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Transcript
Processed Pseudogenes ⢠Processed pseudogenes come from mRNA that has been reverse-transcribed and then randomly inserted into the genome. Processed pseudogenes lack introns because the mRNA was spliced. They also often have poly A tails and they lack promoters and other control regions. â Good example: the ribosomal proteins. There are 79 proteins encoded by 95 functional genes (a few duplications), but also 2090 processed pseudogenes, â Sometimes processed pseudogenes insert into a location that is transcribed. Leads to a new fusion protein or a intronless gene. These are sometimes called retrogenes or âexpressed processed pseudogenesâ. A whole group of them is expressed exclusively in the testes, with introncontaining homologues expressed in other tissues. â RNA genes are especially prone to becoming processed pseudogenes, because they often have internal promoters for pol3. That is, the retrotranscribed sequence contains its own promoter and doesnât need to insert near another promoter. Alu sequences are an example of this: They are modified versions of the signal recognition 7SL RNA .
