17:05-17:20 Zika virus infection in pregnant and non-pregnant rhesus macaques Dr. Dawn Dudley Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, USA. Infectious Diseases Models for Innovative Therapies DRF/IMETI/IMVA 18 route du Panorama F92265 Fontenay-aux-Roses Cedex Tel.: +33 (0) 1 46 54 87 57 Mail: [email protected] idmitcenter.fr