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Timeline of Major Discoveries related to Genetics 1840s – Discovery of chromosomes. 1859 – Darwin publishes on the Origin of Species. 1865 – The laws of inheritance by Mendel. 1868 – Friedrich Miescher discovers DNA and RNA. 1905 – Discovery of sex chromosomes. 1927 – Hermann Muller shows that X-rays can induce mutation. 1928 – Discovery of penicillin. 1941 – Discovery that genes make proteins. 1952 – DNA is the genetic material. A biochemist named Erwin Chargaff finds the arrangement of certain nitrogen bases in DNA always occurs in a 1 to 1 ratio which forms base pairs. 1953 – DNA is a double helix. James Watson and Francis Crick discovered the DNA Molecule. 1960 – Jacques Monod proves messenger RNA is the adaptor molecule. 1961 – Discovery of triplet genetic code. 1966 – Full range of 64 triplets identified. 1970 – Hamilton Smith discovers first site – specific restriction enzyme. 1972 – Walter Fiers determines first gene sequence. 1984 – Genetic fingerprinting developed by Alec Jeffreys. 1990s – Discovery of RNA interference. 2001 – First drafts of human genome. 2006 – Discovery of large-scale copy number variation. 2012 – The ENCODE Project